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The map label for this gene is lysA [H]

Identifier: 74316244

GI number: 74316244

Start: 248334

End: 249578

Strand: Reverse

Name: lysA [H]

Synonym: Tbd_0226

Alternate gene names: 74316244

Gene position: 249578-248334 (Counterclockwise)

Preceding gene: 74316247

Following gene: 74316243

Centisome position: 8.58

GC content: 66.43

Gene sequence:

>1245_bases
TTGAACGCTCCCCATCGCATCGACGGCCGCCTCCATCTCGAGGGCGTGGCCCTGGACACGCTCGCCGAGCGCTGCGGAAC
CCCCCTCTACGTCTACTCGCGTGCCGCCCTCGAAGCCGCGTACCGCGCCTATGAAGAAGCGTTCGCCGCGACGCCGCATC
TGATCTGTTACGCAGTCAAGGCCAACTCGAGCCTGGCCCTCCTGAACCTGTTCGCCCGGATGGGCGCCGGTTTCGACATC
GTCTCCGGCGGCGAGCTCGCCCGCGTACTCTCGGCGCAGGGCGATCCGCGAAAAGTCGTGTTCTCGGGCGTCGGCAAACG
CGTGGACGAGATGCGCGCCGCGCTCGAGGCGGGCATTCTCTGCTTCAACGTCGAATCGACGAGCGAGCTGCACCGGCTGA
ACCGCGTGGCGGGAGAGCTCGGCAAGGTCGCGCCGGTCTCCTTCCGCGTCAATCCGGACGTCGACCCGAAGACCCATCCC
TATATCTCGACGGGGCTCAAGGAGAACAAGTTCGGCGTCCCGATCGCGGAGGCCCCGGCGCTCTATCGCACGGCAGCCGC
ACTTCCGCACATCAGGGTGACCGGCATCGACTGCCACATCGGCTCGCAGCTGCTCGACCTGTCCCCGCTTGCCGACGCAG
CGGACCGCGTGTTCGCACTCGTCGACGCGCTCGCGGCCGAAGGCATTGCGCTCGAACACATCGACCTCGGCGGCGGCGTC
GGAATCTCCTATCGCGGAGAAACCGCGCCCGACCTCGCCGGCTACGGCCGCGTTCTCGCCGAACGCTTTGCCGGCCGGCG
AGAAACGCTGATCGTCGAGCCCGGCCGCTCGCTCGTCGGCAACGCCGGCCTTCTGCTCGCGCGTGTCGAATACCTGAAGC
TGGGCGCAGACAAGAACTTCGCGATCGTCGACGCCGCAATGAACGACCTCATGCGGCCCGCACTGTACGAGGCTTATCAC
GAGATCGTCGAGGTGATCGCGCGCCCGCTGCCCAAGCGGCGCTACGACGTCGTCGGCCCGATCTGCGAGACCGGCGATTT
CCTGGGATCCGCACGCGAGCTTTCGCTCGACGAGGGCGACCTCGTCGCGCTGCTTTCGTCGGGCGCATACGGCATGAGCA
TGTCGTCGAACTACAATTCGCGCCCCCGCGCGGCGGAAATTCTCGTCGACAAGAAAGAAATTCATCTGATTCGCGAGCGC
GAAACGCAGGAAGGCCTGATGGCCGGAGAGCGGCTTCTGGACTGA

Upstream 100 bases:

>100_bases
TAGTGTCCCTGTTGCTCTGCGGGCTCGGTCTGTCGGCCTGCGGCTCCAAGGGTGACCTGTATCTTCCCGAAAATCCTCCC
GCCCCGCAACGGACTTCACC

Downstream 100 bases:

>100_bases
GCTTCCGCGGCATGGACGACAACGTCCGGCGCCGCAATTTCGTATCGACCCGATACTGTTTGCTTGACCGCTACAGCGAC
CGGCCGATTATTTCGGCCGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNAPHRIDGRLHLEGVALDTLAERCGTPLYVYSRAALEAAYRAYEEAFAATPHLICYAVKANSSLALLNLFARMGAGFDI
VSGGELARVLSAQGDPRKVVFSGVGKRVDEMRAALEAGILCFNVESTSELHRLNRVAGELGKVAPVSFRVNPDVDPKTHP
YISTGLKENKFGVPIAEAPALYRTAAALPHIRVTGIDCHIGSQLLDLSPLADAADRVFALVDALAAEGIALEHIDLGGGV
GISYRGETAPDLAGYGRVLAERFAGRRETLIVEPGRSLVGNAGLLLARVEYLKLGADKNFAIVDAAMNDLMRPALYEAYH
EIVEVIARPLPKRRYDVVGPICETGDFLGSARELSLDEGDLVALLSSGAYGMSMSSNYNSRPRAAEILVDKKEIHLIRER
ETQEGLMAGERLLD

Sequences:

>Translated_414_residues
MNAPHRIDGRLHLEGVALDTLAERCGTPLYVYSRAALEAAYRAYEEAFAATPHLICYAVKANSSLALLNLFARMGAGFDI
VSGGELARVLSAQGDPRKVVFSGVGKRVDEMRAALEAGILCFNVESTSELHRLNRVAGELGKVAPVSFRVNPDVDPKTHP
YISTGLKENKFGVPIAEAPALYRTAAALPHIRVTGIDCHIGSQLLDLSPLADAADRVFALVDALAAEGIALEHIDLGGGV
GISYRGETAPDLAGYGRVLAERFAGRRETLIVEPGRSLVGNAGLLLARVEYLKLGADKNFAIVDAAMNDLMRPALYEAYH
EIVEVIARPLPKRRYDVVGPICETGDFLGSARELSLDEGDLVALLSSGAYGMSMSSNYNSRPRAAEILVDKKEIHLIRER
ETQEGLMAGERLLD
>Mature_414_residues
MNAPHRIDGRLHLEGVALDTLAERCGTPLYVYSRAALEAAYRAYEEAFAATPHLICYAVKANSSLALLNLFARMGAGFDI
VSGGELARVLSAQGDPRKVVFSGVGKRVDEMRAALEAGILCFNVESTSELHRLNRVAGELGKVAPVSFRVNPDVDPKTHP
YISTGLKENKFGVPIAEAPALYRTAAALPHIRVTGIDCHIGSQLLDLSPLADAADRVFALVDALAAEGIALEHIDLGGGV
GISYRGETAPDLAGYGRVLAERFAGRRETLIVEPGRSLVGNAGLLLARVEYLKLGADKNFAIVDAAMNDLMRPALYEAYH
EIVEVIARPLPKRRYDVVGPICETGDFLGSARELSLDEGDLVALLSSGAYGMSMSSNYNSRPRAAEILVDKKEIHLIRER
ETQEGLMAGERLLD

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=354, Percent_Identity=25.4237288135593, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=32.9297820823245, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=357, Percent_Identity=22.6890756302521, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=368, Percent_Identity=24.1847826086957, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24586474, Length=384, Percent_Identity=23.9583333333333, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44590; Mature: 44590

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPHRIDGRLHLEGVALDTLAERCGTPLYVYSRAALEAAYRAYEEAFAATPHLICYAVK
CCCCCCCCCEEEEECHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
ANSSLALLNLFARMGAGFDIVSGGELARVLSAQGDPRKVVFSGVGKRVDEMRAALEAGIL
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCEE
CFNVESTSELHRLNRVAGELGKVAPVSFRVNPDVDPKTHPYISTGLKENKFGVPIAEAPA
EEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
LYRTAAALPHIRVTGIDCHIGSQLLDLSPLADAADRVFALVDALAAEGIALEHIDLGGGV
HHHHHHHCCCEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GISYRGETAPDLAGYGRVLAERFAGRRETLIVEPGRSLVGNAGLLLARVEYLKLGADKNF
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCHHHHHHHHHHHCCCCCCE
AIVDAAMNDLMRPALYEAYHEIVEVIARPLPKRRYDVVGPICETGDFLGSARELSLDEGD
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCC
LVALLSSGAYGMSMSSNYNSRPRAAEILVDKKEIHLIRERETQEGLMAGERLLD
EEEEECCCCCCEEECCCCCCCCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAPHRIDGRLHLEGVALDTLAERCGTPLYVYSRAALEAAYRAYEEAFAATPHLICYAVK
CCCCCCCCCEEEEECHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
ANSSLALLNLFARMGAGFDIVSGGELARVLSAQGDPRKVVFSGVGKRVDEMRAALEAGIL
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCEE
CFNVESTSELHRLNRVAGELGKVAPVSFRVNPDVDPKTHPYISTGLKENKFGVPIAEAPA
EEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
LYRTAAALPHIRVTGIDCHIGSQLLDLSPLADAADRVFALVDALAAEGIALEHIDLGGGV
HHHHHHHCCCEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GISYRGETAPDLAGYGRVLAERFAGRRETLIVEPGRSLVGNAGLLLARVEYLKLGADKNF
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCHHHHHHHHHHHCCCCCCE
AIVDAAMNDLMRPALYEAYHEIVEVIARPLPKRRYDVVGPICETGDFLGSARELSLDEGD
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCC
LVALLSSGAYGMSMSSNYNSRPRAAEILVDKKEIHLIRERETQEGLMAGERLLD
EEEEECCCCCCEEECCCCCCCCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]