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The map label for this gene is groEL [H]

Identifier: 73542341

GI number: 73542341

Start: 2914154

End: 2915797

Strand: Reverse

Name: groEL [H]

Synonym: Reut_A2656

Alternate gene names: 73542341

Gene position: 2915797-2914154 (Counterclockwise)

Preceding gene: 73542342

Following gene: 73542340

Centisome position: 76.6

GC content: 62.9

Gene sequence:

>1644_bases
ATGGCAGCAAAAGACGTAGTATTTGGCGACGCCGCCCGTGCCAAGATGGTCGAAGGCGTGAACATTCTCGCCAACGCAGT
GAAGGTTACCCTGGGTCCGAAGGGCCGCAACGTGGTGCTGGAGCGCAGCTTCGGCGGCCCGACCGTGACCAAGGACGGCG
TGTCCGTGGCCAAGGAAATCGAGCTGAAGGACAAGCTGCAGAACATGGGCGCCCAGATGGTCAAGGAAGTGGCTTCCAAG
ACCAGCGACAACGCCGGTGACGGTACCACCACCGCTACCGTTCTGGCCCAGTCGATCGTGCGCGAAGGCATGAAGTTCGT
CGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGTATCGACAAGGCTGTCGCCGCCGCCGTGGAAGAGCTGAAGAAGG
TCAGCAAGCCGACCACCACCAGCAAGGAAATCGCCCAGGTTGGCGCGATCTCGGCCAACAGCGACACCTCGATCGGTGAG
CGCATTGCCGAAGCCATGGACAAGGTCGGCAAGGAAGGCGTGATCACCGTCGAAGACGGCAAGTCGCTGGCCGACGAGCT
GGAAGTCGTGGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCCGAAAAGCAAGTTGTCC
AGCTGGACAGCCCGTTCGTGCTGCTGTTCGACAAGAAGGTTTCGAACATCCGCGACCTGCTGCCGGTGCTGGAGCAAGTG
GCCAAGGCTGGCCGCCCGCTGCTGATCATTGCTGAAGACGTCGAGGGCGAAGCCCTGGCGACCCTGGTGGTCAACAACAT
CCGTGGCATCCTGAAGACCGCCGCCGTCAAGGCTCCGGGCTTCGGCGACCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTGACCGGCGGCACCGTCATCGCTGAAGAAATCGGCCTGACGCTGGAAAAGGCGACCCTGAACGACCTGGGCCAAGCC
AAGCGCATCGAAATCGGCAAGGAAAACACCATCATCATCGACGGCGCCGGCGACGCAGCTGCGATCGAAGGCCGCGTGAA
GCAGATCCGTGCCCAGATCGAAGAAGCGACCTCGGACTACGACCGTGAAAAGCTGCAAGAGCGCGTGGCCAAGCTGGCCG
GCGGTGTTGCCGTGATCAAGGTTGGCGCTGCCACCGAAGTCGAAATGAAGGAAAAGAAGGCCCGCGTGGAAGACGCCCTG
CACGCCACCCGCGCTGCGGTGGAAGAAGGCATCGTCCCCGGCGGCGGTGTGGCCCTGCTGCGTGCCCGCGCTGCGATCTC
GGCACTGACCGGTGAAAACCCGGACCAGAACGCCGGTATCAAGATCGTGCTGCGCGCCATGGAAGAGCCGCTGCGCCAGA
TCGTGCTGAACGCTGGTGAAGAAGCTTCGGTCGTCGTTGCCAAGGTCATCGAAGGCAAGGGCAACTACGGCTACAACGCG
GCTTCGGGCGAGTACGGCGACCTGGTGGAAATGGGCGTGCTGGATCCGACCAAGGTTACCCGCACCGCACTGCAGAACGC
CGCTTCGGTGGCATCGCTGATGCTGACCACGGACTGCGCAGTTGCCGAAACGCCGAAGGAAGAGTCGGCTCCGGCAATGC
CGGGCGGCATGGGCGGCATGGGCGGCATGGAAGGCATGATGTAA

Upstream 100 bases:

>100_bases
CAGGAACTGCTGGTCATGCGCGAAGAAGACATCATGGCCGTGGTGAACAAGTAATCACTTGTTGACGACTAGCACCGTAC
CGAATTAGGAGAATCAGAAC

Downstream 100 bases:

>100_bases
ATCAGGCCGACCGATTGCCGACTGCCTTAACGGGCAGGCTGTCTGAAAAAACCCCCGCAAGCGCGAGCTTGCGGGGGTTT
TTGCTTGTAGCTGTGCCGGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVAAAVEELKKVSKPTTTSKEIAQVGAISANSDTSIGE
RIAEAMDKVGKEGVITVEDGKSLADELEVVEGMQFDRGYLSPYFINNPEKQVVQLDSPFVLLFDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTVIAEEIGLTLEKATLNDLGQA
KRIEIGKENTIIIDGAGDAAAIEGRVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALLRARAAISALTGENPDQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNA
ASGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAETPKEESAPAMPGGMGGMGGMEGMM

Sequences:

>Translated_547_residues
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVAAAVEELKKVSKPTTTSKEIAQVGAISANSDTSIGE
RIAEAMDKVGKEGVITVEDGKSLADELEVVEGMQFDRGYLSPYFINNPEKQVVQLDSPFVLLFDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTVIAEEIGLTLEKATLNDLGQA
KRIEIGKENTIIIDGAGDAAAIEGRVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALLRARAAISALTGENPDQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNA
ASGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAETPKEESAPAMPGGMGGMGGMEGMM
>Mature_546_residues
AAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGIDKAVAAAVEELKKVSKPTTTSKEIAQVGAISANSDTSIGER
IAEAMDKVGKEGVITVEDGKSLADELEVVEGMQFDRGYLSPYFINNPEKQVVQLDSPFVLLFDKKVSNIRDLLPVLEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTVIAEEIGLTLEKATLNDLGQAK
RIEIGKENTIIIDGAGDAAAIEGRVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVPGGGVALLRARAAISALTGENPDQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNAA
SGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAETPKEESAPAMPGGMGGMGGMEGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=54.1509433962264, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=54.1509433962264, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI24307939, Length=462, Percent_Identity=23.8095238095238, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI5453607, Length=538, Percent_Identity=21.1895910780669, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=77.1698113207547, Blast_Score=814, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=53.9622641509434, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=53.3018867924528, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI25147750, Length=131, Percent_Identity=34.3511450381679, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532603, Length=573, Percent_Identity=21.6404886561955, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.4220532319392, Blast_Score=557, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322446, Length=574, Percent_Identity=22.4738675958188, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=556, Percent_Identity=21.4028776978417, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=574, Percent_Identity=22.1254355400697, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.7001897533207, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.7001897533207, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.6129032258064, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.6129032258064, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.6129032258064, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=45.5719557195572, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=37.0300751879699, Blast_Score=344, Evalue=7e-95,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=37.0300751879699, Blast_Score=344, Evalue=7e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57387; Mature: 57256

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00284 SERPIN ; PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKVSKPTTTSKEIAQVGAISANSDTSIGERIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCC
KSLADELEVVEGMQFDRGYLSPYFINNPEKQVVQLDSPFVLLFDKKVSNIRDLLPVLEQV
HHHHHHHHHHHCCCCCCCCCCCEEECCCHHHEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEIGLTLEKATLNDLGQAKRIEIGKENTIIIDGAGDAAAIEGRVKQIRAQIEEATSDY
HHHHHCCEEEHHHHHHCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAAISALTGENPDQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ASGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAETPKEESAPAMPGGMGGM
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCC
GGMEGMM
CCCCCCC
>Mature Secondary Structure 
AAKDVVFGDAARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKFVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKVSKPTTTSKEIAQVGAISANSDTSIGERIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCC
KSLADELEVVEGMQFDRGYLSPYFINNPEKQVVQLDSPFVLLFDKKVSNIRDLLPVLEQV
HHHHHHHHHHHCCCCCCCCCCCEEECCCHHHEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEIGLTLEKATLNDLGQAKRIEIGKENTIIIDGAGDAAAIEGRVKQIRAQIEEATSDY
HHHHHCCEEEHHHHHHCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RARAAISALTGENPDQNAGIKIVLRAMEEPLRQIVLNAGEEASVVVAKVIEGKGNYGYNA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
ASGEYGDLVEMGVLDPTKVTRTALQNAASVASLMLTTDCAVAETPKEESAPAMPGGMGGM
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCC
GGMEGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA