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The map label for this gene is hutI

Identifier: 73542398

GI number: 73542398

Start: 2978763

End: 2980034

Strand: Reverse

Name: hutI

Synonym: Reut_A2713

Alternate gene names: 73542398

Gene position: 2980034-2978763 (Counterclockwise)

Preceding gene: 73542399

Following gene: 73542397

Centisome position: 78.29

GC content: 67.85

Gene sequence:

>1272_bases
ATGAACGCGCCCCTCGCTTCGGGACGCCCCGACATTCAATCCGCCGACGGCATCTGGCACTGCTGCCATTTGCTGCCAGA
TGCCGATCCCGACCGCGCCGTGCGCGACGCAGCGCTGGTTGTCGAGCAGGGCCGCATCGCATGGCTGGGCGCCGAAGCGG
AATTGCCCGCAGACTATCGCAGCCTGCCGCGCCACGATGCGGGTGGAACCTGGATGACGCCCGGACTGGTCGACTGTCAT
ACGCACCTCGTCTATGGCGGCCAGCGTGCCGATGAGTTCGCAATGCGCCTCGCAGGCGCGAGCTATGAAGAGATCGCACG
CGCCGGCGGCGGCATCGTTTCGTCGGTACGCGCCACGCGCGCGGCCGACGAAGACACCCTGTTCTCGCAAGCCGCTGCGC
GCCTCGCGCCGCTGCTGGCGGAAGGCGTGACGGCCATCGAAATCAAGTCGGGCTATGGCCTCGAACTCGAAGCCGAACGC
CGCCAGTTGCGTGTCGCGCGCCGTCTTGGCGAAGCGTTCGGCGTGTCGGTGCATACGACTTTCCTCGGCGCGCATGCCTT
GCCGCCCGAATACGCGGGGCGCGCCGACGATTACATCGACCTGGTCTGCAACACGATGCTGCCGGCACTGGCCGAAGAAG
GACTGGTCGATGCTGTCGATGCGTTCTGCGAATCGGTCGGCTTCTCGCTCGCGCAGACCGAGCGCGTGTTCGAAGCCGCC
GCGCGCCATGGCTTGCGCGTCAAGCTGCATGCCGAGCAACTGAGCAACCTCGGCGGCGCTGCGCTGGCCGCGCGCCACCA
TGCGCTGTCGGCGGACCATCTGGAGCATCTGGACGAGGCTGGCGTAGAAGCCATGGCGGCCGCCGGTACGGTGGCAGTGC
TGCTGCCGGGCGCCTATTATTTCCTGCGTGACACGAACCTGCCGCCGATTGCGCTGCTGCGCAAGCACGGCGTGCCGATA
GCGATTTCCACGGACCACAATCCGGGTACCTCGCCGGTCACATCGCTGCTGCTGATGATGAACATGGCCTGCACGCTGTT
CCGCCTGACGGTGCCCGAGGCGCTGGCCGGCGTGACCACGCATGCGGCGCGCGCGCTCGGCGCACCGGACCGGCATGGAA
AGCTCGCAGTCGGACGCGCAGCGGATTTCGTGCTCTGGCGCGTCGAGTCACCGGCGGAACTGGCTTACTGGTTCGGCCGC
AACCCGGCCGCGGTGGTCGTGCGGCAGGGACGCATCCATCCGGCGACGTCGCAACACGGCGGGAGGGCATGA

Upstream 100 bases:

>100_bases
TCTGGTATCCGACAGGCGTGACCGCTGCATTCCATGCGCTCGCGCCGCTCGAAGGCGATTCGCTGTGCCTTTGCATCACG
CTGGAAACGGAGGCTGACCA

Downstream 100 bases:

>100_bases
GCGCATGAACGAAGCACGCATTCTTGCACCCCACGCGCTGCTGCCCACCGGCTGGGCGCGCGACGTGCTACTGGCATGGG
ATACAACGGGCCGCCTGACA

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNAPLASGRPDIQSADGIWHCCHLLPDADPDRAVRDAALVVEQGRIAWLGAEAELPADYRSLPRHDAGGTWMTPGLVDCH
THLVYGGQRADEFAMRLAGASYEEIARAGGGIVSSVRATRAADEDTLFSQAAARLAPLLAEGVTAIEIKSGYGLELEAER
RQLRVARRLGEAFGVSVHTTFLGAHALPPEYAGRADDYIDLVCNTMLPALAEEGLVDAVDAFCESVGFSLAQTERVFEAA
ARHGLRVKLHAEQLSNLGGAALAARHHALSADHLEHLDEAGVEAMAAAGTVAVLLPGAYYFLRDTNLPPIALLRKHGVPI
AISTDHNPGTSPVTSLLLMMNMACTLFRLTVPEALAGVTTHAARALGAPDRHGKLAVGRAADFVLWRVESPAELAYWFGR
NPAAVVVRQGRIHPATSQHGGRA

Sequences:

>Translated_423_residues
MNAPLASGRPDIQSADGIWHCCHLLPDADPDRAVRDAALVVEQGRIAWLGAEAELPADYRSLPRHDAGGTWMTPGLVDCH
THLVYGGQRADEFAMRLAGASYEEIARAGGGIVSSVRATRAADEDTLFSQAAARLAPLLAEGVTAIEIKSGYGLELEAER
RQLRVARRLGEAFGVSVHTTFLGAHALPPEYAGRADDYIDLVCNTMLPALAEEGLVDAVDAFCESVGFSLAQTERVFEAA
ARHGLRVKLHAEQLSNLGGAALAARHHALSADHLEHLDEAGVEAMAAAGTVAVLLPGAYYFLRDTNLPPIALLRKHGVPI
AISTDHNPGTSPVTSLLLMMNMACTLFRLTVPEALAGVTTHAARALGAPDRHGKLAVGRAADFVLWRVESPAELAYWFGR
NPAAVVVRQGRIHPATSQHGGRA
>Mature_423_residues
MNAPLASGRPDIQSADGIWHCCHLLPDADPDRAVRDAALVVEQGRIAWLGAEAELPADYRSLPRHDAGGTWMTPGLVDCH
THLVYGGQRADEFAMRLAGASYEEIARAGGGIVSSVRATRAADEDTLFSQAAARLAPLLAEGVTAIEIKSGYGLELEAER
RQLRVARRLGEAFGVSVHTTFLGAHALPPEYAGRADDYIDLVCNTMLPALAEEGLVDAVDAFCESVGFSLAQTERVFEAA
ARHGLRVKLHAEQLSNLGGAALAARHHALSADHLEHLDEAGVEAMAAAGTVAVLLPGAYYFLRDTNLPPIALLRKHGVPI
AISTDHNPGTSPVTSLLLMMNMACTLFRLTVPEALAGVTTHAARALGAPDRHGKLAVGRAADFVLWRVESPAELAYWFGR
NPAAVVVRQGRIHPATSQHGGRA

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=354, Percent_Identity=38.135593220339, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17555004, Length=405, Percent_Identity=33.5802469135802, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_CUPPJ (Q46XQ9)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296918.1
- HSSP:   Q8U8Z6
- ProteinModelPortal:   Q46XQ9
- SMR:   Q46XQ9
- GeneID:   3611220
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2713
- NMPDR:   fig|264198.3.peg.2208
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   REUT264198:REUT_A2713-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR013108
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF07969 Amidohydro_3; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 44965; Mature: 44965

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: BINDING 89-89 BINDING 102-102 BINDING 152-152 BINDING 185-185 BINDING 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLASGRPDIQSADGIWHCCHLLPDADPDRAVRDAALVVEQGRIAWLGAEAELPADYR
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHEECCCEEEEECCCCCCHHHH
SLPRHDAGGTWMTPGLVDCHTHLVYGGQRADEFAMRLAGASYEEIARAGGGIVSSVRATR
HCCCCCCCCCCCCCCHHHHHHHEEECCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
AADEDTLFSQAAARLAPLLAEGVTAIEIKSGYGLELEAERRQLRVARRLGEAFGVSVHTT
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCEEEHH
FLGAHALPPEYAGRADDYIDLVCNTMLPALAEEGLVDAVDAFCESVGFSLAQTERVFEAA
HHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHH
ARHGLRVKLHAEQLSNLGGAALAARHHALSADHLEHLDEAGVEAMAAAGTVAVLLPGAYY
HHCCCEEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEE
FLRDTNLPPIALLRKHGVPIAISTDHNPGTSPVTSLLLMMNMACTLFRLTVPEALAGVTT
EEECCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAARALGAPDRHGKLAVGRAADFVLWRVESPAELAYWFGRNPAAVVVRQGRIHPATSQHG
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCCC
GRA
CCC
>Mature Secondary Structure
MNAPLASGRPDIQSADGIWHCCHLLPDADPDRAVRDAALVVEQGRIAWLGAEAELPADYR
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHEECCCEEEEECCCCCCHHHH
SLPRHDAGGTWMTPGLVDCHTHLVYGGQRADEFAMRLAGASYEEIARAGGGIVSSVRATR
HCCCCCCCCCCCCCCHHHHHHHEEECCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
AADEDTLFSQAAARLAPLLAEGVTAIEIKSGYGLELEAERRQLRVARRLGEAFGVSVHTT
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCEEEHH
FLGAHALPPEYAGRADDYIDLVCNTMLPALAEEGLVDAVDAFCESVGFSLAQTERVFEAA
HHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHH
ARHGLRVKLHAEQLSNLGGAALAARHHALSADHLEHLDEAGVEAMAAAGTVAVLLPGAYY
HHCCCEEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEE
FLRDTNLPPIALLRKHGVPIAISTDHNPGTSPVTSLLLMMNMACTLFRLTVPEALAGVTT
EEECCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAARALGAPDRHGKLAVGRAADFVLWRVESPAELAYWFGRNPAAVVVRQGRIHPATSQHG
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCCC
GRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA