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The map label for this gene is iorB [H]

Identifier: 73542194

GI number: 73542194

Start: 2748698

End: 2750977

Strand: Reverse

Name: iorB [H]

Synonym: Reut_A2509

Alternate gene names: 73542194

Gene position: 2750977-2748698 (Counterclockwise)

Preceding gene: 73542196

Following gene: 73542191

Centisome position: 72.27

GC content: 67.41

Gene sequence:

>2280_bases
ATGACTTCGACCATCCTCGATACCGTTCGCGAGGCGGAGGCCCCCACCCCGCGCGTGCAGCGCCTGGCGCTGCTGCAGGC
GCGTGGCGTGCTGCTGATCACGCGTGCGCCGCAGGCCGCGGCGCGACCGGCGGCGGGCCAGCCCGGTGCGGCTTCCGACT
ATGTGCCGGCGCTGCCCGATATCTTCGTCGCCGTACGTGACACCGGCGAAGTGCTGGCTTTCAATGGCCACGTGGATCTG
GGCACTGGCATCCGTACCGCACTCGCGCAGATCGTCGCAGAAGAACTCGACGTGCCGCTCGCGCGCGTGCGCATGGTGCT
CGGCCATACCGACGCGACGCCCAACCAGGGTCCGACGATCGCGAGCGCATCGATCCAGATTTCGGCAATTCCATTGCGGC
GTGCAGCGGCCCAGGCTCGCGCGTGGCTGCAGGCGCGCGCGGCGAACCAGCTCGGCGTAGCAGCGGATGCGCTCGAAGCG
GACGACGGTGTGTTCCGCGTGAAGGGGACGCAGCACGGTATCGGCTACGGTGCGTTGGTGGCCGACGAGCACGTCGAGCT
GCCACTCGCGGATGATGTACAGACCAAGCCTGTCGAGTCGTACCGTATCGTCGGCCGCGGCGCAGGCCGTGTGGATATCC
CCGACAAGGCGCGCGGCGTGCTGACCTTCGTGCATGACGTGCGCGTGCCCGGCATGCTGCACGGCCGCGTGGTGCGCCCG
CCGTACGCCGGCCGCGACAGCGGCGATTTCGTCGGCACGAGCTTGCTCGACGTCGATCGCAATTCCGTGCGCGATGTACC
GGGGCTGGTGGACATCGTGGTGCAGGGCGACTTCATCGGCGTGGTAGCCGAGCGCGAGGAATATGCGGTGATGGCCGCGC
GCCGCCTGCGCGTGCATTGGAAGCCGGTGCCCCCGTTGCCTGCGCTCGACGATCCCGAGCCCGCGCTGCGCGCCAACCCT
GCCACGCGCCGTGAACTGCTCGATGATGGCGAGATACCCGCACCCGACGCTGGCACCACGCTCGAACGCCACTACACCTG
GCCTTACCAGATGCATGGCTCGATCGGGCCGTCATGTGCCGTAGCCGACTGGCGCGAAGATGGCCTGACCGTGTGGTCCG
GCACGCAGAATCCGCATGTACTGCGTATCGATCTGGCGCGCCTCTCCGGGCTGGGCGAGGGCAGCATCGAGATCGTCCGC
ATGGATGCCGCCGGCTGCTACGGTCGCAACTGTGCCGACGACGTTTGCGCCGATGCCGTGCTGCTGTCGCGCGCGGTCGG
CCGTCCCGTACGCGTGCAGCTATCGCGCGAGCAGGAACACCTGTGGGAGCCCAAGGGCGCAGCGCAGCTCATGGATGTCA
GCGCCACGCTCGGCAGCAATGGTGAACTGCTTGGCTACGACTTCGTCAGCCGCTATCCGTCCAACGATGCACCGACGCTC
GCGCTGCTGCTCACCGGACAGTTGCCGAATGCGCGGCGCATGCTTGAGATGGGCGATCGCACCGCGGTACCGCCGTATGC
CTACTCCGGCCGCCGCATCCGCTGCGACGACACCCCGGCGATCGTGCGCGCATCGTGGTTGCGTGGCGTATCGGCGCTGC
CGAATACGTTCGCGCATGAATCCATGATCGATGAACTGGCGGCAGAAGCGGGTGTGGACCCGGTGGATTTCCGCTTGCGA
CATCTCCCCGACAATCGCGCGGCTGACCTGCTGCGTGCCGTGGCAGAGGCCGCGGGCTGGCAACGCGGTGCGAACGGTTC
GCGCGGCGTGCCCGATGCGAACGGAAAACTGCACGGCCGCGGCGTCGCGTATGCGCGATATATCCACAGCCGTTTCCCAG
GCTTCGGCGCGGCATGGGCTGCGTGGATTCTCGATCTGTCGGTCGATGTCGCCAGCGGACAGATCGTCGTCAGGAAGATC
TTCGTGGGTCAGGACACCGGCATGATGGTCAACCCGGACGGCGTACGTCACCAGATCCACGGCAACGTCGTGCAGACGCT
GAGCCGCGTGCTCAAGGAGCAGGTGCGCTTTGATGGCGACGGTGTGGCCAGTCGCGAATGGGGCGGCTATCCGTTGCTGA
CCTTTCCGGAGATTCCACCGATCGAGGTGCTGCTGATGCCGAGGCAGTCAGAGCCGCCGATGGGAGCGGGCGAATCGGCA
TCATTGCCGGGGGCGCCGGCGATTGCGAATGCGCTGTTTGATGCGACGGGTGTTCGGCTGAGACGGCCGCCGTTTGTGCC
GGAGACGGTGTTGGCGGCGCTACAAGGCCGACGCCCCTAG

Upstream 100 bases:

>100_bases
GTCATGTTGGATGGCTCGGCATCATGATGTCTGTTGGAGGGCAGTATAACGGTGGCATAGCGGGTGCCGCCCCACGCAAA
GCGGCAAAAATAATCGACCC

Downstream 100 bases:

>100_bases
CAATCCGCTGTCTTGCTCCCTTCCCCGCTGGCGGGAGAGGGGAGCAAACCGGCGGCACTACTAGCGGGGCTGCTCAACTC
CCACCGTTCCCCTCATCAAT

Product: isoquinoline 1-oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MTSTILDTVREAEAPTPRVQRLALLQARGVLLITRAPQAAARPAAGQPGAASDYVPALPDIFVAVRDTGEVLAFNGHVDL
GTGIRTALAQIVAEELDVPLARVRMVLGHTDATPNQGPTIASASIQISAIPLRRAAAQARAWLQARAANQLGVAADALEA
DDGVFRVKGTQHGIGYGALVADEHVELPLADDVQTKPVESYRIVGRGAGRVDIPDKARGVLTFVHDVRVPGMLHGRVVRP
PYAGRDSGDFVGTSLLDVDRNSVRDVPGLVDIVVQGDFIGVVAEREEYAVMAARRLRVHWKPVPPLPALDDPEPALRANP
ATRRELLDDGEIPAPDAGTTLERHYTWPYQMHGSIGPSCAVADWREDGLTVWSGTQNPHVLRIDLARLSGLGEGSIEIVR
MDAAGCYGRNCADDVCADAVLLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGSNGELLGYDFVSRYPSNDAPTL
ALLLTGQLPNARRMLEMGDRTAVPPYAYSGRRIRCDDTPAIVRASWLRGVSALPNTFAHESMIDELAAEAGVDPVDFRLR
HLPDNRAADLLRAVAEAAGWQRGANGSRGVPDANGKLHGRGVAYARYIHSRFPGFGAAWAAWILDLSVDVASGQIVVRKI
FVGQDTGMMVNPDGVRHQIHGNVVQTLSRVLKEQVRFDGDGVASREWGGYPLLTFPEIPPIEVLLMPRQSEPPMGAGESA
SLPGAPAIANALFDATGVRLRRPPFVPETVLAALQGRRP

Sequences:

>Translated_759_residues
MTSTILDTVREAEAPTPRVQRLALLQARGVLLITRAPQAAARPAAGQPGAASDYVPALPDIFVAVRDTGEVLAFNGHVDL
GTGIRTALAQIVAEELDVPLARVRMVLGHTDATPNQGPTIASASIQISAIPLRRAAAQARAWLQARAANQLGVAADALEA
DDGVFRVKGTQHGIGYGALVADEHVELPLADDVQTKPVESYRIVGRGAGRVDIPDKARGVLTFVHDVRVPGMLHGRVVRP
PYAGRDSGDFVGTSLLDVDRNSVRDVPGLVDIVVQGDFIGVVAEREEYAVMAARRLRVHWKPVPPLPALDDPEPALRANP
ATRRELLDDGEIPAPDAGTTLERHYTWPYQMHGSIGPSCAVADWREDGLTVWSGTQNPHVLRIDLARLSGLGEGSIEIVR
MDAAGCYGRNCADDVCADAVLLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGSNGELLGYDFVSRYPSNDAPTL
ALLLTGQLPNARRMLEMGDRTAVPPYAYSGRRIRCDDTPAIVRASWLRGVSALPNTFAHESMIDELAAEAGVDPVDFRLR
HLPDNRAADLLRAVAEAAGWQRGANGSRGVPDANGKLHGRGVAYARYIHSRFPGFGAAWAAWILDLSVDVASGQIVVRKI
FVGQDTGMMVNPDGVRHQIHGNVVQTLSRVLKEQVRFDGDGVASREWGGYPLLTFPEIPPIEVLLMPRQSEPPMGAGESA
SLPGAPAIANALFDATGVRLRRPPFVPETVLAALQGRRP
>Mature_758_residues
TSTILDTVREAEAPTPRVQRLALLQARGVLLITRAPQAAARPAAGQPGAASDYVPALPDIFVAVRDTGEVLAFNGHVDLG
TGIRTALAQIVAEELDVPLARVRMVLGHTDATPNQGPTIASASIQISAIPLRRAAAQARAWLQARAANQLGVAADALEAD
DGVFRVKGTQHGIGYGALVADEHVELPLADDVQTKPVESYRIVGRGAGRVDIPDKARGVLTFVHDVRVPGMLHGRVVRPP
YAGRDSGDFVGTSLLDVDRNSVRDVPGLVDIVVQGDFIGVVAEREEYAVMAARRLRVHWKPVPPLPALDDPEPALRANPA
TRRELLDDGEIPAPDAGTTLERHYTWPYQMHGSIGPSCAVADWREDGLTVWSGTQNPHVLRIDLARLSGLGEGSIEIVRM
DAAGCYGRNCADDVCADAVLLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGSNGELLGYDFVSRYPSNDAPTLA
LLLTGQLPNARRMLEMGDRTAVPPYAYSGRRIRCDDTPAIVRASWLRGVSALPNTFAHESMIDELAAEAGVDPVDFRLRH
LPDNRAADLLRAVAEAAGWQRGANGSRGVPDANGKLHGRGVAYARYIHSRFPGFGAAWAAWILDLSVDVASGQIVVRKIF
VGQDTGMMVNPDGVRHQIHGNVVQTLSRVLKEQVRFDGDGVASREWGGYPLLTFPEIPPIEVLLMPRQSEPPMGAGESAS
LPGAPAIANALFDATGVRLRRPPFVPETVLAALQGRRP

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789230, Length=407, Percent_Identity=24.0786240786241, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789246, Length=149, Percent_Identity=29.5302013422819, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786478, Length=432, Percent_Identity=23.3796296296296, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 81483; Mature: 81351

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTILDTVREAEAPTPRVQRLALLQARGVLLITRAPQAAARPAAGQPGAASDYVPALPD
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCC
IFVAVRDTGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLARVRMVLGHTDATPNQGPTI
EEEEEECCCCEEEEECCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEE
ASASIQISAIPLRRAAAQARAWLQARAANQLGVAADALEADDGVFRVKGTQHGIGYGALV
EECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCEEEEE
ADEHVELPLADDVQTKPVESYRIVGRGAGRVDIPDKARGVLTFVHDVRVPGMLHGRVVRP
ECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHCHHEEEEHHCCCCCEECCEEECC
PYAGRDSGDFVGTSLLDVDRNSVRDVPGLVDIVVQGDFIGVVAEREEYAVMAARRLRVHW
CCCCCCCCCCCCCEEEECCCHHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHEEEE
KPVPPLPALDDPEPALRANPATRRELLDDGEIPAPDAGTTLERHYTWPYQMHGSIGPSCA
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHEECCCEEECCCCCCCCE
VADWREDGLTVWSGTQNPHVLRIDLARLSGLGEGSIEIVRMDAAGCYGRNCADDVCADAV
EECCCCCCEEEEECCCCCEEEEEEHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGSNGELLGYDFVSRYPSNDAPTL
HHHHHCCCCEEEEECCCHHHCCCCCCCHHHEEEHHHCCCCCCEEEEHHHHHCCCCCCCEE
ALLLTGQLPNARRMLEMGDRTAVPPYAYSGRRIRCDDTPAIVRASWLRGVSALPNTFAHE
EEEEECCCCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHH
SMIDELAAEAGVDPVDFRLRHLPDNRAADLLRAVAEAAGWQRGANGSRGVPDANGKLHGR
HHHHHHHHHHCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECC
GVAYARYIHSRFPGFGAAWAAWILDLSVDVASGQIVVRKIFVGQDTGMMVNPDGVRHQIH
CHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCEEEEEEEEECCCCCEEECCCCCCEECC
GNVVQTLSRVLKEQVRFDGDGVASREWGGYPLLTFPEIPPIEVLLMPRQSEPPMGAGESA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCC
SLPGAPAIANALFDATGVRLRRPPFVPETVLAALQGRRP
CCCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TSTILDTVREAEAPTPRVQRLALLQARGVLLITRAPQAAARPAAGQPGAASDYVPALPD
CHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCC
IFVAVRDTGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLARVRMVLGHTDATPNQGPTI
EEEEEECCCCEEEEECCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEE
ASASIQISAIPLRRAAAQARAWLQARAANQLGVAADALEADDGVFRVKGTQHGIGYGALV
EECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCEEEEE
ADEHVELPLADDVQTKPVESYRIVGRGAGRVDIPDKARGVLTFVHDVRVPGMLHGRVVRP
ECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHCHHEEEEHHCCCCCEECCEEECC
PYAGRDSGDFVGTSLLDVDRNSVRDVPGLVDIVVQGDFIGVVAEREEYAVMAARRLRVHW
CCCCCCCCCCCCCEEEECCCHHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHEEEE
KPVPPLPALDDPEPALRANPATRRELLDDGEIPAPDAGTTLERHYTWPYQMHGSIGPSCA
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHEECCCEEECCCCCCCCE
VADWREDGLTVWSGTQNPHVLRIDLARLSGLGEGSIEIVRMDAAGCYGRNCADDVCADAV
EECCCCCCEEEEECCCCCEEEEEEHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGSNGELLGYDFVSRYPSNDAPTL
HHHHHCCCCEEEEECCCHHHCCCCCCCHHHEEEHHHCCCCCCEEEEHHHHHCCCCCCCEE
ALLLTGQLPNARRMLEMGDRTAVPPYAYSGRRIRCDDTPAIVRASWLRGVSALPNTFAHE
EEEEECCCCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHH
SMIDELAAEAGVDPVDFRLRHLPDNRAADLLRAVAEAAGWQRGANGSRGVPDANGKLHGR
HHHHHHHHHHCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECC
GVAYARYIHSRFPGFGAAWAAWILDLSVDVASGQIVVRKIFVGQDTGMMVNPDGVRHQIH
CHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCEEEEEEEEECCCCCEEECCCCCCEECC
GNVVQTLSRVLKEQVRFDGDGVASREWGGYPLLTFPEIPPIEVLLMPRQSEPPMGAGESA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCC
SLPGAPAIANALFDATGVRLRRPPFVPETVLAALQGRRP
CCCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]