Click here to switch to the map view.

The map label for this gene is zraS [C]

Identifier: 73542499

GI number: 73542499

Start: 3085196

End: 3086527

Strand: Reverse

Name: zraS [C]

Synonym: Reut_A2814

Alternate gene names: 73542499

Gene position: 3086527-3085196 (Counterclockwise)

Preceding gene: 73542500

Following gene: 73542498

Centisome position: 81.08

GC content: 63.44

Gene sequence:

>1332_bases
ATGAGTACGAACCAACTATATGCAGGCTACCAGTCGGAACTCGCGGATTTCCGGCTGGCGTTCAGCCGCGGGGGTGCCTA
CACCGCCATCGCGCTCGTCCTGCTCGGGGTAGGGCTGGACTACGGTCAGTATCCGCAGCAGCAACTCGCCTTTGGCCTGG
CCCGCGTGGTGGTGTCGCTGCTGATTGCCGGCGTGGTGGTCATGCTCTACAGCGCCGCGGGCCGGCGTTTCGCGCCATGG
CTTACGCTGACCTGGCTGCTGCTGCCGCAGATCATGATCGCGTGGATGATCTCGCAGACCGAGGGCGTGGAGTCGCCTTA
TTACGTTGGCCTCAATCTCGCGATCTTCGCCTCGGGCATCGCACTGCCGTTCGGGCTGTGGCAAAACCTGGTGTTCGGCC
TGCTTTCGTACCTGCTGTACGCGGCGGCCTGCCTGCTGCACCACGGCGGCATCGATCCGGTAGGTACCTTCATCGTCAAT
TCGCTGTTCCTGCTGTTTGCGGCGGCCGCCAGCGGGGTCTATACCTTTTTCAACGAGCGCGCGCGCTTCATGCTGTTCCG
GCTCAAGGCCGAGGTGGCCGAGAAGAACGCCGAACTCGAAGTCATCAACCGCAAGCTCGTAGATATCAAAGGCCAGATGC
TGCAGCAGGAAAAGATGGCCGCCATCGGTACGCTCGCGGCCGGCCTGCTGCATGAGGTCAACAACCCGGTCAACTTCTGT
CTGATGGCGATCGAGGTGGCCATGGAAGAGCCGCAGGCCAAGGAAAACCCGTCGCTCGAAGAGTGCCTGGTCGATGCCAA
GCAGGGCATGCAGCGCATCCAGCATATCGTGTCGGACCTGAAGACATTTGCGTACCGCAAGCCTGGTGCCGAGGTCGAAG
GCACGCCGTTCCTGTTCGAAAAGGCGCTGGATTCGTCGATCCGCCTCACGGCCCACGAACTGCGCGGCGTGAAGGTGACG
CGCGAGCTGCCGGACGACACCCTCGTGCTCGGCGACGAAGCTGCTGTCATCGGCGTGCTGATCAACCTGTTCTCGAACGC
CGCGCTGGCGATGCGCAAGGCAGGCACGGCGGCGCCCGCGATCCATACCACGGTCAAGTGGATGGAGAACCGGCTCCATG
TGCGCGTGCAGGACAATGGCCCGGGCATCGCGGAAGAGAACATCGCACGGGTGTTCGAGCCGTTCTTTACCACGCGCGAC
GTGGGCCAGGGACTGGGGCTCGGCCTGTCGATCAGCTACGCGGTGATCGAACGGCATGGCGGCCAGCTCATCGTCGAGAG
CGAATTCGGCCACTGGGCCGCCTTCAGCTTCGACCTGCCGCGCGCGGAGTGA

Upstream 100 bases:

>100_bases
CGGCGTCAACGTATTCGCCGAAGCGACCATTCAATGAGGCACTGACCGTGCATGTTCCGCGCCAGCGGGCTGGCGCGGTG
GGGCACCAACGGACCAGGTC

Downstream 100 bases:

>100_bases
CACGGCCATGACAGAAGCCCAGCAGGCACGGCCCGCCGTGCTCTACGTCGACGATGAAGATATGGCGCGCAAGTACTTTG
CGCGCGCCGTCGGCAACGAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSTNQLYAGYQSELADFRLAFSRGGAYTAIALVLLGVGLDYGQYPQQQLAFGLARVVVSLLIAGVVVMLYSAAGRRFAPW
LTLTWLLLPQIMIAWMISQTEGVESPYYVGLNLAIFASGIALPFGLWQNLVFGLLSYLLYAAACLLHHGGIDPVGTFIVN
SLFLLFAAAASGVYTFFNERARFMLFRLKAEVAEKNAELEVINRKLVDIKGQMLQQEKMAAIGTLAAGLLHEVNNPVNFC
LMAIEVAMEEPQAKENPSLEECLVDAKQGMQRIQHIVSDLKTFAYRKPGAEVEGTPFLFEKALDSSIRLTAHELRGVKVT
RELPDDTLVLGDEAAVIGVLINLFSNAALAMRKAGTAAPAIHTTVKWMENRLHVRVQDNGPGIAEENIARVFEPFFTTRD
VGQGLGLGLSISYAVIERHGGQLIVESEFGHWAAFSFDLPRAE

Sequences:

>Translated_443_residues
MSTNQLYAGYQSELADFRLAFSRGGAYTAIALVLLGVGLDYGQYPQQQLAFGLARVVVSLLIAGVVVMLYSAAGRRFAPW
LTLTWLLLPQIMIAWMISQTEGVESPYYVGLNLAIFASGIALPFGLWQNLVFGLLSYLLYAAACLLHHGGIDPVGTFIVN
SLFLLFAAAASGVYTFFNERARFMLFRLKAEVAEKNAELEVINRKLVDIKGQMLQQEKMAAIGTLAAGLLHEVNNPVNFC
LMAIEVAMEEPQAKENPSLEECLVDAKQGMQRIQHIVSDLKTFAYRKPGAEVEGTPFLFEKALDSSIRLTAHELRGVKVT
RELPDDTLVLGDEAAVIGVLINLFSNAALAMRKAGTAAPAIHTTVKWMENRLHVRVQDNGPGIAEENIARVFEPFFTTRD
VGQGLGLGLSISYAVIERHGGQLIVESEFGHWAAFSFDLPRAE
>Mature_442_residues
STNQLYAGYQSELADFRLAFSRGGAYTAIALVLLGVGLDYGQYPQQQLAFGLARVVVSLLIAGVVVMLYSAAGRRFAPWL
TLTWLLLPQIMIAWMISQTEGVESPYYVGLNLAIFASGIALPFGLWQNLVFGLLSYLLYAAACLLHHGGIDPVGTFIVNS
LFLLFAAAASGVYTFFNERARFMLFRLKAEVAEKNAELEVINRKLVDIKGQMLQQEKMAAIGTLAAGLLHEVNNPVNFCL
MAIEVAMEEPQAKENPSLEECLVDAKQGMQRIQHIVSDLKTFAYRKPGAEVEGTPFLFEKALDSSIRLTAHELRGVKVTR
ELPDDTLVLGDEAAVIGVLINLFSNAALAMRKAGTAAPAIHTTVKWMENRLHVRVQDNGPGIAEENIARVFEPFFTTRDV
GQGLGLGLSISYAVIERHGGQLIVESEFGHWAAFSFDLPRAE

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=288, Percent_Identity=28.4722222222222, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=26.9387755102041, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=306, Percent_Identity=23.5294117647059, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48557; Mature: 48426

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure 
STNQLYAGYQSELADFRLAFSRGGAYTAIALVLLGVGLDYGQYPQQQLAFGLARVVVSL
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LIAGVVVMLYSAAGRRFAPWLTLTWLLLPQIMIAWMISQTEGVESPYYVGLNLAIFASGI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHH
ALPFGLWQNLVFGLLSYLLYAAACLLHHGGIDPVGTFIVNSLFLLFAAAASGVYTFFNER
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFMLFRLKAEVAEKNAELEVINRKLVDIKGQMLQQEKMAAIGTLAAGLLHEVNNPVNFC
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LMAIEVAMEEPQAKENPSLEECLVDAKQGMQRIQHIVSDLKTFAYRKPGAEVEGTPFLFE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
KALDSSIRLTAHELRGVKVTRELPDDTLVLGDEAAVIGVLINLFSNAALAMRKAGTAAPA
HHCCCCCEEEHHHHCCEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IHTTVKWMENRLHVRVQDNGPGIAEENIARVFEPFFTTRDVGQGLGLGLSISYAVIERHG
HHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
GQLIVESEFGHWAAFSFDLPRAE
CEEEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]