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The map label for this gene is holA [H]

Identifier: 73542517

GI number: 73542517

Start: 3103910

End: 3104968

Strand: Reverse

Name: holA [H]

Synonym: Reut_A2832

Alternate gene names: 73542517

Gene position: 3104968-3103910 (Counterclockwise)

Preceding gene: 73542518

Following gene: 73542516

Centisome position: 81.57

GC content: 67.8

Gene sequence:

>1059_bases
ATGCAGCTCAAGCTCGACGGACTCGACGCCCATTTGCGGCAGGCCAAGGCCAAGGGTCTCGCGCCGCTCTACGTCGTTCA
TGGCGACGAGCACTTGCTGGTGCTCGAAGCGGTGGACCGCCTGCGCCAGACCGCGCGCGAGGCCGGTTTCTCCGAGCGCG
ACGTGCTCGTGGCCGAACGCAATTTCCACTGGAGCCAGCTCGTCGAGGCGCAGCAGTCGATGTCGCTGTTCGGTGATCGC
AAGATCGTCGAACTGCGCATTCCGTCCGGCAAGCCTGGCAAAGAGGGTGGCGAGGCGCTGCGCGCCGTGGCGGCTCAGCC
GTCGCCCGACGTGGTGATGCTCGTCACGCTGCCGCGGCTGGATTTCGCCACGTCGAAGTCGGCGTGGTTCCAGGCGCTGG
AAGGTGCGGGCGTATCGATCAAGGTCGACTCCGTGGACCGAACCCGGCTGCCGGCCTGGGTCGGCGAACGCCTGGCCCTG
CAGCAGCAGCGCGTGGAAGGCGGCGAGCCCGGCCGGCGAGCGCTGCAGTTCATTGCCGACAAGGTTGAAGGCAACCTGCT
GGCCGCCCACCAGGAAATCCAGAAGCTCGGCCTGTTGTACCCGACCGGCGAACTGACCTTCGACCAGGTGCACGATGCGG
TGCTCAACGTGGCCCGCTACGACGTCTTCAAACTGTCTGAAGCGATGCTCGGCGGCGACGTGCCGCGGCTGGTGCGCATG
CTCGAAGGGCTGCGAGGCGAGGGCGAAGCCACGGTCCTGGTGCTGTGGGCGCTGACCGAGGAAATTCGCGTATTATCCAA
GGTCCGGCAAGGCATTGCGGCCGGCAAGCCCGCCGCCGTGCTGATGCGCGAACTGCGGGTCTGGGGCGCACGCGAACGGC
TGGTGCCGCAGGCCGCGCAGCGGCTCACGCAGGGCAAACTCGATGCGGCGCTGGCAATGGCAGCGCGGCTGGACCGGCAA
GTGAAGGGTTTGCAAGACCTGCCGCCACCGGGCAGCGCGCCGCTGCCGGCAGAGCCATGGGATGGCTTGCAGCAGCTGGC
GCTGATGATTGCGCGCTGA

Upstream 100 bases:

>100_bases
AGCAGCTCTATCGCGACATGCAGCGCGATATCGTGCAGCAGCTCATGCGCCGGCTGGCCGCGGTCAAGGCCATCTGAGCG
CATCGACGTCCCGCACCGGC

Downstream 100 bases:

>100_bases
TCCTTGCACCGCGCTCCCGCTCGCGGGAACGAAGAAACATTCTCAGACGGCCGTCGTCTGTAGGCCACGAACATGACCGA
GCTCGATCTCAACCAATACA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MQLKLDGLDAHLRQAKAKGLAPLYVVHGDEHLLVLEAVDRLRQTAREAGFSERDVLVAERNFHWSQLVEAQQSMSLFGDR
KIVELRIPSGKPGKEGGEALRAVAAQPSPDVVMLVTLPRLDFATSKSAWFQALEGAGVSIKVDSVDRTRLPAWVGERLAL
QQQRVEGGEPGRRALQFIADKVEGNLLAAHQEIQKLGLLYPTGELTFDQVHDAVLNVARYDVFKLSEAMLGGDVPRLVRM
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGIAAGKPAAVLMRELRVWGARERLVPQAAQRLTQGKLDAALAMAARLDRQ
VKGLQDLPPPGSAPLPAEPWDGLQQLALMIAR

Sequences:

>Translated_352_residues
MQLKLDGLDAHLRQAKAKGLAPLYVVHGDEHLLVLEAVDRLRQTAREAGFSERDVLVAERNFHWSQLVEAQQSMSLFGDR
KIVELRIPSGKPGKEGGEALRAVAAQPSPDVVMLVTLPRLDFATSKSAWFQALEGAGVSIKVDSVDRTRLPAWVGERLAL
QQQRVEGGEPGRRALQFIADKVEGNLLAAHQEIQKLGLLYPTGELTFDQVHDAVLNVARYDVFKLSEAMLGGDVPRLVRM
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGIAAGKPAAVLMRELRVWGARERLVPQAAQRLTQGKLDAALAMAARLDRQ
VKGLQDLPPPGSAPLPAEPWDGLQQLALMIAR
>Mature_352_residues
MQLKLDGLDAHLRQAKAKGLAPLYVVHGDEHLLVLEAVDRLRQTAREAGFSERDVLVAERNFHWSQLVEAQQSMSLFGDR
KIVELRIPSGKPGKEGGEALRAVAAQPSPDVVMLVTLPRLDFATSKSAWFQALEGAGVSIKVDSVDRTRLPAWVGERLAL
QQQRVEGGEPGRRALQFIADKVEGNLLAAHQEIQKLGLLYPTGELTFDQVHDAVLNVARYDVFKLSEAMLGGDVPRLVRM
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGIAAGKPAAVLMRELRVWGARERLVPQAAQRLTQGKLDAALAMAARLDRQ
VKGLQDLPPPGSAPLPAEPWDGLQQLALMIAR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=311, Percent_Identity=30.5466237942122, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38578; Mature: 38578

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKLDGLDAHLRQAKAKGLAPLYVVHGDEHLLVLEAVDRLRQTAREAGFSERDVLVAER
CEEEECCHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEEC
NFHWSQLVEAQQSMSLFGDRKIVELRIPSGKPGKEGGEALRAVAAQPSPDVVMLVTLPRL
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCC
DFATSKSAWFQALEGAGVSIKVDSVDRTRLPAWVGERLALQQQRVEGGEPGRRALQFIAD
CCCCCHHHHHHHHCCCCCEEEECCCCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KVEGNLLAAHQEIQKLGLLYPTGELTFDQVHDAVLNVARYDVFKLSEAMLGGDVPRLVRM
HHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGIAAGKPAAVLMRELRVWGARERLVPQAAQ
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHH
RLTQGKLDAALAMAARLDRQVKGLQDLPPPGSAPLPAEPWDGLQQLALMIAR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQLKLDGLDAHLRQAKAKGLAPLYVVHGDEHLLVLEAVDRLRQTAREAGFSERDVLVAER
CEEEECCHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEEC
NFHWSQLVEAQQSMSLFGDRKIVELRIPSGKPGKEGGEALRAVAAQPSPDVVMLVTLPRL
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCC
DFATSKSAWFQALEGAGVSIKVDSVDRTRLPAWVGERLALQQQRVEGGEPGRRALQFIAD
CCCCCHHHHHHHHCCCCCEEEECCCCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KVEGNLLAAHQEIQKLGLLYPTGELTFDQVHDAVLNVARYDVFKLSEAMLGGDVPRLVRM
HHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LEGLRGEGEATVLVLWALTEEIRVLSKVRQGIAAGKPAAVLMRELRVWGARERLVPQAAQ
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHH
RLTQGKLDAALAMAARLDRQVKGLQDLPPPGSAPLPAEPWDGLQQLALMIAR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]