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The map label for this gene is map [H]

Identifier: 74316802

GI number: 74316802

Start: 827495

End: 828304

Strand: Reverse

Name: map [H]

Synonym: Tbd_0784

Alternate gene names: 74316802

Gene position: 828304-827495 (Counterclockwise)

Preceding gene: 74316819

Following gene: 74316801

Centisome position: 28.47

GC content: 66.17

Gene sequence:

>810_bases
ATGACCGTCTCCATCAAAACCGGCGCCGACATCGACAACATGCGCGTCGCCGGCCGCCTCGCCTCCGAAGTGCTCGACTA
CATCACGCCCTTCGTCAAACCCGGCGTCACGACCGGCGAACTCGACCGGCTATGCCACGCGTACATGGTCGACGTTCAAG
GCACCGTGCCGGCGCCGCTGAACTACGCGCCCTCGGGCCATGCGCCCTACCCCAAATCGATCTGCACTTCGGTGAACAAC
CAGGTCTGCCACGGGGTGCCGGGCGACAAGGTGCTGAAGAACGGCGACATCGTCAACCTCGACATCACGGTCATCAAGGA
CGGGTGGCACGGCGATACGAGCCGCATGTTCGCGGTCGGTGAGGCGACGATCCAGGCCAGGCGGCTGATCCAGATCACCT
ACGAGGCGATGTGGGTCGGCATCGACCGGGTGAAGCCCGGCGCGCGCCTCGGCGACATCGGCCACGCGATCCAGCGTTTC
GCCGAGAACCACGGCTACAGCGTGGTGCGCGAGTTCTGCGGCCACGGCATCGGCCGCAATTTCCACGAGGAACCGCAGGT
CCTGCATTACGGCAAGGCCGGAACCGGCTTGCTGCTCGAACCCGGCATGACCTTCACGATCGAGCCGATGATCAACGCGG
GCCGGCGCGACATCCGGCAGATGCCGGACGGCTGGACGATCGTGACCAAGGACCGCAGCCTGTCCGCGCAATGGGAACAC
ACCGTGCTCGTCACCGACAGCGGCTACGAGGTGCTGACCGTGTCGGCGGGCACGCCGGCCGTGCCCGACCGCATACTTCA
CCCGGCGTGA

Upstream 100 bases:

>100_bases
GTGACGTCGGTGCCCGCCGTTTCTCATCTCCGCCCTGTGGATATGGTTTTTCGCACCGGCGGCGGCGCTAAAATGCGCCT
TTGATTCCCATCTGCCTTAC

Downstream 100 bases:

>100_bases
GCGCCCGGCCGTTCGCCGATCTGCGCGAGCGGCTGAAGTCCGGCCGCGCGAGCCTGGCAGCGGCGTACCGCGAAAAGCCG
CGTGCGGCACACTATCTCGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTVSIKTGADIDNMRVAGRLASEVLDYITPFVKPGVTTGELDRLCHAYMVDVQGTVPAPLNYAPSGHAPYPKSICTSVNN
QVCHGVPGDKVLKNGDIVNLDITVIKDGWHGDTSRMFAVGEATIQARRLIQITYEAMWVGIDRVKPGARLGDIGHAIQRF
AENHGYSVVREFCGHGIGRNFHEEPQVLHYGKAGTGLLLEPGMTFTIEPMINAGRRDIRQMPDGWTIVTKDRSLSAQWEH
TVLVTDSGYEVLTVSAGTPAVPDRILHPA

Sequences:

>Translated_269_residues
MTVSIKTGADIDNMRVAGRLASEVLDYITPFVKPGVTTGELDRLCHAYMVDVQGTVPAPLNYAPSGHAPYPKSICTSVNN
QVCHGVPGDKVLKNGDIVNLDITVIKDGWHGDTSRMFAVGEATIQARRLIQITYEAMWVGIDRVKPGARLGDIGHAIQRF
AENHGYSVVREFCGHGIGRNFHEEPQVLHYGKAGTGLLLEPGMTFTIEPMINAGRRDIRQMPDGWTIVTKDRSLSAQWEH
TVLVTDSGYEVLTVSAGTPAVPDRILHPA
>Mature_268_residues
TVSIKTGADIDNMRVAGRLASEVLDYITPFVKPGVTTGELDRLCHAYMVDVQGTVPAPLNYAPSGHAPYPKSICTSVNNQ
VCHGVPGDKVLKNGDIVNLDITVIKDGWHGDTSRMFAVGEATIQARRLIQITYEAMWVGIDRVKPGARLGDIGHAIQRFA
ENHGYSVVREFCGHGIGRNFHEEPQVLHYGKAGTGLLLEPGMTFTIEPMINAGRRDIRQMPDGWTIVTKDRSLSAQWEHT
VLVTDSGYEVLTVSAGTPAVPDRILHPA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=47.808764940239, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=37.6984126984127, Blast_Score=184, Evalue=5e-47,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=62.3529411764706, Blast_Score=338, Evalue=2e-94,
Organism=Escherichia coli, GI1788728, Length=214, Percent_Identity=26.1682242990654, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=265, Percent_Identity=42.2641509433962, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=43.3070866141732, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI21355531, Length=266, Percent_Identity=43.609022556391, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=40.9638554216867, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29337; Mature: 29206

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSIKTGADIDNMRVAGRLASEVLDYITPFVKPGVTTGELDRLCHAYMVDVQGTVPAPL
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCCCC
NYAPSGHAPYPKSICTSVNNQVCHGVPGDKVLKNGDIVNLDITVIKDGWHGDTSRMFAVG
CCCCCCCCCCCHHHHHHCCCCEECCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEEC
EATIQARRLIQITYEAMWVGIDRVKPGARLGDIGHAIQRFAENHGYSVVREFCGHGIGRN
HHHHHHHHHHEEEEHHHEEEHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
FHEEPQVLHYGKAGTGLLLEPGMTFTIEPMINAGRRDIRQMPDGWTIVTKDRSLSAQWEH
CCCCCCEEEECCCCCCEEECCCCCEEECHHHCCCHHHHHHCCCCCEEEEECCCCCCCCCE
TVLVTDSGYEVLTVSAGTPAVPDRILHPA
EEEEECCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TVSIKTGADIDNMRVAGRLASEVLDYITPFVKPGVTTGELDRLCHAYMVDVQGTVPAPL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCCCC
NYAPSGHAPYPKSICTSVNNQVCHGVPGDKVLKNGDIVNLDITVIKDGWHGDTSRMFAVG
CCCCCCCCCCCHHHHHHCCCCEECCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEEC
EATIQARRLIQITYEAMWVGIDRVKPGARLGDIGHAIQRFAENHGYSVVREFCGHGIGRN
HHHHHHHHHHEEEEHHHEEEHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
FHEEPQVLHYGKAGTGLLLEPGMTFTIEPMINAGRRDIRQMPDGWTIVTKDRSLSAQWEH
CCCCCCEEEECCCCCCEEECCCCCEEECHHHCCCHHHHHHCCCCCEEEEECCCCCCCCCE
TVLVTDSGYEVLTVSAGTPAVPDRILHPA
EEEEECCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]