BacMap

Definition	Ralstonia eutropha JMP134 chromosome 1, complete sequence.
Accession	NC_007347
Length	3,806,533

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The map label for this gene is fadH [H]

Identifier: 73542964

GI number: 73542964

Start: 3588706

End: 3589506

Strand: Direct

Name: fadH [H]

Synonym: Reut_A3281

Alternate gene names: 73542964

Gene position: 3588706-3589506 (Clockwise)

Preceding gene: 73542963

Following gene: 73542965

Centisome position: 94.28

GC content: 67.17

Gene sequence:

>801_bases
ATGTCCAGTGCATTCCGTCCTGACGCGCTCGCCGGCAAGACCGTTTTCGTGGCCGGCGGCTCGTCCGGCATCAACCTTGG
CATCGCGCAGAGCTTTGCGCGCTCCGGCGCGAAGCTCGCGCTGATCAGCCGCGATCCGGAGCGCGTGGCGGCCGCTGCCG
CCACCATCACCGAAGCCGGCGGTACCGCCATCGGGATGGCCGCTGACGTGCGCGACTACGCCGCGGTGGAGGCCGCGCTG
AAACAGGCGCGCGACACGTTTGGCCAGATCGACATCGTCATTTCGGGCGCGGCCGGCAACTTCCTGGCGCCCGTGGTGGG
CATGTCGGCCAATGGCTTCAAGACCGTGGTCGATATCGACCTGATCGGCACGTTCAATGTGTTCCGCGCGTCGTTCGATT
ACCTGAACAAGCCTGGCGCATCGCTGATCGCCATCACCGCGCCGCAGGGCGTGAACGCGATGATGTTCCAGGCCCACGCG
TGCGCGGCCAAGGCCGGCATCAACATGCTCGTGAAGTGCCTGGCGATGGAATGGGGCCCGGCTGGCGTGCGCGTAAACGG
CATCTCGCCCGGCCCGATCGCCGATACCGAAGGCATGGCGCGCCTGGCGCCCACGCCCGAGATGGAGGCGCGCTACAAGG
GTCGCCTGCCGCTGCGCGACTACGGCAGCAAGCAGGACATTGCCGATGCGGCGCTGTATCTGAGCTGCGACAACGCGCGC
TACGTAACCGGCACCATCCTGGATTGCGACGGCGGCAGCAAGCTCGGCGATGCGTCGGCCGATGCCCTGAAGACGAAGTG
A

Upstream 100 bases:

>100_bases
CTGCTTTCCCTGCTCCCCCTCCTCCCTTTACGTGAACCGCCGGCTTGCCATCGGCACGCCGGTGCCTTGTCTCGCTCACC
CATTCAACAGAGGGAATCCC

Downstream 100 bases:

>100_bases
ACCCCGATTCACGAAGGAAAACACCGCAATGACTTCCCCCGTGCTCTACCACGCCAGCGAAGGTGTGGCCACCATCACCC
TGAACCGTCCTGAAGTCCTG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSSAFRPDALAGKTVFVAGGSSGINLGIAQSFARSGAKLALISRDPERVAAAAATITEAGGTAIGMAADVRDYAAVEAAL
KQARDTFGQIDIVISGAAGNFLAPVVGMSANGFKTVVDIDLIGTFNVFRASFDYLNKPGASLIAITAPQGVNAMMFQAHA
CAAKAGINMLVKCLAMEWGPAGVRVNGISPGPIADTEGMARLAPTPEMEARYKGRLPLRDYGSKQDIADAALYLSCDNAR
YVTGTILDCDGGSKLGDASADALKTK

Sequences:

>Translated_266_residues
MSSAFRPDALAGKTVFVAGGSSGINLGIAQSFARSGAKLALISRDPERVAAAAATITEAGGTAIGMAADVRDYAAVEAAL
KQARDTFGQIDIVISGAAGNFLAPVVGMSANGFKTVVDIDLIGTFNVFRASFDYLNKPGASLIAITAPQGVNAMMFQAHA
CAAKAGINMLVKCLAMEWGPAGVRVNGISPGPIADTEGMARLAPTPEMEARYKGRLPLRDYGSKQDIADAALYLSCDNAR
YVTGTILDCDGGSKLGDASADALKTK
>Mature_265_residues
SSAFRPDALAGKTVFVAGGSSGINLGIAQSFARSGAKLALISRDPERVAAAAATITEAGGTAIGMAADVRDYAAVEAALK
QARDTFGQIDIVISGAAGNFLAPVVGMSANGFKTVVDIDLIGTFNVFRASFDYLNKPGASLIAITAPQGVNAMMFQAHAC
AAKAGINMLVKCLAMEWGPAGVRVNGISPGPIADTEGMARLAPTPEMEARYKGRLPLRDYGSKQDIADAALYLSCDNARY
VTGTILDCDGGSKLGDASADALKTK

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=43.3070866141732, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=32.5396825396825, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=26.9662921348315, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=26.4227642276423, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=30.0429184549356, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=27.6, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=26.6393442622951, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40254986, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=28.8537549407115, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI5031737, Length=240, Percent_Identity=23.3333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4503817, Length=212, Percent_Identity=27.8301886792453, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI223718074, Length=205, Percent_Identity=27.3170731707317, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=32.9411764705882, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=29.0983606557377, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=30.9917355371901, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=24.0816326530612, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=25.2, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787545, Length=253, Percent_Identity=28.0632411067194, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=24.5059288537549, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=24.8995983935743, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=29.2682926829268, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=26.5873015873016, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=23.4375, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=33.5907335907336, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=32.4324324324324, Blast_Score=126, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17561272, Length=261, Percent_Identity=32.9501915708812, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=26.1904761904762, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=28.6792452830189, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=29.718875502008, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982365, Length=196, Percent_Identity=29.5918367346939, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558628, Length=204, Percent_Identity=32.843137254902, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=24.8091603053435, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=29.7619047619048, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=24.0458015267176, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=23.265306122449, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=25.8555133079848, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=24.031007751938, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=190, Percent_Identity=25.7894736842105, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=26.4367816091954, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=23.5521235521236, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=25.1908396946565, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=24.5283018867925, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=24.8091603053435, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=24.8148148148148, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=23.9700374531835, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=41.897233201581, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=28, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=245, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357673, Length=191, Percent_Identity=32.9842931937173, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571526, Length=245, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=25, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=28.8537549407115, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=23.7903225806452, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644337, Length=251, Percent_Identity=25.0996015936255, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356301, Length=220, Percent_Identity=28.1818181818182, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 27298; Mature: 27167

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAFRPDALAGKTVFVAGGSSGINLGIAQSFARSGAKLALISRDPERVAAAAATITEAG
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCC
GTAIGMAADVRDYAAVEAALKQARDTFGQIDIVISGAAGNFLAPVVGMSANGFKTVVDID
CCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCCCCCEEEEEEE
LIGTFNVFRASFDYLNKPGASLIAITAPQGVNAMMFQAHACAAKAGINMLVKCLAMEWGP
EECCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
AGVRVNGISPGPIADTEGMARLAPTPEMEARYKGRLPLRDYGSKQDIADAALYLSCDNAR
CCEEECCCCCCCCCCCCCCEECCCCCCCCHHHCCCCCHHHCCCCCCCCCEEEEEEECCCE
YVTGTILDCDGGSKLGDASADALKTK
EEEEEEEECCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SSAFRPDALAGKTVFVAGGSSGINLGIAQSFARSGAKLALISRDPERVAAAAATITEAG
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCC
GTAIGMAADVRDYAAVEAALKQARDTFGQIDIVISGAAGNFLAPVVGMSANGFKTVVDID
CCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCCCCCEEEEEEE
LIGTFNVFRASFDYLNKPGASLIAITAPQGVNAMMFQAHACAAKAGINMLVKCLAMEWGP
EECCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
AGVRVNGISPGPIADTEGMARLAPTPEMEARYKGRLPLRDYGSKQDIADAALYLSCDNAR
CCEEECCCCCCCCCCCCCCEECCCCCCCCHHHCCCCCHHHCCCCCCCCCEEEEEEECCCE
YVTGTILDCDGGSKLGDASADALKTK
EEEEEEEECCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]