Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 73542441

GI number: 73542441

Start: 3026078

End: 3027328

Strand: Reverse

Name: icd [H]

Synonym: Reut_A2756

Alternate gene names: 73542441

Gene position: 3027328-3026078 (Counterclockwise)

Preceding gene: 73542445

Following gene: 73542440

Centisome position: 79.53

GC content: 60.43

Gene sequence:

>1251_bases
ATGTACCAACACATCAAGGTCCCGGCCGGCGAGAAGATCACGGTCAACCAGGATTTCTCGCTGAATGTCCCGGACACTCC
GATCATTCCTTACATTGAAGGCGATGGTACGGGCCTCGACATCACGCCTGTGATGATCAAGGTGGTGGATGCCGCGGTGG
AAAAGGCCTACGCCGGCAAGCGCAAGATCTCGTGGATGGAAATCTACGCCGGCGAGAAGTCCACCAAGGTCTATGGCCCG
GACGTGTGGCTGCCTGACGAAACCCTGGACGTGCTCAAGGAATACGTCGTCTCGATCAAGGGCCCGCTGACCACGCCGGT
CGGCGGCGGCATCCGCTCGCTGAACGTGGCGCTGCGCCAGCAGCTCGACCTGTACGTGTGCCTGCGCCCGGTGCGCTACT
TCAAGGGCGTGCCTTCGCCGGTGCGCGAGCCGGAAAAGACCGACATGGTCATTTTCCGCGAGAACTCGGAAGACATCTAC
GCCGGGATCGAATGGGAGGCCGAAAGCCCGCAGGCCCAGAAGCTGATTGCCTTCCTGCAGAACGAAATGGGTGTGAAGAA
GATCCGCTTCCCGGAAACGTCGGGCATTGGCGTCAAGCCTGTGTCGAAGCAGGGCACCCAGCGCCTGGTGCGCAAGGCTA
TCCAGTACGCCATCGATAACGACAAGCCGTCGGTCACGCTGGTGCACAAGGGCAACATCATGAAGTTCACGGAAGGCGGT
TTCCGTGACTGGGGCTATGAGCTGGCCCAGAAGGAATTCGGCGCCGAGCTGGTCGATGGAGGCCCGTGGTGCAAGTTCAA
GAACTCGAAGACGGGCCGCGACATCGTCATCAAGGACGCCATTGCCGACGCCTTCCTGCAGCAGATCCTGCTGCGCCCGG
CTGAGTATTCAGTGATCGCGACGCTGAACCTGAACGGCGACTATATCTCGGACGCACTGGCAGCACAGGTCGGTGGTATC
GGCATTGCCCCCGGTGCGAACCTGTCCGACTCCGTGGCCATGTTCGAAGCCACGCACGGCACGGCGCCGAAGTACGCTGG
CAAGGACTACGTGAACCCGGGTTCGGAAATCCTGTCGGCAGAAATGATGCTGCGCCACATGGGCTGGACCGAAGCGGCCG
ACCTGATCATCGCCTCGATGGAAAAGTCGATCCTGTCGAAGAAGGTCACTTATGACTTCGCCCGCCTGCTGGAAGGTGCG
ACCCAGGTGTCGTGCTCGGGTTTTGGTCAGGTGATGATCGAAAACATGTGA

Upstream 100 bases:

>100_bases
ACCGGGGTGCCCGGCTACAATGCCTTCGCTACGCCTCCCATATTTCGCTGCCGGGTCGTGTACCGGGCGGCCGTCTTAAC
CGTTCCGTACTGGAGACGTC

Downstream 100 bases:

>100_bases
TCCCGCCCGGCGCCCATGCGCGGGCGCGGCGCGTCAGAACCCCGGTAAGCGATGAGGCTGCCGGGGTTTTTTTCTTGTCT
GCGCGATGCCGGCTGCCTAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYQHIKVPAGEKITVNQDFSLNVPDTPIIPYIEGDGTGLDITPVMIKVVDAAVEKAYAGKRKISWMEIYAGEKSTKVYGP
DVWLPDETLDVLKEYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIY
AGIEWEAESPQAQKLIAFLQNEMGVKKIRFPETSGIGVKPVSKQGTQRLVRKAIQYAIDNDKPSVTLVHKGNIMKFTEGG
FRDWGYELAQKEFGAELVDGGPWCKFKNSKTGRDIVIKDAIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIENM

Sequences:

>Translated_416_residues
MYQHIKVPAGEKITVNQDFSLNVPDTPIIPYIEGDGTGLDITPVMIKVVDAAVEKAYAGKRKISWMEIYAGEKSTKVYGP
DVWLPDETLDVLKEYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIY
AGIEWEAESPQAQKLIAFLQNEMGVKKIRFPETSGIGVKPVSKQGTQRLVRKAIQYAIDNDKPSVTLVHKGNIMKFTEGG
FRDWGYELAQKEFGAELVDGGPWCKFKNSKTGRDIVIKDAIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIENM
>Mature_416_residues
MYQHIKVPAGEKITVNQDFSLNVPDTPIIPYIEGDGTGLDITPVMIKVVDAAVEKAYAGKRKISWMEIYAGEKSTKVYGP
DVWLPDETLDVLKEYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIY
AGIEWEAESPQAQKLIAFLQNEMGVKKIRFPETSGIGVKPVSKQGTQRLVRKAIQYAIDNDKPSVTLVHKGNIMKFTEGG
FRDWGYELAQKEFGAELVDGGPWCKFKNSKTGRDIVIKDAIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIENM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=398, Percent_Identity=31.1557788944724, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=28.125, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=27.5568181818182, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4758582, Length=276, Percent_Identity=28.6231884057971, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI28178838, Length=276, Percent_Identity=28.6231884057971, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=31.4917127071823, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=75.2997601918465, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=26.2599469496021, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=23.1155778894472, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71986051, Length=374, Percent_Identity=31.0160427807487, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=29.5081967213115, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=312, Percent_Identity=28.525641025641, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=364, Percent_Identity=23.6263736263736, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=28.3887468030691, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=366, Percent_Identity=28.1420765027322, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324291, Length=366, Percent_Identity=28.9617486338798, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=369, Percent_Identity=25.2032520325203, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643270, Length=354, Percent_Identity=33.8983050847458, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24643268, Length=354, Percent_Identity=33.8983050847458, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=29.8200514138817, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161078635, Length=306, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161078639, Length=306, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161078633, Length=306, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24650122, Length=306, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161078637, Length=306, Percent_Identity=26.4705882352941, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20130355, Length=357, Percent_Identity=25.2100840336134, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281362242, Length=325, Percent_Identity=27.3846153846154, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24648872, Length=325, Percent_Identity=27.3846153846154, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45710; Mature: 45710

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIKVPAGEKITVNQDFSLNVPDTPIIPYIEGDGTGLDITPVMIKVVDAAVEKAYAGK
CCCEEECCCCCEEEECCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
RKISWMEIYAGEKSTKVYGPDVWLPDETLDVLKEYVVSIKGPLTTPVGGGIRSLNVALRQ
CCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEWEAESPQAQKLIAFLQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHH
NEMGVKKIRFPETSGIGVKPVSKQGTQRLVRKAIQYAIDNDKPSVTLVHKGNIMKFTEGG
HCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWGYELAQKEFGAELVDGGPWCKFKNSKTGRDIVIKDAIADAFLQQILLRPAEYSVIA
CHHHHHHHHHHHHCCEECCCCCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIENM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEECC
>Mature Secondary Structure
MYQHIKVPAGEKITVNQDFSLNVPDTPIIPYIEGDGTGLDITPVMIKVVDAAVEKAYAGK
CCCEEECCCCCEEEECCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
RKISWMEIYAGEKSTKVYGPDVWLPDETLDVLKEYVVSIKGPLTTPVGGGIRSLNVALRQ
CCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEWEAESPQAQKLIAFLQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHH
NEMGVKKIRFPETSGIGVKPVSKQGTQRLVRKAIQYAIDNDKPSVTLVHKGNIMKFTEGG
HCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWGYELAQKEFGAELVDGGPWCKFKNSKTGRDIVIKDAIADAFLQQILLRPAEYSVIA
CHHHHHHHHHHHHCCEECCCCCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIENM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]