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The map label for this gene is tktA [H]

Identifier: 73542526

GI number: 73542526

Start: 3113578

End: 3115611

Strand: Reverse

Name: tktA [H]

Synonym: Reut_A2841

Alternate gene names: 73542526

Gene position: 3115611-3113578 (Counterclockwise)

Preceding gene: 73542530

Following gene: 73542525

Centisome position: 81.85

GC content: 66.08

Gene sequence:

>2034_bases
ATGTCCGCCCTTGCTCATCCCGCCACAAGTCCCTTTGCTTCCCAGCCTGCCAAGCTGATGGCCGATGCCATTCGCGTGCT
TGCCATGGACGCCGTCCAGCAAGCCAATTCCGGCCATCCTGGCGCGCCGATGGGCATGGCCGATATCGCAGTGGCGCTGT
GGGGCCGCCACCTGAAGCACAACCCGGCCAATCCGCACTGGGCGGACCGCGACCGCTTCGTGCTGTCGAACGGCCACGGC
TCGATGCTGATCTACGCGCTGCTGCACCTGACCGGCTATGACCTGCCGATCGAGGAGCTGAAGAACTTCCGCCAGCTTCA
CAGCAAGACCGCCGGTCACCCGGAATACGGCATCACCCCTGGCGTGGAAACGACCACCGGCCCGCTGGGCCAGGGCATCA
CCAATGCCGTCGGCATGGCGCTGGCCGAACGCCTGCTCGGTGAAGAATTCAACCGCCCGGGCTTCAACATTGTCAATCAC
TACACCTACGTGTTCCTCGGCGACGGCTGCCTGATGGAAGGCATCAGCCACGAGGCTTGCTCGCTGGCCGGCACGCTGAA
GCTGAACAAGCTGATCGCACTGTGGGATGACAACGGCATCTCGATCGATGGCGACGTGGTGCACTGGTTCAACGACGACA
CGCCCAAGCGCTTCGAAGCCTACGGCTGGAACGTGATCCGCGGCATCGACGGCCACGACGTGACCGCTGTCGACCTGGCG
ATTTCGCAGGCCAAGGCCAGCGACAAGCCGACCCTGATCTGCTGCCGCACCAAGATCGGCAAGGGCGCGCCCAACAAGGA
AGGCGGTCACGACGTGCACGGCGCCCCGCTTGGCGGCGCCGAAGTGCTGGCCACGCGCGAAGCGCTTGGCTGGGCCCACG
CCCCGTTCGAAGTGCCGGCGGATGTCTACGACGCCTGGGATGCCAAGGCCACCGGCCTCGCCCTGGAAAAGGCCTGGAAC
GCGCTGTTCGAAGGCTACGCCGACCGCCACCCGTATGAAGCCGGTGAATTCCAGCGCCGCATGCGCGGCGAGCTGCCAGG
CAGCTTCGACGCCGCCGTCGACGCCTTCATCGCCAAGTGCGAGGAAAAGGCCGAGACCATCGCTACCCGCAAGGCGAGCC
AGAACACCATCGAGGCCTTCGGCCCGGTGCTGCCCGAATTCCTCGGCGGCTCGGCCGACCTGACCGGCTCGAACCTGACC
AACTGGTCGGGCAGCCAGGCCGTGCGTGTGGATGCCTGGGGCAACCACATCAACTATGGTGTGCGCGAGTTCGGCATGAG
CGCCATCCTGAACGGTATTACGCTGCACGGTGGCTACATCCCCTACGGCGCCACGTTCCTGACCTTCTCGGACTACAGCC
GCAACGCGCTGCGCATGGCGGCGCTGATGAAAATCCGCTCGCTGTTCGTGTTCACCCATGACTCGATCGGCCTGGGCGAA
GACGGCCCGACGCACCAGTCGATCGAACACGTCGCCAGCCTGCGCCTGATCCCGAACATGGACGTCTGGCGTACCGCCGA
CACCACTGAGACCGCCGTGGCCTGGGCCGAGGCGATCCGCCGCGAAAACGGCCCGAGCTGCCTGATCTTCAGCCGCCAGA
ACCTGCCGTTCCAGCAGCGTGACGACGCGACCCGCGCCAATATCGCGCGCGGCGGCTACGTGCTGCGCGACGGCACGAAC
GCGAACACCGGCCGTCCCGACGCCGTGATCCTGGCCACCGGCTCGGAAGTGGGCCTGGCCGTCGGCGCTGCCGACCAGCT
GGCCGCCGAAGGCGTGCACGTGCGCGTGGTATCGATTCCGGCCACGACTGTGTTCGACAAGCAGGACAGCGCCTACAAGG
CGAGCGTCCTGCCGGCCGGCGTGCCCCGCGTGGCCGTGGAAGCCGGTGTGACGGATTTCTGGTGGAAATACCAGGTCCAG
GCTGTTGTGGGCATTGACACCTTCGGCCAGTCGGCGCCGGCCGGCGTGCTGTTCAAGCACTTCGGCTTCACCGTCGAGAA
CGTCGTGCGGACCGTCAAGGACACGCTGCAATAA

Upstream 100 bases:

>100_bases
TGTCCGGTCCGTCCGACGGCAGCGTTGCAGCCGGATTTACCCTTAGCTTCTGCTAAAATTGCTGTTTTCCTGCCGCCAGG
CCCAGCGCCCTTACGCCCGC

Downstream 100 bases:

>100_bases
GAGTCGCGGCGGACAACCCGGCGCCCCAGTTTTCTAGCATCAGGCATTTCAGGAGATAGACATGACCATCAAGATCGGCA
TCAACGGCTTCGGCCGCATC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MSALAHPATSPFASQPAKLMADAIRVLAMDAVQQANSGHPGAPMGMADIAVALWGRHLKHNPANPHWADRDRFVLSNGHG
SMLIYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGMALAERLLGEEFNRPGFNIVNH
YTYVFLGDGCLMEGISHEACSLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRGIDGHDVTAVDLA
ISQAKASDKPTLICCRTKIGKGAPNKEGGHDVHGAPLGGAEVLATREALGWAHAPFEVPADVYDAWDAKATGLALEKAWN
ALFEGYADRHPYEAGEFQRRMRGELPGSFDAAVDAFIAKCEEKAETIATRKASQNTIEAFGPVLPEFLGGSADLTGSNLT
NWSGSQAVRVDAWGNHINYGVREFGMSAILNGITLHGGYIPYGATFLTFSDYSRNALRMAALMKIRSLFVFTHDSIGLGE
DGPTHQSIEHVASLRLIPNMDVWRTADTTETAVAWAEAIRRENGPSCLIFSRQNLPFQQRDDATRANIARGGYVLRDGTN
ANTGRPDAVILATGSEVGLAVGAADQLAAEGVHVRVVSIPATTVFDKQDSAYKASVLPAGVPRVAVEAGVTDFWWKYQVQ
AVVGIDTFGQSAPAGVLFKHFGFTVENVVRTVKDTLQ

Sequences:

>Translated_677_residues
MSALAHPATSPFASQPAKLMADAIRVLAMDAVQQANSGHPGAPMGMADIAVALWGRHLKHNPANPHWADRDRFVLSNGHG
SMLIYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGMALAERLLGEEFNRPGFNIVNH
YTYVFLGDGCLMEGISHEACSLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRGIDGHDVTAVDLA
ISQAKASDKPTLICCRTKIGKGAPNKEGGHDVHGAPLGGAEVLATREALGWAHAPFEVPADVYDAWDAKATGLALEKAWN
ALFEGYADRHPYEAGEFQRRMRGELPGSFDAAVDAFIAKCEEKAETIATRKASQNTIEAFGPVLPEFLGGSADLTGSNLT
NWSGSQAVRVDAWGNHINYGVREFGMSAILNGITLHGGYIPYGATFLTFSDYSRNALRMAALMKIRSLFVFTHDSIGLGE
DGPTHQSIEHVASLRLIPNMDVWRTADTTETAVAWAEAIRRENGPSCLIFSRQNLPFQQRDDATRANIARGGYVLRDGTN
ANTGRPDAVILATGSEVGLAVGAADQLAAEGVHVRVVSIPATTVFDKQDSAYKASVLPAGVPRVAVEAGVTDFWWKYQVQ
AVVGIDTFGQSAPAGVLFKHFGFTVENVVRTVKDTLQ
>Mature_676_residues
SALAHPATSPFASQPAKLMADAIRVLAMDAVQQANSGHPGAPMGMADIAVALWGRHLKHNPANPHWADRDRFVLSNGHGS
MLIYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGMALAERLLGEEFNRPGFNIVNHY
TYVFLGDGCLMEGISHEACSLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRGIDGHDVTAVDLAI
SQAKASDKPTLICCRTKIGKGAPNKEGGHDVHGAPLGGAEVLATREALGWAHAPFEVPADVYDAWDAKATGLALEKAWNA
LFEGYADRHPYEAGEFQRRMRGELPGSFDAAVDAFIAKCEEKAETIATRKASQNTIEAFGPVLPEFLGGSADLTGSNLTN
WSGSQAVRVDAWGNHINYGVREFGMSAILNGITLHGGYIPYGATFLTFSDYSRNALRMAALMKIRSLFVFTHDSIGLGED
GPTHQSIEHVASLRLIPNMDVWRTADTTETAVAWAEAIRRENGPSCLIFSRQNLPFQQRDDATRANIARGGYVLRDGTNA
NTGRPDAVILATGSEVGLAVGAADQLAAEGVHVRVVSIPATTVFDKQDSAYKASVLPAGVPRVAVEAGVTDFWWKYQVQA
VVGIDTFGQSAPAGVLFKHFGFTVENVVRTVKDTLQ

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=27.5919732441472, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=27.5919732441472, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI133778974, Length=580, Percent_Identity=25.8620689655172, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI225637459, Length=261, Percent_Identity=26.8199233716475, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI225637461, Length=159, Percent_Identity=32.7044025157233, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI225637463, Length=159, Percent_Identity=32.7044025157233, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=66.0633484162896, Blast_Score=916, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=60.6334841628959, Blast_Score=831, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=590, Percent_Identity=25.0847457627119, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=48.4351713859911, Blast_Score=596, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=44.7916666666667, Blast_Score=545, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=283, Percent_Identity=34.982332155477, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45550715, Length=283, Percent_Identity=34.982332155477, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24666278, Length=267, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24645119, Length=245, Percent_Identity=35.5102040816327, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72903; Mature: 72772

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALAHPATSPFASQPAKLMADAIRVLAMDAVQQANSGHPGAPMGMADIAVALWGRHLKH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
NPANPHWADRDRFVLSNGHGSMLIYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITP
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
GVETTTGPLGQGITNAVGMALAERLLGEEFNRPGFNIVNHYTYVFLGDGCLMEGISHEAC
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEEEECCCHHHHCCCHHHH
SLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRGIDGHDVTAVDLA
HHHHHEEEEEEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCEEEECCCCCCEEEEHHH
ISQAKASDKPTLICCRTKIGKGAPNKEGGHDVHGAPLGGAEVLATREALGWAHAPFEVPA
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCH
DVYDAWDAKATGLALEKAWNALFEGYADRHPYEAGEFQRRMRGELPGSFDAAVDAFIAKC
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
EEKAETIATRKASQNTIEAFGPVLPEFLGGSADLTGSNLTNWSGSQAVRVDAWGNHINYG
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHH
VREFGMSAILNGITLHGGYIPYGATFLTFSDYSRNALRMAALMKIRSLFVFTHDSIGLGE
HHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCC
DGPTHQSIEHVASLRLIPNMDVWRTADTTETAVAWAEAIRRENGPSCLIFSRQNLPFQQR
CCCCHHHHHHHHHHEECCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
DDATRANIARGGYVLRDGTNANTGRPDAVILATGSEVGLAVGAADQLAAEGVHVRVVSIP
CCCHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCCCEEECCHHHHHHCCEEEEEEEEC
ATTVFDKQDSAYKASVLPAGVPRVAVEAGVTDFWWKYQVQAVVGIDTFGQSAPAGVLFKH
CEEEECCCCCCEEEECCCCCCCHHHHHCCCCHHEEEEEEEEEEEEECCCCCCCCHHHHHH
FGFTVENVVRTVKDTLQ
HCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SALAHPATSPFASQPAKLMADAIRVLAMDAVQQANSGHPGAPMGMADIAVALWGRHLKH
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCC
NPANPHWADRDRFVLSNGHGSMLIYALLHLTGYDLPIEELKNFRQLHSKTAGHPEYGITP
CCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
GVETTTGPLGQGITNAVGMALAERLLGEEFNRPGFNIVNHYTYVFLGDGCLMEGISHEAC
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEEEECCCHHHHCCCHHHH
SLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRGIDGHDVTAVDLA
HHHHHEEEEEEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCEEEECCCCCCEEEEHHH
ISQAKASDKPTLICCRTKIGKGAPNKEGGHDVHGAPLGGAEVLATREALGWAHAPFEVPA
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCH
DVYDAWDAKATGLALEKAWNALFEGYADRHPYEAGEFQRRMRGELPGSFDAAVDAFIAKC
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
EEKAETIATRKASQNTIEAFGPVLPEFLGGSADLTGSNLTNWSGSQAVRVDAWGNHINYG
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHH
VREFGMSAILNGITLHGGYIPYGATFLTFSDYSRNALRMAALMKIRSLFVFTHDSIGLGE
HHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCC
DGPTHQSIEHVASLRLIPNMDVWRTADTTETAVAWAEAIRRENGPSCLIFSRQNLPFQQR
CCCCHHHHHHHHHHEECCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
DDATRANIARGGYVLRDGTNANTGRPDAVILATGSEVGLAVGAADQLAAEGVHVRVVSIP
CCCHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCCCEEECCHHHHHHCCEEEEEEEEC
ATTVFDKQDSAYKASVLPAGVPRVAVEAGVTDFWWKYQVQAVVGIDTFGQSAPAGVLFKH
CEEEECCCCCCEEEECCCCCCCHHHHHCCCCHHEEEEEEEEEEEEECCCCCCCCHHHHHH
FGFTVENVVRTVKDTLQ
HCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]