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The map label for this gene is uvrC

Identifier: 74316719

GI number: 74316719

Start: 742011

End: 743807

Strand: Reverse

Name: uvrC

Synonym: Tbd_0701

Alternate gene names: 74316719

Gene position: 743807-742011 (Counterclockwise)

Preceding gene: 74316720

Following gene: 74316718

Centisome position: 25.56

GC content: 66.39

Gene sequence:

>1797_bases
GTGAGCGTCGACAAGGAATTTCTCGCCTCGCTGCCCACCCTTCCGGGTGTTTATCGCATGGTCGACGCGGCCGGCGCGGT
GCTCTATGTCGGCAAGGCGAAAGATCTGCGCAAACGCGTCGGCAGCTATTTCCTCAAGACCGACCAAAGTCCGCGCATCC
GGCTGATGCTGAAGAGCGTCGATCACATCGACACGACGGTGACGCGCACCGAGGCCGAAGCGCTGCTGCTCGAGAACAAC
CTGATCAAGGGCCTCAAGCCGCGGTTCAACATCCTGTTCCGCGACGACAAGTCCTACCCCTACCTGCTGCTGACCGGCCA
CGGCTACCCGCGCCTGGCGTATTTTCGCGGCGCGCCGAAGAAACGCGACCAGGCCTTCGGCCCCTACCCCAATTCCTACG
CGGTGCGCGAGAGCATCCAGCTCCTGCAGAAGGTGTTCCAGTTGCGCACCTGCGAAGACACGGTGTTCGGCAACCGCTCG
CGCCCCTGTCTGCTGCATCAGATCAAGCGCTGCAGCGCGCCCTGCGTCAGCCTCGTCAGCGCGGAGACCTACGCGCGCGA
CGTCGCCGAGGCCATGCTGCTGCTCAAGGGCGAAGCGACGGCGCTGACCGAGGAAATCACGGCGCAGATGAACGCCGCGG
CGGAAAACCTCGACTTCGAGACCGCAGCCTATCTGCGTGACCGGCTGCGCATGCTCGCGACCGTGCGCGAAAAGCAGTTC
GTCGACACCACCGGCAGCGAGGCCGACGCCGACGTCGTCGCCGTCGCCGAGGTCGGCGGCGTCATCGCGGTCAACCTGAC
CATGATCCGCGGCGGCCGCCATCTCGGCGACCGCAGCTTCTTTCCGCAACACGGCGAAGGGGCGGCGCTCGGCGAAGCGC
TCGAAGCCTTCGTCGCGCAGCACTACCTCGATCACCCGATCCCGGCGCGCATCCTGGTCAGCGAGGCGATCGACAGCGCC
GCGCTGCAGACGCTGCTGAGCGAACAGGCCGGCAAGAAGGTCACGCTGCAGCATCGCGTCACCGGCGAGCGTCGCGTCTG
GATCGCGATGGCGCAGGCCAACGCGCGACTCTCGGCCGAGCGCCGCAGCGCGGACCGCGCCAACCAGTCGCAGCGCCTCG
CCGCGCTGCGCGATACGCTCGAACTGCCGACGCTCAACCGTATCGAATGCTTCGACATTTCACACACCATGGGTGAGGCG
ACGATCGCATCCTGCGTCGTCTACGAAGGCGACGACCTCAAGAAATCGGACTACCGCCGCTACAACATCGAGGGCATCAC
GCCGGGCGACGACTACGCCGCGATGCACGCCGCGCTGATCAAGCGCTTCCACCGCACGGTCGAGGAAAACGGCGTGCTGC
CCGACCTGCTGCTGATCGACGGCGGCAAAGGGCAGGTCGCGATGGCGGTCGAGGCCTTAGCCGAGCTCGGCATCGACGAC
GTCCTGCTACTCGGCGTCGCCAAGGGCGAAAGCCGCAAGCCGGGCCTCGAGACGCTGATCTTCGCCGACGGCCGCGAACT
GAAGCTTGCCCGCGATCATCCCGGTTTCCACCTGATTCAGCAGGTACGCGACGAGGCGCACCGGTTCGCGATCACGGGCC
ACCGGGCCAAGCGCGGCAAGGCGCGCGTGCAGTCGACGCTCGAGGACATCGCCGGCATCGGGCCGAAGCGCCGCAAGCAG
CTGCTCGAACACTTCGGCGGGCTGCAGGGCGTGCGCAACGCGGGCGTGGACGCCCTTGCCTCGGTCAACGGTATCAGCCG
AGAATTGGCGGAAATCATCTATAACGCGCTCCATTGA

Upstream 100 bases:

>100_bases
AATGATTTGCCGCGAGATCGCTCCAACACGCATCGGGGTTTCTCTGTGAAGCGGTCGGCGTGACCGCGCCTGCGCCGCGC
CCTCGCGGCCGCTTTCCACC

Downstream 100 bases:

>100_bases
CCCGATGCCGCTCAATCTCCCGAACCTGCTGACCTGGCTGCGCATCCTGTTCATTCCGCTCATGGCGGGGGTGTTCTATC
TTCCCGACGGCTGGGTCACG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MSVDKEFLASLPTLPGVYRMVDAAGAVLYVGKAKDLRKRVGSYFLKTDQSPRIRLMLKSVDHIDTTVTRTEAEALLLENN
LIKGLKPRFNILFRDDKSYPYLLLTGHGYPRLAYFRGAPKKRDQAFGPYPNSYAVRESIQLLQKVFQLRTCEDTVFGNRS
RPCLLHQIKRCSAPCVSLVSAETYARDVAEAMLLLKGEATALTEEITAQMNAAAENLDFETAAYLRDRLRMLATVREKQF
VDTTGSEADADVVAVAEVGGVIAVNLTMIRGGRHLGDRSFFPQHGEGAALGEALEAFVAQHYLDHPIPARILVSEAIDSA
ALQTLLSEQAGKKVTLQHRVTGERRVWIAMAQANARLSAERRSADRANQSQRLAALRDTLELPTLNRIECFDISHTMGEA
TIASCVVYEGDDLKKSDYRRYNIEGITPGDDYAAMHAALIKRFHRTVEENGVLPDLLLIDGGKGQVAMAVEALAELGIDD
VLLLGVAKGESRKPGLETLIFADGRELKLARDHPGFHLIQQVRDEAHRFAITGHRAKRGKARVQSTLEDIAGIGPKRRKQ
LLEHFGGLQGVRNAGVDALASVNGISRELAEIIYNALH

Sequences:

>Translated_598_residues
MSVDKEFLASLPTLPGVYRMVDAAGAVLYVGKAKDLRKRVGSYFLKTDQSPRIRLMLKSVDHIDTTVTRTEAEALLLENN
LIKGLKPRFNILFRDDKSYPYLLLTGHGYPRLAYFRGAPKKRDQAFGPYPNSYAVRESIQLLQKVFQLRTCEDTVFGNRS
RPCLLHQIKRCSAPCVSLVSAETYARDVAEAMLLLKGEATALTEEITAQMNAAAENLDFETAAYLRDRLRMLATVREKQF
VDTTGSEADADVVAVAEVGGVIAVNLTMIRGGRHLGDRSFFPQHGEGAALGEALEAFVAQHYLDHPIPARILVSEAIDSA
ALQTLLSEQAGKKVTLQHRVTGERRVWIAMAQANARLSAERRSADRANQSQRLAALRDTLELPTLNRIECFDISHTMGEA
TIASCVVYEGDDLKKSDYRRYNIEGITPGDDYAAMHAALIKRFHRTVEENGVLPDLLLIDGGKGQVAMAVEALAELGIDD
VLLLGVAKGESRKPGLETLIFADGRELKLARDHPGFHLIQQVRDEAHRFAITGHRAKRGKARVQSTLEDIAGIGPKRRKQ
LLEHFGGLQGVRNAGVDALASVNGISRELAEIIYNALH
>Mature_597_residues
SVDKEFLASLPTLPGVYRMVDAAGAVLYVGKAKDLRKRVGSYFLKTDQSPRIRLMLKSVDHIDTTVTRTEAEALLLENNL
IKGLKPRFNILFRDDKSYPYLLLTGHGYPRLAYFRGAPKKRDQAFGPYPNSYAVRESIQLLQKVFQLRTCEDTVFGNRSR
PCLLHQIKRCSAPCVSLVSAETYARDVAEAMLLLKGEATALTEEITAQMNAAAENLDFETAAYLRDRLRMLATVREKQFV
DTTGSEADADVVAVAEVGGVIAVNLTMIRGGRHLGDRSFFPQHGEGAALGEALEAFVAQHYLDHPIPARILVSEAIDSAA
LQTLLSEQAGKKVTLQHRVTGERRVWIAMAQANARLSAERRSADRANQSQRLAALRDTLELPTLNRIECFDISHTMGEAT
IASCVVYEGDDLKKSDYRRYNIEGITPGDDYAAMHAALIKRFHRTVEENGVLPDLLLIDGGKGQVAMAVEALAELGIDDV
LLLGVAKGESRKPGLETLIFADGRELKLARDHPGFHLIQQVRDEAHRFAITGHRAKRGKARVQSTLEDIAGIGPKRRKQL
LEHFGGLQGVRNAGVDALASVNGISRELAEIIYNALH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=604, Percent_Identity=48.3443708609272, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1788037, Length=190, Percent_Identity=31.0526315789474, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_THIDA (Q3SKW8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314459.1
- ProteinModelPortal:   Q3SKW8
- STRING:   Q3SKW8
- GeneID:   3672672
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0701
- NMPDR:   fig|292415.3.peg.795
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q3SKW8
- BioCyc:   TDEN292415:TBD_0701-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 65968; Mature: 65837

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2; PS00034 PAIRED_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDKEFLASLPTLPGVYRMVDAAGAVLYVGKAKDLRKRVGSYFLKTDQSPRIRLMLKSV
CCCCHHHHHHCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEHHHHHH
DHIDTTVTRTEAEALLLENNLIKGLKPRFNILFRDDKSYPYLLLTGHGYPRLAYFRGAPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCCC
KRDQAFGPYPNSYAVRESIQLLQKVFQLRTCEDTVFGNRSRPCLLHQIKRCSAPCVSLVS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCHHHHHHH
AETYARDVAEAMLLLKGEATALTEEITAQMNAAAENLDFETAAYLRDRLRMLATVREKQF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VDTTGSEADADVVAVAEVGGVIAVNLTMIRGGRHLGDRSFFPQHGEGAALGEALEAFVAQ
HCCCCCCCCCCEEEEEHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
HYLDHPIPARILVSEAIDSAALQTLLSEQAGKKVTLQHRVTGERRVWIAMAQANARLSAE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCHHHHH
RRSADRANQSQRLAALRDTLELPTLNRIECFDISHTMGEATIASCVVYEGDDLKKSDYRR
HHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECHHHHCHHHHHEEEEECCCCCCCCCCCE
YNIEGITPGDDYAAMHAALIKRFHRTVEENGVLPDLLLIDGGKGQVAMAVEALAELGIDD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
VLLLGVAKGESRKPGLETLIFADGRELKLARDHPGFHLIQQVRDEAHRFAITGHRAKRGK
EEEEEECCCCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHEEEECCCCHHHH
ARVQSTLEDIAGIGPKRRKQLLEHFGGLQGVRNAGVDALASVNGISRELAEIIYNALH
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVDKEFLASLPTLPGVYRMVDAAGAVLYVGKAKDLRKRVGSYFLKTDQSPRIRLMLKSV
CCCHHHHHHCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEHHHHHH
DHIDTTVTRTEAEALLLENNLIKGLKPRFNILFRDDKSYPYLLLTGHGYPRLAYFRGAPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCCC
KRDQAFGPYPNSYAVRESIQLLQKVFQLRTCEDTVFGNRSRPCLLHQIKRCSAPCVSLVS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCCHHHHHHH
AETYARDVAEAMLLLKGEATALTEEITAQMNAAAENLDFETAAYLRDRLRMLATVREKQF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VDTTGSEADADVVAVAEVGGVIAVNLTMIRGGRHLGDRSFFPQHGEGAALGEALEAFVAQ
HCCCCCCCCCCEEEEEHHCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
HYLDHPIPARILVSEAIDSAALQTLLSEQAGKKVTLQHRVTGERRVWIAMAQANARLSAE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEEECCCCHHHHH
RRSADRANQSQRLAALRDTLELPTLNRIECFDISHTMGEATIASCVVYEGDDLKKSDYRR
HHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECHHHHCHHHHHEEEEECCCCCCCCCCCE
YNIEGITPGDDYAAMHAALIKRFHRTVEENGVLPDLLLIDGGKGQVAMAVEALAELGIDD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
VLLLGVAKGESRKPGLETLIFADGRELKLARDHPGFHLIQQVRDEAHRFAITGHRAKRGK
EEEEEECCCCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHEEEECCCCHHHH
ARVQSTLEDIAGIGPKRRKQLLEHFGGLQGVRNAGVDALASVNGISRELAEIIYNALH
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA