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The map label for this gene is parE [H]

Identifier: 73542044

GI number: 73542044

Start: 2599010

End: 2601001

Strand: Reverse

Name: parE [H]

Synonym: Reut_A2358

Alternate gene names: 73542044

Gene position: 2601001-2599010 (Counterclockwise)

Preceding gene: 73542046

Following gene: 73542043

Centisome position: 68.33

GC content: 65.86

Gene sequence:

>1992_bases
ATGGCGAGCAAAACCAGTCAGTACAGCGAATCTTCCATCCGGGTCCTGAAGGGCCTGGAGCCGGTCAAGCAGCGTCCCGG
CATGTACACCCGCACCGACAACCCCCTGCATATCGTGCAGGAGGTGATCGACAACGCGTCCGACGAGGCGCTGGGCGGCT
TCGGTTCCGAGATCCTGGTCACGCTGCACCGCGACGGCAGCGTCAGCGTGGAGGACGACGGCCGCGGTATCCCGGTCGGC
ATCCACCCGGAAGAGGGCGTGCCGGTAGTCGAGATCGTCTTCACGCGGCTGCACGCGGGCGGCAAGTTCGACAAGGGCAA
GGGCGGAGCGTACGCGTTTTCGGGCGGCCTGCACGGCGTGGGCGTGTCGGTGACCAATGCGCTGTCGACGCAGCTTGATG
TGTCGGTCTGGCGCGACGGCATGATGTCCACGCTGACCTTCTCGGGCGGCGACGTGACCGCGCCGCTGACCTCGCGCAAG
CTCGAGCGCGGCGAGAAGAAGAACGGCACGCGCGTCCAGGTCTGGCCGGACGCCAAGTATTTCGATTCGGCCGCGATTCC
GCAGGCTGAACTGCAACGTCTGCTGCGCAGCAAGGCGGTGCTGCTGCCGGGCGTGAAGGTCACGCTGGTGATCGAGAAGT
CTGGCGAAACCCAGACGTGGCAGTACGACCAGGGTCTGAAGGGCTATCTGGTCGAGGCGCTGGCGCAAGGCAGCGGCGCT
GAGCTTGTGATCCCGATGTTCGAAGGCGAGCACTTCGCCGATCCGGACGCAAACCCCGGCGAAGAAGGCTTCGCCGACGG
CGAAGGCGCTTCCTGGGTGGTGGCCTGGACCGAAGAGGGCGCGCCCGTGCGGGAGTCCTACGTCAACCTGATCCCGACCC
CGGCCGGCGGCACGCACGAGTCCGGCCTGCGCGAAGGCCTGTTCCAGGCAGTCAAAAGCTTTATCGAGATGCACGCGCTG
CAGCCCAAGGGCGTCAAGCTGATGAGTGAGGACGTGTTCGCGCGCGCCTCGTTCGTGCTGTCGGCCAAGGTGCTGGACCC
GCAATTCCAGGGCCAGATCAAGGAGCGCCTGAACAGCCGCGACGCGGTGCGACTGGTGTCGACGTTCAGTCGTCCGGCGC
TGGAACTGTGGCTGAACCATCACGTTGAGTACGGCAAGAAGCTGGCCGAACTCGTGATCCGCCAGGCGCAGGCACGCACG
CGCGCCGCGCAGAAGGTCGAGAAGAAGAAGGGCTCCGGCGTCGCCGTGCTGCCGGGCAAGCTGACCGACTGCGAATCGAC
CGACGTCACGCGCAACGAACTGTTCCTGGTCGAGGGCGACTCGGCCGGCGGCTCGGCCAAGATGGGCCGCGACAAGGAAT
TCCAGGCCATCCTGCCGCTGCGCGGCAAGGTGCTCAACACCTGGGAGACCGAGCGCGACCGCCTGTTCGCCAACAACGAG
GTGCACGACATCGCCGTGGCGATCGGCGTGGACCCGCACGGCGCGAACGATGAGCCCGACCTGTCCAACCTGCGCTACGG
CAAGATCTGCATCCTGTCGGACGCGGACGTGGATGGCGCGCACATCCAGGTGCTGCTGCTGACGCTGTTCTTCCGCCACT
TCCCGAAGCTGATCGAGGCTGGCAATGTCTGCGTGGCGCGCCCGCCGCTGTTCCGCGTCGACGCACCTGCGCGCGGCAAG
AAGCCCGCGCAGAAGCTGTATGCGCTCGACGAAGGTGAGCTCGAAGCCATCCAGGACAAGCTGATCAAGGACGGCGTCAA
GGAAGGCAGCTGGCAGATTTCCCGTTTCAAGGGCCTTGGCGAAATGAGCGCCGAACAGCTCTGGGAAACCACCATGAACC
CGGATACGCGCCGCCTGCTGCCCGTGGCGCTCGGCGAATACGACCTGCCGCAGACCGTCGAGATGATGAACATGCTCATG
GGCAAGGGCGAAGCCGCCCAGCGCCGCAGCTGGCTCGAGGAGAAGGGCAACGAAGTCGAGGCGGACATCTGA

Upstream 100 bases:

>100_bases
TTGCCGGTCCGGGCTTCCATTACAATGCAGTGCCCGGCACCCCGGCGCAGCCACGAATGCGCGCCGCAGTGGCCGGGATC
TCCACTTTCGTAGCGACTCC

Downstream 100 bases:

>100_bases
GCGCCAGTCTGTACGCCGTCCGACATTGGGGGATAATGCGCGCTTCGACGTCCTCGCCCGCAAGCCGCAACGCAAGATGA
GAACGAGACCGACCCGCAAA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNASDEALGGFGSEILVTLHRDGSVSVEDDGRGIPVG
IHPEEGVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALSTQLDVSVWRDGMMSTLTFSGGDVTAPLTSRK
LERGEKKNGTRVQVWPDAKYFDSAAIPQAELQRLLRSKAVLLPGVKVTLVIEKSGETQTWQYDQGLKGYLVEALAQGSGA
ELVIPMFEGEHFADPDANPGEEGFADGEGASWVVAWTEEGAPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFIEMHAL
QPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNHHVEYGKKLAELVIRQAQART
RAAQKVEKKKGSGVAVLPGKLTDCESTDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNE
VHDIAVAIGVDPHGANDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRHFPKLIEAGNVCVARPPLFRVDAPARGK
KPAQKLYALDEGELEAIQDKLIKDGVKEGSWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVALGEYDLPQTVEMMNMLM
GKGEAAQRRSWLEEKGNEVEADI

Sequences:

>Translated_663_residues
MASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNASDEALGGFGSEILVTLHRDGSVSVEDDGRGIPVG
IHPEEGVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALSTQLDVSVWRDGMMSTLTFSGGDVTAPLTSRK
LERGEKKNGTRVQVWPDAKYFDSAAIPQAELQRLLRSKAVLLPGVKVTLVIEKSGETQTWQYDQGLKGYLVEALAQGSGA
ELVIPMFEGEHFADPDANPGEEGFADGEGASWVVAWTEEGAPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFIEMHAL
QPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNHHVEYGKKLAELVIRQAQART
RAAQKVEKKKGSGVAVLPGKLTDCESTDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNE
VHDIAVAIGVDPHGANDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRHFPKLIEAGNVCVARPPLFRVDAPARGK
KPAQKLYALDEGELEAIQDKLIKDGVKEGSWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVALGEYDLPQTVEMMNMLM
GKGEAAQRRSWLEEKGNEVEADI
>Mature_662_residues
ASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNASDEALGGFGSEILVTLHRDGSVSVEDDGRGIPVGI
HPEEGVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALSTQLDVSVWRDGMMSTLTFSGGDVTAPLTSRKL
ERGEKKNGTRVQVWPDAKYFDSAAIPQAELQRLLRSKAVLLPGVKVTLVIEKSGETQTWQYDQGLKGYLVEALAQGSGAE
LVIPMFEGEHFADPDANPGEEGFADGEGASWVVAWTEEGAPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFIEMHALQ
PKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNHHVEYGKKLAELVIRQAQARTR
AAQKVEKKKGSGVAVLPGKLTDCESTDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEV
HDIAVAIGVDPHGANDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRHFPKLIEAGNVCVARPPLFRVDAPARGKK
PAQKLYALDEGELEAIQDKLIKDGVKEGSWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVALGEYDLPQTVEMMNMLMG
KGEAAQRRSWLEEKGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=659, Percent_Identity=23.5204855842185, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI19913406, Length=663, Percent_Identity=22.9260935143288, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1789408, Length=661, Percent_Identity=49.0166414523449, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI48994957, Length=591, Percent_Identity=38.409475465313, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI212645845, Length=635, Percent_Identity=24.0944881889764, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17535065, Length=643, Percent_Identity=22.3950233281493, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=212, Percent_Identity=29.7169811320755, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=665, Percent_Identity=23.609022556391, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17136538, Length=658, Percent_Identity=24.3161094224924, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72442; Mature: 72311

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNASDEALGGFGSEILV
CCCCCCCCCHHHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHCCCCCHHHCCCCCEEEE
TLHRDGSVSVEDDGRGIPVGIHPEEGVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGV
EEECCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCC
GVSVTNALSTQLDVSVWRDGMMSTLTFSGGDVTAPLTSRKLERGEKKNGTRVQVWPDAKY
CHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEECCHHHHHHHCCCCCCCCEEEECCCCHH
FDSAAIPQAELQRLLRSKAVLLPGVKVTLVIEKSGETQTWQYDQGLKGYLVEALAQGSGA
CCCCCCCHHHHHHHHHHCCEECCCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHCCCCC
ELVIPMFEGEHFADPDANPGEEGFADGEGASWVVAWTEEGAPVRESYVNLIPTPAGGTHE
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHEECCCCCCCCH
SGLREGLFQAVKSFIEMHALQPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEHHCCHHHHHHHHHHCCCH
DAVRLVSTFSRPALELWLNHHVEYGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
LTDCESTDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNE
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCC
VHDIAVAIGVDPHGANDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRHFPKLIEA
EEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHC
GNVCVARPPLFRVDAPARGKKPAQKLYALDEGELEAIQDKLIKDGVKEGSWQISRFKGLG
CCEEEECCCCEEECCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCC
EMSAEQLWETTMNPDTRRLLPVALGEYDLPQTVEMMNMLMGKGEAAQRRSWLEEKGNEVE
HHHHHHHHHHCCCCCHHEEEHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEC
ADI
CCC
>Mature Secondary Structure 
ASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNASDEALGGFGSEILV
CCCCCCCCHHHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHCCCCCHHHCCCCCEEEE
TLHRDGSVSVEDDGRGIPVGIHPEEGVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGV
EEECCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCC
GVSVTNALSTQLDVSVWRDGMMSTLTFSGGDVTAPLTSRKLERGEKKNGTRVQVWPDAKY
CHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEECCHHHHHHHCCCCCCCCEEEECCCCHH
FDSAAIPQAELQRLLRSKAVLLPGVKVTLVIEKSGETQTWQYDQGLKGYLVEALAQGSGA
CCCCCCCHHHHHHHHHHCCEECCCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHCCCCC
ELVIPMFEGEHFADPDANPGEEGFADGEGASWVVAWTEEGAPVRESYVNLIPTPAGGTHE
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHEECCCCCCCCH
SGLREGLFQAVKSFIEMHALQPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEHHCCHHHHHHHHHHCCCH
DAVRLVSTFSRPALELWLNHHVEYGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
LTDCESTDVTRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNE
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCC
VHDIAVAIGVDPHGANDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRHFPKLIEA
EEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHC
GNVCVARPPLFRVDAPARGKKPAQKLYALDEGELEAIQDKLIKDGVKEGSWQISRFKGLG
CCEEEECCCCEEECCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCC
EMSAEQLWETTMNPDTRRLLPVALGEYDLPQTVEMMNMLMGKGEAAQRRSWLEEKGNEVE
HHHHHHHHHHCCCCCHHEEEHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEC
ADI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]