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The map label for this gene is ykgC [H]

Identifier: 74317490

GI number: 74317490

Start: 1557582

End: 1559003

Strand: Direct

Name: ykgC [H]

Synonym: Tbd_1472

Alternate gene names: 74317490

Gene position: 1557582-1559003 (Clockwise)

Preceding gene: 74317489

Following gene: 74317497

Centisome position: 53.53

GC content: 70.18

Gene sequence:

>1422_bases
ATGGGTTCCGAGACCGACCACGACAACTTCGACGCGGTGATCGTCGGCGCCGGACAAGCCGCGGCGCCGCTCGCCGTCGC
GCTCGGCGCCGCCGGCTGGAGGACCGCCGTCGTCGAGCGCCGGCACGTCGGCGGCTCGTGCATCAACTTCGGCTGCACGC
CGACCAAAGCGATGGCTGCAAGCGCACGCGTCGCCGCCCTCGCGCGCCGGGCGGCCGAATTCGGCCTGCGGGCTGGCACG
GTCGAGGTCGATTTTCCGGCCGTAATGCAACGCGCGCGTGCGATCGTCGCGCGTTTCCGTCGTCGCCTCGAGGCCTCGCT
CGCAGGCGCCGACAATGTCGAACTGATCTTCGGTGACGCCATCTTCCAGGACGCCCGCACGCTCATCGTGCGGCGCCCGG
ACGGCGAATCGCGCACGCTCGCGGCAGCGCACGTCTTCATCAACACCGGCACCCGCGCGGCGCTGCCGCCGATACCCGGC
CTCGAGCGGCTGCCGCTGCTGCACGACGACGCGCTGCTCGCGCTCGAGACGCTGCCGCCGCATCTGCTCGTCATCGGCGG
CGGTTACGTCGGGCTCGAATTCGCGCAGATGTTCCGCCGCTTCGGCAGCGAGGTCAGCCTCATCCAGCGCGACGAACAAC
TCGCGCCACGTGAAGACCCCGACGTCGCCGAGGCGCTGCGCGAAATGCTCGTGGAAGACGGCGTCAAGGTGTACCTCGAG
GCGAAAATCCTCGACGCCGACCGGGGGCGCAGCAGCGACGGCGACAGCATCGCGCTCAACCTCAAGACGCCTACCGGCCC
GTTGCGCCTGCTCGGCTCGCACCTTCTCGTCGCCACCGGCCGCAGGCCCAATAGCGACGACCTCGATCTCGCCGCCGCCG
GCGTGGAGACCGGTGCCGACGGCTACATCCGCGTGAACGATCGGCTTGAAACCAGTGCCGCCGGCATCTATGCGCTGGGC
GACGTCAAGGGCGGACCCGCTTTTACCCACATCGCCTACGACGACGCGCGCGTGCTGAAGACCAATCTGCTCGGCGACGG
CGGCGCGAGCGTCGCGGACCGGCCCGTTCCCTACACGGTATTCACCGATCCGCAACTCGGACGCATCGGTCTTAGCGAGC
GTGAGGCCCGGCAGAGCGGGCGCCGCGTATTGCGCGCGCACCTGCAGATGGCCCAGGTCGCGCGCGCGATCGAGACGGGC
GAGGCCCGCGGCTTCGTCAAGGCGCTCATCGATGCCGACAGCGGAGAGATCCTGGGGGCGGCCGCGCTCGGGGCCGACGG
CGGCGAACTGATGGCGATGCTGCAACTCGCGATGATGGGCCGCATTCCCTACTCCCGCCTGCACGACGCGGTGTTCGCCC
ACCCGACGCTCGCCGAATCGCTCAACGCCCTCTTCGCCGCACCGCAGCCGCTACCGCGTTAG

Upstream 100 bases:

>100_bases
CGCGGTCGTATCGACAACCACTACGGGGCGTGGAGCCGCTATCTGCTCTGAGCGGCCACGGCCATCACGGGTAAAGCGGC
GCGCAGTGACAGGAGGTGCG

Downstream 100 bases:

>100_bases
GTTTCACGCTGTGTTTCGCGCACGACCGGTTCGCTCGCGCACCGTTCCGCCTCGCCCCCGCCATCCCCTCTCGCCTGCGC
ACTCGGGCGGTCGAATGGCT

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MGSETDHDNFDAVIVGAGQAAAPLAVALGAAGWRTAVVERRHVGGSCINFGCTPTKAMAASARVAALARRAAEFGLRAGT
VEVDFPAVMQRARAIVARFRRRLEASLAGADNVELIFGDAIFQDARTLIVRRPDGESRTLAAAHVFINTGTRAALPPIPG
LERLPLLHDDALLALETLPPHLLVIGGGYVGLEFAQMFRRFGSEVSLIQRDEQLAPREDPDVAEALREMLVEDGVKVYLE
AKILDADRGRSSDGDSIALNLKTPTGPLRLLGSHLLVATGRRPNSDDLDLAAAGVETGADGYIRVNDRLETSAAGIYALG
DVKGGPAFTHIAYDDARVLKTNLLGDGGASVADRPVPYTVFTDPQLGRIGLSEREARQSGRRVLRAHLQMAQVARAIETG
EARGFVKALIDADSGEILGAAALGADGGELMAMLQLAMMGRIPYSRLHDAVFAHPTLAESLNALFAAPQPLPR

Sequences:

>Translated_473_residues
MGSETDHDNFDAVIVGAGQAAAPLAVALGAAGWRTAVVERRHVGGSCINFGCTPTKAMAASARVAALARRAAEFGLRAGT
VEVDFPAVMQRARAIVARFRRRLEASLAGADNVELIFGDAIFQDARTLIVRRPDGESRTLAAAHVFINTGTRAALPPIPG
LERLPLLHDDALLALETLPPHLLVIGGGYVGLEFAQMFRRFGSEVSLIQRDEQLAPREDPDVAEALREMLVEDGVKVYLE
AKILDADRGRSSDGDSIALNLKTPTGPLRLLGSHLLVATGRRPNSDDLDLAAAGVETGADGYIRVNDRLETSAAGIYALG
DVKGGPAFTHIAYDDARVLKTNLLGDGGASVADRPVPYTVFTDPQLGRIGLSEREARQSGRRVLRAHLQMAQVARAIETG
EARGFVKALIDADSGEILGAAALGADGGELMAMLQLAMMGRIPYSRLHDAVFAHPTLAESLNALFAAPQPLPR
>Mature_472_residues
GSETDHDNFDAVIVGAGQAAAPLAVALGAAGWRTAVVERRHVGGSCINFGCTPTKAMAASARVAALARRAAEFGLRAGTV
EVDFPAVMQRARAIVARFRRRLEASLAGADNVELIFGDAIFQDARTLIVRRPDGESRTLAAAHVFINTGTRAALPPIPGL
ERLPLLHDDALLALETLPPHLLVIGGGYVGLEFAQMFRRFGSEVSLIQRDEQLAPREDPDVAEALREMLVEDGVKVYLEA
KILDADRGRSSDGDSIALNLKTPTGPLRLLGSHLLVATGRRPNSDDLDLAAAGVETGADGYIRVNDRLETSAAGIYALGD
VKGGPAFTHIAYDDARVLKTNLLGDGGASVADRPVPYTVFTDPQLGRIGLSEREARQSGRRVLRAHLQMAQVARAIETGE
ARGFVKALIDADSGEILGAAALGADGGELMAMLQLAMMGRIPYSRLHDAVFAHPTLAESLNALFAAPQPLPR

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=25.7080610021786, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=26.8558951965066, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI22035672, Length=440, Percent_Identity=29.0909090909091, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI291045266, Length=442, Percent_Identity=25.5656108597285, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI33519430, Length=435, Percent_Identity=23.6781609195402, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI33519428, Length=435, Percent_Identity=23.6781609195402, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI33519426, Length=435, Percent_Identity=23.6781609195402, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI148277065, Length=435, Percent_Identity=23.6781609195402, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=23.6781609195402, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI291045268, Length=435, Percent_Identity=23.9080459770115, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI87081717, Length=463, Percent_Identity=37.3650107991361, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=30.4635761589404, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87082354, Length=474, Percent_Identity=27.6371308016878, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=29.2626728110599, Blast_Score=168, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=27.0152505446623, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71983429, Length=442, Percent_Identity=25.3393665158371, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=346, Percent_Identity=27.7456647398844, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=27.027027027027, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=441, Percent_Identity=24.9433106575964, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=27.2532188841202, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=25.5274261603376, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=23.8900634249471, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=28.4796573875803, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=27.4428274428274, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=27.6955602536998, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=27.6955602536998, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=27.6729559748428, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 50144; Mature: 50013

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSETDHDNFDAVIVGAGQAAAPLAVALGAAGWRTAVVERRHVGGSCINFGCTPTKAMAA
CCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHH
SARVAALARRAAEFGLRAGTVEVDFPAVMQRARAIVARFRRRLEASLAGADNVELIFGDA
HHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHH
IFQDARTLIVRRPDGESRTLAAAHVFINTGTRAALPPIPGLERLPLLHDDALLALETLPP
HHHCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEEECCCC
HLLVIGGGYVGLEFAQMFRRFGSEVSLIQRDEQLAPREDPDVAEALREMLVEDGVKVYLE
EEEEECCCHHHHHHHHHHHHHCCCEEEHHCCHHCCCCCCCHHHHHHHHHHHHCCCEEEEE
AKILDADRGRSSDGDSIALNLKTPTGPLRLLGSHLLVATGRRPNSDDLDLAAAGVETGAD
EEEEECCCCCCCCCCEEEEEEECCCCHHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCC
GYIRVNDRLETSAAGIYALGDVKGGPAFTHIAYDDARVLKTNLLGDGGASVADRPVPYTV
CEEEECCCCCCCCCCEEEEECCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCCCCCEEE
FTDPQLGRIGLSEREARQSGRRVLRAHLQMAQVARAIETGEARGFVKALIDADSGEILGA
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCEEEE
AALGADGGELMAMLQLAMMGRIPYSRLHDAVFAHPTLAESLNALFAAPQPLPR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GSETDHDNFDAVIVGAGQAAAPLAVALGAAGWRTAVVERRHVGGSCINFGCTPTKAMAA
CCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHH
SARVAALARRAAEFGLRAGTVEVDFPAVMQRARAIVARFRRRLEASLAGADNVELIFGDA
HHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHH
IFQDARTLIVRRPDGESRTLAAAHVFINTGTRAALPPIPGLERLPLLHDDALLALETLPP
HHHCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEEECCCC
HLLVIGGGYVGLEFAQMFRRFGSEVSLIQRDEQLAPREDPDVAEALREMLVEDGVKVYLE
EEEEECCCHHHHHHHHHHHHHCCCEEEHHCCHHCCCCCCCHHHHHHHHHHHHCCCEEEEE
AKILDADRGRSSDGDSIALNLKTPTGPLRLLGSHLLVATGRRPNSDDLDLAAAGVETGAD
EEEEECCCCCCCCCCEEEEEEECCCCHHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCC
GYIRVNDRLETSAAGIYALGDVKGGPAFTHIAYDDARVLKTNLLGDGGASVADRPVPYTV
CEEEECCCCCCCCCCEEEEECCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCCCCCEEE
FTDPQLGRIGLSEREARQSGRRVLRAHLQMAQVARAIETGEARGFVKALIDADSGEILGA
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCEEEE
AALGADGGELMAMLQLAMMGRIPYSRLHDAVFAHPTLAESLNALFAAPQPLPR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]