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The map label for this gene is dapL [H]

Identifier: 74317239

GI number: 74317239

Start: 1274784

End: 1275980

Strand: Reverse

Name: dapL [H]

Synonym: Tbd_1221

Alternate gene names: 74317239

Gene position: 1275980-1274784 (Counterclockwise)

Preceding gene: 74317242

Following gene: 74317238

Centisome position: 43.85

GC content: 68.92

Gene sequence:

>1197_bases
ATGAACCCGCGTCTCGACCAACTCCACCCGTATCCGTTCCAGAAACTGCGCGAGCTGCTCGCCGGAACCGAGCCGAACCC
CGAACTCGCGGCGATCAACCTGTCGATCGGCGAACCCAAACACCCGACCCCGGGCTTCATCCGCGACGCGCTGGTCGGCG
GCCTCGACGGGCTGGCGAATTATCCCATCACCCAGGGTTCCGACGCGCTGCGCGCCGCGATCGCCGGCTGGGCCGCGCGC
CGCTATGGCGTCACGCTCGATCCGGCGAGCGAGGTGCTGCCGGTCAACGGCTCGCGCGAAGCCTTGTTCGCCTTCGCCCA
GGCGGCTGTCGACTCGACCCGCCACGGTCGGCGCACGGTGGTCTCGCCCAACCCCTTCTACCAGATCTACGAAGGCGCGA
CGCTGCTCGCCGGCGCCCGCCCGTTCTTCCTCAACACGCTGCCCGAGAACGGCTTCACGATGGACTGGTCGCGCGTGCCG
GAAGACCTCTGGGACAGCATCAGCCTCGTCTACGTCTGCTCGCCTGGCAACCCCACCGGCAAGGTCATGACGCTCGACGA
ATGGCGAACCCTGTTCGCGCTCGCCGACCGACACGGCTTCGTCATCGCCGCCGACGAATGCTATTCGGAGATCTACTTCG
ACGAGGCCCATCCCCCGCTTGGCGCGCTAACAGCGTCGCATCAACTGGGGCGCGGCTGCAGGAACCTCGTGGTCTTCAAC
TCGCTGTCCAAGCGCTCCAACGTGCCCGGGCTGCGCTCGGGCATGGTCGCCGGCGACGCCGAGGTGCTGAAGAAATTCCT
GCTCTACCGCACCTACCACGGCAGCGCGATGAGCCCGGCCGTGCAGGCGGCGAGCATCGCCGCGTGGAACGACGAAGCCC
ACGTCCTCGACAACCGTCGCCAGTACGCCGCGAAATTCGCCGCCGTCATACCGCTGCTGCGCGACGTGCTGTCTTTCGAC
GCGCCCGACGCGGCCTTCTATCTCTGGGCCCGCGTGCCCGGCGGCGACGACGCCGCGTTCGCGCGCGGCCTCTACGCGCA
ACAGCACGTCACTGTGCTGCCCGGCAGCTTCCTCGCGCGCGACGCCGCCGGGGCCAACCCCGGCAAGGGCTTCGTGCGGA
TCGCGCTGGTCGACACGCTCGACGCCTGCGTCGAGGCCGCTGAACGCATCGCGGCCTTCGTCACCGAGGCCGCCTGA

Upstream 100 bases:

>100_bases
TGGGCCTTATAATGTCGGGCTTGAAAAACGATGGCTCAGGGAGCCGGCCGCAAGTATAGAGGCCGGCCGAGAAACCACGG
CACACTCGAACTGCACTGCA

Downstream 100 bases:

>100_bases
CTCTTTCTCCAACTTTCTTGAAACGGACCGCACAGATCATGCAAGAACTCCAGCCCATCATCGAAGAAGCCTTCGAACGC
CGCGCCGACATCACGCCGCG

Product: succinyldiaminopimelate transaminase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNPRLDQLHPYPFQKLRELLAGTEPNPELAAINLSIGEPKHPTPGFIRDALVGGLDGLANYPITQGSDALRAAIAGWAAR
RYGVTLDPASEVLPVNGSREALFAFAQAAVDSTRHGRRTVVSPNPFYQIYEGATLLAGARPFFLNTLPENGFTMDWSRVP
EDLWDSISLVYVCSPGNPTGKVMTLDEWRTLFALADRHGFVIAADECYSEIYFDEAHPPLGALTASHQLGRGCRNLVVFN
SLSKRSNVPGLRSGMVAGDAEVLKKFLLYRTYHGSAMSPAVQAASIAAWNDEAHVLDNRRQYAAKFAAVIPLLRDVLSFD
APDAAFYLWARVPGGDDAAFARGLYAQQHVTVLPGSFLARDAAGANPGKGFVRIALVDTLDACVEAAERIAAFVTEAA

Sequences:

>Translated_398_residues
MNPRLDQLHPYPFQKLRELLAGTEPNPELAAINLSIGEPKHPTPGFIRDALVGGLDGLANYPITQGSDALRAAIAGWAAR
RYGVTLDPASEVLPVNGSREALFAFAQAAVDSTRHGRRTVVSPNPFYQIYEGATLLAGARPFFLNTLPENGFTMDWSRVP
EDLWDSISLVYVCSPGNPTGKVMTLDEWRTLFALADRHGFVIAADECYSEIYFDEAHPPLGALTASHQLGRGCRNLVVFN
SLSKRSNVPGLRSGMVAGDAEVLKKFLLYRTYHGSAMSPAVQAASIAAWNDEAHVLDNRRQYAAKFAAVIPLLRDVLSFD
APDAAFYLWARVPGGDDAAFARGLYAQQHVTVLPGSFLARDAAGANPGKGFVRIALVDTLDACVEAAERIAAFVTEAA
>Mature_398_residues
MNPRLDQLHPYPFQKLRELLAGTEPNPELAAINLSIGEPKHPTPGFIRDALVGGLDGLANYPITQGSDALRAAIAGWAAR
RYGVTLDPASEVLPVNGSREALFAFAQAAVDSTRHGRRTVVSPNPFYQIYEGATLLAGARPFFLNTLPENGFTMDWSRVP
EDLWDSISLVYVCSPGNPTGKVMTLDEWRTLFALADRHGFVIAADECYSEIYFDEAHPPLGALTASHQLGRGCRNLVVFN
SLSKRSNVPGLRSGMVAGDAEVLKKFLLYRTYHGSAMSPAVQAASIAAWNDEAHVLDNRRQYAAKFAAVIPLLRDVLSFD
APDAAFYLWARVPGGDDAAFARGLYAQQHVTVLPGSFLARDAAGANPGKGFVRIALVDTLDACVEAAERIAAFVTEAA

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=329, Percent_Identity=26.7477203647416, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI169881279, Length=329, Percent_Identity=26.7477203647416, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI56713254, Length=394, Percent_Identity=22.5888324873096, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI56713256, Length=394, Percent_Identity=23.0964467005076, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788722, Length=399, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786816, Length=375, Percent_Identity=25.8666666666667, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787909, Length=326, Percent_Identity=25.4601226993865, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994949, Length=294, Percent_Identity=26.8707482993197, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=407, Percent_Identity=24.0786240786241, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=403, Percent_Identity=23.5732009925558, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=403, Percent_Identity=23.5732009925558, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI18859735, Length=401, Percent_Identity=24.9376558603491, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43027; Mature: 43027

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRLDQLHPYPFQKLRELLAGTEPNPELAAINLSIGEPKHPTPGFIRDALVGGLDGLAN
CCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHCC
YPITQGSDALRAAIAGWAARRYGVTLDPASEVLPVNGSREALFAFAQAAVDSTRHGRRTV
CCCCCCCHHHHHHHHHHHHHHCCCEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEE
VSPNPFYQIYEGATLLAGARPFFLNTLPENGFTMDWSRVPEDLWDSISLVYVCSPGNPTG
ECCCCCEEEECCCEEEECCCCCEEECCCCCCCCCCHHHCCHHHHCCEEEEEEECCCCCCC
KVMTLDEWRTLFALADRHGFVIAADECYSEIYFDEAHPPLGALTASHQLGRGCRNLVVFN
EEEEHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEE
SLSKRSNVPGLRSGMVAGDAEVLKKFLLYRTYHGSAMSPAVQAASIAAWNDEAHVLDNRR
CHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHEEEECCCCHHHHHHHH
QYAAKFAAVIPLLRDVLSFDAPDAAFYLWARVPGGDDAAFARGLYAQQHVTVLPGSFLAR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHHH
DAAGANPGKGFVRIALVDTLDACVEAAERIAAFVTEAA
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPRLDQLHPYPFQKLRELLAGTEPNPELAAINLSIGEPKHPTPGFIRDALVGGLDGLAN
CCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHCC
YPITQGSDALRAAIAGWAARRYGVTLDPASEVLPVNGSREALFAFAQAAVDSTRHGRRTV
CCCCCCCHHHHHHHHHHHHHHCCCEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEE
VSPNPFYQIYEGATLLAGARPFFLNTLPENGFTMDWSRVPEDLWDSISLVYVCSPGNPTG
ECCCCCEEEECCCEEEECCCCCEEECCCCCCCCCCHHHCCHHHHCCEEEEEEECCCCCCC
KVMTLDEWRTLFALADRHGFVIAADECYSEIYFDEAHPPLGALTASHQLGRGCRNLVVFN
EEEEHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEE
SLSKRSNVPGLRSGMVAGDAEVLKKFLLYRTYHGSAMSPAVQAASIAAWNDEAHVLDNRR
CHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHEEEECCCCHHHHHHHH
QYAAKFAAVIPLLRDVLSFDAPDAAFYLWARVPGGDDAAFARGLYAQQHVTVLPGSFLAR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHHH
DAAGANPGKGFVRIALVDTLDACVEAAERIAAFVTEAA
HCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA