Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 74317286

GI number: 74317286

Start: 1331609

End: 1333954

Strand: Direct

Name: luxQ [H]

Synonym: Tbd_1268

Alternate gene names: 74317286

Gene position: 1331609-1333954 (Clockwise)

Preceding gene: 74317285

Following gene: 74317287

Centisome position: 45.76

GC content: 67.65

Gene sequence:

>2346_bases
ATGAGCCCCGAGGGAACGTCGACGACGCTGCGGGCGCGGCTGCGGCGCACGAGCCTGATCACGCTCGCGGTCGCCCTCGG
CATCGTCGCCGTGATCATCATGGCGAGCAGTTTCGCGGCCGGCCTCATCTCGCTCGCCAGCACCAATCGCGTCGAGGCCA
GGGTACTCGCGGAAAACGTCAGCGCGAGCCTGTTGTTCGAAGACCGCACTTCGGCGGAGGAACTGCTGCATTCACTTCGT
CATTCGCGCGTGGTTCACGGCGCCGCGGTCTACGACAACGCCCGGCGTGTATTCGCGCGCTACGAGCATGGCAGCGACCG
CGTGCCCGCCATACTCGGGCCGCTGAGCGAAGGCGTTGATTACGGACTGCGCAGGGTCACGGTCGTGCAGCCCGTCATGC
TCGACGGCAGGCAGGTCGGCAGCGTTCTGCTCTCGGTCGGCCTCGAATCCCTCTATGCGCAGATCGGCTGGCAGGCGCTG
GTCACGCTGCTCGCCGCGGCGCTGGCCATGCTCGTGGCGAATCGGCTGCTCGGCCGTCTGAACGAATCGGTCGTGGTTCC
ACTCGCTCGCCTGTCCGCACTGATGCTGAGAATTTCGAGCCGCAACGACTATACCGTGCGGGCCGCCGGAAGCGAGATCG
CCGAAATGAATACGCTGGCTCGCGGCTTCAACGACATGCTCGGGCAGATCCAGCAGCGCGACCAGGAGCTTGCCGAGCAT
CGCGCCCGGCTCGAGGACCAGGTCGCGCATCGCACCGTCGCGCTGAAGGCTGCGGAGGCGGCGAGTCAAGCGAAGAGCGA
TTTCCTCGCGACCATGAGTCACGAGATCCGCACGCCGATGAATGGCGTCCTCGGCATGAACGAGCTGCTGCTCGGAAGCA
GCCTCGACCCGCAGCAGCGCATGTGGGCCGAGTCCGTCCAGCATTCGGGCCAGCATCTGCTCGGTGTCATCAACGACATC
CTGGATTTCTCGAAAATCGAGTCGGGCCATCTGTCGCTCGAAACCGTCGACTTCGACCTCGTCGAACTGATCGACGACAC
GATGAGGATGTTCGCGCATCAGGCCGAGCACAAGGGCCTCGAACTCGCCTGCCGAATCACCCCGTCGCAGCGCACCATCG
GCCTGCGCGGCGATCCGTTCCGCCTGCGCCAGATCGTCGCCAACCTCGTCGGCAACGCGATCAAGTTCACCGAGCACGGC
GCGGTCGTCGTCCACGCCACCGTGAATGACAACGGCGACGCCGCCGCTGTCGGCCTGTGCGTGGAGGACACCGGGATCGG
CATCGCACCCGAGGCGCAGGCGCGGATATTCGAGCATTTTTCCCAGGCCGACGGCTCGACGACGCGCCGCTTCGGCGGCA
CCGGACTCGGCCTTGCGATCTGCAGGCGCCTCGCCAACCTCATGGGGAGCGACATCACGGTCGCGAGCGCCCCGGGGCAA
GGCGCGCGTTTCTGCCTCGATCTTCGCCTTGCGCGCGCGAGCGCCGACTTCGAGCGCCCCGATCCTGCGGGCGAGGCGAG
CGGCGCGGGGACGTCGGCCCCGGCGTTCCAGGGACGGGGCGAACGCGTCTTGCTGGTCGAGGACAATCCGGTCAACCAGC
AGGTCGCGCAAGCGATGCTGGCGAAGCTGGGACTGGCGACGACGGTCGCGAGCGACGGGCGCGAAGCGGTCGACCTCGTC
GCATCCCGCGCATTCGACGCCGTGCTGATGGATTGCCAGATGCCGGTCATGGACGGCTACGAGGCGACGCGGGCGATCCG
GCGCCTGCCGGGCGCGCGCTTGCCGGTGATCGCGCTGACGGCCAACGCGTTGCACGGAGACCGGCAGAAATGCCTCGATT
CCGGCATGGACGACTTCCTGCCCAAACCCTACTCGCTGGCACAATTGCAGGCGACGCTGGCGCGCTGGCTGCGGCCGACG
AACCCGACCCCGGAAGCACAGGCGGCGGCACCGCAGCACGGCCCCGATGGGGAGATCGCGTCACCGCAGGCGCCGGCCAT
CAACATGAAGACACTGAACGCCTTGCGCGAACTCGACCCCGAAGGCGGCATGGGCCTCGCGCACCAGATCGTGCGAACCT
TCCTCGAGTCGGCGCAGACGTGGGTCGACCGCGTCGAGCAGGCGGTGGCAGGCGGCGACGGCGACGCGCTGCGGCAGTCC
GCCCATGCGCTCAAGTCGAGCTCGGCCAATGTCGGCGCCGAACGTCTATCGGGTCTGTACCGGCAGATGGAAAAGCTCGG
GCGCGAGCGGCGGCTCGACGAGGCGCGCGAAGCGCTCGGCGAAGTACGGGGCGAATACGCTCGCGCGGTATCCGAAATGC
ACGCGATCCTGACGGGAGGACGTTGA

Upstream 100 bases:

>100_bases
GGCAGGACCGCGTCGCGTTCGAGGTGAATCTGGGCGCGACGCGCGCTGCGCGGCTCGGCCTGAGTTCGAAGCTGCTGCGG
CTCGCGAGCGAGGTGCGGCG

Downstream 100 bases:

>100_bases
TGGCCGCTGCGACGCGTATCCTCGTCGCCGACGACGAGCCGACGGCCCGCCTGCTCATGGCGGCCGCCCTCGAGAAGGCC
GGCTTCGAGGTCGCCGTGGC

Product: Hpt sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MSPEGTSTTLRARLRRTSLITLAVALGIVAVIIMASSFAAGLISLASTNRVEARVLAENVSASLLFEDRTSAEELLHSLR
HSRVVHGAAVYDNARRVFARYEHGSDRVPAILGPLSEGVDYGLRRVTVVQPVMLDGRQVGSVLLSVGLESLYAQIGWQAL
VTLLAAALAMLVANRLLGRLNESVVVPLARLSALMLRISSRNDYTVRAAGSEIAEMNTLARGFNDMLGQIQQRDQELAEH
RARLEDQVAHRTVALKAAEAASQAKSDFLATMSHEIRTPMNGVLGMNELLLGSSLDPQQRMWAESVQHSGQHLLGVINDI
LDFSKIESGHLSLETVDFDLVELIDDTMRMFAHQAEHKGLELACRITPSQRTIGLRGDPFRLRQIVANLVGNAIKFTEHG
AVVVHATVNDNGDAAAVGLCVEDTGIGIAPEAQARIFEHFSQADGSTTRRFGGTGLGLAICRRLANLMGSDITVASAPGQ
GARFCLDLRLARASADFERPDPAGEASGAGTSAPAFQGRGERVLLVEDNPVNQQVAQAMLAKLGLATTVASDGREAVDLV
ASRAFDAVLMDCQMPVMDGYEATRAIRRLPGARLPVIALTANALHGDRQKCLDSGMDDFLPKPYSLAQLQATLARWLRPT
NPTPEAQAAAPQHGPDGEIASPQAPAINMKTLNALRELDPEGGMGLAHQIVRTFLESAQTWVDRVEQAVAGGDGDALRQS
AHALKSSSANVGAERLSGLYRQMEKLGRERRLDEAREALGEVRGEYARAVSEMHAILTGGR

Sequences:

>Translated_781_residues
MSPEGTSTTLRARLRRTSLITLAVALGIVAVIIMASSFAAGLISLASTNRVEARVLAENVSASLLFEDRTSAEELLHSLR
HSRVVHGAAVYDNARRVFARYEHGSDRVPAILGPLSEGVDYGLRRVTVVQPVMLDGRQVGSVLLSVGLESLYAQIGWQAL
VTLLAAALAMLVANRLLGRLNESVVVPLARLSALMLRISSRNDYTVRAAGSEIAEMNTLARGFNDMLGQIQQRDQELAEH
RARLEDQVAHRTVALKAAEAASQAKSDFLATMSHEIRTPMNGVLGMNELLLGSSLDPQQRMWAESVQHSGQHLLGVINDI
LDFSKIESGHLSLETVDFDLVELIDDTMRMFAHQAEHKGLELACRITPSQRTIGLRGDPFRLRQIVANLVGNAIKFTEHG
AVVVHATVNDNGDAAAVGLCVEDTGIGIAPEAQARIFEHFSQADGSTTRRFGGTGLGLAICRRLANLMGSDITVASAPGQ
GARFCLDLRLARASADFERPDPAGEASGAGTSAPAFQGRGERVLLVEDNPVNQQVAQAMLAKLGLATTVASDGREAVDLV
ASRAFDAVLMDCQMPVMDGYEATRAIRRLPGARLPVIALTANALHGDRQKCLDSGMDDFLPKPYSLAQLQATLARWLRPT
NPTPEAQAAAPQHGPDGEIASPQAPAINMKTLNALRELDPEGGMGLAHQIVRTFLESAQTWVDRVEQAVAGGDGDALRQS
AHALKSSSANVGAERLSGLYRQMEKLGRERRLDEAREALGEVRGEYARAVSEMHAILTGGR
>Mature_780_residues
SPEGTSTTLRARLRRTSLITLAVALGIVAVIIMASSFAAGLISLASTNRVEARVLAENVSASLLFEDRTSAEELLHSLRH
SRVVHGAAVYDNARRVFARYEHGSDRVPAILGPLSEGVDYGLRRVTVVQPVMLDGRQVGSVLLSVGLESLYAQIGWQALV
TLLAAALAMLVANRLLGRLNESVVVPLARLSALMLRISSRNDYTVRAAGSEIAEMNTLARGFNDMLGQIQQRDQELAEHR
ARLEDQVAHRTVALKAAEAASQAKSDFLATMSHEIRTPMNGVLGMNELLLGSSLDPQQRMWAESVQHSGQHLLGVINDIL
DFSKIESGHLSLETVDFDLVELIDDTMRMFAHQAEHKGLELACRITPSQRTIGLRGDPFRLRQIVANLVGNAIKFTEHGA
VVVHATVNDNGDAAAVGLCVEDTGIGIAPEAQARIFEHFSQADGSTTRRFGGTGLGLAICRRLANLMGSDITVASAPGQG
ARFCLDLRLARASADFERPDPAGEASGAGTSAPAFQGRGERVLLVEDNPVNQQVAQAMLAKLGLATTVASDGREAVDLVA
SRAFDAVLMDCQMPVMDGYEATRAIRRLPGARLPVIALTANALHGDRQKCLDSGMDDFLPKPYSLAQLQATLARWLRPTN
PTPEAQAAAPQHGPDGEIASPQAPAINMKTLNALRELDPEGGMGLAHQIVRTFLESAQTWVDRVEQAVAGGDGDALRQSA
HALKSSSANVGAERLSGLYRQMEKLGRERRLDEAREALGEVRGEYARAVSEMHAILTGGR

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=533, Percent_Identity=32.4577861163227, Blast_Score=234, Evalue=2e-62,
Organism=Escherichia coli, GI48994928, Length=534, Percent_Identity=32.2097378277154, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1788713, Length=521, Percent_Identity=31.6698656429942, Blast_Score=224, Evalue=2e-59,
Organism=Escherichia coli, GI87081816, Length=591, Percent_Identity=30.4568527918782, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI145693157, Length=235, Percent_Identity=42.5531914893617, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=30.672268907563, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788393, Length=395, Percent_Identity=25.0632911392405, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=29.0598290598291, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.9661016949153, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=29.1139240506329, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=28.4518828451883, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=27.0916334661355, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=30.3317535545024, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082012, Length=110, Percent_Identity=34.5454545454545, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1789402, Length=120, Percent_Identity=35, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=338, Percent_Identity=22.7810650887574, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=34.453781512605, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788394, Length=126, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=120, Percent_Identity=35.8333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=255, Percent_Identity=25.0980392156863, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=25.462962962963, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=166, Percent_Identity=34.3373493975904, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322044, Length=121, Percent_Identity=39.6694214876033, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323034, Length=142, Percent_Identity=30.2816901408451, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83862; Mature: 83730

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50885 HAMP ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPEGTSTTLRARLRRTSLITLAVALGIVAVIIMASSFAAGLISLASTNRVEARVLAENV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
SASLLFEDRTSAEELLHSLRHSRVVHGAAVYDNARRVFARYEHGSDRVPAILGPLSEGVD
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YGLRRVTVVQPVMLDGRQVGSVLLSVGLESLYAQIGWQALVTLLAAALAMLVANRLLGRL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NESVVVPLARLSALMLRISSRNDYTVRAAGSEIAEMNTLARGFNDMLGQIQQRDQELAEH
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARLEDQVAHRTVALKAAEAASQAKSDFLATMSHEIRTPMNGVLGMNELLLGSSLDPQQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHCCCCCHHHH
MWAESVQHSGQHLLGVINDILDFSKIESGHLSLETVDFDLVELIDDTMRMFAHQAEHKGL
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
ELACRITPSQRTIGLRGDPFRLRQIVANLVGNAIKFTEHGAVVVHATVNDNGDAAAVGLC
EEEEEECCCCCEECCCCCHHHHHHHHHHHHCCCEEEECCCEEEEEEEECCCCCEEEEEEE
VEDTGIGIAPEAQARIFEHFSQADGSTTRRFGGTGLGLAICRRLANLMGSDITVASAPGQ
EECCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCC
GARFCLDLRLARASADFERPDPAGEASGAGTSAPAFQGRGERVLLVEDNPVNQQVAQAML
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
AKLGLATTVASDGREAVDLVASRAFDAVLMDCQMPVMDGYEATRAIRRLPGARLPVIALT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
ANALHGDRQKCLDSGMDDFLPKPYSLAQLQATLARWLRPTNPTPEAQAAAPQHGPDGEIA
HHHHCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SPQAPAINMKTLNALRELDPEGGMGLAHQIVRTFLESAQTWVDRVEQAVAGGDGDALRQS
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AHALKSSSANVGAERLSGLYRQMEKLGRERRLDEAREALGEVRGEYARAVSEMHAILTGG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
R
C
>Mature Secondary Structure 
SPEGTSTTLRARLRRTSLITLAVALGIVAVIIMASSFAAGLISLASTNRVEARVLAENV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
SASLLFEDRTSAEELLHSLRHSRVVHGAAVYDNARRVFARYEHGSDRVPAILGPLSEGVD
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YGLRRVTVVQPVMLDGRQVGSVLLSVGLESLYAQIGWQALVTLLAAALAMLVANRLLGRL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NESVVVPLARLSALMLRISSRNDYTVRAAGSEIAEMNTLARGFNDMLGQIQQRDQELAEH
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARLEDQVAHRTVALKAAEAASQAKSDFLATMSHEIRTPMNGVLGMNELLLGSSLDPQQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHCCCCCHHHH
MWAESVQHSGQHLLGVINDILDFSKIESGHLSLETVDFDLVELIDDTMRMFAHQAEHKGL
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
ELACRITPSQRTIGLRGDPFRLRQIVANLVGNAIKFTEHGAVVVHATVNDNGDAAAVGLC
EEEEEECCCCCEECCCCCHHHHHHHHHHHHCCCEEEECCCEEEEEEEECCCCCEEEEEEE
VEDTGIGIAPEAQARIFEHFSQADGSTTRRFGGTGLGLAICRRLANLMGSDITVASAPGQ
EECCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCC
GARFCLDLRLARASADFERPDPAGEASGAGTSAPAFQGRGERVLLVEDNPVNQQVAQAML
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
AKLGLATTVASDGREAVDLVASRAFDAVLMDCQMPVMDGYEATRAIRRLPGARLPVIALT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEE
ANALHGDRQKCLDSGMDDFLPKPYSLAQLQATLARWLRPTNPTPEAQAAAPQHGPDGEIA
HHHHCCHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SPQAPAINMKTLNALRELDPEGGMGLAHQIVRTFLESAQTWVDRVEQAVAGGDGDALRQS
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AHALKSSSANVGAERLSGLYRQMEKLGRERRLDEAREALGEVRGEYARAVSEMHAILTGG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]