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The map label for this gene is pkn1 [H]

Identifier: 74317296

GI number: 74317296

Start: 1344181

End: 1345056

Strand: Reverse

Name: pkn1 [H]

Synonym: Tbd_1278

Alternate gene names: 74317296

Gene position: 1345056-1344181 (Counterclockwise)

Preceding gene: 74317297

Following gene: 74317295

Centisome position: 46.22

GC content: 70.55

Gene sequence:

>876_bases
ATGAACCTCGATTCCGTCGCCGAGCCGCTTCCCAACACCTTCGCCCTGCACGAAGGCGAGTTGATCGCGCTGCAGGTGCG
CGCCGCCCAGGCCTTCTCGCTGCCCGACGTCGTCTTCAGCGATGCGCTGCGCGCCGGCGGCAGCGGCCCGCTGCTCGCGA
CGATTCCGGCGGGCGCCTTCGAATACGGCGCCGCGACCGACGAGGCCGCGCCCGCCCACGAGCGGCCGCGTCGCGCGGCC
TTGATCGAGCGCAGTTTTGCCCTGGGCGTCTGCCCCGTCACCACCGAGGAATTCGAAGCCTTCGCGCACGCGACCGGGTG
GCGGCCGCGCGCCGAGCTGGTCTGGCTTTCCGGTCGCAAGCCCGCGATCAACGTACGTCAGACCGATGCACGCGACTACT
GCGCATGGCTGTCCGAGCAGTCGGGACAGCGCTATCGCCTGCCCACCGAGCAGGAGTGGGAGTACGCCTGCCGCGCCGGC
GCCGCGAGCGCCTACCCCTGCGGCAACTGCATCACCGCTTCGCAGGCGCGCTACAACACGCGTGGCGGCTTCGACGCCAT
TCACCCGCGGCGCCCCTATCTGCTGGCGCGCCGTTTCATCGGCCGCGGTGCGACCGAGGTCGGCCGGAACGCGCCCAATC
GCTGGGGTCTGCACGACATGCCCGGCAACGTCTGGGAGTTCACGGCGAGCCCCTGGACCGAGAGCCATAGCCGTCTGCCC
GAGCGGCCGGCGCAGGGCAAACCGCAGGCCATCGTCACCAAGGGCGGCTCCTGGTTCGACGGCCCCGAGGATTGCCGTGC
CGCCGCACGCAGGCGGCGCCTCGAAGACGAACTCGACATCAATCTCGGCTTTCGTGTCCTGCGCGAACTCGCGTAA

Upstream 100 bases:

>100_bases
AGCGTGTCGCTCAAGTTCTAGCGGCAGACGCGCCGGCCGCCCCTGCCCGCGGGGCTCGCCGAAACTGGCATAATCGGATC
TGTCTGCCCGCCGCCTGCCC

Downstream 100 bases:

>100_bases
GTCCAACCCGCCCGTGGGCGACCCGTCGCGCCGCTTTGCTGCGCAACCGGTCGCGCACCGATAGCCGAGGAAACGCCCCT
GCTCCCAGAAACCGAACATC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNLDSVAEPLPNTFALHEGELIALQVRAAQAFSLPDVVFSDALRAGGSGPLLATIPAGAFEYGAATDEAAPAHERPRRAA
LIERSFALGVCPVTTEEFEAFAHATGWRPRAELVWLSGRKPAINVRQTDARDYCAWLSEQSGQRYRLPTEQEWEYACRAG
AASAYPCGNCITASQARYNTRGGFDAIHPRRPYLLARRFIGRGATEVGRNAPNRWGLHDMPGNVWEFTASPWTESHSRLP
ERPAQGKPQAIVTKGGSWFDGPEDCRAAARRRRLEDELDINLGFRVLRELA

Sequences:

>Translated_291_residues
MNLDSVAEPLPNTFALHEGELIALQVRAAQAFSLPDVVFSDALRAGGSGPLLATIPAGAFEYGAATDEAAPAHERPRRAA
LIERSFALGVCPVTTEEFEAFAHATGWRPRAELVWLSGRKPAINVRQTDARDYCAWLSEQSGQRYRLPTEQEWEYACRAG
AASAYPCGNCITASQARYNTRGGFDAIHPRRPYLLARRFIGRGATEVGRNAPNRWGLHDMPGNVWEFTASPWTESHSRLP
ERPAQGKPQAIVTKGGSWFDGPEDCRAAARRRRLEDELDINLGFRVLRELA
>Mature_291_residues
MNLDSVAEPLPNTFALHEGELIALQVRAAQAFSLPDVVFSDALRAGGSGPLLATIPAGAFEYGAATDEAAPAHERPRRAA
LIERSFALGVCPVTTEEFEAFAHATGWRPRAELVWLSGRKPAINVRQTDARDYCAWLSEQSGQRYRLPTEQEWEYACRAG
AASAYPCGNCITASQARYNTRGGFDAIHPRRPYLLARRFIGRGATEVGRNAPNRWGLHDMPGNVWEFTASPWTESHSRLP
ERPAQGKPQAIVTKGGSWFDGPEDCRAAARRRRLEDELDINLGFRVLRELA

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=266, Percent_Identity=30.8270676691729, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI38202250, Length=291, Percent_Identity=28.1786941580756, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI194248087, Length=285, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI194248088, Length=300, Percent_Identity=26, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI226437577, Length=180, Percent_Identity=31.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI257470977, Length=287, Percent_Identity=25.7839721254355, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32128; Mature: 32128

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDSVAEPLPNTFALHEGELIALQVRAAQAFSLPDVVFSDALRAGGSGPLLATIPAGAF
CCHHHHHHCCCCCEEECCCCEEEEEEECHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCH
EYGAATDEAAPAHERPRRAALIERSFALGVCPVTTEEFEAFAHATGWRPRAELVWLSGRK
HCCCCCCCCCCCHHCCHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
PAINVRQTDARDYCAWLSEQSGQRYRLPTEQEWEYACRAGAASAYPCGNCITASQARYNT
CEEEEECCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCC
RGGFDAIHPRRPYLLARRFIGRGATEVGRNAPNRWGLHDMPGNVWEFTASPWTESHSRLP
CCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHCCC
ERPAQGKPQAIVTKGGSWFDGPEDCRAAARRRRLEDELDINLGFRVLRELA
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHC
>Mature Secondary Structure
MNLDSVAEPLPNTFALHEGELIALQVRAAQAFSLPDVVFSDALRAGGSGPLLATIPAGAF
CCHHHHHHCCCCCEEECCCCEEEEEEECHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCH
EYGAATDEAAPAHERPRRAALIERSFALGVCPVTTEEFEAFAHATGWRPRAELVWLSGRK
HCCCCCCCCCCCHHCCHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
PAINVRQTDARDYCAWLSEQSGQRYRLPTEQEWEYACRAGAASAYPCGNCITASQARYNT
CEEEEECCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCC
RGGFDAIHPRRPYLLARRFIGRGATEVGRNAPNRWGLHDMPGNVWEFTASPWTESHSRLP
CCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHCCC
ERPAQGKPQAIVTKGGSWFDGPEDCRAAARRRRLEDELDINLGFRVLRELA
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]