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The map label for this gene is proA [H]

Identifier: 73542516

GI number: 73542516

Start: 3102557

End: 3103837

Strand: Reverse

Name: proA [H]

Synonym: Reut_A2831

Alternate gene names: 73542516

Gene position: 3103837-3102557 (Counterclockwise)

Preceding gene: 73542517

Following gene: 73542515

Centisome position: 81.54

GC content: 65.65

Gene sequence:

>1281_bases
ATGACCGAGCTCGATCTCAACCAATACATGGACCGCGTCGGCCGCCAGGCACGCGCGGCATCGCGCGCGATGGCGCGCGC
CTCCACTGCCGACAAGAACCGCGCGCTGCTGACCATTGCCGCGGCGATCCGCCGTGATGCCGACAAGCTCAAGGCCGTCA
ACGCGCGTGACGTCGAGCGTGCCCGCGCCAACGGCCAGGATGCGGCCTTCGTCGACCGCCTGACCCTGTCGGACAAGGCC
ATCAAGACCATGGCTGAAGGCCTTGAGCAGATCGCCGCGCTGGCCGATCCGATCGGCGAGATCTCGAACATGAAATTCCG
CCCGACCGGCATCCAGGTCGGCCAGATGCGCGTGCCGCTCGGCGTGATCGGCATCATCTACGAATCGCGTCCGAACGTGA
CCATTGATGCAGCGGCGCTGTGTCTGAAGTCGGGCAATGCGACGATCCTGCGCGGCGGCTCGGAGGCCATCGAATCGAAC
ACCGCGCTGGCCGCGCTCGTCGCTGAAGGCCTGGCGTCCGCCGGCCTGCCGCCCGAGGCCGTGCAAGTCGTCGAAACCAC
GGACCGCGCTGCGGTCGGCCGCCTGATCACGATGACCGAGTACGTCGACGTGATCGTGCCGCGTGGCGGCAAGAGCCTGA
TCGCGCGTCTGATGGAAGAAGCGCGCGTGCCGATGATCAAGCATCTGGACGGCATCTGCCACGTGTTCATCGACGCCGAC
GCGGACCTCGACAAGGCCGTGCGCGTCTGCGACAACGCCAAGACCCAGCGCTACGCGCCGTGCAACACCATGGAGACGCT
CCTGGTGTCGCAGGACATCGCCGCGCGCGCGCTGCCGCCGCTGTGCCGCATCTACCAGGAAAAGGGCGTCGAGCTGCGTG
TCTGCCCGGCTACGCGCGCCATGCTGGAAGCCGCGGGCTTCAGCGGGCTTGTCGATGCGCACGAAGAAGACTGGCGCCTG
GAGTACCTGGCCCCGATCCTCGCCATCAAGACAGTGGCCGGACTTGACGAGGCCATCGCGCATATCAACGAATACGGCTC
GCACCATACCGATTCGATCATCACCGAGAACTACTCGACCGGCATGCGCTTTATCCGCGAAGTCGATTCGGCGAGCGTGA
TGATCAACGCGTCGACGCGCTTTGCTGACGGCTTCGAGTACGGCCTTGGCGCGGAGATCGGCATTTCCAACGACAAGCTG
CACGCACGCGGCCCGGTCGGACTGGAAGGGCTGACGTCGCTGAAGTATGTGGTGTTCGGCCACGGCGAGATCCGTACCTG
A

Upstream 100 bases:

>100_bases
GCAGCTGGCGCTGATGATTGCGCGCTGATCCTTGCACCGCGCTCCCGCTCGCGGGAACGAAGAAACATTCTCAGACGGCC
GTCGTCTGTAGGCCACGAAC

Downstream 100 bases:

>100_bases
GAACGCGCCGGCGGGCGATCATGCCCGCCGCAAAGAACAACAACTGCTCCGCAAACGCTTCGCTGAATGCTCTGGGTCAA
AGCGCTTCATATCGTCTTTG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTELDLNQYMDRVGRQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVERARANGQDAAFVDRLTLSDKA
IKTMAEGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEAIESN
TALAALVAEGLASAGLPPEAVQVVETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVFIDAD
ADLDKAVRVCDNAKTQRYAPCNTMETLLVSQDIAARALPPLCRIYQEKGVELRVCPATRAMLEAAGFSGLVDAHEEDWRL
EYLAPILAIKTVAGLDEAIAHINEYGSHHTDSIITENYSTGMRFIREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT

Sequences:

>Translated_426_residues
MTELDLNQYMDRVGRQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVERARANGQDAAFVDRLTLSDKA
IKTMAEGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEAIESN
TALAALVAEGLASAGLPPEAVQVVETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVFIDAD
ADLDKAVRVCDNAKTQRYAPCNTMETLLVSQDIAARALPPLCRIYQEKGVELRVCPATRAMLEAAGFSGLVDAHEEDWRL
EYLAPILAIKTVAGLDEAIAHINEYGSHHTDSIITENYSTGMRFIREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT
>Mature_425_residues
TELDLNQYMDRVGRQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVERARANGQDAAFVDRLTLSDKAI
KTMAEGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEAIESNT
ALAALVAEGLASAGLPPEAVQVVETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVFIDADA
DLDKAVRVCDNAKTQRYAPCNTMETLLVSQDIAARALPPLCRIYQEKGVELRVCPATRAMLEAAGFSGLVDAHEEDWRLE
YLAPILAIKTVAGLDEAIAHINEYGSHHTDSIITENYSTGMRFIREVDSASVMINASTRFADGFEYGLGAEIGISNDKLH
ARGPVGLEGLTSLKYVVFGHGEIRT

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=35.4066985645933, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=35.4066985645933, Blast_Score=253, Evalue=3e-67,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=43.5096153846154, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17569967, Length=419, Percent_Identity=36.2768496420048, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17569969, Length=419, Percent_Identity=36.2768496420048, Blast_Score=268, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=38.0184331797235, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=38.1067961165049, Blast_Score=274, Evalue=8e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45898; Mature: 45767

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELDLNQYMDRVGRQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHH
ARANGQDAAFVDRLTLSDKAIKTMAEGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECCEECCE
GVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEAIESNTALAALVAEGLASAGLPPEA
EEEEEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHH
VQVVETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVFIDAD
HHHHHHCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEECC
ADLDKAVRVCDNAKTQRYAPCNTMETLLVSQDIAARALPPLCRIYQEKGVELRVCPATRA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECHHHHH
MLEAAGFSGLVDAHEEDWRLEYLAPILAIKTVAGLDEAIAHINEYGSHHTDSIITENYST
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHH
GMRFIREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEE
HGEIRT
CCCCCC
>Mature Secondary Structure 
TELDLNQYMDRVGRQARAASRAMARASTADKNRALLTIAAAIRRDADKLKAVNARDVER
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHH
ARANGQDAAFVDRLTLSDKAIKTMAEGLEQIAALADPIGEISNMKFRPTGIQVGQMRVPL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECCEECCE
GVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEAIESNTALAALVAEGLASAGLPPEA
EEEEEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHH
VQVVETTDRAAVGRLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVFIDAD
HHHHHHCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEECC
ADLDKAVRVCDNAKTQRYAPCNTMETLLVSQDIAARALPPLCRIYQEKGVELRVCPATRA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECHHHHH
MLEAAGFSGLVDAHEEDWRLEYLAPILAIKTVAGLDEAIAHINEYGSHHTDSIITENYST
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHH
GMRFIREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEE
HGEIRT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA