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The map label for this gene is xseA

Identifier: 74317529

GI number: 74317529

Start: 1599187

End: 1600542

Strand: Direct

Name: xseA

Synonym: Tbd_1511

Alternate gene names: 74317529

Gene position: 1599187-1600542 (Clockwise)

Preceding gene: 74317506

Following gene: 74317531

Centisome position: 54.96

GC content: 71.09

Gene sequence:

>1356_bases
ATGGACTGGAGCGAAGACCCTGGGATGCCGCCGCCCGCGCCGCCGGTGCTGAGCGTGAGCGAACTCAACCGCATGGCCCG
GCGCGCGCTTGAAAGCCAACTGCCGCTTTTGTGGGTCGAGGGCGAAGTCTCGAACTTCATGCGTGCGGCGTCGGGTCACT
GGTACTTTTCGCTCAAGGACGCGACCGCGCAGGTGCGCTGCGTCATGTTCCGCGGCCGCAACCAGTTCGCCGAGTTCACG
CCGGCGAATGGCGACCACGTCGAGATCCGCGCGCTCCCCTCGCTCTACGAAGCACGCGGCGAGTTCCAGCTCGGTGCCGA
GTCGATCCGCCGCGCCGGCGCGGGGCGGCTCTACGAAGCCTTTGTCCGGCTCAAAGCCAAGCTCGAAGGCGAAGGCCTGT
TCGACCCGGCGAAAAAGCGTGCGCTTCCGCGTTTCCCGCGCTGTCTCGGCGTCGTCACTTCGCCGCAGGCAGCCGCCTTG
CGTGACGTCCTGACCGCGCTCGGCCGTCGCATGCCGGGCCTACCGGTGATTCTCTACCCCACGCCCGTGCAAGGCAGCGG
CGCAGGCGCCCAGATCGCGGCGGCGATCCGCGCCGCCGGGACACGTGCCGAATGCGACGTACTGTTGGTCTGCCGCGGCG
GCGGCGCGCTCGAAGACCTGTGGGCATTCAACGATGAGGCGGTGGCGCGGGCGATTGCAGCGAGTCCGATACCGGTCGTC
AGCGGCGTCGGCCACGAAACCGATTTCACGCTCGCGGATTTTGCCGCCGATCTGCGGGCGCCGACGCCGACCGCGGCCGC
CGAGCTGGCAAGCCCGGTCGCCGAGGAGATGCTGCGCGCGCTCGAGCGCCACGCCCGCCTGTTGCGTCAGCACCACGCCC
GGCGCCAGCAGGCCGACATGCAGCGGCTCGACTATCTGGCACGGCGCTTGATACATCCTGCCCAACAGCTAAGGCGCCGC
CAGCTCGGCATCGCCCAACTCGCGCAGCGTCTGCACGGCGCCGTGCGGGCGCGCCTGACGCGTGAGCAGCTCCGGATCGC
ACAGCTCGGCGAGCGGCGCACGAGCCCGCGCCACGCGCTCCAGCGCCAGCAGCAGGTCCTCGAATCTCTCGGCGCGCGCG
CGGCGCGTGCGGCCGAGAGCGCGCGCATCGGGCGGGGGCTGACGCTCGCCCGGCTCGCGAGCAGCCTCGCGCACCTGAAC
CCCGACAACGTGCTCGCGCGCGGCTACAGCATCGTCCAGCAGGAAAACGGCGCGGTTGTCCACGACGCCGCGACGCTGCG
CGCCGGTGACGGGCTCGAGATCCGTTTCCATCGCGGCGCGGCGCACGCGCGGGTCGAGTCGGCGCAGCCCGAATAG

Upstream 100 bases:

>100_bases
AAATCAAACTTCCGTCAATAGGGTTATCAGTATTTTTTTATGCCCGCTGTCTCGCCTGTGCATGAAGCGGGCGCCGCCGC
AAGCCTGATATCCTGCGGGC

Downstream 100 bases:

>100_bases
GCGACTCAGGCGCCGAGGTGGGCAGCGACGAGAGCTGCGGCCCGGGACTCGAGGTCGTCCGCCAGGCAGTCGAGCGTCAC
CGCCCCCGGCCATGAACGCA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDWSEDPGMPPPAPPVLSVSELNRMARRALESQLPLLWVEGEVSNFMRAASGHWYFSLKDATAQVRCVMFRGRNQFAEFT
PANGDHVEIRALPSLYEARGEFQLGAESIRRAGAGRLYEAFVRLKAKLEGEGLFDPAKKRALPRFPRCLGVVTSPQAAAL
RDVLTALGRRMPGLPVILYPTPVQGSGAGAQIAAAIRAAGTRAECDVLLVCRGGGALEDLWAFNDEAVARAIAASPIPVV
SGVGHETDFTLADFAADLRAPTPTAAAELASPVAEEMLRALERHARLLRQHHARRQQADMQRLDYLARRLIHPAQQLRRR
QLGIAQLAQRLHGAVRARLTREQLRIAQLGERRTSPRHALQRQQQVLESLGARAARAAESARIGRGLTLARLASSLAHLN
PDNVLARGYSIVQQENGAVVHDAATLRAGDGLEIRFHRGAAHARVESAQPE

Sequences:

>Translated_451_residues
MDWSEDPGMPPPAPPVLSVSELNRMARRALESQLPLLWVEGEVSNFMRAASGHWYFSLKDATAQVRCVMFRGRNQFAEFT
PANGDHVEIRALPSLYEARGEFQLGAESIRRAGAGRLYEAFVRLKAKLEGEGLFDPAKKRALPRFPRCLGVVTSPQAAAL
RDVLTALGRRMPGLPVILYPTPVQGSGAGAQIAAAIRAAGTRAECDVLLVCRGGGALEDLWAFNDEAVARAIAASPIPVV
SGVGHETDFTLADFAADLRAPTPTAAAELASPVAEEMLRALERHARLLRQHHARRQQADMQRLDYLARRLIHPAQQLRRR
QLGIAQLAQRLHGAVRARLTREQLRIAQLGERRTSPRHALQRQQQVLESLGARAARAAESARIGRGLTLARLASSLAHLN
PDNVLARGYSIVQQENGAVVHDAATLRAGDGLEIRFHRGAAHARVESAQPE
>Mature_451_residues
MDWSEDPGMPPPAPPVLSVSELNRMARRALESQLPLLWVEGEVSNFMRAASGHWYFSLKDATAQVRCVMFRGRNQFAEFT
PANGDHVEIRALPSLYEARGEFQLGAESIRRAGAGRLYEAFVRLKAKLEGEGLFDPAKKRALPRFPRCLGVVTSPQAAAL
RDVLTALGRRMPGLPVILYPTPVQGSGAGAQIAAAIRAAGTRAECDVLLVCRGGGALEDLWAFNDEAVARAIAASPIPVV
SGVGHETDFTLADFAADLRAPTPTAAAELASPVAEEMLRALERHARLLRQHHARRQQADMQRLDYLARRLIHPAQQLRRR
QLGIAQLAQRLHGAVRARLTREQLRIAQLGERRTSPRHALQRQQQVLESLGARAARAAESARIGRGLTLARLASSLAHLN
PDNVLARGYSIVQQENGAVVHDAATLRAGDGLEIRFHRGAAHARVESAQPE

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=459, Percent_Identity=43.7908496732026, Blast_Score=355, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_THIDA (Q3SIR1)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315269.1
- STRING:   Q3SIR1
- GeneID:   3672924
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1511
- NMPDR:   fig|292415.3.peg.1511
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   LVWPVKV
- PhylomeDB:   Q3SIR1
- BioCyc:   TDEN292415:TBD_1511-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49205; Mature: 49205

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWSEDPGMPPPAPPVLSVSELNRMARRALESQLPLLWVEGEVSNFMRAASGHWYFSLKD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCEEEEEEC
ATAQVRCVMFRGRNQFAEFTPANGDHVEIRALPSLYEARGEFQLGAESIRRAGAGRLYEA
CCCEEEEEEEECCCCCCCCCCCCCCEEEEEECHHHHHCCCCCCCCHHHHHHCCCHHHHHH
FVRLKAKLEGEGLFDPAKKRALPRFPRCLGVVTSPQAAALRDVLTALGRRMPGLPVILYP
HHHHHHHHCCCCCCCHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
TPVQGSGAGAQIAAAIRAAGTRAECDVLLVCRGGGALEDLWAFNDEAVARAIAASPIPVV
CCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHCCCCCHH
SGVGHETDFTLADFAADLRAPTPTAAAELASPVAEEMLRALERHARLLRQHHARRQQADM
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRLDYLARRLIHPAQQLRRRQLGIAQLAQRLHGAVRARLTREQLRIAQLGERRTSPRHAL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QRQQQVLESLGARAARAAESARIGRGLTLARLASSLAHLNPDNVLARGYSIVQQENGAVV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEE
HDAATLRAGDGLEIRFHRGAAHARVESAQPE
ECCHHEECCCCCEEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MDWSEDPGMPPPAPPVLSVSELNRMARRALESQLPLLWVEGEVSNFMRAASGHWYFSLKD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCEEEEEEC
ATAQVRCVMFRGRNQFAEFTPANGDHVEIRALPSLYEARGEFQLGAESIRRAGAGRLYEA
CCCEEEEEEEECCCCCCCCCCCCCCEEEEEECHHHHHCCCCCCCCHHHHHHCCCHHHHHH
FVRLKAKLEGEGLFDPAKKRALPRFPRCLGVVTSPQAAALRDVLTALGRRMPGLPVILYP
HHHHHHHHCCCCCCCHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
TPVQGSGAGAQIAAAIRAAGTRAECDVLLVCRGGGALEDLWAFNDEAVARAIAASPIPVV
CCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHCCCCCHH
SGVGHETDFTLADFAADLRAPTPTAAAELASPVAEEMLRALERHARLLRQHHARRQQADM
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRLDYLARRLIHPAQQLRRRQLGIAQLAQRLHGAVRARLTREQLRIAQLGERRTSPRHAL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QRQQQVLESLGARAARAAESARIGRGLTLARLASSLAHLNPDNVLARGYSIVQQENGAVV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEE
HDAATLRAGDGLEIRFHRGAAHARVESAQPE
ECCHHEECCCCCEEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA