Click here to switch to the map view.

The map label for this gene is mcl1 [H]

Identifier: 73542014

GI number: 73542014

Start: 2567057

End: 2568037

Strand: Direct

Name: mcl1 [H]

Synonym: Reut_A2328

Alternate gene names: 73542014

Gene position: 2567057-2568037 (Clockwise)

Preceding gene: 73542013

Following gene: 73542015

Centisome position: 67.44

GC content: 65.34

Gene sequence:

>981_bases
GTGCATCCCTCCGAGGTCTTGTTCCAGGGCGAAGCCATCCCCATCCAGTTGCCGGTGTGTGACCACTACGCGGGCAGCGA
AAAGCTGATGCTCAAGTCGCTGGCCCTGCAGCAAGAGCTTGGCCCCGTTTTCGACATCACGTTCGATTGCGAGGACGGTG
CCGCCGTCGGCCTGGAACGCGAACACGCCGAACTGTGCGCAAGCCTGATCAACGGTCCGCTCAACGCCCACAACCGTGTG
GGCGTACGCATCCATGACCCGGCCCATTCGTGCTGGAAGCAGGATGTCGACGTGCTGGTGCGCGCGGCAGGTACCCGGCT
GGCCTACGTGGTCGTGCCCAAGGTGACCGACGTCGTCGAAGTGGCGCGCGTGACCGACCACGTCAACCAGGCAGCCCGCG
CGGCAGGCATTGCCCGTCACATCCCAATCCATGTGCTGATCGAGACGCACGCGGCGCTAGAGCAGGCATTCGACATCGCT
TCGCTGGTGCAGGTGGAATGCCTGAGCTTTGGGCTGATGGACTTCGTGTCGGCCCACCATGGCGCCATTCCCGGCGAGGC
CATGCGCTCGCCGCAGCAGTTCGAACATCCCCTGGTCCGCCGCGCGATGCTGGAGATCTCCGCAGCGTGCCACCGCCACG
GCAAGGTGCCTTCGCATAACGTCAGCACCGACGTCCAGGTGCCCCAGCGCGCGGGCGATGATGCGCACCGCGCGCGCAGC
GAGTTCGGATACCTGCGCAAGTGGAGCATCCACCCGGGACAGATCGAGCCGATCGTCGCCGCGTTCCGACCCGGCATCGA
GGAAATCGGCGCGGCCAGCCAGATTCTGCTGGCCGCCCATGAAAACAATTGGGCCCCGATCCGGCACGACGGCCAACTGC
ATGACCGTGCCAGCTACCGTTACTACTGGTCGCTGCTGCAACGCGCTCACGCCACCGGCACGCCGCTGCCGAAGAACGTG
GCCGAGTTGTTCTTCGACTAG

Upstream 100 bases:

>100_bases
CAACGATTCACGAATCGGCGCGGGCTCCGGTTTTTTTGTATTGGGCCCCTACCCTCGACTGTTTCGGCCCATCCCACAAC
CTTTCCCCACTGAAATCCAA

Downstream 100 bases:

>100_bases
TCCGCGGCCCGCCCTGCACGCGCACAACAAGCATCCGGCATAGACCGATTCCAAAGGAGAACAGGATGTCCGCAGCCAAT
CACACCACCCCGGCAGACGC

Product: putative citrate lyase beta subunit

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MHPSEVLFQGEAIPIQLPVCDHYAGSEKLMLKSLALQQELGPVFDITFDCEDGAAVGLEREHAELCASLINGPLNAHNRV
GVRIHDPAHSCWKQDVDVLVRAAGTRLAYVVVPKVTDVVEVARVTDHVNQAARAAGIARHIPIHVLIETHAALEQAFDIA
SLVQVECLSFGLMDFVSAHHGAIPGEAMRSPQQFEHPLVRRAMLEISAACHRHGKVPSHNVSTDVQVPQRAGDDAHRARS
EFGYLRKWSIHPGQIEPIVAAFRPGIEEIGAASQILLAAHENNWAPIRHDGQLHDRASYRYYWSLLQRAHATGTPLPKNV
AELFFD

Sequences:

>Translated_326_residues
MHPSEVLFQGEAIPIQLPVCDHYAGSEKLMLKSLALQQELGPVFDITFDCEDGAAVGLEREHAELCASLINGPLNAHNRV
GVRIHDPAHSCWKQDVDVLVRAAGTRLAYVVVPKVTDVVEVARVTDHVNQAARAAGIARHIPIHVLIETHAALEQAFDIA
SLVQVECLSFGLMDFVSAHHGAIPGEAMRSPQQFEHPLVRRAMLEISAACHRHGKVPSHNVSTDVQVPQRAGDDAHRARS
EFGYLRKWSIHPGQIEPIVAAFRPGIEEIGAASQILLAAHENNWAPIRHDGQLHDRASYRYYWSLLQRAHATGTPLPKNV
AELFFD
>Mature_326_residues
MHPSEVLFQGEAIPIQLPVCDHYAGSEKLMLKSLALQQELGPVFDITFDCEDGAAVGLEREHAELCASLINGPLNAHNRV
GVRIHDPAHSCWKQDVDVLVRAAGTRLAYVVVPKVTDVVEVARVTDHVNQAARAAGIARHIPIHVLIETHAALEQAFDIA
SLVQVECLSFGLMDFVSAHHGAIPGEAMRSPQQFEHPLVRRAMLEISAACHRHGKVPSHNVSTDVQVPQRAGDDAHRARS
EFGYLRKWSIHPGQIEPIVAAFRPGIEEIGAASQILLAAHENNWAPIRHDGQLHDRASYRYYWSLLQRAHATGTPLPKNV
AELFFD

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 35915; Mature: 35915

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPSEVLFQGEAIPIQLPVCDHYAGSEKLMLKSLALQQELGPVFDITFDCEDGAAVGLER
CCCHHEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCH
EHAELCASLINGPLNAHNRVGVRIHDPAHSCWKQDVDVLVRAAGTRLAYVVVPKVTDVVE
HHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
VARVTDHVNQAARAAGIARHIPIHVLIETHAALEQAFDIASLVQVECLSFGLMDFVSAHH
HHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAIPGEAMRSPQQFEHPLVRRAMLEISAACHRHGKVPSHNVSTDVQVPQRAGDDAHRARS
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHHH
EFGYLRKWSIHPGQIEPIVAAFRPGIEEIGAASQILLAAHENNWAPIRHDGQLHDRASYR
HHCCCEEECCCCCCCCHHHHHHCCCHHHHCCHHEEEEEEECCCCCCCCCCCCCCCCHHHH
YYWSLLQRAHATGTPLPKNVAELFFD
HHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MHPSEVLFQGEAIPIQLPVCDHYAGSEKLMLKSLALQQELGPVFDITFDCEDGAAVGLER
CCCHHEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCH
EHAELCASLINGPLNAHNRVGVRIHDPAHSCWKQDVDVLVRAAGTRLAYVVVPKVTDVVE
HHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
VARVTDHVNQAARAAGIARHIPIHVLIETHAALEQAFDIASLVQVECLSFGLMDFVSAHH
HHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAIPGEAMRSPQQFEHPLVRRAMLEISAACHRHGKVPSHNVSTDVQVPQRAGDDAHRARS
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHHH
EFGYLRKWSIHPGQIEPIVAAFRPGIEEIGAASQILLAAHENNWAPIRHDGQLHDRASYR
HHCCCEEECCCCCCCCHHHHHHCCCHHHHCCHHEEEEEEECCCCCCCCCCCCCCCCHHHH
YYWSLLQRAHATGTPLPKNVAELFFD
HHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA