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The map label for this gene is kbl [C]

Identifier: 74316687

GI number: 74316687

Start: 709675

End: 711015

Strand: Reverse

Name: kbl [C]

Synonym: Tbd_0669

Alternate gene names: 74316687

Gene position: 711015-709675 (Counterclockwise)

Preceding gene: 74316690

Following gene: 74316686

Centisome position: 24.44

GC content: 63.24

Gene sequence:

>1341_bases
ATGGCCACATGTCCAGATTGTTTCTGCCGTGTGGACTCCTACATTTCAGCATCGTCGCATGGGCCCATGGGACACGTACA
CGAACATCCGAAGGACGTACAGGAGACCACCATGAACGATTTAGCCCCGGTCGAAGACGCGATGCTCAATGGCGATTTGT
TTGCGAAAGCCTTTGTCGCGAGGAAACACAGCGCACTGAACCGCGTGAAACCGGAATACCTCGCGCTGGCCATGCGCAAG
ATCGATGCCGTGAGCGAACGTGAAGTCGTCTTCGCGGGGCGCCGGATGCTCATGCTGTCGTCCAACAACTATCTCGGACT
GGCGAGCGACCCTCGCCTCTCGCAGGCCGGCGTCGAGGCGATCCGCTACTGGGGCAACAGCACCAGCGGCAGCCGGCTGC
TCAACGGGACCAACGACCTGCACGAGGAACTCGAACGCAAGCTGTCATGGTTCAAGCAGGTCGAAACGGTCGTCGCCTTC
CAGAGCGGCTACATGGCGAATCTCGGCGTGCTGAGCGCGCTGCTCTCGAAAGACGACGTCGCGATCGTCGACAAGCTCGT
GCACGCCAGCATCCTCGACGGGTGCGCGCTCGCCCATGCGCAGGTGCGCAGCTTTCGCCACCAGGACATGGCGTCGCTCG
AGCGCGTCCTCAACGACGTCGGACACAAGGCGAACAAGCTCATCGTAGTCGACGGCATCTACAGCATGGACGGCGATTTT
GCGCGGCTGCCCGAGATCATGGCGCTCGCGCGGCGCTACGGCGCGCGCGTGATGGTCGACGACGCGCACGCGACCGGCGT
CGCCGGGCCGCACGGACGCGGCACCGCCGATCATTTCGGCATCGACGAGCCCGACATCATCACCGGCACGCTGTCCAAGG
CCTTCGGCTGCATCGGCGGCTTCGTCGGCGCCACGAAGGAGGTGATGGACTTCATCAAGTACAACTCGCACGCCTTCATC
TATTCGACCAGCATCAGCCCGTCGGTCACGGCCTCGCTGATCCGGGCCGTACGCATCATCGAGGACGAGCCGCAGAAGCG
CGTCAACCTGTGGGCCTGCACCCACCACCTGCTGAGCGGGCTGAAATCGCTCGGCTTCGATACCGGCGTGAGCGAAACGC
CGATCATCCCGATCGTGCTCGGCGATGAAATCACGATGTTCGAACTGGTCGCGCGCATGGACGCCGACGACATCTTCGCG
AGCCCGGTGATCTATCCGGCGTGTCCCCGCAACAAGCCGCGCGTACGCATCAGCCTCTGTGCCGAGCACACCCTTTCGGA
CATGGACCGGGTGCTCGATTCGGTCTCGCGCCACGGCCGCGACCTCGGCATCATCCAGTAA

Upstream 100 bases:

>100_bases
AAAAATATAACACCTGTGCTACCCGCTCACCATGTCCCATTCGTCTAGGTCGGCTGCGTTTCCATCTAGCCATCCGGGTG
GGGTCGCGTCTCCCCCTTTG

Downstream 100 bases:

>100_bases
CGGGAGGCCGTCATGTCGGAAACGATCGCCGCGCGGCTGCTGACGCTGCACGACCGGCTGGCGCGGGCCGCACTCGACTG
CGCGCGTGATCCGCGCGCCG

Product: glycine C-acetyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MATCPDCFCRVDSYISASSHGPMGHVHEHPKDVQETTMNDLAPVEDAMLNGDLFAKAFVARKHSALNRVKPEYLALAMRK
IDAVSEREVVFAGRRMLMLSSNNYLGLASDPRLSQAGVEAIRYWGNSTSGSRLLNGTNDLHEELERKLSWFKQVETVVAF
QSGYMANLGVLSALLSKDDVAIVDKLVHASILDGCALAHAQVRSFRHQDMASLERVLNDVGHKANKLIVVDGIYSMDGDF
ARLPEIMALARRYGARVMVDDAHATGVAGPHGRGTADHFGIDEPDIITGTLSKAFGCIGGFVGATKEVMDFIKYNSHAFI
YSTSISPSVTASLIRAVRIIEDEPQKRVNLWACTHHLLSGLKSLGFDTGVSETPIIPIVLGDEITMFELVARMDADDIFA
SPVIYPACPRNKPRVRISLCAEHTLSDMDRVLDSVSRHGRDLGIIQ

Sequences:

>Translated_446_residues
MATCPDCFCRVDSYISASSHGPMGHVHEHPKDVQETTMNDLAPVEDAMLNGDLFAKAFVARKHSALNRVKPEYLALAMRK
IDAVSEREVVFAGRRMLMLSSNNYLGLASDPRLSQAGVEAIRYWGNSTSGSRLLNGTNDLHEELERKLSWFKQVETVVAF
QSGYMANLGVLSALLSKDDVAIVDKLVHASILDGCALAHAQVRSFRHQDMASLERVLNDVGHKANKLIVVDGIYSMDGDF
ARLPEIMALARRYGARVMVDDAHATGVAGPHGRGTADHFGIDEPDIITGTLSKAFGCIGGFVGATKEVMDFIKYNSHAFI
YSTSISPSVTASLIRAVRIIEDEPQKRVNLWACTHHLLSGLKSLGFDTGVSETPIIPIVLGDEITMFELVARMDADDIFA
SPVIYPACPRNKPRVRISLCAEHTLSDMDRVLDSVSRHGRDLGIIQ
>Mature_445_residues
ATCPDCFCRVDSYISASSHGPMGHVHEHPKDVQETTMNDLAPVEDAMLNGDLFAKAFVARKHSALNRVKPEYLALAMRKI
DAVSEREVVFAGRRMLMLSSNNYLGLASDPRLSQAGVEAIRYWGNSTSGSRLLNGTNDLHEELERKLSWFKQVETVVAFQ
SGYMANLGVLSALLSKDDVAIVDKLVHASILDGCALAHAQVRSFRHQDMASLERVLNDVGHKANKLIVVDGIYSMDGDFA
RLPEIMALARRYGARVMVDDAHATGVAGPHGRGTADHFGIDEPDIITGTLSKAFGCIGGFVGATKEVMDFIKYNSHAFIY
STSISPSVTASLIRAVRIIEDEPQKRVNLWACTHHLLSGLKSLGFDTGVSETPIIPIVLGDEITMFELVARMDADDIFAS
PVIYPACPRNKPRVRISLCAEHTLSDMDRVLDSVSRHGRDLGIIQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=352, Percent_Identity=36.9318181818182, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI284448556, Length=352, Percent_Identity=36.9318181818182, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=32.7823691460055, Blast_Score=202, Evalue=7e-52,
Organism=Homo sapiens, GI119220554, Length=371, Percent_Identity=30.9973045822102, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI83977440, Length=360, Percent_Identity=29.4444444444444, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI83977442, Length=360, Percent_Identity=29.4444444444444, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI83977444, Length=360, Percent_Identity=29.4444444444444, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI5454084, Length=307, Percent_Identity=28.9902280130293, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI4502025, Length=368, Percent_Identity=28.2608695652174, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI40316939, Length=368, Percent_Identity=28.2608695652174, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1790046, Length=385, Percent_Identity=33.5064935064935, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=30.9859154929577, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=361, Percent_Identity=32.409972299169, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=32.425068119891, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=371, Percent_Identity=32.0754716981132, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=371, Percent_Identity=32.0754716981132, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71982625, Length=391, Percent_Identity=25.5754475703325, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=391, Percent_Identity=25.5754475703325, Blast_Score=134, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=32.8767123287671, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6320438, Length=402, Percent_Identity=29.6019900497512, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=255, Percent_Identity=29.0196078431373, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24662918, Length=374, Percent_Identity=32.3529411764706, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=33.2432432432432, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=30.028328611898, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24653280, Length=299, Percent_Identity=26.4214046822742, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24653276, Length=299, Percent_Identity=26.4214046822742, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24653278, Length=299, Percent_Identity=26.4214046822742, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 48833; Mature: 48702

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00028 ZINC_FINGER_C2H2_1 ; PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATCPDCFCRVDSYISASSHGPMGHVHEHPKDVQETTMNDLAPVEDAMLNGDLFAKAFVA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
RKHSALNRVKPEYLALAMRKIDAVSEREVVFAGRRMLMLSSNNYLGLASDPRLSQAGVEA
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
IRYWGNSTSGSRLLNGTNDLHEELERKLSWFKQVETVVAFQSGYMANLGVLSALLSKDDV
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHH
AIVDKLVHASILDGCALAHAQVRSFRHQDMASLERVLNDVGHKANKLIVVDGIYSMDGDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCH
ARLPEIMALARRYGARVMVDDAHATGVAGPHGRGTADHFGIDEPDIITGTLSKAFGCIGG
HHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
FVGATKEVMDFIKYNSHAFIYSTSISPSVTASLIRAVRIIEDEPQKRVNLWACTHHLLSG
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LKSLGFDTGVSETPIIPIVLGDEITMFELVARMDADDIFASPVIYPACPRNKPRVRISLC
HHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHCCCCEECCCCCCCCCEEEEEH
AEHTLSDMDRVLDSVSRHGRDLGIIQ
HHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATCPDCFCRVDSYISASSHGPMGHVHEHPKDVQETTMNDLAPVEDAMLNGDLFAKAFVA
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHH
RKHSALNRVKPEYLALAMRKIDAVSEREVVFAGRRMLMLSSNNYLGLASDPRLSQAGVEA
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
IRYWGNSTSGSRLLNGTNDLHEELERKLSWFKQVETVVAFQSGYMANLGVLSALLSKDDV
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHH
AIVDKLVHASILDGCALAHAQVRSFRHQDMASLERVLNDVGHKANKLIVVDGIYSMDGDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCH
ARLPEIMALARRYGARVMVDDAHATGVAGPHGRGTADHFGIDEPDIITGTLSKAFGCIGG
HHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHH
FVGATKEVMDFIKYNSHAFIYSTSISPSVTASLIRAVRIIEDEPQKRVNLWACTHHLLSG
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LKSLGFDTGVSETPIIPIVLGDEITMFELVARMDADDIFASPVIYPACPRNKPRVRISLC
HHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHCCCCEECCCCCCCCCEEEEEH
AEHTLSDMDRVLDSVSRHGRDLGIIQ
HHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA