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The map label for this gene is pcm

Identifier: 74316854

GI number: 74316854

Start: 886713

End: 887393

Strand: Direct

Name: pcm

Synonym: Tbd_0836

Alternate gene names: 74316854

Gene position: 886713-887393 (Clockwise)

Preceding gene: 74316853

Following gene: 74316855

Centisome position: 30.47

GC content: 69.75

Gene sequence:

>681_bases
GTGGCTGAAACCCTGAACCCGCGCGCCGGCATCGGCATGACCTCGGCGCGGACCCGCGGCCGCATGGTCGAGCGTCTGCG
CGAGCAGGGCATCAAGGACGAAATGGTGCTGGCGGCGATGGGCATGGTCCCGCGTCACCTCTACGTCGACCAGGCGCTCG
AGTCGCGCGCCTACGAGGACACGGCCCTGCCGATCGGCTTCGGCCAGACCATATCCAATCCCTACATCGTCGCGCGCATG
GCCGAGCTCGCCCGCCACGGCGAAAACGGCAAGGGGCAGACGCTCGGCCGCGTGCTCGAGATCGGCCTCGGCTGCGGCTA
CCAGGCCGCGGTGCTCGGCAAGCTTGCGCGCGAGGTGGTGTCGATCGAGCGCATCGCTGCGCTCGTCGGCAAGACGCGCG
CCCGCCTGCGCGAACTGCGCGTCAACAACGTCAAGCCGAAGCACGGCGACGGCATGAACGGCGCCCGGGATTTCGCGCCC
TTCGATGCCATCGTGCTCGCGGCGGCCTTCGCCGAGGTCCCGCAGGCCTTGCTTGCGCAGCTGGCCGATGGCGGCCGCCT
GGTGATGCCGCTCGGCAACGCCACCCAGACGCTGTGCCTGATCGAGCGTCAAGGCGAAGCCTTCGTCGAACAGCGCCTCG
AAGGGGTGAAATTCGTGCCGCTGCTGCCGGGGGTCGCGTGA

Upstream 100 bases:

>100_bases
GCGAGGGCACGGACTTCCATGCCGTCGCCAACGGCTATGTTTCGATCACCCCGCTGCAAATGGACCTCACCCGTTTCAGC
CAGATGGAAAGCGTGACGGC

Downstream 100 bases:

>100_bases
AGGGCCTGGCCGTCGCCTTGGCGCTGCTGCTCGGGCTGGCCGGTTGTGCGGCGCCCGGCTACGCGCCGGTCAGCGACCGG
ACCTCCGGCCGCGGGGCGGC

Product: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MAETLNPRAGIGMTSARTRGRMVERLREQGIKDEMVLAAMGMVPRHLYVDQALESRAYEDTALPIGFGQTISNPYIVARM
AELARHGENGKGQTLGRVLEIGLGCGYQAAVLGKLAREVVSIERIAALVGKTRARLRELRVNNVKPKHGDGMNGARDFAP
FDAIVLAAAFAEVPQALLAQLADGGRLVMPLGNATQTLCLIERQGEAFVEQRLEGVKFVPLLPGVA

Sequences:

>Translated_226_residues
MAETLNPRAGIGMTSARTRGRMVERLREQGIKDEMVLAAMGMVPRHLYVDQALESRAYEDTALPIGFGQTISNPYIVARM
AELARHGENGKGQTLGRVLEIGLGCGYQAAVLGKLAREVVSIERIAALVGKTRARLRELRVNNVKPKHGDGMNGARDFAP
FDAIVLAAAFAEVPQALLAQLADGGRLVMPLGNATQTLCLIERQGEAFVEQRLEGVKFVPLLPGVA
>Mature_225_residues
AETLNPRAGIGMTSARTRGRMVERLREQGIKDEMVLAAMGMVPRHLYVDQALESRAYEDTALPIGFGQTISNPYIVARMA
ELARHGENGKGQTLGRVLEIGLGCGYQAAVLGKLAREVVSIERIAALVGKTRARLRELRVNNVKPKHGDGMNGARDFAPF
DAIVLAAAFAEVPQALLAQLADGGRLVMPLGNATQTLCLIERQGEAFVEQRLEGVKFVPLLPGVA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=216, Percent_Identity=31.4814814814815, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1789100, Length=212, Percent_Identity=47.6415094339623, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71983477, Length=220, Percent_Identity=29.0909090909091, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193207222, Length=219, Percent_Identity=28.310502283105, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17981723, Length=218, Percent_Identity=32.1100917431193, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_THIDA (Q3SKJ2)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314594.1
- ProteinModelPortal:   Q3SKJ2
- SMR:   Q3SKJ2
- STRING:   Q3SKJ2
- GeneID:   3673533
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0836
- NMPDR:   fig|292415.3.peg.222
- eggNOG:   COG2518
- HOGENOM:   HBG699907
- OMA:   YSVERIR
- PhylomeDB:   Q3SKJ2
- BioCyc:   TDEN292415:TBD_0836-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 24356; Mature: 24225

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETLNPRAGIGMTSARTRGRMVERLREQGIKDEMVLAAMGMVPRHLYVDQALESRAYED
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TALPIGFGQTISNPYIVARMAELARHGENGKGQTLGRVLEIGLGCGYQAAVLGKLAREVV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SIERIAALVGKTRARLRELRVNNVKPKHGDGMNGARDFAPFDAIVLAAAFAEVPQALLAQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LADGGRLVMPLGNATQTLCLIERQGEAFVEQRLEGVKFVPLLPGVA
HCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
AETLNPRAGIGMTSARTRGRMVERLREQGIKDEMVLAAMGMVPRHLYVDQALESRAYED
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TALPIGFGQTISNPYIVARMAELARHGENGKGQTLGRVLEIGLGCGYQAAVLGKLAREVV
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SIERIAALVGKTRARLRELRVNNVKPKHGDGMNGARDFAPFDAIVLAAAFAEVPQALLAQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LADGGRLVMPLGNATQTLCLIERQGEAFVEQRLEGVKFVPLLPGVA
HCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA