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The map label for this gene is qacF [H]

Identifier: 73542050

GI number: 73542050

Start: 2608118

End: 2608450

Strand: Direct

Name: qacF [H]

Synonym: Reut_A2364

Alternate gene names: 73542050

Gene position: 2608118-2608450 (Clockwise)

Preceding gene: 73542048

Following gene: 73542051

Centisome position: 68.52

GC content: 63.06

Gene sequence:

>333_bases
ATGAACGGATACCTGCTCCTTGCCCTGGCCATCGTTGCCGAGGTCATCGCCACCAGCAGCCTCAAGGCCGCCGAGAACTT
CACGCGCCTGGTGCCCAGCATCCTCGTGGTAGCGGGCTATGCCTGCGCCTTCTATCTGCTCATGCTGGTCATGAAGACCG
TACCAGTGGGCGTCGCTTATGCCATCTGGAGCGGCGCGGGCATCGTCCTGGTCACGCTGATCGCCATGGTGCTGTACCGC
CAGGTACCCGACCTCGCCGCCTGCGCCGGCATTGGCCTGATCATCGCCGGTGTGGCGGTGATCCAGCTATTCTCGAAAAC
CAGCGGGCATTGA

Upstream 100 bases:

>100_bases
ACCACCGCAAGGGAGGGCATAACGTTTCACCAAAGCGCCGCTTACGCTACATTGCCGCCTGCCGTCTGTCCTTCCACCCC
TTCGCCATCGCGTTTCGCCT

Downstream 100 bases:

>100_bases
CAACGGTGCGGCCTAGAATGGATGTGGTTCCTGCCACGGGAGACCGCCATGCTTACCGCCCTGCTCCTCGCCGCAATCAT
CGTCGCGCTGTACATCCTGG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSILVVAGYACAFYLLMLVMKTVPVGVAYAIWSGAGIVLVTLIAMVLYR
QVPDLAACAGIGLIIAGVAVIQLFSKTSGH

Sequences:

>Translated_110_residues
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSILVVAGYACAFYLLMLVMKTVPVGVAYAIWSGAGIVLVTLIAMVLYR
QVPDLAACAGIGLIIAGVAVIQLFSKTSGH
>Mature_110_residues
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSILVVAGYACAFYLLMLVMKTVPVGVAYAIWSGAGIVLVTLIAMVLYR
QVPDLAACAGIGLIIAGVAVIQLFSKTSGH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=46.3636363636364, Blast_Score=98, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11426; Mature: 11426

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSILVVAGYACAFYLLMLVMKTVPVGVAY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGAGIVLVTLIAMVLYRQVPDLAACAGIGLIIAGVAVIQLFSKTSGH
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSILVVAGYACAFYLLMLVMKTVPVGVAY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGAGIVLVTLIAMVLYRQVPDLAACAGIGLIIAGVAVIQLFSKTSGH
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]