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The map label for this gene is pucD [H]

Identifier: 73542112

GI number: 73542112

Start: 2657819

End: 2660200

Strand: Direct

Name: pucD [H]

Synonym: Reut_A2426

Alternate gene names: 73542112

Gene position: 2657819-2660200 (Clockwise)

Preceding gene: 73542111

Following gene: 73542113

Centisome position: 69.82

GC content: 66.04

Gene sequence:

>2382_bases
ATGAACAAGCAAACCGAACCGTTCCTGCTCGACGCCAGCGTGGCCGACGAGGCCGTGCCCCAGGTCGGCATCTCGCGTCC
GCATGAATCGGCGCACCTGCACGTGGCAGGCACCGCCACCTATACCGACGATATTCCCGAGCTCGCCGGCACGCTGCACG
CGGCGCTCGGCATGAGCAGCCGCGCCCATGCGCGCATCAAATCCATCTCGCTCGACAAGGTGCGCACCGCGCCCGGCGTG
GTGGACGTGCTGACCGTGGATGACATTCCCGGCGTCAACGACTGCGGCCCGATCATCCACGACGACCCGATCCTGGTGCG
CGACGTGGTGCAGTTTATCGGCCAGCCGATCTTCGTGGTGGTTGCCACGTCGCATGACGCGGCACGCCGCGCTGCCCGCC
TGGGCGTGATTGAATACGAAGACCTGCCACCGGTACTCTCGCCGGAGGCCGCGCACGAGGCCGGCAGCTACGTGCTGCCG
CCGATGCACCTGACCCGGGGCGAGCCGCAACAGCATCTGGCAGCCGCCGCGCACCGCGATGCGGGCAAGATCCGCCTCGG
CGGACAGGAGCAGTTCTATCTGGAAGGCCAGATCGCCTACGCCGCGCCGCGCGAAAACGACGGCATGCACGTGTGGTGCT
CGACCCAGCACCCGACCGAGATGCAGCACGCCGTGGCCCATATGCTCGGCTGGCACGCGCACCAGGTGCTGGTGGAATGC
CGCCGCATGGGCGGCGGCTTCGGCGGCAAGGAATCGCAGTCGGCCATGTTCGCGTGCTGCGCATCGCTGGCGGCATGGAA
GCTCATGTGCCCGGTCAAGCTGCGTCCGGACCGCGACGACGACATGATGATCACCGGCAAGCGCCACGACTTCGTGTTCG
ATTTCGACGTCGGTCATGACACTGATGGCCGCATCGAAGGCGTGCAGATCGAGATGGTGTCGCGCGCCGGCTTCTCGGCC
GACCTGTCGGGCCCGGTGATGACGCGCGCGATCTGCCACTTCGACAATGCCTACTGGCTGCCGAACGTGCAGATCGACGG
CTACTGCGGCAAGACGAATACGCAGAGCAATACCGCATTCCGCGGCTTCGGCGGCCCGCAGGGCGCGTTCGCGATCGAGT
ACATCCTCGACAACGTGGCACGCAATGTCGGCAAGGATTCGCTCGATGTGCGCCGCGCCAACTTCTATGGCAAGACCGAG
CGCAACGTCACGCCGTATGGCCAGACCGTGGAAGACAATGTCATCCACGAACTGATCGACGAACTCGTGGCCACCAGCGA
ATACCGTGGGCGCCGCGAGGCCACGCGTGCGTTCAATGCGACGAGCCCAATCCTCAAGAAGGGCATCGCGATCACGCCGG
TGAAGTTCGGCATCTCGTTCAACGTGGCGCACTACAACCAGGCCGGCGCGCTCGTGCACGTGTACAACGACGGCTCGGTG
CTGGTGAATCACGGCGGCACCGAAATGGGCCAGGGCCTGAACACCAAGGTTGCGATGGTGGTGGCGCACGAGCTCGGTAT
CCGCATGGAACGCGTACGCGTGACCGCAACGGATACCAGCAAGGTGGCCAACACCTCGGCGACTGCGGCATCGACCGGCG
CTGACCTGAACGGCAAGGCCGCGCAGGACGCCGCGCGCCAGATTCGCGAGCGCCTGGCCGAGTTTGCCGCGCGCAAGGCC
GGCGTGACGCCTGACAGCGTGCGCTTCAACGACGATCTCGTGATCGCCGGCGAGCTGCGCGTGCCATTCGGCGAACTGGC
CCGCGAAGCGTACCTGGCACGCGTGCAGCTCTGGTCGGACGGCTTCTACACGACGCCGAAGCTGCATTGGGACCAGAAGA
AGCTGCAGGGCCGCCCGTTCTACTACTTTGCCTACGGTGCGGCGTGCTCCGAGGTGCTGGTCGACACGCTGACCGGCGAA
TGGAAGCTGCTGCGCGCCGACGCGCTGCACGATGCAGGCAAGTCGCTGAACCCGGCCATCGATATCGGCCAGGTCGAAGG
CGCCTTCATCCAGGGCATGGGCTGGCTGACGACCGAGGAACTGTGGTGGAACAAGGACGGCAAGCTGATGACGCATGCGC
CGTCCACCTACAAGATCCCGACGATCAACGACTGCCCTGAAGACTTCAACGTGCGCCTGTTCCAGAACCGGAACGTGGAA
GACAGCATCCACCGCTCCAAGGCTGTGGGCGAACCGCCGCTGCTGCTGCCGTTCTCGGTGTTCTTCGCGATCCGCGACGC
GATCGCGGCCGTGGCTGACTACCAGGTCAACCCGCCGCTGCGCGCGCCGGCTACCAGCGAAGCCATCCTGGACGCGGTGG
AAGCAGTACGCGCGACATGCGCGGCGAGCGCGGTCGGCGAAACCGCCGCACAGCCGGCCTGA

Upstream 100 bases:

>100_bases
GCTGGAGACGCGCGCCGATGCGCTGCCCGCATCCGCTGTCAACGTCCGCGCGCCTGGCGCTGGCGCCACTGCAACCGTCA
CGGCCTGAGGAGAGATCGGC

Downstream 100 bases:

>100_bases
CGCGCGCGCCTGCCGGGCCTGCCGGACTTTCCCCCCTGTTCCGCTCTTGGCGGATCAGGGGCCGGCCGCCCGCGCAGGTG
CGCGCCACCCCCGGCGCAAA

Product: xanthine oxidase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 793; Mature: 793

Protein sequence:

>793_residues
MNKQTEPFLLDASVADEAVPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSSRAHARIKSISLDKVRTAPGV
VDVLTVDDIPGVNDCGPIIHDDPILVRDVVQFIGQPIFVVVATSHDAARRAARLGVIEYEDLPPVLSPEAAHEAGSYVLP
PMHLTRGEPQQHLAAAAHRDAGKIRLGGQEQFYLEGQIAYAAPRENDGMHVWCSTQHPTEMQHAVAHMLGWHAHQVLVEC
RRMGGGFGGKESQSAMFACCASLAAWKLMCPVKLRPDRDDDMMITGKRHDFVFDFDVGHDTDGRIEGVQIEMVSRAGFSA
DLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAFRGFGGPQGAFAIEYILDNVARNVGKDSLDVRRANFYGKTE
RNVTPYGQTVEDNVIHELIDELVATSEYRGRREATRAFNATSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKAAQDAARQIRERLAEFAARKA
GVTPDSVRFNDDLVIAGELRVPFGELAREAYLARVQLWSDGFYTTPKLHWDQKKLQGRPFYYFAYGAACSEVLVDTLTGE
WKLLRADALHDAGKSLNPAIDIGQVEGAFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPTINDCPEDFNVRLFQNRNVE
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVADYQVNPPLRAPATSEAILDAVEAVRATCAASAVGETAAQPA

Sequences:

>Translated_793_residues
MNKQTEPFLLDASVADEAVPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSSRAHARIKSISLDKVRTAPGV
VDVLTVDDIPGVNDCGPIIHDDPILVRDVVQFIGQPIFVVVATSHDAARRAARLGVIEYEDLPPVLSPEAAHEAGSYVLP
PMHLTRGEPQQHLAAAAHRDAGKIRLGGQEQFYLEGQIAYAAPRENDGMHVWCSTQHPTEMQHAVAHMLGWHAHQVLVEC
RRMGGGFGGKESQSAMFACCASLAAWKLMCPVKLRPDRDDDMMITGKRHDFVFDFDVGHDTDGRIEGVQIEMVSRAGFSA
DLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAFRGFGGPQGAFAIEYILDNVARNVGKDSLDVRRANFYGKTE
RNVTPYGQTVEDNVIHELIDELVATSEYRGRREATRAFNATSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKAAQDAARQIRERLAEFAARKA
GVTPDSVRFNDDLVIAGELRVPFGELAREAYLARVQLWSDGFYTTPKLHWDQKKLQGRPFYYFAYGAACSEVLVDTLTGE
WKLLRADALHDAGKSLNPAIDIGQVEGAFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPTINDCPEDFNVRLFQNRNVE
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVADYQVNPPLRAPATSEAILDAVEAVRATCAASAVGETAAQPA
>Mature_793_residues
MNKQTEPFLLDASVADEAVPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSSRAHARIKSISLDKVRTAPGV
VDVLTVDDIPGVNDCGPIIHDDPILVRDVVQFIGQPIFVVVATSHDAARRAARLGVIEYEDLPPVLSPEAAHEAGSYVLP
PMHLTRGEPQQHLAAAAHRDAGKIRLGGQEQFYLEGQIAYAAPRENDGMHVWCSTQHPTEMQHAVAHMLGWHAHQVLVEC
RRMGGGFGGKESQSAMFACCASLAAWKLMCPVKLRPDRDDDMMITGKRHDFVFDFDVGHDTDGRIEGVQIEMVSRAGFSA
DLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAFRGFGGPQGAFAIEYILDNVARNVGKDSLDVRRANFYGKTE
RNVTPYGQTVEDNVIHELIDELVATSEYRGRREATRAFNATSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKAAQDAARQIRERLAEFAARKA
GVTPDSVRFNDDLVIAGELRVPFGELAREAYLARVQLWSDGFYTTPKLHWDQKKLQGRPFYYFAYGAACSEVLVDTLTGE
WKLLRADALHDAGKSLNPAIDIGQVEGAFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPTINDCPEDFNVRLFQNRNVE
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVADYQVNPPLRAPATSEAILDAVEAVRATCAASAVGETAAQPA

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=775, Percent_Identity=42.0645161290323, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI71773480, Length=762, Percent_Identity=38.0577427821522, Blast_Score=472, Evalue=1e-133,
Organism=Escherichia coli, GI1789230, Length=754, Percent_Identity=26.9230769230769, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1789246, Length=736, Percent_Identity=26.7663043478261, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI1786478, Length=725, Percent_Identity=24.8275862068966, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=769, Percent_Identity=41.3524057217165, Blast_Score=522, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI32566215, Length=708, Percent_Identity=31.7796610169492, Blast_Score=335, Evalue=7e-92,
Organism=Caenorhabditis elegans, GI17539860, Length=717, Percent_Identity=33.1938633193863, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI17737937, Length=761, Percent_Identity=41.9185282522996, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24647193, Length=776, Percent_Identity=30.798969072165, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24647199, Length=761, Percent_Identity=31.6688567674113, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24647201, Length=757, Percent_Identity=30.6472919418758, Blast_Score=282, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24647195, Length=766, Percent_Identity=28.8511749347258, Blast_Score=278, Evalue=9e-75,
Organism=Drosophila melanogaster, GI24647197, Length=766, Percent_Identity=28.8511749347258, Blast_Score=278, Evalue=9e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 86302; Mature: 86302

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQTEPFLLDASVADEAVPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSS
CCCCCCCEEEECHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
RAHARIKSISLDKVRTAPGVVDVLTVDDIPGVNDCGPIIHDDPILVRDVVQFIGQPIFVV
HHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
VATSHDAARRAARLGVIEYEDLPPVLSPEAAHEAGSYVLPPMHLTRGEPQQHLAAAAHRD
EECCCHHHHHHHHCCCEEECCCCCCCCCCHHHHCCCEECCCHHCCCCCHHHHHHHHHHCC
AGKIRLGGQEQFYLEGQIAYAAPRENDGMHVWCSTQHPTEMQHAVAHMLGWHAHQVLVEC
CCEEEECCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
RRMGGGFGGKESQSAMFACCASLAAWKLMCPVKLRPDRDDDMMITGKRHDFVFDFDVGHD
HHHCCCCCCCCCHHHHHHHHHHHHHHHEECCEEECCCCCCCEEEEECCCCEEEEECCCCC
TDGRIEGVQIEMVSRAGFSADLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAF
CCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCEEECCCCCCCCCCCCCEE
RGFGGPQGAFAIEYILDNVARNVGKDSLDVRRANFYGKTERNVTPYGQTVEDNVIHELID
ECCCCCCCHHHHHHHHHHHHHHCCCCCHHEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELVATSEYRGRREATRAFNATSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
HHHHHHHHCCHHHHHHHHCCCCHHHHCCCEEEEEEECEEEEEEEECCCCCEEEEEECCEE
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKA
EEECCCHHHCCCCCCEEEEEEEHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHH
AQDAARQIRERLAEFAARKAGVTPDSVRFNDDLVIAGELRVPFGELAREAYLARVQLWSD
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHEEEECC
GFYTTPKLHWDQKKLQGRPFYYFAYGAACSEVLVDTLTGEWKLLRADALHDAGKSLNPAI
CCEECCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCE
DIGQVEGAFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPTINDCPEDFNVRLFQNRNVE
ECCCCCCHHCCCCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCCCCCEEEEECCCCH
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVADYQVNPPLRAPATSEAILDAVEAVRATC
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AASAVGETAAQPA
HHHHHCCCCCCCC
>Mature Secondary Structure
MNKQTEPFLLDASVADEAVPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSS
CCCCCCCEEEECHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
RAHARIKSISLDKVRTAPGVVDVLTVDDIPGVNDCGPIIHDDPILVRDVVQFIGQPIFVV
HHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
VATSHDAARRAARLGVIEYEDLPPVLSPEAAHEAGSYVLPPMHLTRGEPQQHLAAAAHRD
EECCCHHHHHHHHCCCEEECCCCCCCCCCHHHHCCCEECCCHHCCCCCHHHHHHHHHHCC
AGKIRLGGQEQFYLEGQIAYAAPRENDGMHVWCSTQHPTEMQHAVAHMLGWHAHQVLVEC
CCEEEECCCCEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
RRMGGGFGGKESQSAMFACCASLAAWKLMCPVKLRPDRDDDMMITGKRHDFVFDFDVGHD
HHHCCCCCCCCCHHHHHHHHHHHHHHHEECCEEECCCCCCCEEEEECCCCEEEEECCCCC
TDGRIEGVQIEMVSRAGFSADLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAF
CCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCEEECCCCCCCCCCCCCEE
RGFGGPQGAFAIEYILDNVARNVGKDSLDVRRANFYGKTERNVTPYGQTVEDNVIHELID
ECCCCCCCHHHHHHHHHHHHHHCCCCCHHEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELVATSEYRGRREATRAFNATSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
HHHHHHHHCCHHHHHHHHCCCCHHHHCCCEEEEEEECEEEEEEEECCCCCEEEEEECCEE
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKA
EEECCCHHHCCCCCCEEEEEEEHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHH
AQDAARQIRERLAEFAARKAGVTPDSVRFNDDLVIAGELRVPFGELAREAYLARVQLWSD
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHEEEECC
GFYTTPKLHWDQKKLQGRPFYYFAYGAACSEVLVDTLTGEWKLLRADALHDAGKSLNPAI
CCEECCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCE
DIGQVEGAFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPTINDCPEDFNVRLFQNRNVE
ECCCCCCHHCCCCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCCCCCEEEEECCCCH
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVADYQVNPPLRAPATSEAILDAVEAVRATC
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AASAVGETAAQPA
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]