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The map label for this gene is livM [H]

Identifier: 73542003

GI number: 73542003

Start: 2555439

End: 2556716

Strand: Reverse

Name: livM [H]

Synonym: Reut_A2317

Alternate gene names: 73542003

Gene position: 2556716-2555439 (Counterclockwise)

Preceding gene: 73542004

Following gene: 73542002

Centisome position: 67.17

GC content: 65.96

Gene sequence:

>1278_bases
ATGACAAACCGGACTTCTGCAATGCCCGCAAACCGGGCTTCTGCCCTGCCCGCAGGGCAATCCCTGAAGAATGCCGTGGT
GGCCGCGGTGATGACGGCCATCCTGACCATTCCCGTGCTCGGCCTGCAACTCAAGCTGGACGGCTACAAGGTCGTGCTGG
AGTCGCACTGGCGGCCGGTGTGGATCGCCGTGGCGGCGGTCTTCCTGTTCCAGCTGTTCAAGCCGCTGCTGTCGCGTGCC
GGCAGCGCCGTGCGCATGCCGGCCATGCCGCAACTCGGCGTCGGCCAGCAGCGCGCGGCGGTGTGGGTGCTGCTGGCCGT
GGGCCTCGTGTGGCCTTTCTTCGGCTCGCGCGGTGCGGTGGATGTGGCGACGCTTGCGTTGATCTACGTGATTCTCGGGC
TTGGCCTGAATATCGTGGTCGGCTTCGCCGGACTGCTGGACCTTGGCTACGTGGGCTTCTACGCCGTGGGTGGCTATACC
TACGCCATGCTGAACCAGTACTTCGGCCTCGGCTTCTGGGAATGCCTGCCGATTGCTGCAGCGATGTCTGCCACCTTCGG
CTTCCTGCTCGGCTTCCCTGTGCTGCGCCTGCGCGGTGACTACCTGGCCATCGTGACGCTGGGCTTCGGCGAGATCATCC
GCCTGCTCGCGCGCAACCTGACCGAGTACACCGGCGGCCCGGACGGAATCTCGGGCATTCCGAAGCCCACTGTATTCGGC
TTCGAGATGGCGCGCAGCGCCACCGTCGAAGGCGCACGCACTTTCCATGAGCTGATCGGGCTGGACTACAAGGGCGAGCA
CATGGTGATCTTCCTGTACCTGCTCGCGCTGCTGCTGGTGGGCTTCACGCTGTTCGTAACCAGCCGCCTGATCCGCATGC
CGATGGGCCGTGCGTGGGAAGCGCTGCGCGAGGACGAGATCGCGTGCCGATCGCTGGGCATGAACCCGACCCGCATCAAG
CTGTCGGCGTTCACGCTGGGGGCGGCGTTCGCGGGCATCGGCGGCGCGTTCTTCGCGGCCCGCCAGGGACTGGTCAATCC
GGAATCGTTCACCTTCATCGAATCGGCGCTGGTGCTGGCCGTGGTGGTGCTGGGCGGCATGGGTTCGCAGCTGGGCGTGA
TCCTCGCCGCGATCCTGCTGACCGTGCTGCCCGAAGTGGCGCGCGGTTTCGCCGAATACCGCATGCTGATTTTCGGCCTG
GTGATGGTGCTGATGATGATGTGGCGTCCGCAGGGCCTGCTGCCCGCGAGCCGTCCGCACGTGGAGCTTCCCCGATGA

Upstream 100 bases:

>100_bases
GGACGTGGTGGCCTTCAGCCTGCTGGTGCTGGTGCTGCTGTTCCGCCCGACCGGCCTGCTCGGCAAGCCAGACGTGGAAA
AGGTCTGAGGGAGACGCGAC

Downstream 100 bases:

>100_bases
GTACGGCGATGAATGCAAATGCGGAATTGCTGAAAGTTTCCGGCCTGCAGATGCGCTTCGGCGGCCTGCTGGCGGTGGAT
GGCATCGAGTTCGATGTCAT

Product: leucine/isoleucine/valine transporter permease subunit

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTNRTSAMPANRASALPAGQSLKNAVVAAVMTAILTIPVLGLQLKLDGYKVVLESHWRPVWIAVAAVFLFQLFKPLLSRA
GSAVRMPAMPQLGVGQQRAAVWVLLAVGLVWPFFGSRGAVDVATLALIYVILGLGLNIVVGFAGLLDLGYVGFYAVGGYT
YAMLNQYFGLGFWECLPIAAAMSATFGFLLGFPVLRLRGDYLAIVTLGFGEIIRLLARNLTEYTGGPDGISGIPKPTVFG
FEMARSATVEGARTFHELIGLDYKGEHMVIFLYLLALLLVGFTLFVTSRLIRMPMGRAWEALREDEIACRSLGMNPTRIK
LSAFTLGAAFAGIGGAFFAARQGLVNPESFTFIESALVLAVVVLGGMGSQLGVILAAILLTVLPEVARGFAEYRMLIFGL
VMVLMMMWRPQGLLPASRPHVELPR

Sequences:

>Translated_425_residues
MTNRTSAMPANRASALPAGQSLKNAVVAAVMTAILTIPVLGLQLKLDGYKVVLESHWRPVWIAVAAVFLFQLFKPLLSRA
GSAVRMPAMPQLGVGQQRAAVWVLLAVGLVWPFFGSRGAVDVATLALIYVILGLGLNIVVGFAGLLDLGYVGFYAVGGYT
YAMLNQYFGLGFWECLPIAAAMSATFGFLLGFPVLRLRGDYLAIVTLGFGEIIRLLARNLTEYTGGPDGISGIPKPTVFG
FEMARSATVEGARTFHELIGLDYKGEHMVIFLYLLALLLVGFTLFVTSRLIRMPMGRAWEALREDEIACRSLGMNPTRIK
LSAFTLGAAFAGIGGAFFAARQGLVNPESFTFIESALVLAVVVLGGMGSQLGVILAAILLTVLPEVARGFAEYRMLIFGL
VMVLMMMWRPQGLLPASRPHVELPR
>Mature_424_residues
TNRTSAMPANRASALPAGQSLKNAVVAAVMTAILTIPVLGLQLKLDGYKVVLESHWRPVWIAVAAVFLFQLFKPLLSRAG
SAVRMPAMPQLGVGQQRAAVWVLLAVGLVWPFFGSRGAVDVATLALIYVILGLGLNIVVGFAGLLDLGYVGFYAVGGYTY
AMLNQYFGLGFWECLPIAAAMSATFGFLLGFPVLRLRGDYLAIVTLGFGEIIRLLARNLTEYTGGPDGISGIPKPTVFGF
EMARSATVEGARTFHELIGLDYKGEHMVIFLYLLALLLVGFTLFVTSRLIRMPMGRAWEALREDEIACRSLGMNPTRIKL
SAFTLGAAFAGIGGAFFAARQGLVNPESFTFIESALVLAVVVLGGMGSQLGVILAAILLTVLPEVARGFAEYRMLIFGLV
MVLMMMWRPQGLLPASRPHVELPR

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=410, Percent_Identity=60.7317073170732, Blast_Score=442, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 45795; Mature: 45664

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRTSAMPANRASALPAGQSLKNAVVAAVMTAILTIPVLGLQLKLDGYKVVLESHWRPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEEHHCCCCHH
WIAVAAVFLFQLFKPLLSRAGSAVRMPAMPQLGVGQQRAAVWVLLAVGLVWPFFGSRGAV
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
DVATLALIYVILGLGLNIVVGFAGLLDLGYVGFYAVGGYTYAMLNQYFGLGFWECLPIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AMSATFGFLLGFPVLRLRGDYLAIVTLGFGEIIRLLARNLTEYTGGPDGISGIPKPTVFG
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
FEMARSATVEGARTFHELIGLDYKGEHMVIFLYLLALLLVGFTLFVTSRLIRMPMGRAWE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALREDEIACRSLGMNPTRIKLSAFTLGAAFAGIGGAFFAARQGLVNPESFTFIESALVLA
HHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VVVLGGMGSQLGVILAAILLTVLPEVARGFAEYRMLIFGLVMVLMMMWRPQGLLPASRPH
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VELPR
CCCCC
>Mature Secondary Structure 
TNRTSAMPANRASALPAGQSLKNAVVAAVMTAILTIPVLGLQLKLDGYKVVLESHWRPV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEEHHCCCCHH
WIAVAAVFLFQLFKPLLSRAGSAVRMPAMPQLGVGQQRAAVWVLLAVGLVWPFFGSRGAV
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
DVATLALIYVILGLGLNIVVGFAGLLDLGYVGFYAVGGYTYAMLNQYFGLGFWECLPIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AMSATFGFLLGFPVLRLRGDYLAIVTLGFGEIIRLLARNLTEYTGGPDGISGIPKPTVFG
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
FEMARSATVEGARTFHELIGLDYKGEHMVIFLYLLALLLVGFTLFVTSRLIRMPMGRAWE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALREDEIACRSLGMNPTRIKLSAFTLGAAFAGIGGAFFAARQGLVNPESFTFIESALVLA
HHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VVVLGGMGSQLGVILAAILLTVLPEVARGFAEYRMLIFGLVMVLMMMWRPQGLLPASRPH
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VELPR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]