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The map label for this gene is intA [H]

Identifier: 73542051

GI number: 73542051

Start: 2609137

End: 2610351

Strand: Direct

Name: intA [H]

Synonym: Reut_A2365

Alternate gene names: 73542051

Gene position: 2609137-2610351 (Clockwise)

Preceding gene: 73542050

Following gene: 73542052

Centisome position: 68.54

GC content: 65.1

Gene sequence:

>1215_bases
ATGCCCCGAACGGTCGAACCCCTCACTGATACCAAAATCCGCAACGCCAAGCCGCGCGAGCGTTCCTACAAGCTTTTCGA
CGGCGGCGGTCTCTACCTCGAGGTAATGACCGACGGGCGAAAGCTCTGGCGGTTCAAATATGTGCGCCCATCCGGCAGCG
AGAGCCGGCTGGGCTTCGGCGTCTACCCTGCCGTGTCATTGGCCCAGGCTCGCACGCAGCGGGAGACCGCACGCGGCATC
GTGGCCGACGGCCGCGACCCGGGCGCAGTGAAGCAGGAAGAACGGCGCGCGGCACGCATCGCCGCCGGTAATTCGTTCGA
GGCAGTGGCAAGGGACTGGCATAACACCCAGAAAAGCAGCTGGAACGACGTTTATGCAGGCAAGGTTCTGGCGTCGCTCG
AGAATGACGTCTTCCCCGTCCTGGGTAGCACGCCCATCGCCGACATCAAGGCGCCTGCCATCCTGGACCTGCTGAGGAAG
GTCGAGGCGCGCGGCGTGCGCGACACCACGAAGCGAATCCTGCAGCGCATGCGCGCGGTGTTCCAGTACGGGATCATCTA
TGGCCTGTGCGACCGCAACCCGGCCGCCGACATCGACAGCGCCGCGGCACTGAAGTCCGAGTCGGTCCAGCACCAGGCCC
GCGTGTCTCCGCTCGAGCTGCCGCAGCTGTTGCGCGACATCGATGCATACGAGGGCGACGCCGTCACCCGCCTGGCACTG
CAGTTCATGACGCTGACCTTCGTGCGCACAACGGAGATGATCCAGGCGCGCTGGGTCGAGATCGACGAGGCCAAGGCCGA
GTGGAGGATTCCGGCCGACCGGATGAAGATGCGCGACCCGCACGTCGTGCCACTGTCCACCCAGGCGCTGGCTGTACTGG
CCGAGCTGCGCGCGATCAACGGGCACCGCGATCTAGTCTTTTACAGCCCCCGAGGCAAGTCGGGCCACATCAGCAACAAC
ACGATGTTGTATGCCCTGTACCGCATGGGGTACCACTCGCGGATGACCGGGCACGGGTTCCGGGGCCTTGCCTCAACGGC
GCTGAACGAGCTGGGCTTCCGGCCGGACGTCATTGAGCGCCAGCTGGCGCACGTGGAGAGGAACAAGGTGCGCGCTGCGT
ACAACCACGCGCAGTATTTGCCCGAGCGACGCCAAATGATGCAGAGTTGGGCGGACCACGTGCATGCGCTGCGCATGCCG
GCGGTTACCGAATGA

Upstream 100 bases:

>100_bases
GACGTTCGCTAGAGTTCGCCTTTGACCGTTGGCATCCGTCACTTTTTGGGGCATCCTTTGGGGCATTATCGAATGCCCCT
ATTTTCGGTGCCCCTACGCA

Downstream 100 bases:

>100_bases
GCAACGACGCGAAGGCAATGACAGAGCACCTGGAGAAGACGTTCGCAATGCGGGCGCCAGCGGACTTCTTTGCGAAGCTG
CAATGGGAAGCCGCAAAGCT

Product: Phage integrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MPRTVEPLTDTKIRNAKPRERSYKLFDGGGLYLEVMTDGRKLWRFKYVRPSGSESRLGFGVYPAVSLAQARTQRETARGI
VADGRDPGAVKQEERRAARIAAGNSFEAVARDWHNTQKSSWNDVYAGKVLASLENDVFPVLGSTPIADIKAPAILDLLRK
VEARGVRDTTKRILQRMRAVFQYGIIYGLCDRNPAADIDSAAALKSESVQHQARVSPLELPQLLRDIDAYEGDAVTRLAL
QFMTLTFVRTTEMIQARWVEIDEAKAEWRIPADRMKMRDPHVVPLSTQALAVLAELRAINGHRDLVFYSPRGKSGHISNN
TMLYALYRMGYHSRMTGHGFRGLASTALNELGFRPDVIERQLAHVERNKVRAAYNHAQYLPERRQMMQSWADHVHALRMP
AVTE

Sequences:

>Translated_404_residues
MPRTVEPLTDTKIRNAKPRERSYKLFDGGGLYLEVMTDGRKLWRFKYVRPSGSESRLGFGVYPAVSLAQARTQRETARGI
VADGRDPGAVKQEERRAARIAAGNSFEAVARDWHNTQKSSWNDVYAGKVLASLENDVFPVLGSTPIADIKAPAILDLLRK
VEARGVRDTTKRILQRMRAVFQYGIIYGLCDRNPAADIDSAAALKSESVQHQARVSPLELPQLLRDIDAYEGDAVTRLAL
QFMTLTFVRTTEMIQARWVEIDEAKAEWRIPADRMKMRDPHVVPLSTQALAVLAELRAINGHRDLVFYSPRGKSGHISNN
TMLYALYRMGYHSRMTGHGFRGLASTALNELGFRPDVIERQLAHVERNKVRAAYNHAQYLPERRQMMQSWADHVHALRMP
AVTE
>Mature_403_residues
PRTVEPLTDTKIRNAKPRERSYKLFDGGGLYLEVMTDGRKLWRFKYVRPSGSESRLGFGVYPAVSLAQARTQRETARGIV
ADGRDPGAVKQEERRAARIAAGNSFEAVARDWHNTQKSSWNDVYAGKVLASLENDVFPVLGSTPIADIKAPAILDLLRKV
EARGVRDTTKRILQRMRAVFQYGIIYGLCDRNPAADIDSAAALKSESVQHQARVSPLELPQLLRDIDAYEGDAVTRLALQ
FMTLTFVRTTEMIQARWVEIDEAKAEWRIPADRMKMRDPHVVPLSTQALAVLAELRAINGHRDLVFYSPRGKSGHISNNT
MLYALYRMGYHSRMTGHGFRGLASTALNELGFRPDVIERQLAHVERNKVRAAYNHAQYLPERRQMMQSWADHVHALRMPA
VTE

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788974, Length=397, Percent_Identity=41.0579345088161, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI145693166, Length=394, Percent_Identity=38.0710659898477, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1788690, Length=386, Percent_Identity=34.7150259067358, Blast_Score=232, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 45651; Mature: 45520

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTVEPLTDTKIRNAKPRERSYKLFDGGGLYLEVMTDGRKLWRFKYVRPSGSESRLGFG
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEEEEECCCCCCCCCCCC
VYPAVSLAQARTQRETARGIVADGRDPGAVKQEERRAARIAAGNSFEAVARDWHNTQKSS
CCHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
WNDVYAGKVLASLENDVFPVLGSTPIADIKAPAILDLLRKVEARGVRDTTKRILQRMRAV
CCHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FQYGIIYGLCDRNPAADIDSAAALKSESVQHQARVSPLELPQLLRDIDAYEGDAVTRLAL
HHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHH
QFMTLTFVRTTEMIQARWVEIDEAKAEWRIPADRMKMRDPHVVPLSTQALAVLAELRAIN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEECCCHHHHHHHHHHHHCC
GHRDLVFYSPRGKSGHISNNTMLYALYRMGYHSRMTGHGFRGLASTALNELGFRPDVIER
CCCCEEEECCCCCCCCCCCCCEEEHHHHHCHHCCCCCCCCHHHHHHHHHHCCCCCHHHHH
QLAHVERNKVRAAYNHAQYLPERRQMMQSWADHVHALRMPAVTE
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PRTVEPLTDTKIRNAKPRERSYKLFDGGGLYLEVMTDGRKLWRFKYVRPSGSESRLGFG
CCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEEEEECCCCCCCCCCCC
VYPAVSLAQARTQRETARGIVADGRDPGAVKQEERRAARIAAGNSFEAVARDWHNTQKSS
CCHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
WNDVYAGKVLASLENDVFPVLGSTPIADIKAPAILDLLRKVEARGVRDTTKRILQRMRAV
CCHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FQYGIIYGLCDRNPAADIDSAAALKSESVQHQARVSPLELPQLLRDIDAYEGDAVTRLAL
HHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHH
QFMTLTFVRTTEMIQARWVEIDEAKAEWRIPADRMKMRDPHVVPLSTQALAVLAELRAIN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEECCCHHHHHHHHHHHHCC
GHRDLVFYSPRGKSGHISNNTMLYALYRMGYHSRMTGHGFRGLASTALNELGFRPDVIER
CCCCEEEECCCCCCCCCCCCCEEEHHHHHCHHCCCCCCCCHHHHHHHHHHCCCCCHHHHH
QLAHVERNKVRAAYNHAQYLPERRQMMQSWADHVHALRMPAVTE
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7511583; 9278503; 9205837; 7524073 [H]