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The map label for this gene is lrp [H]

Identifier: 73542231

GI number: 73542231

Start: 2790055

End: 2790558

Strand: Reverse

Name: lrp [H]

Synonym: Reut_A2546

Alternate gene names: 73542231

Gene position: 2790558-2790055 (Counterclockwise)

Preceding gene: 73542233

Following gene: 73542230

Centisome position: 73.31

GC content: 62.9

Gene sequence:

>504_bases
ATGAGAACGAGTCGCCAGCCCGTCCGCGCCCTTGACCGGCTCGACCGCAAGATCCTCGCGCTGCTGCAGGCTGACGGCCG
GATGTCGATGAAGGACCTGGCCGAGGCAGTCGGGCTGACCATCACGCCATGCATCGAGCGCGTCAAGCGCATGGAGCGCG
ATGGTGTCATCATGGGCTACTACGCACGGCTCAATCCGACTCTGCTGGGCAGCGCGCTGCTGGTGTTTGTCGAGATCTCG
CTGGGGAACAAGTCGGGCAATATGTTCGAGCAGTTCCGCCGCGAAGTGCTGCGGATTCCCGAAGTGCTCGAGTGCCACCT
GGTGTCGGGCGATTTCGACTACCTGATCAAGGCGCGCATCCGGGAGATCGGCGAATACCGGCGGCTGCTCGGCGACATCC
TGCTGCAGTTGCCCGGTGCGGCGCAGTCGAAGAGCTATGTGGTGATGGAAGAGATCAAGGAGACGCTGGCCATTTCCGTG
GAGGAGAAGGCCCAGTCAGCCTGA

Upstream 100 bases:

>100_bases
CTCCTAACCAGGATGTCAGGGTATTGAAGGATTTGTCTCTATACTATTGAAACTAATCCAGTCATAGTTATTGAATTTCT
CAGGAAAACAGGAATAAGTC

Downstream 100 bases:

>100_bases
CGATGAGACGTTCCCCGCCGGATTCCGCCCCCGATACCCGCCGTGAGAGTCGACGCGAACGCGATGCCGATGACGTTGGC
ATCGCGGAAGGCACTCGTGC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MRTSRQPVRALDRLDRKILALLQADGRMSMKDLAEAVGLTITPCIERVKRMERDGVIMGYYARLNPTLLGSALLVFVEIS
LGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARIREIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAISV
EEKAQSA

Sequences:

>Translated_167_residues
MRTSRQPVRALDRLDRKILALLQADGRMSMKDLAEAVGLTITPCIERVKRMERDGVIMGYYARLNPTLLGSALLVFVEIS
LGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARIREIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAISV
EEKAQSA
>Mature_167_residues
MRTSRQPVRALDRLDRKILALLQADGRMSMKDLAEAVGLTITPCIERVKRMERDGVIMGYYARLNPTLLGSALLVFVEIS
LGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARIREIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAISV
EEKAQSA

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=52.9411764705882, Blast_Score=176, Evalue=9e-46,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=38.4105960264901, Blast_Score=116, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18898; Mature: 18898

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSRQPVRALDRLDRKILALLQADGRMSMKDLAEAVGLTITPCIERVKRMERDGVIMGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEH
YARLNPTLLGSALLVFVEISLGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARI
HHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHH
REIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAISVEEKAQSA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTSRQPVRALDRLDRKILALLQADGRMSMKDLAEAVGLTITPCIERVKRMERDGVIMGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEH
YARLNPTLLGSALLVFVEISLGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARI
HHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHH
REIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAISVEEKAQSA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]