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The map label for this gene is pdhA [H]

Identifier: 74316673

GI number: 74316673

Start: 695706

End: 696707

Strand: Reverse

Name: pdhA [H]

Synonym: Tbd_0655

Alternate gene names: 74316673

Gene position: 696707-695706 (Counterclockwise)

Preceding gene: 74316675

Following gene: 74316672

Centisome position: 23.94

GC content: 63.37

Gene sequence:

>1002_bases
ATGAAGATTGAAGACAAGAAACGTGTGCTGCGCGAAATGGTGTTGCACCGCCGTTTTGAAGAGCGCTGTTATCAGGCTTA
TATCGAACGCAAGATCGGCGGTTTCCTGCACCTCTACCCGGGTCAGGAAGCGTGCTGCAACGGCGTCATGGAAGCCGCGC
GCCCCGGGCACGACTACGTGATCACCGGCTACCGCGATCACGTGCACGCGATCAAGTGCGGCGCCGATCCGAAGGAAGTC
ATGGCCGAGCTGTACGGCAAGGAAACCGGCTCATCCAAGGGCCGCGGCGGCTCGATGCACATCTTCGACGCGGGCAAGCG
TTTCATGGGCGGCTACGCGCTGGTCGGCGGTCCCTTCCCGCTCGCCGCCGGCATCGCCAAGGCGATCCAGCTGAAGGGCG
GCGACGAGATCGCGATCTGCTTCCTCGGTGACGCGGCCAACAACCAGGGCACCTTCCACGAGACCATGAACATGGCCGCG
CTGTGGAAGCTGCCGGTGCTGTTCGTCTGCGAGAACAACCTCTACGGCATCGGCACCTCGATCGAGCGCTCGACCGCCGT
CGTGCACCAGCACAAGCGCGTCGCGGCCTACAACATTCCCGCCGACGAATGCGACGGCCAGGACATCGAGGTCGTCTACG
AGCACGCACGCAAGGCCGTCGATCACGTGCGCGCGGGCAACGGCCCGTTCTTCCTCGAACTGATGACCTACCGCTATCGC
GGCCACTCGATGTCCGACTCACGCGGCTATCGCACGCGCGAGGAAGAAGAACTGTGGAAGCAGCGCGACCCGATCTTCAT
CCTGCGCGACCGCCTGATCAAGGAAGGCGCGACGACGATGGCCGAATTCGAGGCGCTCGAGAAGGAAACCGACGCCTACA
TCGAGAACGAGGTCATCAAGTTCGCCGAAGCCTCGCCCGAGCCGAGCGTCGACGAACTCGAGAAATACGTACTCGCCGAT
CGCGAGAGCCAGCTGCCCTGGCTCACCGGCAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
GGGAGAGGCGTTTTCTTGATGGTCGACGGGGTTTCTCGGATAATTGCGCGTTTGCATTTTCCCGGCGCTTTTTCCGAGCC
CGTCCGACAAGGGTAACCGA

Downstream 100 bases:

>100_bases
GGCCGGCGCCGCGTTCACGCGACACTGAATCAGAAGGAATAAACAGCATGGCAAACATCATGTACTGGGAGGCGATCCAG
CGCGCCCACGACGAAGAAAT

Product: dehydrogenase complex, E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKIEDKKRVLREMVLHRRFEERCYQAYIERKIGGFLHLYPGQEACCNGVMEAARPGHDYVITGYRDHVHAIKCGADPKEV
MAELYGKETGSSKGRGGSMHIFDAGKRFMGGYALVGGPFPLAAGIAKAIQLKGGDEIAICFLGDAANNQGTFHETMNMAA
LWKLPVLFVCENNLYGIGTSIERSTAVVHQHKRVAAYNIPADECDGQDIEVVYEHARKAVDHVRAGNGPFFLELMTYRYR
GHSMSDSRGYRTREEEELWKQRDPIFILRDRLIKEGATTMAEFEALEKETDAYIENEVIKFAEASPEPSVDELEKYVLAD
RESQLPWLTGKAA

Sequences:

>Translated_333_residues
MKIEDKKRVLREMVLHRRFEERCYQAYIERKIGGFLHLYPGQEACCNGVMEAARPGHDYVITGYRDHVHAIKCGADPKEV
MAELYGKETGSSKGRGGSMHIFDAGKRFMGGYALVGGPFPLAAGIAKAIQLKGGDEIAICFLGDAANNQGTFHETMNMAA
LWKLPVLFVCENNLYGIGTSIERSTAVVHQHKRVAAYNIPADECDGQDIEVVYEHARKAVDHVRAGNGPFFLELMTYRYR
GHSMSDSRGYRTREEEELWKQRDPIFILRDRLIKEGATTMAEFEALEKETDAYIENEVIKFAEASPEPSVDELEKYVLAD
RESQLPWLTGKAA
>Mature_333_residues
MKIEDKKRVLREMVLHRRFEERCYQAYIERKIGGFLHLYPGQEACCNGVMEAARPGHDYVITGYRDHVHAIKCGADPKEV
MAELYGKETGSSKGRGGSMHIFDAGKRFMGGYALVGGPFPLAAGIAKAIQLKGGDEIAICFLGDAANNQGTFHETMNMAA
LWKLPVLFVCENNLYGIGTSIERSTAVVHQHKRVAAYNIPADECDGQDIEVVYEHARKAVDHVRAGNGPFFLELMTYRYR
GHSMSDSRGYRTREEEELWKQRDPIFILRDRLIKEGATTMAEFEALEKETDAYIENEVIKFAEASPEPSVDELEKYVLAD
RESQLPWLTGKAA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=43.7689969604863, Blast_Score=257, Evalue=9e-69,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=45.1923076923077, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=45.1923076923077, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI291084744, Length=319, Percent_Identity=44.2006269592476, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI291084757, Length=312, Percent_Identity=40.7051282051282, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI11386135, Length=320, Percent_Identity=28.125, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI258645172, Length=325, Percent_Identity=28.3076923076923, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32564172, Length=303, Percent_Identity=44.2244224422442, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17536047, Length=303, Percent_Identity=44.2244224422442, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI86563357, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321026, Length=303, Percent_Identity=43.8943894389439, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=40.5660377358491, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24639744, Length=304, Percent_Identity=41.1184210526316, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI28571106, Length=304, Percent_Identity=41.1184210526316, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24639740, Length=304, Percent_Identity=41.1184210526316, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=40.7166123778502, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21355903, Length=326, Percent_Identity=26.0736196319018, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37461; Mature: 37461

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEDKKRVLREMVLHRRFEERCYQAYIERKIGGFLHLYPGQEACCNGVMEAARPGHDYV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCEE
ITGYRDHVHAIKCGADPKEVMAELYGKETGSSKGRGGSMHIFDAGKRFMGGYALVGGPFP
EECCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHCCEEEECCCHH
LAAGIAKAIQLKGGDEIAICFLGDAANNQGTFHETMNMAALWKLPVLFVCENNLYGIGTS
HHHHHHHHHEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEECCCEEECCCC
IERSTAVVHQHKRVAAYNIPADECDGQDIEVVYEHARKAVDHVRAGNGPFFLELMTYRYR
CHHHHHHHHHHHHEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHC
GHSMSDSRGYRTREEEELWKQRDPIFILRDRLIKEGATTMAEFEALEKETDAYIENEVIK
CCCCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FAEASPEPSVDELEKYVLADRESQLPWLTGKAA
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIEDKKRVLREMVLHRRFEERCYQAYIERKIGGFLHLYPGQEACCNGVMEAARPGHDYV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCCEE
ITGYRDHVHAIKCGADPKEVMAELYGKETGSSKGRGGSMHIFDAGKRFMGGYALVGGPFP
EECCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHCCEEEECCCHH
LAAGIAKAIQLKGGDEIAICFLGDAANNQGTFHETMNMAALWKLPVLFVCENNLYGIGTS
HHHHHHHHHEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEECCCEEECCCC
IERSTAVVHQHKRVAAYNIPADECDGQDIEVVYEHARKAVDHVRAGNGPFFLELMTYRYR
CHHHHHHHHHHHHEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHC
GHSMSDSRGYRTREEEELWKQRDPIFILRDRLIKEGATTMAEFEALEKETDAYIENEVIK
CCCCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FAEASPEPSVDELEKYVLADRESQLPWLTGKAA
HHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA