Click here to switch to the map view.

The map label for this gene is pdhD [H]

Identifier: 74316670

GI number: 74316670

Start: 691241

End: 694237

Strand: Reverse

Name: pdhD [H]

Synonym: Tbd_0652

Alternate gene names: 74316670

Gene position: 694237-691241 (Counterclockwise)

Preceding gene: 74316671

Following gene: 74316669

Centisome position: 23.86

GC content: 67.97

Gene sequence:

>2997_bases
ATGAACCACTACGCCATCACCATGCCGCAGCTCTCGGACACCATGACCGAGGGCGTCGTCGTCACCTGGGAAAAGCAGCC
GGGGGACCGCGTCGAGCGCGGCGACATCGTCGCGACGGTCGAGACCGACAAGGCGATCATGGACGTCGAGGTGTTCAAGG
CCGGCTATCTGGCCGGCCCGCTCGCCGACGTCGGCGCGACGATCGCGGTCGGGGCGGCGCTCGGCTACATCACCGACACG
GCCGGGGACGTCGCGATCGCGGCCGACGAAGTCGTGGCGGAGCAGGCGCAGACGGAAATGATCCCGCACCATGCGGGCAC
GCCGATCGTCATGCCGCAGCTTTCCGACACGATGACCGAAGGCGTCGTCGTGACCTGGGAAAAGCAGCCCGGCGAAGCCA
TCAAGCGCGGCGACATCGTCGCCACGGTCGAGACCGACAAGGCGATCATGGACGTCGAGGTGTTCCAGGAGGGCTTCCTG
TCGGGGCCGATCGCCGACATCGGCAGCGTCGTCGAGGTCGGCCACCCGATGGCCTTCATCGTCGACGACGCCGCCAAGGC
GAACGACACGGGCGTGACCATTTCCGCCGACCACAAGGTCAAGGACACGCACAAGGTCGCCCCGCCCGCGGCTGACAAGC
CGGCGCATTTGCCGATTCCGAAGACTGCGCCTTCACAGGTCGCCGCAGCCGGTAACGCGGTGCCCGTACCGCGCCCGCAG
GGCCGCCAGGCAAGCCCGTACGCACGCAAGGTCGCCGCCCAGCTCGGGGTGAACCTCACGGGTCTTGCCGGCTCGGGACC
CTCGGGGGTCCTCGTCGCCGCCGACGTCGCGCGTGCGCGGCCGTCGATGCAGGAAGTCGCCCACGCGCTGCCGCAGGTCG
ACGTGCCGGGCCAGGGTCGCCCGATGACGTCGATGGAAAAGGCTGTCAGCCACGCGATGACCGCCTCGCTGACGCTGCCG
ACGTTCAATGTCACGGTGAACATCGACACCGCCGCGCTGACCGCCGCCACCAAGGCGAAGAAGGTCTCGGTGACGGTGGC
GATCGCGAAGGCCTGCTCGGTCGCGATGGCGAAGTTCCCGCGCATGAACTGGGCCTACCAGCCGGTCGACAAACTCGTCG
AGCGTGCGAATCACGACTTCGGCGTCGCTGTGATGTCGAACGACGGCGGCCTCGTCGTGCCGATCCTGCACGGCGTCGAG
AAAAAGTCGCTCGAGGCCCTCCAGGGGGACTGGACCGGACTCGTCGAGCGCGCGCGGGTCAGGAAGCTCGCCCCGCCCGA
GTATTCCAATCCGACCTTCACGATCTCCAATATGGGCATGCTCGGCGTGTCCCACTTCACCGCAATTCCGACGCCGGGCA
TTTCGGCGATCCTCGCGATCGCGGCCAACGGCCCGCAGGGCACGCCGTTCACGATCACGGGCGACCACCGCGTGCTGAAC
GGCGCGGACGTCGCGCTCTATCTCACGACGCTCAAGCAGACGATCGAAGCGCCGGACGCCTGGCTTTCCGGCGGCACGGC
CGCGGAAACGGCCGGCGCTGCCGCCACCACGAGCGCACCGGTCTCACCCATCCCCGAAGGCAACTGGGACGTCCAGGTCG
TCGTCGTCGGCGGCGGCCCCGGCGGCGAAGACTGCGCGCGCGACCTCGCCGACCACGGCGTCAAGGTGATGATGGTCAAC
AACGAGCCCTTCCCCGGCGGCGAATGCCTGTGGCGCGGCTGCATCCCGTCGAAGGCGTGGCGCGCCGCGGCGGACAACAT
CCGCAACCGCGCGCACGACGCCGAGATGGGCGTCGACGGCACGGCGAACCCCAAGCTCAACTGGGCGCAGGTCGAGAAGC
ACCGCCGCTGGGTGCAGACCAGCCGCGGCGAAATGGCGCTCAAGGCCGACAAGGGCATGAAGATCGACGTGCGCGAAGGC
TACGGCGAATTCGTCGACGCCCACACGCTGAAAATCACTCCGCCCGAAGGCGAGGCGTACACGGTCAGCTTCGGCGCCGC
AGTCATCGCGACCGGCGCGCCGGCTTTCGTTCCGCCGATCCCCGGCGCGCGCGAGAACCTGGCGACCGGCGGCGTCGTCA
CCTCCGACACGATCTGGAACCTCGCCAACCCGCCGAAGAAGCTCGGCATCGTCGGCGGCGGCGTGATCGGCGTCGAGATG
GCGCAGATCTTCCGTGACTTCGGCACCGAGGTGCTGATGCTCGAGCGCCACGACCGCATCCTCGCCGAAATCGAGGAGGA
GATCGGCAAGGTCCTGATCGCCTCGCTGGAGAAGGAAATCACGGTCGTGACCAGCGCCGACATCAGGGAAGTCGGCGGCA
AGCCCGGCAAGATGACGTTGCGCTACGCCGACAAGGAAGGCGCCGAATCGACCTTCGACTGCGACGTCGTGTTGATGGCG
ACCGGCAAGCGTCCCGACACCAGCCGGCTCAACCTCGACAAGGTCGGCGTCGCGCTCGACGGCGCGGCGATCAAGGTCGA
CGCCCGCTGCTGCACGAGCACGCCGAACATCTACGCCGTCGGCGACGTCATCGGCGGCTACATGCTCGCACACACCGCCG
CGACGCAGGGCCGCGTCGCCGCATCGAACCTGCTCGGCCACGCCAGCGAGTACGACCAGGACCGTGATTGCGGCGTGACC
TTCTCGCGCCCGCAGGCCGGCTTCGTGGGCCTCTCGGTCGCACAGGCCAAGGCCAAGGGCATCGACGCGGTCGAAGCGAA
GATGCCGATGAGTATCGACGCCAAGGCGATGATCACCGGCGAGACCGAGGGCATGATCAAGCTCGTCGCCGACAAGACGA
CCGGCCGCATCATCGGCGTGCATTATCTGGCCGACCACACCGACACGCTGATCGGCACCGGCGTGATGATGGTCGCAGGC
GAGATGACGCTGACTCAGGTCGCGAAGGCGATCTTCCCGCACCCGACGCAGACCGAACTCTTCGGCGAACTCGCGCGGCG
TTTGCTGAATCGCCTCCGCCGCACCGCGAAGAAATAA

Upstream 100 bases:

>100_bases
AAACCAATGAACTCGGAAGGATGCTGCACGGCCTGCGTAGCGCGCTAACCGCAAAGCTTGCGCCAAGCTCCCTGAACCCT
GAATCCTGACCCTGAATCTT

Downstream 100 bases:

>100_bases
GGCCGTCACACGGCAAAGGTGCGATTTCGCGTCCATTGAAGCGAAAGGGGCCCGACATACGCGGCCCCTTTTCGTTTTTG
CCCGTCGGCGTCGCCGCGTT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; S complex, 50 kDa subunit [H]

Number of amino acids: Translated: 998; Mature: 998

Protein sequence:

>998_residues
MNHYAITMPQLSDTMTEGVVVTWEKQPGDRVERGDIVATVETDKAIMDVEVFKAGYLAGPLADVGATIAVGAALGYITDT
AGDVAIAADEVVAEQAQTEMIPHHAGTPIVMPQLSDTMTEGVVVTWEKQPGEAIKRGDIVATVETDKAIMDVEVFQEGFL
SGPIADIGSVVEVGHPMAFIVDDAAKANDTGVTISADHKVKDTHKVAPPAADKPAHLPIPKTAPSQVAAAGNAVPVPRPQ
GRQASPYARKVAAQLGVNLTGLAGSGPSGVLVAADVARARPSMQEVAHALPQVDVPGQGRPMTSMEKAVSHAMTASLTLP
TFNVTVNIDTAALTAATKAKKVSVTVAIAKACSVAMAKFPRMNWAYQPVDKLVERANHDFGVAVMSNDGGLVVPILHGVE
KKSLEALQGDWTGLVERARVRKLAPPEYSNPTFTISNMGMLGVSHFTAIPTPGISAILAIAANGPQGTPFTITGDHRVLN
GADVALYLTTLKQTIEAPDAWLSGGTAAETAGAAATTSAPVSPIPEGNWDVQVVVVGGGPGGEDCARDLADHGVKVMMVN
NEPFPGGECLWRGCIPSKAWRAAADNIRNRAHDAEMGVDGTANPKLNWAQVEKHRRWVQTSRGEMALKADKGMKIDVREG
YGEFVDAHTLKITPPEGEAYTVSFGAAVIATGAPAFVPPIPGARENLATGGVVTSDTIWNLANPPKKLGIVGGGVIGVEM
AQIFRDFGTEVLMLERHDRILAEIEEEIGKVLIASLEKEITVVTSADIREVGGKPGKMTLRYADKEGAESTFDCDVVLMA
TGKRPDTSRLNLDKVGVALDGAAIKVDARCCTSTPNIYAVGDVIGGYMLAHTAATQGRVAASNLLGHASEYDQDRDCGVT
FSRPQAGFVGLSVAQAKAKGIDAVEAKMPMSIDAKAMITGETEGMIKLVADKTTGRIIGVHYLADHTDTLIGTGVMMVAG
EMTLTQVAKAIFPHPTQTELFGELARRLLNRLRRTAKK

Sequences:

>Translated_998_residues
MNHYAITMPQLSDTMTEGVVVTWEKQPGDRVERGDIVATVETDKAIMDVEVFKAGYLAGPLADVGATIAVGAALGYITDT
AGDVAIAADEVVAEQAQTEMIPHHAGTPIVMPQLSDTMTEGVVVTWEKQPGEAIKRGDIVATVETDKAIMDVEVFQEGFL
SGPIADIGSVVEVGHPMAFIVDDAAKANDTGVTISADHKVKDTHKVAPPAADKPAHLPIPKTAPSQVAAAGNAVPVPRPQ
GRQASPYARKVAAQLGVNLTGLAGSGPSGVLVAADVARARPSMQEVAHALPQVDVPGQGRPMTSMEKAVSHAMTASLTLP
TFNVTVNIDTAALTAATKAKKVSVTVAIAKACSVAMAKFPRMNWAYQPVDKLVERANHDFGVAVMSNDGGLVVPILHGVE
KKSLEALQGDWTGLVERARVRKLAPPEYSNPTFTISNMGMLGVSHFTAIPTPGISAILAIAANGPQGTPFTITGDHRVLN
GADVALYLTTLKQTIEAPDAWLSGGTAAETAGAAATTSAPVSPIPEGNWDVQVVVVGGGPGGEDCARDLADHGVKVMMVN
NEPFPGGECLWRGCIPSKAWRAAADNIRNRAHDAEMGVDGTANPKLNWAQVEKHRRWVQTSRGEMALKADKGMKIDVREG
YGEFVDAHTLKITPPEGEAYTVSFGAAVIATGAPAFVPPIPGARENLATGGVVTSDTIWNLANPPKKLGIVGGGVIGVEM
AQIFRDFGTEVLMLERHDRILAEIEEEIGKVLIASLEKEITVVTSADIREVGGKPGKMTLRYADKEGAESTFDCDVVLMA
TGKRPDTSRLNLDKVGVALDGAAIKVDARCCTSTPNIYAVGDVIGGYMLAHTAATQGRVAASNLLGHASEYDQDRDCGVT
FSRPQAGFVGLSVAQAKAKGIDAVEAKMPMSIDAKAMITGETEGMIKLVADKTTGRIIGVHYLADHTDTLIGTGVMMVAG
EMTLTQVAKAIFPHPTQTELFGELARRLLNRLRRTAKK
>Mature_998_residues
MNHYAITMPQLSDTMTEGVVVTWEKQPGDRVERGDIVATVETDKAIMDVEVFKAGYLAGPLADVGATIAVGAALGYITDT
AGDVAIAADEVVAEQAQTEMIPHHAGTPIVMPQLSDTMTEGVVVTWEKQPGEAIKRGDIVATVETDKAIMDVEVFQEGFL
SGPIADIGSVVEVGHPMAFIVDDAAKANDTGVTISADHKVKDTHKVAPPAADKPAHLPIPKTAPSQVAAAGNAVPVPRPQ
GRQASPYARKVAAQLGVNLTGLAGSGPSGVLVAADVARARPSMQEVAHALPQVDVPGQGRPMTSMEKAVSHAMTASLTLP
TFNVTVNIDTAALTAATKAKKVSVTVAIAKACSVAMAKFPRMNWAYQPVDKLVERANHDFGVAVMSNDGGLVVPILHGVE
KKSLEALQGDWTGLVERARVRKLAPPEYSNPTFTISNMGMLGVSHFTAIPTPGISAILAIAANGPQGTPFTITGDHRVLN
GADVALYLTTLKQTIEAPDAWLSGGTAAETAGAAATTSAPVSPIPEGNWDVQVVVVGGGPGGEDCARDLADHGVKVMMVN
NEPFPGGECLWRGCIPSKAWRAAADNIRNRAHDAEMGVDGTANPKLNWAQVEKHRRWVQTSRGEMALKADKGMKIDVREG
YGEFVDAHTLKITPPEGEAYTVSFGAAVIATGAPAFVPPIPGARENLATGGVVTSDTIWNLANPPKKLGIVGGGVIGVEM
AQIFRDFGTEVLMLERHDRILAEIEEEIGKVLIASLEKEITVVTSADIREVGGKPGKMTLRYADKEGAESTFDCDVVLMA
TGKRPDTSRLNLDKVGVALDGAAIKVDARCCTSTPNIYAVGDVIGGYMLAHTAATQGRVAASNLLGHASEYDQDRDCGVT
FSRPQAGFVGLSVAQAKAKGIDAVEAKMPMSIDAKAMITGETEGMIKLVADKTTGRIIGVHYLADHTDTLIGTGVMMVAG
EMTLTQVAKAIFPHPTQTELFGELARRLLNRLRRTAKK

Specific function: Catalyzes the oxidation of dihydrolipoamide to lipoamide [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=562, Percent_Identity=28.6476868327402, Blast_Score=204, Evalue=5e-52,
Organism=Homo sapiens, GI91199540, Length=486, Percent_Identity=29.2181069958848, Blast_Score=183, Evalue=7e-46,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=28.5407725321888, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI203098753, Length=462, Percent_Identity=25.5411255411255, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI203098816, Length=462, Percent_Identity=25.5411255411255, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI291045266, Length=475, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=1e-20,
Organism=Homo sapiens, GI291045268, Length=355, Percent_Identity=27.6056338028169, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI110671329, Length=459, Percent_Identity=22.0043572984749, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI148277071, Length=478, Percent_Identity=23.8493723849372, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI33519430, Length=478, Percent_Identity=23.8493723849372, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI33519428, Length=478, Percent_Identity=23.8493723849372, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI33519426, Length=478, Percent_Identity=23.8493723849372, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI148277065, Length=478, Percent_Identity=23.8493723849372, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=30.4157549234136, Blast_Score=190, Evalue=3e-49,
Organism=Escherichia coli, GI87082354, Length=486, Percent_Identity=27.9835390946502, Blast_Score=164, Evalue=3e-41,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=28.1659388646288, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=29.4663573085847, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1786946, Length=430, Percent_Identity=25.8139534883721, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1786305, Length=296, Percent_Identity=26.6891891891892, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1789065, Length=266, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=30.5010893246187, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17560088, Length=443, Percent_Identity=32.2799097065463, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17557007, Length=495, Percent_Identity=26.0606060606061, Blast_Score=109, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=364, Percent_Identity=27.7472527472527, Blast_Score=106, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71983419, Length=364, Percent_Identity=27.7472527472527, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17537937, Length=447, Percent_Identity=23.7136465324385, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25146366, Length=431, Percent_Identity=26.4501160092807, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982272, Length=359, Percent_Identity=27.0194986072423, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324258, Length=455, Percent_Identity=31.6483516483516, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=29.0870488322718, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=454, Percent_Identity=26.8722466960352, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=24.7334754797441, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320352, Length=428, Percent_Identity=25.4672897196262, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321632, Length=195, Percent_Identity=28.7179487179487, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=29.9785867237687, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24640553, Length=506, Percent_Identity=28.8537549407115, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640549, Length=487, Percent_Identity=28.952772073922, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640551, Length=501, Percent_Identity=28.9421157684631, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20129315, Length=437, Percent_Identity=30.8924485125858, Blast_Score=129, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24582497, Length=420, Percent_Identity=30.4761904761905, Blast_Score=119, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=27.6859504132231, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18859875, Length=304, Percent_Identity=25.6578947368421, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 104866; Mature: 104866

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHYAITMPQLSDTMTEGVVVTWEKQPGDRVERGDIVATVETDKAIMDVEVFKAGYLAGP
CCCEEEECCCHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEHHHHHCCCCCCC
LADVGATIAVGAALGYITDTAGDVAIAADEVVAEQAQTEMIPHHAGTPIVMPQLSDTMTE
HHHHCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHC
GVVVTWEKQPGEAIKRGDIVATVETDKAIMDVEVFQEGFLSGPIADIGSVVEVGHPMAFI
CEEEEEECCCCCHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEE
VDDAAKANDTGVTISADHKVKDTHKVAPPAADKPAHLPIPKTAPSQVAAAGNAVPVPRPQ
EECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
GRQASPYARKVAAQLGVNLTGLAGSGPSGVLVAADVARARPSMQEVAHALPQVDVPGQGR
CCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEHHHHCCCCHHHHHHHCCCCCCCCCCC
PMTSMEKAVSHAMTASLTLPTFNVTVNIDTAALTAATKAKKVSVTVAIAKACSVAMAKFP
CCHHHHHHHHHHHHEEEEEEEEEEEEEECHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCC
RMNWAYQPVDKLVERANHDFGVAVMSNDGGLVVPILHGVEKKSLEALQGDWTGLVERARV
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHH
RKLAPPEYSNPTFTISNMGMLGVSHFTAIPTPGISAILAIAANGPQGTPFTITGDHRVLN
HHCCCCCCCCCCEEEECCCEEEHHHHCCCCCCCCEEEEEEEECCCCCCCEEEECCCEEEC
GADVALYLTTLKQTIEAPDAWLSGGTAAETAGAAATTSAPVSPIPEGNWDVQVVVVGGGP
CCCEEEHHHHHHHHHCCCCHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCC
GGEDCARDLADHGVKVMMVNNEPFPGGECLWRGCIPSKAWRAAADNIRNRAHDAEMGVDG
CHHHHHHHHHHCCEEEEEECCCCCCCHHHEEECCCCHHHHHHHHHHHHHHCCHHHCCCCC
TANPKLNWAQVEKHRRWVQTSRGEMALKADKGMKIDVREGYGEFVDAHTLKITPPEGEAY
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCEE
TVSFGAAVIATGAPAFVPPIPGARENLATGGVVTSDTIWNLANPPKKLGIVGGGVIGVEM
EEEECEEEEECCCCCCCCCCCCCHHCCCCCCEEECCCEECCCCCCHHEEEECCCHHHHHH
AQIFRDFGTEVLMLERHDRILAEIEEEIGKVLIASLEKEITVVTSADIREVGGKPGKMTL
HHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCEEEE
RYADKEGAESTFDCDVVLMATGKRPDTSRLNLDKVGVALDGAAIKVDARCCTSTPNIYAV
EECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCEEECCCEEEEECEEECCCCCEEEE
GDVIGGYMLAHTAATQGRVAASNLLGHASEYDQDRDCGVTFSRPQAGFVGLSVAQAKAKG
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHCCCCCCCCEEECCCCCCEEEEEHHHHHHCC
IDAVEAKMPMSIDAKAMITGETEGMIKLVADKTTGRIIGVHYLADHTDTLIGTGVMMVAG
CCHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHCCCEEEEC
EMTLTQVAKAIFPHPTQTELFGELARRLLNRLRRTAKK
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNHYAITMPQLSDTMTEGVVVTWEKQPGDRVERGDIVATVETDKAIMDVEVFKAGYLAGP
CCCEEEECCCHHHHHHCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEHHHHHCCCCCCC
LADVGATIAVGAALGYITDTAGDVAIAADEVVAEQAQTEMIPHHAGTPIVMPQLSDTMTE
HHHHCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHC
GVVVTWEKQPGEAIKRGDIVATVETDKAIMDVEVFQEGFLSGPIADIGSVVEVGHPMAFI
CEEEEEECCCCCHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEE
VDDAAKANDTGVTISADHKVKDTHKVAPPAADKPAHLPIPKTAPSQVAAAGNAVPVPRPQ
EECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
GRQASPYARKVAAQLGVNLTGLAGSGPSGVLVAADVARARPSMQEVAHALPQVDVPGQGR
CCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEHHHHCCCCHHHHHHHCCCCCCCCCCC
PMTSMEKAVSHAMTASLTLPTFNVTVNIDTAALTAATKAKKVSVTVAIAKACSVAMAKFP
CCHHHHHHHHHHHHEEEEEEEEEEEEEECHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCC
RMNWAYQPVDKLVERANHDFGVAVMSNDGGLVVPILHGVEKKSLEALQGDWTGLVERARV
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHH
RKLAPPEYSNPTFTISNMGMLGVSHFTAIPTPGISAILAIAANGPQGTPFTITGDHRVLN
HHCCCCCCCCCCEEEECCCEEEHHHHCCCCCCCCEEEEEEEECCCCCCCEEEECCCEEEC
GADVALYLTTLKQTIEAPDAWLSGGTAAETAGAAATTSAPVSPIPEGNWDVQVVVVGGGP
CCCEEEHHHHHHHHHCCCCHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCC
GGEDCARDLADHGVKVMMVNNEPFPGGECLWRGCIPSKAWRAAADNIRNRAHDAEMGVDG
CHHHHHHHHHHCCEEEEEECCCCCCCHHHEEECCCCHHHHHHHHHHHHHHCCHHHCCCCC
TANPKLNWAQVEKHRRWVQTSRGEMALKADKGMKIDVREGYGEFVDAHTLKITPPEGEAY
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCEE
TVSFGAAVIATGAPAFVPPIPGARENLATGGVVTSDTIWNLANPPKKLGIVGGGVIGVEM
EEEECEEEEECCCCCCCCCCCCCHHCCCCCCEEECCCEECCCCCCHHEEEECCCHHHHHH
AQIFRDFGTEVLMLERHDRILAEIEEEIGKVLIASLEKEITVVTSADIREVGGKPGKMTL
HHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCEEEE
RYADKEGAESTFDCDVVLMATGKRPDTSRLNLDKVGVALDGAAIKVDARCCTSTPNIYAV
EECCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCEEECCCEEEEECEEECCCCCEEEE
GDVIGGYMLAHTAATQGRVAASNLLGHASEYDQDRDCGVTFSRPQAGFVGLSVAQAKAKG
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHCCCCCCCCEEECCCCCCEEEEEHHHHHHCC
IDAVEAKMPMSIDAKAMITGETEGMIKLVADKTTGRIIGVHYLADHTDTLIGTGVMMVAG
CCHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHCCCEEEEC
EMTLTQVAKAIFPHPTQTELFGELARRLLNRLRRTAKK
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1697575; 8969500; 9384377; 1936936 [H]