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The map label for this gene is czcD [H]

Identifier: 74316744

GI number: 74316744

Start: 768674

End: 769615

Strand: Reverse

Name: czcD [H]

Synonym: Tbd_0726

Alternate gene names: 74316744

Gene position: 769615-768674 (Counterclockwise)

Preceding gene: 74316745

Following gene: 74316743

Centisome position: 26.45

GC content: 73.89

Gene sequence:

>942_bases
GTGGCCGCGCATAAGCACGACCACGCCGGCCACACGCACTTTCACGGCGCGCACGCGGGCGGGAGCCGCACGCTGCTCGT
CGCGCTACTGCTGACGCTCGCGTTCGCCGGCATCGAGGCCGCGGCGGGCCTGTGGTCGGGCTCGCTCGCGCTGCTCTCCG
ACGCCGCGCACATGGTCGCCGACAGTTCGGCGCTCGGACTCGCCGCGGCAGCGGCCTGGCTCGCGCGGCGCCCGCCGAGC
ATGCGCCACTCCTACGGCCTCGTGCGCGCCGAGGTGCTCGCGGCGCTGCTCAACAGCCTGCTCGTGCTCGTGCTGGTCGG
CTTCATCGTGCACGAAGCGCTCGAACGCATCGGCAGCCCGCGCGACGTCGCCGGCGGCGCCGTCATCGGCGTCGCCGTAA
TCGGTCTCGCGGTCAACCTGACGGTCGCCTGGGTGCTCTCGCGCGGCGCGCACAGCCTCAACAGCCGCGCCGCCCTGCTC
CACGTGCTCGGCGACGCGCTCGGCTCGGTCGCGGCGATCGCCGCCGGCATCGTCGTCGTCACGACCGGCTGGACGCCGAT
CGACCCGCTGCTGTCGATCCTCGTCGCCGTCTTGATCCTCGTCTCCGCGCTGCGGCTGCTGCGCGAGGTCGTCCACGTGC
TGATGGAAGGCGTGCCGCTCGACGTCGAACTCGAAGCGGTCGGCCGCGACCTCGCCGCGCTCGACGGCGTGCTGCGCGTT
CACGACCTGCACGTGTGGACCCTCTCGACCGGCACCGTGGCGCTCTCGGCCCACCTGGAACTGCGCGACCTCGCCGACTG
GCCGGGCATTCTCGCGGCCGCGCGCAGGGACATGGACGCGCGGCACGGCATCCGCCACGTCACGCTGCAACCCGAGACGC
TCGCCGCGCTGCCCCTGCAGCGCGCGGAATGGCCGCCGCGGGAAAGCCGCCCGCACGGCTGA

Upstream 100 bases:

>100_bases
GCGCTGCGCGAATCGGCGCGTTATGCCGAGGCGCTGCACCACGTCGCCGGGCTCGGCCGGGATTCCGCCGAACTCGATCT
GTCCGACCCGACCGACTACT

Downstream 100 bases:

>100_bases
TGAGTCAGGCGAGCGGCCGCCAGGCCGCCGTCGCGCCGCGCGTTCGTGGCTCCGCCGGGTCTTGCGGTCACACCCGATAA
CCCGTTTCGCCCGTTTTTGG

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MAAHKHDHAGHTHFHGAHAGGSRTLLVALLLTLAFAGIEAAAGLWSGSLALLSDAAHMVADSSALGLAAAAAWLARRPPS
MRHSYGLVRAEVLAALLNSLLVLVLVGFIVHEALERIGSPRDVAGGAVIGVAVIGLAVNLTVAWVLSRGAHSLNSRAALL
HVLGDALGSVAAIAAGIVVVTTGWTPIDPLLSILVAVLILVSALRLLREVVHVLMEGVPLDVELEAVGRDLAALDGVLRV
HDLHVWTLSTGTVALSAHLELRDLADWPGILAAARRDMDARHGIRHVTLQPETLAALPLQRAEWPPRESRPHG

Sequences:

>Translated_313_residues
MAAHKHDHAGHTHFHGAHAGGSRTLLVALLLTLAFAGIEAAAGLWSGSLALLSDAAHMVADSSALGLAAAAAWLARRPPS
MRHSYGLVRAEVLAALLNSLLVLVLVGFIVHEALERIGSPRDVAGGAVIGVAVIGLAVNLTVAWVLSRGAHSLNSRAALL
HVLGDALGSVAAIAAGIVVVTTGWTPIDPLLSILVAVLILVSALRLLREVVHVLMEGVPLDVELEAVGRDLAALDGVLRV
HDLHVWTLSTGTVALSAHLELRDLADWPGILAAARRDMDARHGIRHVTLQPETLAALPLQRAEWPPRESRPHG
>Mature_312_residues
AAHKHDHAGHTHFHGAHAGGSRTLLVALLLTLAFAGIEAAAGLWSGSLALLSDAAHMVADSSALGLAAAAAWLARRPPSM
RHSYGLVRAEVLAALLNSLLVLVLVGFIVHEALERIGSPRDVAGGAVIGVAVIGLAVNLTVAWVLSRGAHSLNSRAALLH
VLGDALGSVAAIAAGIVVVTTGWTPIDPLLSILVAVLILVSALRLLREVVHVLMEGVPLDVELEAVGRDLAALDGVLRVH
DLHVWTLSTGTVALSAHLELRDLADWPGILAAARRDMDARHGIRHVTLQPETLAALPLQRAEWPPRESRPHG

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=29.9674267100977, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI21359890, Length=299, Percent_Identity=28.7625418060201, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI21361112, Length=314, Percent_Identity=31.5286624203822, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI64762489, Length=255, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI289803013, Length=307, Percent_Identity=30.9446254071661, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI289803009, Length=307, Percent_Identity=30.9446254071661, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI289803007, Length=307, Percent_Identity=30.9446254071661, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI289803003, Length=307, Percent_Identity=30.9446254071661, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI20070323, Length=326, Percent_Identity=28.5276073619632, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI14210520, Length=219, Percent_Identity=30.1369863013699, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI222080086, Length=126, Percent_Identity=38.8888888888889, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI40255009, Length=126, Percent_Identity=38.8888888888889, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI52351208, Length=172, Percent_Identity=31.3953488372093, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI52352803, Length=214, Percent_Identity=26.6355140186916, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786966, Length=276, Percent_Identity=41.304347826087, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=31.0975609756098, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17555794, Length=310, Percent_Identity=31.9354838709677, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17555796, Length=282, Percent_Identity=32.2695035460993, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564488, Length=297, Percent_Identity=29.6296296296296, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550440, Length=123, Percent_Identity=34.1463414634146, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17550442, Length=123, Percent_Identity=34.1463414634146, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=152, Percent_Identity=33.5526315789474, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=176, Percent_Identity=34.6590909090909, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=152, Percent_Identity=30.9210526315789, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583858, Length=334, Percent_Identity=29.940119760479, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24584409, Length=150, Percent_Identity=34.6666666666667, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574430, Length=150, Percent_Identity=34.6666666666667, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656728, Length=145, Percent_Identity=40.6896551724138, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656724, Length=145, Percent_Identity=40.6896551724138, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656720, Length=145, Percent_Identity=40.6896551724138, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656715, Length=145, Percent_Identity=40.6896551724138, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357035, Length=145, Percent_Identity=40.6896551724138, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645863, Length=120, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32720; Mature: 32588

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHKHDHAGHTHFHGAHAGGSRTLLVALLLTLAFAGIEAAAGLWSGSLALLSDAAHMVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
DSSALGLAAAAAWLARRPPSMRHSYGLVRAEVLAALLNSLLVLVLVGFIVHEALERIGSP
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RDVAGGAVIGVAVIGLAVNLTVAWVLSRGAHSLNSRAALLHVLGDALGSVAAIAAGIVVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
TTGWTPIDPLLSILVAVLILVSALRLLREVVHVLMEGVPLDVELEAVGRDLAALDGVLRV
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHH
HDLHVWTLSTGTVALSAHLELRDLADWPGILAAARRDMDARHGIRHVTLQPETLAALPLQ
EEEEEEEEECCCEEEEECCHHHHHHCCHHHHHHHHHCCHHHCCCEEEEECCHHHHHCCCH
RAEWPPRESRPHG
HCCCCCCCCCCCC
>Mature Secondary Structure 
AAHKHDHAGHTHFHGAHAGGSRTLLVALLLTLAFAGIEAAAGLWSGSLALLSDAAHMVA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
DSSALGLAAAAAWLARRPPSMRHSYGLVRAEVLAALLNSLLVLVLVGFIVHEALERIGSP
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RDVAGGAVIGVAVIGLAVNLTVAWVLSRGAHSLNSRAALLHVLGDALGSVAAIAAGIVVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
TTGWTPIDPLLSILVAVLILVSALRLLREVVHVLMEGVPLDVELEAVGRDLAALDGVLRV
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHH
HDLHVWTLSTGTVALSAHLELRDLADWPGILAAARRDMDARHGIRHVTLQPETLAALPLQ
EEEEEEEEECCCEEEEECCHHHHHHCCHHHHHHHHHCCHHHCCCEEEEECCHHHHHCCCH
RAEWPPRESRPHG
HCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]