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The map label for this gene is pgi1

Identifier: 74316992

GI number: 74316992

Start: 1038582

End: 1040234

Strand: Reverse

Name: pgi1

Synonym: Tbd_0974

Alternate gene names: 74316992

Gene position: 1040234-1038582 (Counterclockwise)

Preceding gene: 74316994

Following gene: 74316990

Centisome position: 35.75

GC content: 64.67

Gene sequence:

>1653_bases
ATGAAACCACTCAAGACCCTCCCCGCCTGGAAAGCGCTCGAGCAGCACTTCAAGAGCATGCGCAACTTCGACATGCGCGC
GGCCTTCCGCGAGGACGCCGCACGTTTCGAGACCCTGTCGCTGCGTTGCGGAAATCTGCTGCTCGACTACTCGAAGAATC
GCGTGACGCAGGAGACGATGCGGCATCTCGCGCAACTGGCGCGCGAATCCGAGCTCGAGGAGATGCGCAACGCCATGTGC
ACGGGCGAGCGCATCAACTTCACCGAGAAGCGTGCCGTGCTGCACGTGGCCCTGCGTGCGCCGGTACGACCCGCCCTGAT
GGTCGAAGGCGTCGACGTCGAACGCGAGATCGCCAAGGTGCTGCACCGCATGCAGCGCTTCGTCGAATCGGTCCACAACG
GCAGCTGGCGCGGCCACACCGGCAAGCCGATCCGCAATGTCGTCAACATCGGAATCGGCGGCTCGGACCTCGGTCCCGCG
ATGGTGTGCCACGCGCTCGACCACTACGCCGTCGAAAACGTGCGCGTGCATTTTGTTTCCAACCTCGATCCGTCGCATCT
TGCCGGAACGCTCGCCCAGCTCGATCCCGAGACGACGCTGTTCATCGTCGCCTCGAAAACCTTCACCACCCTCGAGACGC
TCGCCAACGCCAACTCGGCCAAGGCCTGGCTGCTTGCAGCGCTGCGGGCACCCGAAGCCGTGGCGCGCCACTTCGTCGCC
TTGTCGACCAACGCGCAGGCGGTCGAAGCCTTCGGCATCGATCCGGAGAACATGTTCATCTTCTGGGACTGGGTCGGCGG
CCGTTATTCACTGTGGTCGGCGATCGGGCTGTCGATCGCGCTGCAGATCGGCTGGGGCAACTTCCAGGCCCTGCTCGCCG
GTGCGCACGCAATGGACGTCCACTTCAAGGAGGCACCGCTCGAGGCCAACATGCCGGTCATTCTGGGCATGCTCGGCATC
TGGTACGCGAACTTCTGGGGCACCGACACCTACGGCGTCTTTCCCTACGACCAGCGTCTGCGCCTGCTCGTGCCGTTCCT
GCAGCAGCTCGACATGGAGTCGAACGGCAAGAACGTCAACCGCGCCAACAAGCTCGTCAATTACAACACCGGGCCGATCG
TGTGGGGCGCGCCCGGCACCAACGGCCAGCACGCCTTCTTCGAACTCGTGCATCAGGGGACGCGGCTGATTCCGACCGAC
TTCCTGGTCGCCGCCGTCAACCTCACGCCGCTGGCCGACCAGCACGAATGGCTGCTCGCCAACTGTCTCGCACAGACCGA
GGCGCTGTTGAAAGGCAAGTCGCGCGCGGTCATCGAAGCCGAACTGATCGCACAGGGGATGACCCGCGACGACGCCCGCG
CGCTCGCTCCGCACAAGGTTTTTCCGGGCAACCGTCCGAGCAACACGCTGCTCTACCAGAAGCTCGACCCGCACACGCTC
GGCATGCTGATCGCGCTCTACGAGCACAAGGTCTTCGTGCAGGGCGTGATCTGGCAGATCAACAGTTTCGACCAGTGGGG
CGTCGAGCTCGGCAAGCAGCTCGCACCGCCGATTCGCGCGGCGCTCAGTTCGGTACGCGTGATCGGCGAACACGACGGCT
CGACCCAGGGCCTCATCGCCGACATCCGGCGGCGCCGCGGCCTCAGTACCTAA

Upstream 100 bases:

>100_bases
CTGTCTCATCCTGAACCGTCGAAAGAAAGGCGCACGCCCCGGCGGCGACGCTGCCGCTGCTTATGATACCTTCGAAGCCC
GGCCGACTGATCGCACGTCC

Downstream 100 bases:

>100_bases
CGCACGCCCCGACGCCGTCGCGCCGCCGCCATTCCACGCGGCGAGCCCTACTGCATCAGGCCCTTGACGCGCACGCGATA
AACGAGCGTCGCTTTGCCGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI 1; Phosphoglucose isomerase 1; PGI 1; Phosphohexose isomerase 1; PHI 1

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MKPLKTLPAWKALEQHFKSMRNFDMRAAFREDAARFETLSLRCGNLLLDYSKNRVTQETMRHLAQLARESELEEMRNAMC
TGERINFTEKRAVLHVALRAPVRPALMVEGVDVEREIAKVLHRMQRFVESVHNGSWRGHTGKPIRNVVNIGIGGSDLGPA
MVCHALDHYAVENVRVHFVSNLDPSHLAGTLAQLDPETTLFIVASKTFTTLETLANANSAKAWLLAALRAPEAVARHFVA
LSTNAQAVEAFGIDPENMFIFWDWVGGRYSLWSAIGLSIALQIGWGNFQALLAGAHAMDVHFKEAPLEANMPVILGMLGI
WYANFWGTDTYGVFPYDQRLRLLVPFLQQLDMESNGKNVNRANKLVNYNTGPIVWGAPGTNGQHAFFELVHQGTRLIPTD
FLVAAVNLTPLADQHEWLLANCLAQTEALLKGKSRAVIEAELIAQGMTRDDARALAPHKVFPGNRPSNTLLYQKLDPHTL
GMLIALYEHKVFVQGVIWQINSFDQWGVELGKQLAPPIRAALSSVRVIGEHDGSTQGLIADIRRRRGLST

Sequences:

>Translated_550_residues
MKPLKTLPAWKALEQHFKSMRNFDMRAAFREDAARFETLSLRCGNLLLDYSKNRVTQETMRHLAQLARESELEEMRNAMC
TGERINFTEKRAVLHVALRAPVRPALMVEGVDVEREIAKVLHRMQRFVESVHNGSWRGHTGKPIRNVVNIGIGGSDLGPA
MVCHALDHYAVENVRVHFVSNLDPSHLAGTLAQLDPETTLFIVASKTFTTLETLANANSAKAWLLAALRAPEAVARHFVA
LSTNAQAVEAFGIDPENMFIFWDWVGGRYSLWSAIGLSIALQIGWGNFQALLAGAHAMDVHFKEAPLEANMPVILGMLGI
WYANFWGTDTYGVFPYDQRLRLLVPFLQQLDMESNGKNVNRANKLVNYNTGPIVWGAPGTNGQHAFFELVHQGTRLIPTD
FLVAAVNLTPLADQHEWLLANCLAQTEALLKGKSRAVIEAELIAQGMTRDDARALAPHKVFPGNRPSNTLLYQKLDPHTL
GMLIALYEHKVFVQGVIWQINSFDQWGVELGKQLAPPIRAALSSVRVIGEHDGSTQGLIADIRRRRGLST
>Mature_550_residues
MKPLKTLPAWKALEQHFKSMRNFDMRAAFREDAARFETLSLRCGNLLLDYSKNRVTQETMRHLAQLARESELEEMRNAMC
TGERINFTEKRAVLHVALRAPVRPALMVEGVDVEREIAKVLHRMQRFVESVHNGSWRGHTGKPIRNVVNIGIGGSDLGPA
MVCHALDHYAVENVRVHFVSNLDPSHLAGTLAQLDPETTLFIVASKTFTTLETLANANSAKAWLLAALRAPEAVARHFVA
LSTNAQAVEAFGIDPENMFIFWDWVGGRYSLWSAIGLSIALQIGWGNFQALLAGAHAMDVHFKEAPLEANMPVILGMLGI
WYANFWGTDTYGVFPYDQRLRLLVPFLQQLDMESNGKNVNRANKLVNYNTGPIVWGAPGTNGQHAFFELVHQGTRLIPTD
FLVAAVNLTPLADQHEWLLANCLAQTEALLKGKSRAVIEAELIAQGMTRDDARALAPHKVFPGNRPSNTLLYQKLDPHTL
GMLIALYEHKVFVQGVIWQINSFDQWGVELGKQLAPPIRAALSSVRVIGEHDGSTQGLIADIRRRRGLST

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=553, Percent_Identity=54.0687160940326, Blast_Score=613, Evalue=1e-175,
Organism=Homo sapiens, GI296080693, Length=553, Percent_Identity=50.8137432188065, Blast_Score=558, Evalue=1e-159,
Organism=Escherichia coli, GI1790457, Length=548, Percent_Identity=53.4671532846715, Blast_Score=600, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71996708, Length=521, Percent_Identity=54.89443378119, Blast_Score=584, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71996703, Length=521, Percent_Identity=54.89443378119, Blast_Score=584, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=51.9195612431444, Blast_Score=561, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24651916, Length=551, Percent_Identity=53.7205081669691, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24651914, Length=551, Percent_Identity=53.7205081669691, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI17737445, Length=551, Percent_Identity=53.7205081669691, Blast_Score=586, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI1_THIDA (Q3SK65)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314732.1
- ProteinModelPortal:   Q3SK65
- SMR:   Q3SK65
- STRING:   Q3SK65
- GeneID:   3671197
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0974
- NMPDR:   fig|292415.3.peg.601
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   AHTHAIM
- PhylomeDB:   Q3SK65
- BioCyc:   TDEN292415:TBD_0974-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61248; Mature: 61248

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 353-353 ACT_SITE 384-384 ACT_SITE 512-512

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLKTLPAWKALEQHFKSMRNFDMRAAFREDAARFETLSLRCGNLLLDYSKNRVTQETM
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCEEEECCCCHHHHHHH
RHLAQLARESELEEMRNAMCTGERINFTEKRAVLHVALRAPVRPALMVEGVDVEREIAKV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
LHRMQRFVESVHNGSWRGHTGKPIRNVVNIGIGGSDLGPAMVCHALDHYAVENVRVHFVS
HHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEC
NLDPSHLAGTLAQLDPETTLFIVASKTFTTLETLANANSAKAWLLAALRAPEAVARHFVA
CCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHE
LSTNAQAVEAFGIDPENMFIFWDWVGGRYSLWSAIGLSIALQIGWGNFQALLAGAHAMDV
ECCCCHHHHEECCCCCCEEEEEEECCCCHHHHHHHCEEEEEEECCCCHHHHHHCCHHEEE
HFKEAPLEANMPVILGMLGIWYANFWGTDTYGVFPYDQRLRLLVPFLQQLDMESNGKNVN
EEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
RANKLVNYNTGPIVWGAPGTNGQHAFFELVHQGTRLIPTDFLVAAVNLTPLADQHEWLLA
HHHHEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCCHHHHHH
NCLAQTEALLKGKSRAVIEAELIAQGMTRDDARALAPHKVFPGNRPSNTLLYQKLDPHTL
HHHHHHHHHHCCCCCCEEEHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCCCHHH
GMLIALYEHKVFVQGVIWQINSFDQWGVELGKQLAPPIRAALSSVRVIGEHDGSTQGLIA
HHHHHHHHHHHHEEEHEEEECCCHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCHHHH
DIRRRRGLST
HHHHHCCCCC
>Mature Secondary Structure
MKPLKTLPAWKALEQHFKSMRNFDMRAAFREDAARFETLSLRCGNLLLDYSKNRVTQETM
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCEEEECCCCHHHHHHH
RHLAQLARESELEEMRNAMCTGERINFTEKRAVLHVALRAPVRPALMVEGVDVEREIAKV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
LHRMQRFVESVHNGSWRGHTGKPIRNVVNIGIGGSDLGPAMVCHALDHYAVENVRVHFVS
HHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEC
NLDPSHLAGTLAQLDPETTLFIVASKTFTTLETLANANSAKAWLLAALRAPEAVARHFVA
CCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHE
LSTNAQAVEAFGIDPENMFIFWDWVGGRYSLWSAIGLSIALQIGWGNFQALLAGAHAMDV
ECCCCHHHHEECCCCCCEEEEEEECCCCHHHHHHHCEEEEEEECCCCHHHHHHCCHHEEE
HFKEAPLEANMPVILGMLGIWYANFWGTDTYGVFPYDQRLRLLVPFLQQLDMESNGKNVN
EEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
RANKLVNYNTGPIVWGAPGTNGQHAFFELVHQGTRLIPTDFLVAAVNLTPLADQHEWLLA
HHHHEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHEEEEECCCCCCCHHHHHH
NCLAQTEALLKGKSRAVIEAELIAQGMTRDDARALAPHKVFPGNRPSNTLLYQKLDPHTL
HHHHHHHHHHCCCCCCEEEHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCEEEECCCCHHH
GMLIALYEHKVFVQGVIWQINSFDQWGVELGKQLAPPIRAALSSVRVIGEHDGSTQGLIA
HHHHHHHHHHHHEEEHEEEECCCHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCCCHHHH
DIRRRRGLST
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA