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The map label for this gene is pepA [H]

Identifier: 73542368

GI number: 73542368

Start: 2946446

End: 2947978

Strand: Reverse

Name: pepA [H]

Synonym: Reut_A2683

Alternate gene names: 73542368

Gene position: 2947978-2946446 (Counterclockwise)

Preceding gene: 73542376

Following gene: 73542367

Centisome position: 77.45

GC content: 67.38

Gene sequence:

>1533_bases
ATGGAATTTAGCACAAAAGCCCTGGATTGGAGCAAAGCCGGCCAAAATGGTTTCCTGGCGACCAAGACCGACTGCCTCGT
GGTCGGCGTGTTCGAAGGACAGAATCTGGCGGGCGTGGCCAAGGCCCTCGACGTGGCAACCAAGGGCTTGGTCGCACGGT
TGCTGAAGCAGGGCGACTTCGAAGGCAAGCGCGGCACGCAGCTGACGCTGCATGAGGTGGCCGGCGTGGGCGCGGCCCGC
GTGCTGCTGGTAGGCCTGGGCAAGGAGGCGGATTTCAACGACAAGGCCTTTGCCGAAGCCGTGCGCACGGCCGTGCGTGC
CTTGTCGTCCACGCGCGCCACCTCGGCGCTGTGGTGCCTGTCGCAGCAGCCGCCGCAGCAGCGCGATATCGGCTGGGCGG
TCATCACCACCATCTCGCTCGTGCGCGATGCGGGCTACCGCCTGCTGGAGCGCCACCCGGGCCTGAAGCGCGCCAACGGC
AAGCCCGGCGCCGCCGACAAGGCGACACTGCGCAAGGTCGTGCTGGCCGTGGACGCCAACGACGCCAAGGCGGCGACCCA
GGCCGTGGTGCGCGGCACTGCCATTGCCAACGGCATGGAACTGACCCGCGACCTCGGCAACCTGCCGTCCAATATCTGCA
CCCCGACCTACCTGGCCAACACGGCGCGCGCGATTGCCAAGCGCCACAAGCTCAAGGTGGAAGTGCTGGGCCGCAAGCAG
ATCGAAGCGCTGAACATGGGCTCGTTCCTGGCCGTGACCAAGGGCAGCGTCGAGCCGCCGCAGTTCATCGTGCTGCGCTA
TGACGGCGCGGGCGCCAAGCAGGCGCCGGTGGTACTGGTCGGCAAGGGCATCACCTTCGATACCGGCGGCATCTCGCTCA
AGCCGGGCGAGGGCATGGACGAGATGAAGTACGACATGTGCGGTGCCGCGTCGGTGCTCGGCACGCTGCAGGCCGTGGCC
GAAATGGGCCTGAAGCTCAATGTGATCGCCGTGGTGCCGACCTGCGAGAACATGCCCAGCGGTGTCGCCACCAAGCCCGG
CGACGTGGTGACCAGCATGTCGGGCCAGACGATCGAGATCCTGAACACGGACGCCGAAGGCCGCCTGATCCTGTGCGATG
CGCTGACCTATGTCGAACGCTTCAAGCCGGCCGCCGTGGTCGATGTCGCGACGCTGACGGGCGCCTGCATCATCGCGCTC
GGCCATATCAACACCGGGCTGTACGCGCGCAGCGACATGCTGGCCGACCAGCTGCTGCAGGCCGGCCGCAAGTCCATGGA
CACCGCCTGGCGCATGCCGCTGGACGACGAATACCAGGATCAGCTCAAATCGAACTTTGCCGACATGGCCAATATCGGCG
GCCGCCCGGCAGGCAGCGTGACCGCGGCCTGCTTCCTGGCGCGCTTCACCGAAAAGTACGACTGGGCCCACCTGGACATC
GCCGGCACGGCCTGGAAGAGCGGCGCGGCCAAGGGCGCCACCGGCCGCCCGGTGCCGCTGCTCACGCAGTTCCTGATGGA
CCGCGCGGCCTGA

Upstream 100 bases:

>100_bases
CGCAGGACAGCGGGCTGCAGGCGGGGCGGATCGGCAGGTCGCGGATAAAAATCGCGGATAATGGAGGCTTTCGTGTCTAC
GAGCCCCTGAAGGAAGCGCG

Downstream 100 bases:

>100_bases
CGGGCGCAAGAGGCAGGCAGTCATGACGCGCATCGATTTCCACAGCAACGTGCCGGACAAGCTCGGCTATATCTGCCGGC
TGGTCCGCAAGGCCTACGGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MEFSTKALDWSKAGQNGFLATKTDCLVVGVFEGQNLAGVAKALDVATKGLVARLLKQGDFEGKRGTQLTLHEVAGVGAAR
VLLVGLGKEADFNDKAFAEAVRTAVRALSSTRATSALWCLSQQPPQQRDIGWAVITTISLVRDAGYRLLERHPGLKRANG
KPGAADKATLRKVVLAVDANDAKAATQAVVRGTAIANGMELTRDLGNLPSNICTPTYLANTARAIAKRHKLKVEVLGRKQ
IEALNMGSFLAVTKGSVEPPQFIVLRYDGAGAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLQAVA
EMGLKLNVIAVVPTCENMPSGVATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVVDVATLTGACIIAL
GHINTGLYARSDMLADQLLQAGRKSMDTAWRMPLDDEYQDQLKSNFADMANIGGRPAGSVTAACFLARFTEKYDWAHLDI
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA

Sequences:

>Translated_510_residues
MEFSTKALDWSKAGQNGFLATKTDCLVVGVFEGQNLAGVAKALDVATKGLVARLLKQGDFEGKRGTQLTLHEVAGVGAAR
VLLVGLGKEADFNDKAFAEAVRTAVRALSSTRATSALWCLSQQPPQQRDIGWAVITTISLVRDAGYRLLERHPGLKRANG
KPGAADKATLRKVVLAVDANDAKAATQAVVRGTAIANGMELTRDLGNLPSNICTPTYLANTARAIAKRHKLKVEVLGRKQ
IEALNMGSFLAVTKGSVEPPQFIVLRYDGAGAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLQAVA
EMGLKLNVIAVVPTCENMPSGVATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVVDVATLTGACIIAL
GHINTGLYARSDMLADQLLQAGRKSMDTAWRMPLDDEYQDQLKSNFADMANIGGRPAGSVTAACFLARFTEKYDWAHLDI
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA
>Mature_510_residues
MEFSTKALDWSKAGQNGFLATKTDCLVVGVFEGQNLAGVAKALDVATKGLVARLLKQGDFEGKRGTQLTLHEVAGVGAAR
VLLVGLGKEADFNDKAFAEAVRTAVRALSSTRATSALWCLSQQPPQQRDIGWAVITTISLVRDAGYRLLERHPGLKRANG
KPGAADKATLRKVVLAVDANDAKAATQAVVRGTAIANGMELTRDLGNLPSNICTPTYLANTARAIAKRHKLKVEVLGRKQ
IEALNMGSFLAVTKGSVEPPQFIVLRYDGAGAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLQAVA
EMGLKLNVIAVVPTCENMPSGVATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVVDVATLTGACIIAL
GHINTGLYARSDMLADQLLQAGRKSMDTAWRMPLDDEYQDQLKSNFADMANIGGRPAGSVTAACFLARFTEKYDWAHLDI
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=329, Percent_Identity=45.8966565349544, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI47155554, Length=313, Percent_Identity=34.8242811501597, Blast_Score=132, Evalue=1e-30,
Organism=Escherichia coli, GI1790710, Length=513, Percent_Identity=50.0974658869396, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=37.6175548589342, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=325, Percent_Identity=33.5384615384615, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=239, Percent_Identity=32.2175732217573, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI20129969, Length=329, Percent_Identity=37.9939209726444, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21355645, Length=333, Percent_Identity=36.9369369369369, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24662223, Length=333, Percent_Identity=36.9369369369369, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24662227, Length=329, Percent_Identity=37.3860182370821, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21355725, Length=321, Percent_Identity=36.7601246105919, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI161077148, Length=337, Percent_Identity=37.0919881305638, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20130057, Length=337, Percent_Identity=37.0919881305638, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=36.7601246105919, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20129963, Length=509, Percent_Identity=31.434184675835, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI19922386, Length=507, Percent_Identity=31.5581854043393, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=34.8387096774194, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=34.8387096774194, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=34.8387096774194, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646701, Length=360, Percent_Identity=28.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=360, Percent_Identity=28.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=360, Percent_Identity=28.3333333333333, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53932; Mature: 53932

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSTKALDWSKAGQNGFLATKTDCLVVGVFEGQNLAGVAKALDVATKGLVARLLKQGDF
CCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EGKRGTQLTLHEVAGVGAARVLLVGLGKEADFNDKAFAEAVRTAVRALSSTRATSALWCL
CCCCCCEEEHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHEEEC
SQQPPQQRDIGWAVITTISLVRDAGYRLLERHPGLKRANGKPGAADKATLRKVVLAVDAN
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEEEECCC
DAKAATQAVVRGTAIANGMELTRDLGNLPSNICTPTYLANTARAIAKRHKLKVEVLGRKQ
CHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHCEEEEECCCHH
IEALNMGSFLAVTKGSVEPPQFIVLRYDGAGAKQAPVVLVGKGITFDTGGISLKPGEGMD
HHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHH
EMKYDMCGAASVLGTLQAVAEMGLKLNVIAVVPTCENMPSGVATKPGDVVTSMSGQTIEI
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEE
LNTDAEGRLILCDALTYVERFKPAAVVDVATLTGACIIALGHINTGLYARSDMLADQLLQ
EECCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHH
AGRKSMDTAWRMPLDDEYQDQLKSNFADMANIGGRPAGSVTAACFLARFTEKYDWAHLDI
HHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEFSTKALDWSKAGQNGFLATKTDCLVVGVFEGQNLAGVAKALDVATKGLVARLLKQGDF
CCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EGKRGTQLTLHEVAGVGAARVLLVGLGKEADFNDKAFAEAVRTAVRALSSTRATSALWCL
CCCCCCEEEHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHEEEC
SQQPPQQRDIGWAVITTISLVRDAGYRLLERHPGLKRANGKPGAADKATLRKVVLAVDAN
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEEEECCC
DAKAATQAVVRGTAIANGMELTRDLGNLPSNICTPTYLANTARAIAKRHKLKVEVLGRKQ
CHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHCEEEEECCCHH
IEALNMGSFLAVTKGSVEPPQFIVLRYDGAGAKQAPVVLVGKGITFDTGGISLKPGEGMD
HHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHH
EMKYDMCGAASVLGTLQAVAEMGLKLNVIAVVPTCENMPSGVATKPGDVVTSMSGQTIEI
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEE
LNTDAEGRLILCDALTYVERFKPAAVVDVATLTGACIIALGHINTGLYARSDMLADQLLQ
EECCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHH
AGRKSMDTAWRMPLDDEYQDQLKSNFADMANIGGRPAGSVTAACFLARFTEKYDWAHLDI
HHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA