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The map label for this gene is accA

Identifier: 74316606

GI number: 74316606

Start: 616878

End: 617846

Strand: Direct

Name: accA

Synonym: Tbd_0588

Alternate gene names: 74316606

Gene position: 616878-617846 (Clockwise)

Preceding gene: 74316605

Following gene: 74316607

Centisome position: 21.2

GC content: 64.29

Gene sequence:

>969_bases
ATGAAAACCACTTTCCTCGATTTCGAGCAGCCGATCGCGGAGCTCGAAGCCAAAATCGAAGAACTGCGCTTCGTGCAGGA
CGACTCCGCGCTGGACATTTCCGAGGAAATCCGCCGTCTTCAGAAGAAGAGCCAGGCGCTGACCAAGGACATCTACGCCA
AGCTCAATGCCTGGCAGGTGTCGCAGGTCGCACGCCACCCGCAGCGTCCCTATACCCTCGACTACATACAGGGGCTGTTC
ACCGACTTCGTCGAACTGCATGGCGATCGCGCCTACGCCGACGATGCCGCGATCGTCGGCGGAATGGCACGCTTCAACGG
CGAGCCCGTCATGGTGATCGGGCACCAGAAGGGGCGCGACACCAAGGAAAAGATCTTCCGTAATTTCGGCATGCCGCGGC
CAGAGGGCTACCGCAAGGCGCTGCGTCTGATGCGGCTCGCGGAAAAATTCCGCCTGCCGATCCTGACCTTCATCGACACC
CCGGGCGCCTATCCCGGGATCGGTGCAGAGGAGCGCGGCCAGTCGGAAGCGATCGCCCGCAACCTCTATGTCATGGCCGA
ACTGCAGACGCCGATCGTGTGCACGATCGTCGGCGAGGGCGGCTCGGGCGGCGCGCTGGCGATCGGCGTCGGCGACCGCA
CGCTGATTCTCCAGTATTCGACCTACTCGGTGATTTCGCCCGAAGGCTGTGCGTCGATCCTCTGGAAGAGCGCGGACAAG
GCCTCGGTCGCGGCGGAAACGCTCGGGATCACGGCCGACCGCCTGAAAGCGAACGGCCTCGTCGATCGCATCATCGAGGA
ACCGCTCGGCGGCGCGCAGCGCGACTGGGACGCGATGTTCCAGTCGATGCGGCGCGCGCTCACCGATACCCTCGCGGAAT
TGCGCAAGCAGCCGACGGAGGCCATGCTCGGCGCGCGGTATCAGCGCCTGCGGGCGTATGGCAGCTTCAAGGAAGCCCCT
GCCCGGTAA

Upstream 100 bases:

>100_bases
CACGGCCACCATCACCACTGAGCCAGGACGTCCCCCACACGCACGGGCGGGTCGCCGGGCTGCTAGAATGCCCGGCTAAC
CTCTTTGCCCTGACTGTCTG

Downstream 100 bases:

>100_bases
GGCGCCCGCCGACGCGGTGGGCGACGCGCTCGCCCGCCATGTCTTCTCCGGCGCGCGGCTCGTGCTCGCGCTGTCGGGCG
GCCTCGATTCGGTGGTTCTG

Product: acetyl-CoA carboxylase carboxyltransferase subunit alpha

Products: NA

Alternate protein names: ACCase subunit alpha; Acetyl-CoA carboxylase carboxyltransferase subunit alpha

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKTTFLDFEQPIAELEAKIEELRFVQDDSALDISEEIRRLQKKSQALTKDIYAKLNAWQVSQVARHPQRPYTLDYIQGLF
TDFVELHGDRAYADDAAIVGGMARFNGEPVMVIGHQKGRDTKEKIFRNFGMPRPEGYRKALRLMRLAEKFRLPILTFIDT
PGAYPGIGAEERGQSEAIARNLYVMAELQTPIVCTIVGEGGSGGALAIGVGDRTLILQYSTYSVISPEGCASILWKSADK
ASVAAETLGITADRLKANGLVDRIIEEPLGGAQRDWDAMFQSMRRALTDTLAELRKQPTEAMLGARYQRLRAYGSFKEAP
AR

Sequences:

>Translated_322_residues
MKTTFLDFEQPIAELEAKIEELRFVQDDSALDISEEIRRLQKKSQALTKDIYAKLNAWQVSQVARHPQRPYTLDYIQGLF
TDFVELHGDRAYADDAAIVGGMARFNGEPVMVIGHQKGRDTKEKIFRNFGMPRPEGYRKALRLMRLAEKFRLPILTFIDT
PGAYPGIGAEERGQSEAIARNLYVMAELQTPIVCTIVGEGGSGGALAIGVGDRTLILQYSTYSVISPEGCASILWKSADK
ASVAAETLGITADRLKANGLVDRIIEEPLGGAQRDWDAMFQSMRRALTDTLAELRKQPTEAMLGARYQRLRAYGSFKEAP
AR
>Mature_322_residues
MKTTFLDFEQPIAELEAKIEELRFVQDDSALDISEEIRRLQKKSQALTKDIYAKLNAWQVSQVARHPQRPYTLDYIQGLF
TDFVELHGDRAYADDAAIVGGMARFNGEPVMVIGHQKGRDTKEKIFRNFGMPRPEGYRKALRLMRLAEKFRLPILTFIDT
PGAYPGIGAEERGQSEAIARNLYVMAELQTPIVCTIVGEGGSGGALAIGVGDRTLILQYSTYSVISPEGCASILWKSADK
ASVAAETLGITADRLKANGLVDRIIEEPLGGAQRDWDAMFQSMRRALTDTLAELRKQPTEAMLGARYQRLRAYGSFKEAP
AR

Specific function: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-Co

COG id: COG0825

COG function: function code I; Acetyl-CoA carboxylase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AccA family

Homologues:

Organism=Escherichia coli, GI1786382, Length=317, Percent_Identity=67.5078864353312, Blast_Score=433, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCA_THIDA (Q3SL76)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314346.1
- ProteinModelPortal:   Q3SL76
- SMR:   Q3SL76
- STRING:   Q3SL76
- GeneID:   3673698
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0588
- NMPDR:   fig|292415.3.peg.390
- eggNOG:   COG0825
- HOGENOM:   HBG286557
- OMA:   QLTKDIY
- PhylomeDB:   Q3SL76
- ProtClustDB:   PRK05724
- BioCyc:   TDEN292415:TBD_0588-MONOMER
- HAMAP:   MF_00823
- InterPro:   IPR001095
- InterPro:   IPR011763
- PANTHER:   PTHR22855:SF3
- PRINTS:   PR01069
- TIGRFAMs:   TIGR00513

Pfam domain/function: PF03255 ACCA

EC number: =6.4.1.2

Molecular weight: Translated: 35851; Mature: 35851

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTFLDFEQPIAELEAKIEELRFVQDDSALDISEEIRRLQKKSQALTKDIYAKLNAWQV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SQVARHPQRPYTLDYIQGLFTDFVELHGDRAYADDAAIVGGMARFNGEPVMVIGHQKGRD
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
TKEKIFRNFGMPRPEGYRKALRLMRLAEKFRLPILTFIDTPGAYPGIGAEERGQSEAIAR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
NLYVMAELQTPIVCTIVGEGGSGGALAIGVGDRTLILQYSTYSVISPEGCASILWKSADK
HHEEEEECCCCEEEEEEECCCCCCEEEEECCCEEEEEEECCCCEECCHHHHHHHHCCCCH
ASVAAETLGITADRLKANGLVDRIIEEPLGGAQRDWDAMFQSMRRALTDTLAELRKQPTE
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
AMLGARYQRLRAYGSFKEAPAR
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKTTFLDFEQPIAELEAKIEELRFVQDDSALDISEEIRRLQKKSQALTKDIYAKLNAWQV
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SQVARHPQRPYTLDYIQGLFTDFVELHGDRAYADDAAIVGGMARFNGEPVMVIGHQKGRD
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
TKEKIFRNFGMPRPEGYRKALRLMRLAEKFRLPILTFIDTPGAYPGIGAEERGQSEAIAR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
NLYVMAELQTPIVCTIVGEGGSGGALAIGVGDRTLILQYSTYSVISPEGCASILWKSADK
HHEEEEECCCCEEEEEEECCCCCCEEEEECCCEEEEEEECCCCEECCHHHHHHHHCCCCH
ASVAAETLGITADRLKANGLVDRIIEEPLGGAQRDWDAMFQSMRRALTDTLAELRKQPTE
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
AMLGARYQRLRAYGSFKEAPAR
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA