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The map label for this gene is acsA [H]

Identifier: 73541916

GI number: 73541916

Start: 2459563

End: 2461545

Strand: Reverse

Name: acsA [H]

Synonym: Reut_A2229

Alternate gene names: 73541916

Gene position: 2461545-2459563 (Counterclockwise)

Preceding gene: 73541921

Following gene: 73541915

Centisome position: 64.67

GC content: 64.55

Gene sequence:

>1983_bases
ATGTCCGCCATCGAATCGGTGATGCAAGAGCATCGCGTTTTCAACCCGCCCGAGTCCTTCGTCCGGCAAGCCGCGATTCC
AGGCATGGACGCCTACCGCGCGCTGTGCGCCGAGGCGGAGCGCGACTACGAGGGCTTCTGGGCCAGCCGTGCGCGCGACC
TGCTGCACTGGAACAAGCCCTTCACCAAGGTGCTGGATGAAAGCAATGCACCGTTCTACAAGTGGTTCGAGGATGGCGAA
CTGAACGCTTCGTACAACTGCCTGGACCGCAACCTGCAGAACGGCAATGCCGACAAGACCGCGATCGTGTTCGAGGCCGA
CGACGGCACCGCGACGCGCGTGTCGTATCGCGACCTGCACGCCAAGGTCTGCCGCTTCGCCAATGGCCTGAAGGCGCTTG
GCATCAAGAAGGGCGATCGCGTGGTGATCTACATGCCGATGTCGGTCGAAGGCGTGGTGGCCATGCAGGCGTGCGCGCGT
CTAGGTGCCACGCATTCTGTGGTGTTCGGCGGGTTCTCGGCCAAGTCGCTGCAGGAGCGGCTGGTGGACGTCGGCGCCGT
GGCGCTGATCACCGCGGACGAGCAGATGCGCGGCGGCAAGGCGCTACCGCTCAAGGCGATTGCCGACGATGCGCTGGCGC
TCGGCGGCTGCGAGGCGGTCAAAAACGTGATCGTCTATCGCCGCACCGGCGGCAAGGTCAACTGGGTCGAAGGCCGTGAC
CGCTGGATGGAAGACGTATCCGCCGGCCAGCCCGACACCTGCGAGGCCGTGCCCGTGAGCGCCGAGCATCCGCTGTTCGT
GCTCTACACCTCGGGCTCCACCGGCAAGCCCAAGGGCGTGCAGCACAGCACCGGCGGCTACCTGCTGTGGGCGCTGATGA
CGATGCAGTGGACCTTCGACATCAAGCCCGACGACCTGTTCTGGTGTACTGCCGACATCGGCTGGGTCACCGGTCACACC
TATATCGCGTACGGCCCGCTGGCCGCCGGTGCCACGCAGATCATCTTCGAAGGCGTGCCGACCTATCCGAACGCAGGCCG
CTTCTGGGACATGATCGCGCGCCATAAGGTCAGCATCTTCTACACCGCGCCGACCGCGATTCGCTCGCTGATCAAGGCCG
CCGAGGCAGACGAGAAGATCCATCCGAAGCAGTACGACCTTTCCAGCCTGCGCCTGCTCGGCACCGTGGGCGAGCCGATC
AACCCCGAAGCCTGGATGTGGTACTACAAGAACATCGGCAATGAGCGCTGCCCGATCGTCGATACGTTCTGGCAGACCGA
GACCGGTGGCCACATGATTACGCCGCTGCCGGGCGCCACGCCGCTGGTGCCGGGCTCGTGCACGCTGCCGCTGCCGGGTA
TCATGGCGGCGATCGTCGACGAGACTGGACATGACGTACCTAACGGGAGCGGCGGCATCCTGGTGGTCAAGCGCCCGTGG
CCGGCGATGATCCGCACGATCTGGGGCGATCCGGAACGCTTCAAGAAGAGCTACTTCCCGGAAGAACTCGGCGGCAAGCT
GTACCTGGCCGGCGATGGCTCGATCCGCGACAAGGAGACCGGCTACTTCACCATCATGGGCCGTATCGATGATGTGCTGA
ACGTGTCGGGCCACCGCATGGGCACGATGGAAATCGAATCGGCGCTGGTCGCGAACCCGATCGTGGCTGAAGCCGCCGTG
GTCGGTCGCCCGGACGACACTACGGGCGAGGCCATCTGCGCATTCGTGGTGCTCAAGCGTGCGCGTCCGAGCGATGCCGA
GGCGCAGCAGATCGCCACCGAACTGCGCAACTGGGTCGCGAAGGAAATCGGTCCGATCGCCAAGCCCAAGGACATCCGCT
TCGGCGACAACCTGCCGAAGACGCGCTCGGGCAAGATCATGCGCCGCCTGCTGCGTTCGCTGGCCAAGGGTGAGGAAATC
ACGCAGGACACCTCGACGCTGGAGAACCCTGCGATCCTTGATCAATTGAAGCAGGCGCAATAA

Upstream 100 bases:

>100_bases
CGGGCATGCTTTTGCCGCGCAAGGGAGCGTCAGGTTTAAGTAAGCCGCCGCGCGTACTTTTGCAGCCAAGCCGTTCAGTC
AAATACCAGGAGACCCGCCT

Downstream 100 bases:

>100_bases
CCGGTCCATTCGGTAACGGCTCGTCCGACAGAACCCGCCGCCGCGTGAATCGCGCCGGCGGGTTCTTTACTCTAGATTTC
CCTCACAGCCAGATCCTTGC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVMQEHRVFNPPESFVRQAAIPGMDAYRALCAEAERDYEGFWASRARDLLHWNKPFTKVLDESNAPFYKWFEDGE
LNASYNCLDRNLQNGNADKTAIVFEADDGTATRVSYRDLHAKVCRFANGLKALGIKKGDRVVIYMPMSVEGVVAMQACAR
LGATHSVVFGGFSAKSLQERLVDVGAVALITADEQMRGGKALPLKAIADDALALGGCEAVKNVIVYRRTGGKVNWVEGRD
RWMEDVSAGQPDTCEAVPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMQWTFDIKPDDLFWCTADIGWVTGHT
YIAYGPLAAGATQIIFEGVPTYPNAGRFWDMIARHKVSIFYTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPI
NPEAWMWYYKNIGNERCPIVDTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGSGGILVVKRPW
PAMIRTIWGDPERFKKSYFPEELGGKLYLAGDGSIRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPIVAEAAV
VGRPDDTTGEAICAFVVLKRARPSDAEAQQIATELRNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEI
TQDTSTLENPAILDQLKQAQ

Sequences:

>Translated_660_residues
MSAIESVMQEHRVFNPPESFVRQAAIPGMDAYRALCAEAERDYEGFWASRARDLLHWNKPFTKVLDESNAPFYKWFEDGE
LNASYNCLDRNLQNGNADKTAIVFEADDGTATRVSYRDLHAKVCRFANGLKALGIKKGDRVVIYMPMSVEGVVAMQACAR
LGATHSVVFGGFSAKSLQERLVDVGAVALITADEQMRGGKALPLKAIADDALALGGCEAVKNVIVYRRTGGKVNWVEGRD
RWMEDVSAGQPDTCEAVPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMQWTFDIKPDDLFWCTADIGWVTGHT
YIAYGPLAAGATQIIFEGVPTYPNAGRFWDMIARHKVSIFYTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPI
NPEAWMWYYKNIGNERCPIVDTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGSGGILVVKRPW
PAMIRTIWGDPERFKKSYFPEELGGKLYLAGDGSIRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPIVAEAAV
VGRPDDTTGEAICAFVVLKRARPSDAEAQQIATELRNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEI
TQDTSTLENPAILDQLKQAQ
>Mature_659_residues
SAIESVMQEHRVFNPPESFVRQAAIPGMDAYRALCAEAERDYEGFWASRARDLLHWNKPFTKVLDESNAPFYKWFEDGEL
NASYNCLDRNLQNGNADKTAIVFEADDGTATRVSYRDLHAKVCRFANGLKALGIKKGDRVVIYMPMSVEGVVAMQACARL
GATHSVVFGGFSAKSLQERLVDVGAVALITADEQMRGGKALPLKAIADDALALGGCEAVKNVIVYRRTGGKVNWVEGRDR
WMEDVSAGQPDTCEAVPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMQWTFDIKPDDLFWCTADIGWVTGHTY
IAYGPLAAGATQIIFEGVPTYPNAGRFWDMIARHKVSIFYTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPIN
PEAWMWYYKNIGNERCPIVDTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGSGGILVVKRPWP
AMIRTIWGDPERFKKSYFPEELGGKLYLAGDGSIRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPIVAEAAVV
GRPDDTTGEAICAFVVLKRARPSDAEAQQIATELRNWVAKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEIT
QDTSTLENPAILDQLKQAQ

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=679, Percent_Identity=45.360824742268, Blast_Score=581, Evalue=1e-165,
Organism=Homo sapiens, GI253970489, Length=690, Percent_Identity=44.4927536231884, Blast_Score=576, Evalue=1e-164,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=45.4113924050633, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI13375727, Length=640, Percent_Identity=37.5, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=28.1954887218045, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI38505220, Length=535, Percent_Identity=29.1588785046729, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=27.9773156899811, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI31982927, Length=644, Percent_Identity=23.7577639751553, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI115511026, Length=631, Percent_Identity=26.4659270998415, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI58082049, Length=519, Percent_Identity=27.1676300578035, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI157311624, Length=519, Percent_Identity=26.3969171483622, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI157311622, Length=519, Percent_Identity=26.3969171483622, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI187761345, Length=404, Percent_Identity=25.990099009901, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI187761343, Length=404, Percent_Identity=25.990099009901, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI195947378, Length=415, Percent_Identity=25.0602409638554, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI42544134, Length=324, Percent_Identity=24.0740740740741, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1790505, Length=636, Percent_Identity=53.1446540880503, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=627, Percent_Identity=38.9154704944179, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=571, Percent_Identity=26.0945709281961, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI145693145, Length=543, Percent_Identity=24.1252302025783, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=22.9755178907721, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786801, Length=502, Percent_Identity=24.1035856573705, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=664, Percent_Identity=43.3734939759036, Blast_Score=505, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71982997, Length=666, Percent_Identity=43.2432432432432, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569507, Length=658, Percent_Identity=23.2522796352584, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71985884, Length=603, Percent_Identity=25.0414593698176, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557194, Length=580, Percent_Identity=24.4827586206897, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17559526, Length=563, Percent_Identity=24.5115452930728, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=574, Percent_Identity=23.8675958188153, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=574, Percent_Identity=23.5191637630662, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=574, Percent_Identity=23.8675958188153, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538037, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=649, Percent_Identity=46.8412942989214, Blast_Score=564, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6323182, Length=674, Percent_Identity=45.5489614243323, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6319699, Length=556, Percent_Identity=21.9424460431655, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24667955, Length=671, Percent_Identity=46.795827123696, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=50, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24667959, Length=527, Percent_Identity=49.5256166982922, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21355225, Length=645, Percent_Identity=34.2635658914729, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI21355181, Length=554, Percent_Identity=24.5487364620939, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656500, Length=369, Percent_Identity=27.6422764227642, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24581924, Length=541, Percent_Identity=23.1053604436229, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72489; Mature: 72357

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVMQEHRVFNPPESFVRQAAIPGMDAYRALCAEAERDYEGFWASRARDLLHWNKP
CHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
FTKVLDESNAPFYKWFEDGELNASYNCLDRNLQNGNADKTAIVFEADDGTATRVSYRDLH
HHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCEEEEHHHHHH
AKVCRFANGLKALGIKKGDRVVIYMPMSVEGVVAMQACARLGATHSVVFGGFSAKSLQER
HHHHHHHCCHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
LVDVGAVALITADEQMRGGKALPLKAIADDALALGGCEAVKNVIVYRRTGGKVNWVEGRD
HHHHCEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCHHHHHCEEEEEECCCEEEEECCHH
RWMEDVSAGQPDTCEAVPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMQWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHEEEHHHHHEEEE
IKPDDLFWCTADIGWVTGHTYIAYGPLAAGATQIIFEGVPTYPNAGRFWDMIARHKVSIF
CCCCCEEEEECCCCEEECCCEEEECCHHCCCHHHHCCCCCCCCCCCHHHHHHHHCEEEEE
YTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPINPEAWMWYYKNIGNERCPIV
EECHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEECCCCCCCCCCEEHHHHHCCCCCCCEE
DTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGSGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFKKSYFPEELGGKLYLAGDGSIRDKETGYFTIMGRIDDVLNVSGHRM
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVANPIVAEAAVVGRPDDTTGEAICAFVVLKRARPSDAEAQQIATELRNWVA
EHHHHHHHHHCCCHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEITQDTSTLENPAILDQLKQAQ
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAIESVMQEHRVFNPPESFVRQAAIPGMDAYRALCAEAERDYEGFWASRARDLLHWNKP
HHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
FTKVLDESNAPFYKWFEDGELNASYNCLDRNLQNGNADKTAIVFEADDGTATRVSYRDLH
HHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCEEEEHHHHHH
AKVCRFANGLKALGIKKGDRVVIYMPMSVEGVVAMQACARLGATHSVVFGGFSAKSLQER
HHHHHHHCCHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
LVDVGAVALITADEQMRGGKALPLKAIADDALALGGCEAVKNVIVYRRTGGKVNWVEGRD
HHHHCEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCHHHHHCEEEEEECCCEEEEECCHH
RWMEDVSAGQPDTCEAVPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMQWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHEEEHHHHHEEEE
IKPDDLFWCTADIGWVTGHTYIAYGPLAAGATQIIFEGVPTYPNAGRFWDMIARHKVSIF
CCCCCEEEEECCCCEEECCCEEEECCHHCCCHHHHCCCCCCCCCCCHHHHHHHHCEEEEE
YTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPINPEAWMWYYKNIGNERCPIV
EECHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEECCCCCCCCCCEEHHHHHCCCCCCCEE
DTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGSGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFKKSYFPEELGGKLYLAGDGSIRDKETGYFTIMGRIDDVLNVSGHRM
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVANPIVAEAAVVGRPDDTTGEAICAFVVLKRARPSDAEAQQIATELRNWVA
EHHHHHHHHHCCCHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEITQDTSTLENPAILDQLKQAQ
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1356967 [H]