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The map label for this gene is folE [H]

Identifier: 74316260

GI number: 74316260

Start: 265418

End: 266038

Strand: Reverse

Name: folE [H]

Synonym: Tbd_0242

Alternate gene names: 74316260

Gene position: 266038-265418 (Counterclockwise)

Preceding gene: 74316270

Following gene: 74316256

Centisome position: 9.14

GC content: 66.18

Gene sequence:

>621_bases
ATGACTCAGCCTCCTTCCGACACACCCCAGCGGCCCACGCGCGAAGCGGCCGAAGAAGCCGTGCGCACGCTGATCGCCTG
GGCCGGCGACGACCCGTCGCGCGAAGGCCTGATCGACACGCCGGCCCGCGTCGTCCGCGCCTACGAGGAATACTTCGCCG
GCTATCCCGACGACCCGGCGCAAGTGCTGGCGCGCACGTTTTCCGAAGTCGACGGCTACGACGAAATGATCGTCATGACC
GACATCCGTTTCGAAAGCCATTGCGAGCACCACATGGCGCCGATCATCGGCAAGGCCCACGTCGCCTACCTTCCCACGCA
CCGCGTCGTCGGCATTTCGAAGCTCGCGCGCCTCGTCGACCTCTACGCCAAGCGCCTGCAGATCCAGGAAAGAATGACCG
TGCAGATCGCCGACACGCTCAACAACGTGTTGCAGCCGCAAGGCGTCGCCGTCGTGATTGAGGGCTCGCATCAGTGCATG
ACGACGCGCGGTGTGCACAAGCCGGGCGCGGCGATGGTCACGAGCCGCATGCTCGGCGTCTTCCGCTCCAACGTTGCGAC
GCGCCGCGAGTTTCTGGCGATGATCGGCCGCACCGGCGCGGGGCCGCTGAGCAATACCTGA

Upstream 100 bases:

>100_bases
AGCAGCCTGCCCGCGCGCGCCGAGCGGTTCGGCTATTACAAGAAACAGCACCGCGCCACGCCCCCACCCCCACGGACAAG
ACTGCACGCGAAAGGACATC

Downstream 100 bases:

>100_bases
GGCATCGTCGGCGCGCACGTCCACGCTTCGGCCGTGCCGCCGTCCGCTGCCCGACTCAATAAAAAGGGGCGCCCTGCAGA
GCGCCCCAGACCTCCAGCAG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTQPPSDTPQRPTREAAEEAVRTLIAWAGDDPSREGLIDTPARVVRAYEEYFAGYPDDPAQVLARTFSEVDGYDEMIVMT
DIRFESHCEHHMAPIIGKAHVAYLPTHRVVGISKLARLVDLYAKRLQIQERMTVQIADTLNNVLQPQGVAVVIEGSHQCM
TTRGVHKPGAAMVTSRMLGVFRSNVATRREFLAMIGRTGAGPLSNT

Sequences:

>Translated_206_residues
MTQPPSDTPQRPTREAAEEAVRTLIAWAGDDPSREGLIDTPARVVRAYEEYFAGYPDDPAQVLARTFSEVDGYDEMIVMT
DIRFESHCEHHMAPIIGKAHVAYLPTHRVVGISKLARLVDLYAKRLQIQERMTVQIADTLNNVLQPQGVAVVIEGSHQCM
TTRGVHKPGAAMVTSRMLGVFRSNVATRREFLAMIGRTGAGPLSNT
>Mature_205_residues
TQPPSDTPQRPTREAAEEAVRTLIAWAGDDPSREGLIDTPARVVRAYEEYFAGYPDDPAQVLARTFSEVDGYDEMIVMTD
IRFESHCEHHMAPIIGKAHVAYLPTHRVVGISKLARLVDLYAKRLQIQERMTVQIADTLNNVLQPQGVAVVIEGSHQCMT
TRGVHKPGAAMVTSRMLGVFRSNVATRREFLAMIGRTGAGPLSNT

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=176, Percent_Identity=45.4545454545455, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI4503949, Length=176, Percent_Identity=45.4545454545455, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI66932970, Length=146, Percent_Identity=40.4109589041096, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI66932972, Length=137, Percent_Identity=42.3357664233577, Blast_Score=128, Evalue=4e-30,
Organism=Escherichia coli, GI1788476, Length=198, Percent_Identity=37.8787878787879, Blast_Score=120, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17560486, Length=197, Percent_Identity=42.6395939086294, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6321706, Length=178, Percent_Identity=46.6292134831461, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24656782, Length=188, Percent_Identity=45.7446808510638, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24656791, Length=189, Percent_Identity=45.5026455026455, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24656796, Length=189, Percent_Identity=45.5026455026455, Blast_Score=158, Evalue=3e-39,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22770; Mature: 22639

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPPSDTPQRPTREAAEEAVRTLIAWAGDDPSREGLIDTPARVVRAYEEYFAGYPDDPA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
QVLARTFSEVDGYDEMIVMTDIRFESHCEHHMAPIIGKAHVAYLPTHRVVGISKLARLVD
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHH
LYAKRLQIQERMTVQIADTLNNVLQPQGVAVVIEGSHQCMTTRGVHKPGAAMVTSRMLGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHCCCCCCCHHHHHHHHHHH
FRSNVATRREFLAMIGRTGAGPLSNT
HHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TQPPSDTPQRPTREAAEEAVRTLIAWAGDDPSREGLIDTPARVVRAYEEYFAGYPDDPA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
QVLARTFSEVDGYDEMIVMTDIRFESHCEHHMAPIIGKAHVAYLPTHRVVGISKLARLVD
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHH
LYAKRLQIQERMTVQIADTLNNVLQPQGVAVVIEGSHQCMTTRGVHKPGAAMVTSRMLGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHCCCCCCCHHHHHHHHHHH
FRSNVATRREFLAMIGRTGAGPLSNT
HHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]