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The map label for this gene is lpxK

Identifier: 74317526

GI number: 74317526

Start: 1596725

End: 1597714

Strand: Reverse

Name: lpxK

Synonym: Tbd_1508

Alternate gene names: 74317526

Gene position: 1597714-1596725 (Counterclockwise)

Preceding gene: 74317527

Following gene: 74317525

Centisome position: 54.91

GC content: 71.92

Gene sequence:

>990_bases
GTGCTTTCGCTTCCCCGCCTGTGGACGCACACGGGCCCGCTCACCTTATTGCTGCTGCCCGTCGCGTGGTTCTTCGCGAG
CCTCGTCACCGTGCGTCGGCTGGCCTTCCGGCGCGGCTGGCTAACGCGTGTCGACGTCGGGATCCCGGTCATCGTCGTCG
GTAACATCACGGCCGGCGGCAGCGGCAAGACCCCGCTCGTGATCTGGCTGACGAACTGGTTGCGCGAGCAGGGGCACCGC
CCGGGCGTGGTCAGCCGCGGATACGGCGGCAAGGCGCGCCGCTGCGTCGAGCTCGGCGCCGAGAGCACGGCGGCCGAAGT
CGGCGACGAGCCGCTCCTGATCCACCGCAAGACCGGTGCGCCGGTCGTGGTCGGGCGCGATCGTCCGGCCGCGGCCCGGG
TCCTGCGGGCACGCCACCCCGAGGTCGACATCATCGTCTCCGACGATGGCCTGCAGCATTACCGCCTCGGACGCGCCCTG
GAGCTCGCGGTGCTCGACGCTGCGACTGGCTTCGGCAACGGCTGGCCGCTACCGGCCGGGCCCTTGCGCGAGCCGTTCAG
GCGTCTGCACGAGGTCGACGGCGTCGTCCAGGTCGTCCGCGGTGGCGGCGCCTGGCGCACCTATCTCGGCCTCAAGACCT
GGCGCGCCGACTACCGCGCGGGCGACGCCCGGCGCCTGCGCGCTCCGGAGGAAAGAAAGCCGCTGCGTGCGCTGGCGCAG
CGCGAGTGGCTCGCCGCGACCGGAATCGGCCGGCCCGAAGGGTTTTTTGCCATGCTCGAGGCCCACGGCGTGCGGCATCG
GCCTCGCGCCTTCCCCGACCATCACGCGTTTCGCCCCGACGACCTGCCGGCGGGCGGCGCCGTACTGATGACCGAAAAAG
ACGCGGTAAAATGCGCCGACTTCGCCGGCCCGGACTGGTGGGCGGTCGACCTCGAAGTGGTCCCCGAGGCGGGGTTCGTC
GAGTGGTTGCGGACACGGCTCGGATCCTGA

Upstream 100 bases:

>100_bases
GAGGCGCCGGTATCCAGCGTGACGCAGCCGACTTCGTCCGCGCCCGGAAACCGCTGGCCACCGTGTTCGCCCCCCCGTGA
GCGCGGCTAGGGCGTCTCGC

Downstream 100 bases:

>100_bases
AAGAGCCGGAACTGGGCAGGGAGGAGGCAGCATGGCAATGCACCATTCGGACCGGGGCGAACGCGCCTGCCGCCGGAAAA
CCGACGAGGAGGATGGCGCG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MLSLPRLWTHTGPLTLLLLPVAWFFASLVTVRRLAFRRGWLTRVDVGIPVIVVGNITAGGSGKTPLVIWLTNWLREQGHR
PGVVSRGYGGKARRCVELGAESTAAEVGDEPLLIHRKTGAPVVVGRDRPAAARVLRARHPEVDIIVSDDGLQHYRLGRAL
ELAVLDAATGFGNGWPLPAGPLREPFRRLHEVDGVVQVVRGGGAWRTYLGLKTWRADYRAGDARRLRAPEERKPLRALAQ
REWLAATGIGRPEGFFAMLEAHGVRHRPRAFPDHHAFRPDDLPAGGAVLMTEKDAVKCADFAGPDWWAVDLEVVPEAGFV
EWLRTRLGS

Sequences:

>Translated_329_residues
MLSLPRLWTHTGPLTLLLLPVAWFFASLVTVRRLAFRRGWLTRVDVGIPVIVVGNITAGGSGKTPLVIWLTNWLREQGHR
PGVVSRGYGGKARRCVELGAESTAAEVGDEPLLIHRKTGAPVVVGRDRPAAARVLRARHPEVDIIVSDDGLQHYRLGRAL
ELAVLDAATGFGNGWPLPAGPLREPFRRLHEVDGVVQVVRGGGAWRTYLGLKTWRADYRAGDARRLRAPEERKPLRALAQ
REWLAATGIGRPEGFFAMLEAHGVRHRPRAFPDHHAFRPDDLPAGGAVLMTEKDAVKCADFAGPDWWAVDLEVVPEAGFV
EWLRTRLGS
>Mature_329_residues
MLSLPRLWTHTGPLTLLLLPVAWFFASLVTVRRLAFRRGWLTRVDVGIPVIVVGNITAGGSGKTPLVIWLTNWLREQGHR
PGVVSRGYGGKARRCVELGAESTAAEVGDEPLLIHRKTGAPVVVGRDRPAAARVLRARHPEVDIIVSDDGLQHYRLGRAL
ELAVLDAATGFGNGWPLPAGPLREPFRRLHEVDGVVQVVRGGGAWRTYLGLKTWRADYRAGDARRLRAPEERKPLRALAQ
REWLAATGIGRPEGFFAMLEAHGVRHRPRAFPDHHAFRPDDLPAGGAVLMTEKDAVKCADFAGPDWWAVDLEVVPEAGFV
EWLRTRLGS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=42.4615384615385, Blast_Score=221, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_THIDA (Q3SIR4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315266.1
- STRING:   Q3SIR4
- GeneID:   3672921
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1508
- NMPDR:   fig|292415.3.peg.1508
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- PhylomeDB:   Q3SIR4
- BioCyc:   TDEN292415:TBD_1508-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36270; Mature: 36270

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLPRLWTHTGPLTLLLLPVAWFFASLVTVRRLAFRRGWLTRVDVGIPVIVVGNITAGG
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECEECCC
SGKTPLVIWLTNWLREQGHRPGVVSRGYGGKARRCVELGAESTAAEVGDEPLLIHRKTGA
CCCCCEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCEEEEECCCC
PVVVGRDRPAAARVLRARHPEVDIIVSDDGLQHYRLGRALELAVLDAATGFGNGWPLPAG
CEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHCCEEEEEEEECCCCCCCCCCCCCC
PLREPFRRLHEVDGVVQVVRGGGAWRTYLGLKTWRADYRAGDARRLRAPEERKPLRALAQ
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHH
REWLAATGIGRPEGFFAMLEAHGVRHRPRAFPDHHAFRPDDLPAGGAVLMTEKDAVKCAD
HHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHH
FAGPDWWAVDLEVVPEAGFVEWLRTRLGS
CCCCCEEEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLSLPRLWTHTGPLTLLLLPVAWFFASLVTVRRLAFRRGWLTRVDVGIPVIVVGNITAGG
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECEECCC
SGKTPLVIWLTNWLREQGHRPGVVSRGYGGKARRCVELGAESTAAEVGDEPLLIHRKTGA
CCCCCEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCEEEEECCCC
PVVVGRDRPAAARVLRARHPEVDIIVSDDGLQHYRLGRALELAVLDAATGFGNGWPLPAG
CEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHCCEEEEEEEECCCCCCCCCCCCCC
PLREPFRRLHEVDGVVQVVRGGGAWRTYLGLKTWRADYRAGDARRLRAPEERKPLRALAQ
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHH
REWLAATGIGRPEGFFAMLEAHGVRHRPRAFPDHHAFRPDDLPAGGAVLMTEKDAVKCAD
HHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHH
FAGPDWWAVDLEVVPEAGFVEWLRTRLGS
CCCCCEEEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA