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The map label for this gene is fabH

Identifier: 73541952

GI number: 73541952

Start: 2497306

End: 2498286

Strand: Reverse

Name: fabH

Synonym: Reut_A2265

Alternate gene names: 73541952

Gene position: 2498286-2497306 (Counterclockwise)

Preceding gene: 73541953

Following gene: 73541951

Centisome position: 65.63

GC content: 65.24

Gene sequence:

>981_bases
ATGACCAAGTACGCAAAAATCATCGGTACCGGGAGCTACCTGCCCCCGCGGCGTGTGACCAACCAGGATCTGGCGGCGCA
ACTGGCCGAGAAGGGCATCGAGACCAGCGACGAGTGGATCTTCTCGCGCAGCGGCATCTCGGCACGCCACTGGGCCGACC
CGGACGTGGCCAGCAGCGACCTGGCCGTCAAGGCGGCCGAGCAGGCGATCGAAGCGGCTGGCATCGACCGCCAGAGCATC
GACCTGATCCTGGTCGCGACGTCGACGCCAGACTTCGTGTTCCCGAGCACCGCGTGCATCATCCAGAACAAGCTGGGCAT
CAATAACCAGTGCGCCGCCTTCGACCTGCAAGCGGTGTGCTCGGGCTTCGTGTATGCGCTGGCCACGGCCGACAAGTTCA
TCCGCAGTGGTTCGCACCGCAATGTGCTGGTGATTGGCACCGAAGTGTTCTCGCGGATCCTGGACTTCAACGACCGTACG
ACTTGTGTGCTGTTTGGCGACGGCGCCGGTGCAGTCGTGCTGTCGGCATCCGACGAGCCCGGCATCCTGTCGACGGCCAT
GCATTCCGATGGCAGCCATGTGGGCATCCTGTGCGTGCCGGGCAACGTCCACGGCGGCGCGATCGCAGGCAATGCTTTCC
TGCACATGGACGGCCAGGCAGTGTTCAAGCTTGCCGTGACCGTGCTAGACAAGGTCGCGCGCGAAACCATGGCGGCGGCC
GAGATCCAGCCCGAGCAGATCGACTGGCTCATTCCCCATCAGGCCAATATCCGCATCATGCAGGGCACCGCGCGCAAGCT
CGGCCTGCCCGCCGAGCGCATGATTGCGGTCGTCCACGAACACGGCAATACCTCGGCCGCGTCAATTCCGCTGGCACTGG
ATGCCGCGGTGCGCGACGGCCGCATCCGTCCCGGCCAGACCGTGCTGATGGAAGGCGTGGGCGGGGGCTTCACCTGGGGC
GCTGCGCTGCTGCGCATGTAA

Upstream 100 bases:

>100_bases
GCCCGGAGACAGCCCCGACCCCGCACCCCAGCACCCGCGCCGCCTGATGCATCGGGCCGGCGCCTGAGGCTGCCATACGG
ACAAATCGATCCGACACTAC

Downstream 100 bases:

>100_bases
CGACAGCCGGCGCGGCGGGCGAGACCGGACGCGCGGCTACCGGTATTCAAATCTAGGATTGCACTCCGATGAAATTTGCA
TTCGTATTTCCTGGCCAGGG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTKYAKIIGTGSYLPPRRVTNQDLAAQLAEKGIETSDEWIFSRSGISARHWADPDVASSDLAVKAAEQAIEAAGIDRQSI
DLILVATSTPDFVFPSTACIIQNKLGINNQCAAFDLQAVCSGFVYALATADKFIRSGSHRNVLVIGTEVFSRILDFNDRT
TCVLFGDGAGAVVLSASDEPGILSTAMHSDGSHVGILCVPGNVHGGAIAGNAFLHMDGQAVFKLAVTVLDKVARETMAAA
EIQPEQIDWLIPHQANIRIMQGTARKLGLPAERMIAVVHEHGNTSAASIPLALDAAVRDGRIRPGQTVLMEGVGGGFTWG
AALLRM

Sequences:

>Translated_326_residues
MTKYAKIIGTGSYLPPRRVTNQDLAAQLAEKGIETSDEWIFSRSGISARHWADPDVASSDLAVKAAEQAIEAAGIDRQSI
DLILVATSTPDFVFPSTACIIQNKLGINNQCAAFDLQAVCSGFVYALATADKFIRSGSHRNVLVIGTEVFSRILDFNDRT
TCVLFGDGAGAVVLSASDEPGILSTAMHSDGSHVGILCVPGNVHGGAIAGNAFLHMDGQAVFKLAVTVLDKVARETMAAA
EIQPEQIDWLIPHQANIRIMQGTARKLGLPAERMIAVVHEHGNTSAASIPLALDAAVRDGRIRPGQTVLMEGVGGGFTWG
AALLRM
>Mature_325_residues
TKYAKIIGTGSYLPPRRVTNQDLAAQLAEKGIETSDEWIFSRSGISARHWADPDVASSDLAVKAAEQAIEAAGIDRQSID
LILVATSTPDFVFPSTACIIQNKLGINNQCAAFDLQAVCSGFVYALATADKFIRSGSHRNVLVIGTEVFSRILDFNDRTT
CVLFGDGAGAVVLSASDEPGILSTAMHSDGSHVGILCVPGNVHGGAIAGNAFLHMDGQAVFKLAVTVLDKVARETMAAAE
IQPEQIDWLIPHQANIRIMQGTARKLGLPAERMIAVVHEHGNTSAASIPLALDAAVRDGRIRPGQTVLMEGVGGGFTWGA
ALLRM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=52.0123839009288, Blast_Score=335, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CUPPJ (Q46Z05)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296472.1
- ProteinModelPortal:   Q46Z05
- SMR:   Q46Z05
- GeneID:   3610608
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2265
- NMPDR:   fig|264198.3.peg.2868
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- ProtClustDB:   PRK09352
- BioCyc:   REUT264198:REUT_A2265-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34501; Mature: 34370

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: ACT_SITE 120-120 ACT_SITE 253-253 ACT_SITE 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYAKIIGTGSYLPPRRVTNQDLAAQLAEKGIETSDEWIFSRSGISARHWADPDVASSD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
LAVKAAEQAIEAAGIDRQSIDLILVATSTPDFVFPSTACIIQNKLGINNQCAAFDLQAVC
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEECCCEEEEEECCCCCCCCCHHEEHHHHH
SGFVYALATADKFIRSGSHRNVLVIGTEVFSRILDFNDRTTCVLFGDGAGAVVLSASDEP
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCC
GILSTAMHSDGSHVGILCVPGNVHGGAIAGNAFLHMDGQAVFKLAVTVLDKVARETMAAA
CEEEEEECCCCCEEEEEEECCCCCCCEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EIQPEQIDWLIPHQANIRIMQGTARKLGLPAERMIAVVHEHGNTSAASIPLALDAAVRDG
CCCCCCEEEECCCCCCEEEEECCHHHHCCCHHHHEEEEECCCCCCCEECCEEEEHHHCCC
RIRPGQTVLMEGVGGGFTWGAALLRM
CCCCCCEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TKYAKIIGTGSYLPPRRVTNQDLAAQLAEKGIETSDEWIFSRSGISARHWADPDVASSD
CCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
LAVKAAEQAIEAAGIDRQSIDLILVATSTPDFVFPSTACIIQNKLGINNQCAAFDLQAVC
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEECCCEEEEEECCCCCCCCCHHEEHHHHH
SGFVYALATADKFIRSGSHRNVLVIGTEVFSRILDFNDRTTCVLFGDGAGAVVLSASDEP
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCC
GILSTAMHSDGSHVGILCVPGNVHGGAIAGNAFLHMDGQAVFKLAVTVLDKVARETMAAA
CEEEEEECCCCCEEEEEEECCCCCCCEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EIQPEQIDWLIPHQANIRIMQGTARKLGLPAERMIAVVHEHGNTSAASIPLALDAAVRDG
CCCCCCEEEECCCCCCEEEEECCHHHHCCCHHHHEEEEECCCCCCCEECCEEEEHHHCCC
RIRPGQTVLMEGVGGGFTWGAALLRM
CCCCCCEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA