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The map label for this gene is polC [H]

Identifier: 74316107

GI number: 74316107

Start: 93724

End: 94425

Strand: Reverse

Name: polC [H]

Synonym: Tbd_0089

Alternate gene names: 74316107

Gene position: 94425-93724 (Counterclockwise)

Preceding gene: 74316108

Following gene: 74316101

Centisome position: 3.25

GC content: 69.09

Gene sequence:

>702_bases
ATGAACTGGCTGGCGCCTCGCTTCGGCAGAAAACCGGAACTCTCGCCGCAGCAGGCCGCGCGTCTGGCCGCCTGGCGCGC
GCTGCCGTCGCCGCGCCACGATCTGCCCCTCGACGAGGGCCGCTGCGTGGTGGTCGACGTCGAAACGAGCGGACTCGACC
CTCGCCGCGATCGCCTGATCGCGATCGGCGCGGTCGCCGTCTCCCGAGGCAAGGTGCAGCTCGGCGACAGCCTCGAAATC
GTGCTGCAACAGGACACCGTCAGCGAGAAGGGCAACATCCTGATCCACGGCATCGGCGGCACGGCGCAGCGCGCGGGCGT
GCCGCCCGCCGACGCCTTGCTCGCCTTTCTCGAATACCTCGGCAAGGACCCGCTCGTCGCCTTCCATGTCGCCTTCGACG
CGCCGATGATCCGCCGTGCGATGAAAGCCTTTCTCGGGCTCGATTTCAGCCACGCCTGGGCCGACCTGGCCTACGTTGCG
CCGGCGCTCTACCCGCGGCTCGCCCGGCGGCGCCGCAGTCTCGACGACTGGATGAGCGAATTCAAAATCGGCAACTACGC
GCGCCATAACGCGCTGGCCGACGCCCTCTCCACCGCGCAGTTGCTGCTCGCCCTGCGCAAGGCGCTCGATGCCCGCGGAA
GCGCGAGCTTTGCCGGCCTCAAGGACCTCGAGTACACGCAGCGCCGCCAGTCCGGTTTCTGA

Upstream 100 bases:

>100_bases
TCGACCCCGACACGCTCAACAATCTCGACAGCCGCATCCTCAAGGAAGCCTTCCGCCAGGCGCGCAAGCTGCAGACCAAG
CTCGGCCTGCACTACCAGGT

Downstream 100 bases:

>100_bases
GCCGGTGCACAAACAAAAACCCCCGCCGCGGCGGGGGTCTCGTCGAGCGGCCGGCGGCTCAGTGCGCCTGCGCCGTGCCG
GCGCCGCGCGGGTAGCGGAT

Product: exonuclease

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MNWLAPRFGRKPELSPQQAARLAAWRALPSPRHDLPLDEGRCVVVDVETSGLDPRRDRLIAIGAVAVSRGKVQLGDSLEI
VLQQDTVSEKGNILIHGIGGTAQRAGVPPADALLAFLEYLGKDPLVAFHVAFDAPMIRRAMKAFLGLDFSHAWADLAYVA
PALYPRLARRRRSLDDWMSEFKIGNYARHNALADALSTAQLLLALRKALDARGSASFAGLKDLEYTQRRQSGF

Sequences:

>Translated_233_residues
MNWLAPRFGRKPELSPQQAARLAAWRALPSPRHDLPLDEGRCVVVDVETSGLDPRRDRLIAIGAVAVSRGKVQLGDSLEI
VLQQDTVSEKGNILIHGIGGTAQRAGVPPADALLAFLEYLGKDPLVAFHVAFDAPMIRRAMKAFLGLDFSHAWADLAYVA
PALYPRLARRRRSLDDWMSEFKIGNYARHNALADALSTAQLLLALRKALDARGSASFAGLKDLEYTQRRQSGF
>Mature_233_residues
MNWLAPRFGRKPELSPQQAARLAAWRALPSPRHDLPLDEGRCVVVDVETSGLDPRRDRLIAIGAVAVSRGKVQLGDSLEI
VLQQDTVSEKGNILIHGIGGTAQRAGVPPADALLAFLEYLGKDPLVAFHVAFDAPMIRRAMKAFLGLDFSHAWADLAYVA
PALYPRLARRRRSLDDWMSEFKIGNYARHNALADALSTAQLLLALRKALDARGSASFAGLKDLEYTQRRQSGF

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 25607; Mature: 25607

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLAPRFGRKPELSPQQAARLAAWRALPSPRHDLPLDEGRCVVVDVETSGLDPRRDRLI
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEE
AIGAVAVSRGKVQLGDSLEIVLQQDTVSEKGNILIHGIGGTAQRAGVPPADALLAFLEYL
EEEHHHHCCCCEEECCCEEEEEECCCCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHH
GKDPLVAFHVAFDAPMIRRAMKAFLGLDFSHAWADLAYVAPALYPRLARRRRSLDDWMSE
CCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FKIGNYARHNALADALSTAQLLLALRKALDARGSASFAGLKDLEYTQRRQSGF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNWLAPRFGRKPELSPQQAARLAAWRALPSPRHDLPLDEGRCVVVDVETSGLDPRRDRLI
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEE
AIGAVAVSRGKVQLGDSLEIVLQQDTVSEKGNILIHGIGGTAQRAGVPPADALLAFLEYL
EEEHHHHCCCCEEECCCEEEEEECCCCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHH
GKDPLVAFHVAFDAPMIRRAMKAFLGLDFSHAWADLAYVAPALYPRLARRRRSLDDWMSE
CCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FKIGNYARHNALADALSTAQLLLALRKALDARGSASFAGLKDLEYTQRRQSGF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9826752; 10360571 [H]