Click here to switch to the map view.

The map label for this gene is nrdZ [H]

Identifier: 74316076

GI number: 74316076

Start: 60870

End: 62672

Strand: Reverse

Name: nrdZ [H]

Synonym: Tbd_0058

Alternate gene names: 74316076

Gene position: 62672-60870 (Counterclockwise)

Preceding gene: 74316082

Following gene: 74316075

Centisome position: 2.15

GC content: 70.6

Gene sequence:

>1803_bases
ATGAAGACGCACGACCCTTTCCGCATGGAGATCTCCCGCCACATCTGGGAGACCCGCTATCGCTTCGCCGGCGAGCCCGA
CATCCGCGCGAGCTGGCAACGCGTCGCGCAGGCGGTCGCGCAGGCCGAAGTCGACGCACGCGCGCTCTGGGCCGACCGCT
TCTACGCCCTGCTCGACGATTTCCGCTTTCTGCCGGGCGGAAGAATTCTCGCCGGCGCCGGCAGCGGACACCGCGTCACG
CTGTTCAACTGTTTCGTCATGGGCGAGATCGCCGACGACATCGAGGACATCTTCGAGGCGCTCAAGGAAGGCGCGCTGAC
GATGCAGCACGGTGGCGGCGTCGGCTACGACTTCTCGACGCTCCGTCCGGCCGGCACGATCGCGCAGGCGACCGGCACGA
TCGCGTCGGGGCCGGTGTCGTTCATGCACATCTGGGACGCGATGTGCGCGACCGTGCTGTCGACCGGCGCACGGCGCGGC
GCGATGATGGCGACGCTACGCTGCGACCATCCCGACATCGAGGCCTTCGTCGACGCCAAGCGCGACCCTGCCGTGTTGCG
GCACTTCAATCTTTCGGTGCAGGTCAGCGACGCGTTCATCGCCGCCGTCGACGCCGATGCCGACTGGCCGCTCGTCTTCC
CGCTGCGCGACGGCGAGCCGGCCGACGGCGCGGTCGTCCGCCGGCACTGGACCGGTTCGACGACCGCCGTGCCCTGCCGC
GTCCTGCGCACGGTGCGCGCCCGCGCGCTGTGGCAGCGGATCCTGCGCGCGGCCTACGACACGGCCGAGCCGGGCGTGCT
GTTCGTCGACACGATCAACCGCGACAACACGCTCGCCGGCCGCGAGACGCTGACCACGACCAATCCCTGCGGCGAGATTC
CGCTTCCTGCCTATGGCGCGTGCGATCTCGGCTCGCTCAACCTGACCGCTTTCGTCGTCGCGCCCTTCGCCGCCGACGCG
CGCCTCGATCTCGCCGCGCTCGGCGACGCGGCGGCGCTTGCGGTGCGTTTCCTCGACGACGTCATCGACGTCTCGCGCTA
CCCCTTGCAGGCGCAGGCGCGGGAGGCACGCTTCAAACGCCGCATCGGCCTCGGTATCACCGGGCTCGCCGACGCGCTCG
TGTTGCTCGGTCTCGACTACGACAGCGAGCCCGCGCGCCAGCTCGCCGAGCGCGCGATGCGCACGGTGCGCGACGCGGCC
TACCGCGCGTCGATCGATCTCGCGCGCGAAAAAGGCGGCTTTCCCGCGCTCGAGCGCAGCGCGTTTCTCGCCAGCGGCTT
CGCCGGCCGCCTTCCGCCCGAGATCCGCGACGGCATCGCCAGGGACGGCATCCGCAACAGCCATCTGCTCGCGATCGCGC
CGGCCGGGACGATCAGCCTCCTGGCGAACAATCTGTCCAGCGGAATCGAACCGATCTTCGCGGCCGAGGCGTCGCGCCGC
ATCCTCCAGCCCGACGGCAGCTACCGCAGCCACGCCGTCAGCGACTACGCCTGCCTGCTCTGGCGCGCGCACGGCGGCGT
CGGCCAGCCCCCCGCGCTGGTCGAGGCGCAACAGCTCGACCCCGTTGCCCATCTGGCGATGCAGGCAGCCCTGCAGCCGG
CCGTCGACAACGCGATCTCGAAGACGATCAACGTCGCCGCCGACATCGCCTTCGCACGCTTCGAAGCGCTCTACCGCCAG
GCGCACGCGCTCGGCCTCAAGGGCTGCACCGTGTTCCGGCCGAATCCGGTCACGGGCGCGATCCTCGCCGAGCCCGAGAG
CGAGCGCGTGCATTGCTGCGGGATCGAGCGTGAGGCCGACTGA

Upstream 100 bases:

>100_bases
CGGTCATGGGGCAGGCCGGGACCTATGCTCAAAGAGCGGCTACCCGGATCGCACAGGAAGAACAGATAATGCCTCAACTC
GTCGCTTCCATCGTCATCGC

Downstream 100 bases:

>100_bases
AGCCTTGGTGAGCGCGCCGCGCATCGGCCTCGCGCTCGGCAGCGGCTCGGCCCGCGGCTGGGCGCATATCGGCGTGCTGC
GCGCGCTGGCCGAGGCCGGG

Product: ribonucleoside-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MKTHDPFRMEISRHIWETRYRFAGEPDIRASWQRVAQAVAQAEVDARALWADRFYALLDDFRFLPGGRILAGAGSGHRVT
LFNCFVMGEIADDIEDIFEALKEGALTMQHGGGVGYDFSTLRPAGTIAQATGTIASGPVSFMHIWDAMCATVLSTGARRG
AMMATLRCDHPDIEAFVDAKRDPAVLRHFNLSVQVSDAFIAAVDADADWPLVFPLRDGEPADGAVVRRHWTGSTTAVPCR
VLRTVRARALWQRILRAAYDTAEPGVLFVDTINRDNTLAGRETLTTTNPCGEIPLPAYGACDLGSLNLTAFVVAPFAADA
RLDLAALGDAAALAVRFLDDVIDVSRYPLQAQAREARFKRRIGLGITGLADALVLLGLDYDSEPARQLAERAMRTVRDAA
YRASIDLAREKGGFPALERSAFLASGFAGRLPPEIRDGIARDGIRNSHLLAIAPAGTISLLANNLSSGIEPIFAAEASRR
ILQPDGSYRSHAVSDYACLLWRAHGGVGQPPALVEAQQLDPVAHLAMQAALQPAVDNAISKTINVAADIAFARFEALYRQ
AHALGLKGCTVFRPNPVTGAILAEPESERVHCCGIEREAD

Sequences:

>Translated_600_residues
MKTHDPFRMEISRHIWETRYRFAGEPDIRASWQRVAQAVAQAEVDARALWADRFYALLDDFRFLPGGRILAGAGSGHRVT
LFNCFVMGEIADDIEDIFEALKEGALTMQHGGGVGYDFSTLRPAGTIAQATGTIASGPVSFMHIWDAMCATVLSTGARRG
AMMATLRCDHPDIEAFVDAKRDPAVLRHFNLSVQVSDAFIAAVDADADWPLVFPLRDGEPADGAVVRRHWTGSTTAVPCR
VLRTVRARALWQRILRAAYDTAEPGVLFVDTINRDNTLAGRETLTTTNPCGEIPLPAYGACDLGSLNLTAFVVAPFAADA
RLDLAALGDAAALAVRFLDDVIDVSRYPLQAQAREARFKRRIGLGITGLADALVLLGLDYDSEPARQLAERAMRTVRDAA
YRASIDLAREKGGFPALERSAFLASGFAGRLPPEIRDGIARDGIRNSHLLAIAPAGTISLLANNLSSGIEPIFAAEASRR
ILQPDGSYRSHAVSDYACLLWRAHGGVGQPPALVEAQQLDPVAHLAMQAALQPAVDNAISKTINVAADIAFARFEALYRQ
AHALGLKGCTVFRPNPVTGAILAEPESERVHCCGIEREAD
>Mature_600_residues
MKTHDPFRMEISRHIWETRYRFAGEPDIRASWQRVAQAVAQAEVDARALWADRFYALLDDFRFLPGGRILAGAGSGHRVT
LFNCFVMGEIADDIEDIFEALKEGALTMQHGGGVGYDFSTLRPAGTIAQATGTIASGPVSFMHIWDAMCATVLSTGARRG
AMMATLRCDHPDIEAFVDAKRDPAVLRHFNLSVQVSDAFIAAVDADADWPLVFPLRDGEPADGAVVRRHWTGSTTAVPCR
VLRTVRARALWQRILRAAYDTAEPGVLFVDTINRDNTLAGRETLTTTNPCGEIPLPAYGACDLGSLNLTAFVVAPFAADA
RLDLAALGDAAALAVRFLDDVIDVSRYPLQAQAREARFKRRIGLGITGLADALVLLGLDYDSEPARQLAERAMRTVRDAA
YRASIDLAREKGGFPALERSAFLASGFAGRLPPEIRDGIARDGIRNSHLLAIAPAGTISLLANNLSSGIEPIFAAEASRR
ILQPDGSYRSHAVSDYACLLWRAHGGVGQPPALVEAQQLDPVAHLAMQAALQPAVDNAISKTINVAADIAFARFEALYRQ
AHALGLKGCTVFRPNPVTGAILAEPESERVHCCGIEREAD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=476, Percent_Identity=28.781512605042, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1789030, Length=472, Percent_Identity=25.8474576271186, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI2367133, Length=542, Percent_Identity=23.2472324723247, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=461, Percent_Identity=29.5010845986985, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322123, Length=459, Percent_Identity=28.322440087146, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320914, Length=459, Percent_Identity=28.1045751633987, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17352481, Length=601, Percent_Identity=26.7886855241265, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 64827; Mature: 64827

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHDPFRMEISRHIWETRYRFAGEPDIRASWQRVAQAVAQAEVDARALWADRFYALLDD
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRFLPGGRILAGAGSGHRVTLFNCFVMGEIADDIEDIFEALKEGALTMQHGGGVGYDFST
HHCCCCCEEEEECCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
LRPAGTIAQATGTIASGPVSFMHIWDAMCATVLSTGARRGAMMATLRCDHPDIEAFVDAK
CCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHCCC
RDPAVLRHFNLSVQVSDAFIAAVDADADWPLVFPLRDGEPADGAVVRRHWTGSTTAVPCR
CCCHHHHEECEEEEECCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHH
VLRTVRARALWQRILRAAYDTAEPGVLFVDTINRDNTLAGRETLTTTNPCGEIPLPAYGA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCC
CDLGSLNLTAFVVAPFAADARLDLAALGDAAALAVRFLDDVIDVSRYPLQAQAREARFKR
CCCCCCCEEEEEEECCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RIGLGITGLADALVLLGLDYDSEPARQLAERAMRTVRDAAYRASIDLAREKGGFPALERS
HHCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AFLASGFAGRLPPEIRDGIARDGIRNSHLLAIAPAGTISLLANNLSSGIEPIFAAEASRR
HHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCC
ILQPDGSYRSHAVSDYACLLWRAHGGVGQPPALVEAQQLDPVAHLAMQAALQPAVDNAIS
EECCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHH
KTINVAADIAFARFEALYRQAHALGLKGCTVFRPNPVTGAILAEPESERVHCCGIEREAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKTHDPFRMEISRHIWETRYRFAGEPDIRASWQRVAQAVAQAEVDARALWADRFYALLDD
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRFLPGGRILAGAGSGHRVTLFNCFVMGEIADDIEDIFEALKEGALTMQHGGGVGYDFST
HHCCCCCEEEEECCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
LRPAGTIAQATGTIASGPVSFMHIWDAMCATVLSTGARRGAMMATLRCDHPDIEAFVDAK
CCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHCCC
RDPAVLRHFNLSVQVSDAFIAAVDADADWPLVFPLRDGEPADGAVVRRHWTGSTTAVPCR
CCCHHHHEECEEEEECCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHH
VLRTVRARALWQRILRAAYDTAEPGVLFVDTINRDNTLAGRETLTTTNPCGEIPLPAYGA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCC
CDLGSLNLTAFVVAPFAADARLDLAALGDAAALAVRFLDDVIDVSRYPLQAQAREARFKR
CCCCCCCEEEEEEECCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RIGLGITGLADALVLLGLDYDSEPARQLAERAMRTVRDAAYRASIDLAREKGGFPALERS
HHCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AFLASGFAGRLPPEIRDGIARDGIRNSHLLAIAPAGTISLLANNLSSGIEPIFAAEASRR
HHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCC
ILQPDGSYRSHAVSDYACLLWRAHGGVGQPPALVEAQQLDPVAHLAMQAALQPAVDNAIS
EECCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHH
KTINVAADIAFARFEALYRQAHALGLKGCTVFRPNPVTGAILAEPESERVHCCGIEREAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]