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The map label for this gene is bioC [H]

Identifier: 74316340

GI number: 74316340

Start: 345807

End: 346727

Strand: Direct

Name: bioC [H]

Synonym: Tbd_0322

Alternate gene names: 74316340

Gene position: 345807-346727 (Clockwise)

Preceding gene: 74316339

Following gene: 74316341

Centisome position: 11.88

GC content: 70.79

Gene sequence:

>921_bases
ATGACCGAAGCCGAGCTTGATTACGCCGAGGTCCGCCGCGCCTTCGACCACGCGGCCGCCGCCTACGACGCGCATGCCGT
GCTGCAGCGCGAAGTCTGCGACCGCCTGCTCGAAAGGCTCGATTACACGACGATCCAGCCCGCGCGGGTGCTCGACGTCG
GCAGCGGGACCGGCTACGGGACCGCGCACCTGAGGGCGCGCTACCCCGAGGCCGAGCTGTGCGCGCTCGACATCGCACCC
GCGATGCTCGCCGCGACGCGCAGCCGCTTTCCGCGCCCGACCTGGACGCAGCGCGCGCTCGGGCGCCTCGGCTCCGCGGC
GCCGCGCCCGGTCGAGCTGATCTGCGCGGACATGGGGCGGCTGCCGCTCGCGGCCAACAGCTGCAACCTTGTCTGGTCGA
GCCTTGCGCTGCAATGGGCGCAGGATCTGACGGCAAGCTTCCGTGGCTTCCACCGCGTCCTCGCGCCCGGCGGCTTGCTG
ATGTTCGCGACCTTCGGGCCGGACACGCTGAAGGAGTTGCGCGCGGCGTTTTCCGCAATCGACGACGCGCCCCACGTCAA
TGCCTTCGTCGACCTCCACGACATCGGCGACATGCTGATCGACGCCGGCTTCGCCAATCCCGTGATGGAAATGGAAATGC
TGACGCTGACCTACGGCGACCTCAAGGCGTTGATGCGGGACCTCAAAGGCATCGGCGCCCACAACGCGGCGGCGGCCCGG
CGCCGCGGCCTGCTCGGCAAGTCGGCCTGGGCGCGGCTCGAGCAGGCCTACGAAGCGACGCGCAGCGAGGGCCGCCTGCC
GGCGACCTTCGAGGTTGTCTACGGCCACGCGTGGGCCGGCGACAAGACCCACCTCGAGGACGGGCGCCAGGTCATCCAGT
TCGCGATCGGCGAGCGCCTGCGCAAGCGCGGTCGCGCATGA

Upstream 100 bases:

>100_bases
ATCTGCGCGCAGCGCGCCACGTCGAACTCGAGCGGGCTGCGCACGCGCCGCATCTGTCGCATCCCGACGATGTCGCGCGC
GAGATCGAACGGTTTTGCCT

Downstream 100 bases:

>100_bases
GCGCGCGCGGCCTGTTCGTCACAGGGACCGACACCGGCGTCGGCAAGACCCGCGTGGCGGTTGCCCTGATTCACGCGCTG
CGCGCGCAAGGACTGAACGT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTEAELDYAEVRRAFDHAAAAYDAHAVLQREVCDRLLERLDYTTIQPARVLDVGSGTGYGTAHLRARYPEAELCALDIAP
AMLAATRSRFPRPTWTQRALGRLGSAAPRPVELICADMGRLPLAANSCNLVWSSLALQWAQDLTASFRGFHRVLAPGGLL
MFATFGPDTLKELRAAFSAIDDAPHVNAFVDLHDIGDMLIDAGFANPVMEMEMLTLTYGDLKALMRDLKGIGAHNAAAAR
RRGLLGKSAWARLEQAYEATRSEGRLPATFEVVYGHAWAGDKTHLEDGRQVIQFAIGERLRKRGRA

Sequences:

>Translated_306_residues
MTEAELDYAEVRRAFDHAAAAYDAHAVLQREVCDRLLERLDYTTIQPARVLDVGSGTGYGTAHLRARYPEAELCALDIAP
AMLAATRSRFPRPTWTQRALGRLGSAAPRPVELICADMGRLPLAANSCNLVWSSLALQWAQDLTASFRGFHRVLAPGGLL
MFATFGPDTLKELRAAFSAIDDAPHVNAFVDLHDIGDMLIDAGFANPVMEMEMLTLTYGDLKALMRDLKGIGAHNAAAAR
RRGLLGKSAWARLEQAYEATRSEGRLPATFEVVYGHAWAGDKTHLEDGRQVIQFAIGERLRKRGRA
>Mature_305_residues
TEAELDYAEVRRAFDHAAAAYDAHAVLQREVCDRLLERLDYTTIQPARVLDVGSGTGYGTAHLRARYPEAELCALDIAPA
MLAATRSRFPRPTWTQRALGRLGSAAPRPVELICADMGRLPLAANSCNLVWSSLALQWAQDLTASFRGFHRVLAPGGLLM
FATFGPDTLKELRAAFSAIDDAPHVNAFVDLHDIGDMLIDAGFANPVMEMEMLTLTYGDLKALMRDLKGIGAHNAAAARR
RGLLGKSAWARLEQAYEATRSEGRLPATFEVVYGHAWAGDKTHLEDGRQVIQFAIGERLRKRGRA

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=258, Percent_Identity=29.4573643410853, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI86792933, Length=151, Percent_Identity=31.7880794701987, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786994, Length=254, Percent_Identity=32.6771653543307, Blast_Score=124, Evalue=6e-30,
Organism=Drosophila melanogaster, GI19922210, Length=278, Percent_Identity=29.8561151079137, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 33587; Mature: 33456

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAELDYAEVRRAFDHAAAAYDAHAVLQREVCDRLLERLDYTTIQPARVLDVGSGTGYG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCC
TAHLRARYPEAELCALDIAPAMLAATRSRFPRPTWTQRALGRLGSAAPRPVELICADMGR
CHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCC
LPLAANSCNLVWSSLALQWAQDLTASFRGFHRVLAPGGLLMFATFGPDTLKELRAAFSAI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
DDAPHVNAFVDLHDIGDMLIDAGFANPVMEMEMLTLTYGDLKALMRDLKGIGAHNAAAAR
CCCCCCHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RRGLLGKSAWARLEQAYEATRSEGRLPATFEVVYGHAWAGDKTHLEDGRQVIQFAIGERL
HHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
RKRGRA
HHCCCC
>Mature Secondary Structure 
TEAELDYAEVRRAFDHAAAAYDAHAVLQREVCDRLLERLDYTTIQPARVLDVGSGTGYG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCC
TAHLRARYPEAELCALDIAPAMLAATRSRFPRPTWTQRALGRLGSAAPRPVELICADMGR
CHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCC
LPLAANSCNLVWSSLALQWAQDLTASFRGFHRVLAPGGLLMFATFGPDTLKELRAAFSAI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
DDAPHVNAFVDLHDIGDMLIDAGFANPVMEMEMLTLTYGDLKALMRDLKGIGAHNAAAAR
CCCCCCHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RRGLLGKSAWARLEQAYEATRSEGRLPATFEVVYGHAWAGDKTHLEDGRQVIQFAIGERL
HHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
RKRGRA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]