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The map label for this gene is recQ [H]

Identifier: 74316914

GI number: 74316914

Start: 944968

End: 946764

Strand: Direct

Name: recQ [H]

Synonym: Tbd_0896

Alternate gene names: 74316914

Gene position: 944968-946764 (Clockwise)

Preceding gene: 74316908

Following gene: 74316915

Centisome position: 32.48

GC content: 68.84

Gene sequence:

>1797_bases
ATGCCCGAAACCCCTTTAAGCCTCCTCAACCGCGTCTTCGGCTATCCCGCGTTCCGTGGTGAGCAGGCCGCGATCGTCGA
TACGGTCGTCGCCGGCGACGATGCGCTGGTGCTGATGCCGACGGGCGGCGGCAAGTCGCTGTGCTACCAGATCCCCGCGC
TGTTGCGCGAAGGCTGCGCGGTCGTCGTCTCGCCGCTGATCGCGCTTATGCAGGACCAGGTCGCGGCGCTGCAGGAGTTG
GGCATCGCCGCCGCCTTCCTGAATTCGAGCCTCGACGGCGCCACCGCCGCGCGGGTCGAGCGCGATTTCGTTTCGGGGCA
GTTGAAGCTGCTCTACGTCGCCCCCGAGCGCCTGTTGACGCCGCGTTTTCAGAGCCTGCTCGCCGAGGCACGCATCGCGT
TGTTCGCGATCGACGAGGCGCACTGCGTGTCGCAATGGGGCCACGACTTCCGCCCGGAATACCTCGGCCTGTCGGCGCTG
CACGAACGCTTCCCCGAGGTGCCGCGCATCGCGCTGACCGCGACGGCCGACGCCGCGACGCGCGCCGAAATCCTGCAACG
CCTTGATCTAGGCGCCGCGCGCGTCTTCGTCGCGAGTTTCGACCGCCCCAACATCCGCTACCGTATCGCCGAGAAAACCG
AGCCGCGCCGGCAACTGCTCGACTTCCTCGCCGAACACACAGGCGAGGCCGGCATCGTCTATTGCAGCACGCGCAAGAAA
GTCGAAGAAACCGCCGACGCGCTGAAGCAGGCCGGCCTCACGGCGCTGCCGTATCACGGCGGCATGGACAACGACACGCG
TCGCCGCCATCAGGAAAAATTCCTGCGCGAGGAGGGCGTCGTCATGGTCGCGACGCTCGCGTTCGGCATGGGCATCGACA
AGCCCGACGTGCGCTTCGTCGCCCACCTCGACCTGCCGCGCTCGGTCGAGGGCTACTACCAGGAAACCGGCCGCGCCGGC
CGCGACGGCGAGCCGGCCGAGGCGTGGATGGCCTGGGGCCTGCAGGACGTCGTCACCCAGCGCCGCTTCATCGATGAAGG
CGAGGCCGGAGACGCGCACAAGCGCATCGGCCACGCCAAGCTCGACGCCCTGGTCGGCCTGTGCGAAGCGGCCAGCTGCC
GCCGCGTCGCGCTATTGAGCTACTTCGGCGAAGCCAGCCAGCCCTGCGGCAACTGCGACGTCTGCCTCAATCCGCCCACG
CTGTGGGACGGCACCGAGGCCGCACAGAAATTGTTAAGCACCGTCTACCGCACCGGCCAGCGCTTCGGCGCCGGGCACGT
GATCGACGTGCTGCTCGGCAAGACGACCGAGAAGATCGACCGCTTCGGCCACAGCCAGCTGAGCGTGTTCGGCATCGGCG
CCAGCCAGACCGACAAGGTGTGGCGCGCCGTGCTGCGGCAGCTGGTGGTGCGCGGCCTGCTGGAGGTGGACCACAGTGCC
TACGGCGCGCTCAAGCTCACCCAAGCCGCGAAGCCCGTGCTCAAAGGCGAGGAAACCGTGATGCTGCGCGCCATCGAAGC
GCGCCCGGCGCGCAAGAAATCGCGCCTCGCCCCCAGTTCCGGCGCCGGCGTCCACGACGACGAAGACCCGCTGTTCCTCT
CCCTGCGCGCCTGGCGCCGCGAAACCGCCAACGAAAAGGGCGTGCCCGCCTACGTCATCCTGCACGACGCCACGCTGCGC
GAGATCGCCGCGCGCCGCCCCGCCACGCTGGCCGAGCTGGGCGAGATATCCGGGCTGGGGACGAAGAAGCTGGAAGCATA
CGGCGAGGACGTGTTGGCGGTGGTGGCGGAGGGGTGA

Upstream 100 bases:

>100_bases
CATGGCAGCCTCCCGGGGGAAAAAACAGCGCAAAACGTGACACAATTATAGCGAATGTGACACATCGCCCGCCAGTTCGC
CTTACCTTTAATCCAGCTTC

Downstream 100 bases:

>100_bases
GGCGGGGGCGCCGCCCCGCATGTTCCTGTCGACAGGTTTTACACCCCGGTGGGGGCGCCTGCCTTCGATTTGCCTGAAAG
CCCGACGAATCCTGCGTTTG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MPETPLSLLNRVFGYPAFRGEQAAIVDTVVAGDDALVLMPTGGGKSLCYQIPALLREGCAVVVSPLIALMQDQVAALQEL
GIAAAFLNSSLDGATAARVERDFVSGQLKLLYVAPERLLTPRFQSLLAEARIALFAIDEAHCVSQWGHDFRPEYLGLSAL
HERFPEVPRIALTATADAATRAEILQRLDLGAARVFVASFDRPNIRYRIAEKTEPRRQLLDFLAEHTGEAGIVYCSTRKK
VEETADALKQAGLTALPYHGGMDNDTRRRHQEKFLREEGVVMVATLAFGMGIDKPDVRFVAHLDLPRSVEGYYQETGRAG
RDGEPAEAWMAWGLQDVVTQRRFIDEGEAGDAHKRIGHAKLDALVGLCEAASCRRVALLSYFGEASQPCGNCDVCLNPPT
LWDGTEAAQKLLSTVYRTGQRFGAGHVIDVLLGKTTEKIDRFGHSQLSVFGIGASQTDKVWRAVLRQLVVRGLLEVDHSA
YGALKLTQAAKPVLKGEETVMLRAIEARPARKKSRLAPSSGAGVHDDEDPLFLSLRAWRRETANEKGVPAYVILHDATLR
EIAARRPATLAELGEISGLGTKKLEAYGEDVLAVVAEG

Sequences:

>Translated_598_residues
MPETPLSLLNRVFGYPAFRGEQAAIVDTVVAGDDALVLMPTGGGKSLCYQIPALLREGCAVVVSPLIALMQDQVAALQEL
GIAAAFLNSSLDGATAARVERDFVSGQLKLLYVAPERLLTPRFQSLLAEARIALFAIDEAHCVSQWGHDFRPEYLGLSAL
HERFPEVPRIALTATADAATRAEILQRLDLGAARVFVASFDRPNIRYRIAEKTEPRRQLLDFLAEHTGEAGIVYCSTRKK
VEETADALKQAGLTALPYHGGMDNDTRRRHQEKFLREEGVVMVATLAFGMGIDKPDVRFVAHLDLPRSVEGYYQETGRAG
RDGEPAEAWMAWGLQDVVTQRRFIDEGEAGDAHKRIGHAKLDALVGLCEAASCRRVALLSYFGEASQPCGNCDVCLNPPT
LWDGTEAAQKLLSTVYRTGQRFGAGHVIDVLLGKTTEKIDRFGHSQLSVFGIGASQTDKVWRAVLRQLVVRGLLEVDHSA
YGALKLTQAAKPVLKGEETVMLRAIEARPARKKSRLAPSSGAGVHDDEDPLFLSLRAWRRETANEKGVPAYVILHDATLR
EIAARRPATLAELGEISGLGTKKLEAYGEDVLAVVAEG
>Mature_597_residues
PETPLSLLNRVFGYPAFRGEQAAIVDTVVAGDDALVLMPTGGGKSLCYQIPALLREGCAVVVSPLIALMQDQVAALQELG
IAAAFLNSSLDGATAARVERDFVSGQLKLLYVAPERLLTPRFQSLLAEARIALFAIDEAHCVSQWGHDFRPEYLGLSALH
ERFPEVPRIALTATADAATRAEILQRLDLGAARVFVASFDRPNIRYRIAEKTEPRRQLLDFLAEHTGEAGIVYCSTRKKV
EETADALKQAGLTALPYHGGMDNDTRRRHQEKFLREEGVVMVATLAFGMGIDKPDVRFVAHLDLPRSVEGYYQETGRAGR
DGEPAEAWMAWGLQDVVTQRRFIDEGEAGDAHKRIGHAKLDALVGLCEAASCRRVALLSYFGEASQPCGNCDVCLNPPTL
WDGTEAAQKLLSTVYRTGQRFGAGHVIDVLLGKTTEKIDRFGHSQLSVFGIGASQTDKVWRAVLRQLVVRGLLEVDHSAY
GALKLTQAAKPVLKGEETVMLRAIEARPARKKSRLAPSSGAGVHDDEDPLFLSLRAWRRETANEKGVPAYVILHDATLRE
IAARRPATLAELGEISGLGTKKLEAYGEDVLAVVAEG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=639, Percent_Identity=33.9593114241002, Blast_Score=356, Evalue=4e-98,
Organism=Homo sapiens, GI14591902, Length=453, Percent_Identity=35.9823399558499, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI14591904, Length=453, Percent_Identity=35.9823399558499, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI169218196, Length=514, Percent_Identity=34.8249027237354, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI110735439, Length=514, Percent_Identity=34.8249027237354, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI148612816, Length=423, Percent_Identity=39.9527186761229, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI51242943, Length=393, Percent_Identity=39.6946564885496, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI51242947, Length=393, Percent_Identity=39.6946564885496, Blast_Score=263, Evalue=5e-70,
Organism=Homo sapiens, GI284005309, Length=356, Percent_Identity=37.0786516853933, Blast_Score=186, Evalue=7e-47,
Organism=Homo sapiens, GI20149629, Length=338, Percent_Identity=24.2603550295858, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994977, Length=590, Percent_Identity=48.4745762711864, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1787605, Length=340, Percent_Identity=26.7647058823529, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25145561, Length=644, Percent_Identity=34.472049689441, Blast_Score=342, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI71987997, Length=533, Percent_Identity=34.7091932457786, Blast_Score=305, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI71987993, Length=533, Percent_Identity=34.7091932457786, Blast_Score=304, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI32564293, Length=500, Percent_Identity=35.6, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17552866, Length=420, Percent_Identity=36.4285714285714, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17555296, Length=332, Percent_Identity=26.5060240963855, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71987143, Length=328, Percent_Identity=23.780487804878, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533224, Length=323, Percent_Identity=24.1486068111455, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507121, Length=337, Percent_Identity=23.4421364985163, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71995724, Length=337, Percent_Identity=23.1454005934718, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17510307, Length=335, Percent_Identity=23.2835820895522, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510309, Length=335, Percent_Identity=23.2835820895522, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995514, Length=335, Percent_Identity=23.2835820895522, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=554, Percent_Identity=35.9205776173285, Blast_Score=339, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6320224, Length=344, Percent_Identity=21.2209302325581, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323947, Length=334, Percent_Identity=23.0538922155689, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646066, Length=633, Percent_Identity=36.650868878357, Blast_Score=358, Evalue=5e-99,
Organism=Drosophila melanogaster, GI24664226, Length=448, Percent_Identity=37.0535714285714, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24664230, Length=448, Percent_Identity=37.0535714285714, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI62472181, Length=448, Percent_Identity=37.0535714285714, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI21358123, Length=352, Percent_Identity=34.375, Blast_Score=192, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 65177; Mature: 65046

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETPLSLLNRVFGYPAFRGEQAAIVDTVVAGDDALVLMPTGGGKSLCYQIPALLREGCA
CCCCHHHHHHHHHCCCCCCCCCHHHEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCHH
VVVSPLIALMQDQVAALQELGIAAAFLNSSLDGATAARVERDFVSGQLKLLYVAPERLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHC
PRFQSLLAEARIALFAIDEAHCVSQWGHDFRPEYLGLSALHERFPEVPRIALTATADAAT
HHHHHHHHHHHHEEEEECHHHHHHHCCCCCCCHHCCHHHHHHHCCCCCCEEEEECCCHHH
RAEILQRLDLGAARVFVASFDRPNIRYRIAEKTEPRRQLLDFLAEHTGEAGIVYCSTRKK
HHHHHHHHCCCHHEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCHHH
VEETADALKQAGLTALPYHGGMDNDTRRRHQEKFLREEGVVMVATLAFGMGIDKPDVRFV
HHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCEEE
AHLDLPRSVEGYYQETGRAGRDGEPAEAWMAWGLQDVVTQRRFIDEGEAGDAHKRIGHAK
EEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LDALVGLCEAASCRRVALLSYFGEASQPCGNCDVCLNPPTLWDGTEAAQKLLSTVYRTGQ
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
RFGAGHVIDVLLGKTTEKIDRFGHSQLSVFGIGASQTDKVWRAVLRQLVVRGLLEVDHSA
HCCCCHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCH
YGALKLTQAAKPVLKGEETVMLRAIEARPARKKSRLAPSSGAGVHDDEDPLFLSLRAWRR
HCCEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCEEEEHHHHHH
ETANEKGVPAYVILHDATLREIAARRPATLAELGEISGLGTKKLEAYGEDVLAVVAEG
HCCCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
PETPLSLLNRVFGYPAFRGEQAAIVDTVVAGDDALVLMPTGGGKSLCYQIPALLREGCA
CCCHHHHHHHHHCCCCCCCCCHHHEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCHH
VVVSPLIALMQDQVAALQELGIAAAFLNSSLDGATAARVERDFVSGQLKLLYVAPERLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHC
PRFQSLLAEARIALFAIDEAHCVSQWGHDFRPEYLGLSALHERFPEVPRIALTATADAAT
HHHHHHHHHHHHEEEEECHHHHHHHCCCCCCCHHCCHHHHHHHCCCCCCEEEEECCCHHH
RAEILQRLDLGAARVFVASFDRPNIRYRIAEKTEPRRQLLDFLAEHTGEAGIVYCSTRKK
HHHHHHHHCCCHHEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCHHH
VEETADALKQAGLTALPYHGGMDNDTRRRHQEKFLREEGVVMVATLAFGMGIDKPDVRFV
HHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCEEE
AHLDLPRSVEGYYQETGRAGRDGEPAEAWMAWGLQDVVTQRRFIDEGEAGDAHKRIGHAK
EEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LDALVGLCEAASCRRVALLSYFGEASQPCGNCDVCLNPPTLWDGTEAAQKLLSTVYRTGQ
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
RFGAGHVIDVLLGKTTEKIDRFGHSQLSVFGIGASQTDKVWRAVLRQLVVRGLLEVDHSA
HCCCCHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCH
YGALKLTQAAKPVLKGEETVMLRAIEARPARKKSRLAPSSGAGVHDDEDPLFLSLRAWRR
HCCEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCEEEEHHHHHH
ETANEKGVPAYVILHDATLREIAARRPATLAELGEISGLGTKKLEAYGEDVLAVVAEG
HCCCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]