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The map label for this gene is glxR [H]

Identifier: 74316099

GI number: 74316099

Start: 83363

End: 84241

Strand: Reverse

Name: glxR [H]

Synonym: Tbd_0081

Alternate gene names: 74316099

Gene position: 84241-83363 (Counterclockwise)

Preceding gene: 74316100

Following gene: 74316098

Centisome position: 2.9

GC content: 66.44

Gene sequence:

>879_bases
ATGAAAATCGGATTCATCGGCAGCGGCATCATGGGGCGTCCGATGGCGGAGAACCTGTTGCGCGCCGGCCACCAGCTGTA
CGTCTACGGGCGCCGCTTTGACCGCATCGAACCGATGCTCGTGATGGGCGCGCTCGGCAAGGGCACGCCCGCCGAGGTCG
CGGCCGAATCCGACATCACCTTCACGGTCGTCTCCGACACCACCGACGTCGAACAGATCATCCTCGGCGACCGCGGCATC
GTTCACGGCGCCCGCCCGGGTCACACCGTCATCGACATGAGCACGGTATCGCCGGCAGCGACGCGGCGCATCGCGGCCGC
GCTGGCCGAGCGCGGCATCCATATGCTGGACGCACCGGTCTCAGGCGGTGAAACGGGCGCCCGCGAAGGCACACTCTCGA
TCATGGTCGGCGGCGAGGCGCCGATCTTCGAAAAAATTCGTCCGCTGTTCGAAACGCTGGGCAAAAGCATCGTGCACGTC
GGCGGCCACGGCGCCGGTCAAGTCGTCAAGTGCTGCAACCAGATCGTGGTCGGCCTCACCTTCGAGGGCGTCGCCGAGGC
GATCCTGCTCGCGCGCCGCAACGGCGTCGACCCGGTCAAGATGCGCGAAGCCCTGCTCGGCGGCTTCGCCGGCAGCCGCA
TTCTCGAAGTCCACGGCCAGCGCATGCTCGACTCCAACTACAAGCCCGGCTTCAAGGTGAAGCTGCACCACAAGGACATG
GCGATCGTCATGGACAACGCACAGGAGACCGCGACGCCGCTACCGGGCGCCGCGCTGATCGCGCAGCAGATGAATGCATT
GATGGGGGCCGGTGACAGCGAACTCGATTCCTCGGCCCTCATGCGGGCGCTCGAACGGCTGACCGCCGACTCCAGGTGA

Upstream 100 bases:

>100_bases
GCCTCGACGCGCGTCTCGCCGGGCTTGTCATGGGCTGGTCAACGCTGGCGGGATTGGTTACGCTGCCATCCTGGCTATGG
CTGTTGAAAGGGCTCGCATC

Downstream 100 bases:

>100_bases
AGGGCAAGGAGCGGATCGTCTTTCTCGATCGCGCCGCCTTCGTTGCGGACGACCTGCCCATCCCCGACTTCGATCACAAC
TGGAGCGAGTATCCGGCCAC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKIGFIGSGIMGRPMAENLLRAGHQLYVYGRRFDRIEPMLVMGALGKGTPAEVAAESDITFTVVSDTTDVEQIILGDRGI
VHGARPGHTVIDMSTVSPAATRRIAAALAERGIHMLDAPVSGGETGAREGTLSIMVGGEAPIFEKIRPLFETLGKSIVHV
GGHGAGQVVKCCNQIVVGLTFEGVAEAILLARRNGVDPVKMREALLGGFAGSRILEVHGQRMLDSNYKPGFKVKLHHKDM
AIVMDNAQETATPLPGAALIAQQMNALMGAGDSELDSSALMRALERLTADSR

Sequences:

>Translated_292_residues
MKIGFIGSGIMGRPMAENLLRAGHQLYVYGRRFDRIEPMLVMGALGKGTPAEVAAESDITFTVVSDTTDVEQIILGDRGI
VHGARPGHTVIDMSTVSPAATRRIAAALAERGIHMLDAPVSGGETGAREGTLSIMVGGEAPIFEKIRPLFETLGKSIVHV
GGHGAGQVVKCCNQIVVGLTFEGVAEAILLARRNGVDPVKMREALLGGFAGSRILEVHGQRMLDSNYKPGFKVKLHHKDM
AIVMDNAQETATPLPGAALIAQQMNALMGAGDSELDSSALMRALERLTADSR
>Mature_292_residues
MKIGFIGSGIMGRPMAENLLRAGHQLYVYGRRFDRIEPMLVMGALGKGTPAEVAAESDITFTVVSDTTDVEQIILGDRGI
VHGARPGHTVIDMSTVSPAATRRIAAALAERGIHMLDAPVSGGETGAREGTLSIMVGGEAPIFEKIRPLFETLGKSIVHV
GGHGAGQVVKCCNQIVVGLTFEGVAEAILLARRNGVDPVKMREALLGGFAGSRILEVHGQRMLDSNYKPGFKVKLHHKDM
AIVMDNAQETATPLPGAALIAQQMNALMGAGDSELDSSALMRALERLTADSR

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=30.7692307692308, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=51.219512195122, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=42.8571428571429, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=29.6819787985866, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=29.5138888888889, Blast_Score=114, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17557316, Length=277, Percent_Identity=31.0469314079422, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=29.1095890410959, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=29.1095890410959, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=26.4285714285714, Blast_Score=121, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30930; Mature: 30930

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGSGIMGRPMAENLLRAGHQLYVYGRRFDRIEPMLVMGALGKGTPAEVAAESDIT
CEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHEEECCCCCCCHHHCCCCCEE
FTVVSDTTDVEQIILGDRGIVHGARPGHTVIDMSTVSPAATRRIAAALAERGIHMLDAPV
EEEEECCCCHHHHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCC
SGGETGAREGTLSIMVGGEAPIFEKIRPLFETLGKSIVHVGGHGAGQVVKCCNQIVVGLT
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCC
FEGVAEAILLARRNGVDPVKMREALLGGFAGSRILEVHGQRMLDSNYKPGFKVKLHHKDM
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCHHHHCCCCCCCCEEEEECCCE
AIVMDNAQETATPLPGAALIAQQMNALMGAGDSELDSSALMRALERLTADSR
EEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGFIGSGIMGRPMAENLLRAGHQLYVYGRRFDRIEPMLVMGALGKGTPAEVAAESDIT
CEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHEEECCCCCCCHHHCCCCCEE
FTVVSDTTDVEQIILGDRGIVHGARPGHTVIDMSTVSPAATRRIAAALAERGIHMLDAPV
EEEEECCCCHHHHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCC
SGGETGAREGTLSIMVGGEAPIFEKIRPLFETLGKSIVHVGGHGAGQVVKCCNQIVVGLT
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCC
FEGVAEAILLARRNGVDPVKMREALLGGFAGSRILEVHGQRMLDSNYKPGFKVKLHHKDM
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCHHHHCCCCCCCCEEEEECCCE
AIVMDNAQETATPLPGAALIAQQMNALMGAGDSELDSSALMRALERLTADSR
EEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]