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The map label for this gene is hflK [H]

Identifier: 73541767

GI number: 73541767

Start: 2285439

End: 2286812

Strand: Reverse

Name: hflK [H]

Synonym: Reut_A2079

Alternate gene names: 73541767

Gene position: 2286812-2285439 (Counterclockwise)

Preceding gene: 73541768

Following gene: 73541766

Centisome position: 60.08

GC content: 64.48

Gene sequence:

>1374_bases
ATGCCCCAGTTCTCCCGGAATCCTGAATCGAGCCTGACCCCGGGCGGCCGATTTCCGCTGCGTGCGGGATGGCAGCGCCT
GCGCGCAATTTTCTCGCTGAACGATCCCCGCTGGGGACGCGATGGCCAGGACGAGGAAGACAAGGACGGCCGCGCGAACG
ACCGGGACGGGAACCGTCAGCAGAACCAGCGTCCGCAGGATGGCCCGCCTGACCTCGACGAGCTCTGGCGCGACTTCAAC
CGGCGCCTGAACGGGCTGCTTGGCCGCAAGGAAAACGGTGGCGGCAACAACCAGGGATTTGGCGGACCGCGGACGCCGGG
CAAGAGCTCAGGCGTGGGCGTGGGCGTCGTCGCAGCCGCGATCGTCGGCATCTGGCTGGCCAGTGGTTTCTTCATGGTGC
AGGAAGGCCAGACGGCCGTGATCCTGCAGTTCGGCAAGTTCAAGTATTCGACCGGCCCCGGCATCAACTGGCGCCTGCCC
TGGCCGATCCAGTCGGCGGAGGTCGTCAACCTGTCGGCCGTGCGTTCGGTGGAAGTGGGGCGCTCCACTTCCATCAAGGA
CAGCAACCTGAAGGACTCGTCGATGTTGACGCAGGACGAGAACATCATCGATGTCCGCTTCACGGTGCAGTACGCCATTC
AGGATGCAAGCGAATTCCTGTTCTTCAACAAGACCGACCGCGGTGGCGATGAAGAGCTCGTGACGCAGGCTGCCGAGACT
TCGGTGCGCGAGATCGTCGGCCGCAACAAGATGGATGCGGTGCTTTACGAGAACCGCGAGCAGATTGCGCAAGGTCTGGC
CAAGTCGATCCAGTCGATCCTGTCTGCCTACAAGACCGGTATTCGCGTGATCTCGGTGAACGTGCAGAGCGTGCAGCCAC
CCGAGCAGGTACAGGCCGCGTTCGACGACGTGAACAAGGCCAGCCAGGATCGCGAGCGTGCGATCAGCGAAGGGCAGGCT
TACGCCAATGACGTAATTCCGCGCGCCAAGGGTACGGCGGCGCGCTTGAAGGAAGAAGCCGAGGCCTATCGTGCGCGCGT
GGTGGCACAGGCCGAGGGCGACGCTTCGCGCTTCCGTTCGGTGCAGGGCGAATACGCCAAGGCGCCGCAGGTGACGCGCG
ACCGCATCTATATCGAAACCATGCAGCAGATCTACGCCAACTCGAACAAGATACTGGTGGATGCCCGCCAGGGCAGCAAC
CTGCTTTATCTTCCGCTCGACAAGCTGATGGCGCAGAGTCAGGCCGATGGCCGCGGCGCGCAGACGCCGTCGCAGCCGGC
CAGCGGTGCCGGCACGCCAGCGCCCACGCAGGATTCCCCCGGCGACAACCGGTCGCGCGAATCCCTGCGCAACCGTGACC
GCGATTCGCGCTGA

Upstream 100 bases:

>100_bases
TTTCGGCGAGATTCGCGGCCGGATTACGCGCATTGGCCAAAAGTGGCGCAGATGACTGCTAGAATCCCCCTGTTACAAAC
TTCCCGGACCCGTGCACTTC

Downstream 100 bases:

>100_bases
GGAGACCGTCATGAACCGACTGATTTCCTTTGCGATCGGCGCTTTCATCGTGCTCGCCGTGGCGTCTTCGATGATGTTCG
TCGTGGATCAGCGCCAGTAC

Product: HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MPQFSRNPESSLTPGGRFPLRAGWQRLRAIFSLNDPRWGRDGQDEEDKDGRANDRDGNRQQNQRPQDGPPDLDELWRDFN
RRLNGLLGRKENGGGNNQGFGGPRTPGKSSGVGVGVVAAAIVGIWLASGFFMVQEGQTAVILQFGKFKYSTGPGINWRLP
WPIQSAEVVNLSAVRSVEVGRSTSIKDSNLKDSSMLTQDENIIDVRFTVQYAIQDASEFLFFNKTDRGGDEELVTQAAET
SVREIVGRNKMDAVLYENREQIAQGLAKSIQSILSAYKTGIRVISVNVQSVQPPEQVQAAFDDVNKASQDRERAISEGQA
YANDVIPRAKGTAARLKEEAEAYRARVVAQAEGDASRFRSVQGEYAKAPQVTRDRIYIETMQQIYANSNKILVDARQGSN
LLYLPLDKLMAQSQADGRGAQTPSQPASGAGTPAPTQDSPGDNRSRESLRNRDRDSR

Sequences:

>Translated_457_residues
MPQFSRNPESSLTPGGRFPLRAGWQRLRAIFSLNDPRWGRDGQDEEDKDGRANDRDGNRQQNQRPQDGPPDLDELWRDFN
RRLNGLLGRKENGGGNNQGFGGPRTPGKSSGVGVGVVAAAIVGIWLASGFFMVQEGQTAVILQFGKFKYSTGPGINWRLP
WPIQSAEVVNLSAVRSVEVGRSTSIKDSNLKDSSMLTQDENIIDVRFTVQYAIQDASEFLFFNKTDRGGDEELVTQAAET
SVREIVGRNKMDAVLYENREQIAQGLAKSIQSILSAYKTGIRVISVNVQSVQPPEQVQAAFDDVNKASQDRERAISEGQA
YANDVIPRAKGTAARLKEEAEAYRARVVAQAEGDASRFRSVQGEYAKAPQVTRDRIYIETMQQIYANSNKILVDARQGSN
LLYLPLDKLMAQSQADGRGAQTPSQPASGAGTPAPTQDSPGDNRSRESLRNRDRDSR
>Mature_456_residues
PQFSRNPESSLTPGGRFPLRAGWQRLRAIFSLNDPRWGRDGQDEEDKDGRANDRDGNRQQNQRPQDGPPDLDELWRDFNR
RLNGLLGRKENGGGNNQGFGGPRTPGKSSGVGVGVVAAAIVGIWLASGFFMVQEGQTAVILQFGKFKYSTGPGINWRLPW
PIQSAEVVNLSAVRSVEVGRSTSIKDSNLKDSSMLTQDENIIDVRFTVQYAIQDASEFLFFNKTDRGGDEELVTQAAETS
VREIVGRNKMDAVLYENREQIAQGLAKSIQSILSAYKTGIRVISVNVQSVQPPEQVQAAFDDVNKASQDRERAISEGQAY
ANDVIPRAKGTAARLKEEAEAYRARVVAQAEGDASRFRSVQGEYAKAPQVTRDRIYIETMQQIYANSNKILVDARQGSNL
LYLPLDKLMAQSQADGRGAQTPSQPASGAGTPAPTQDSPGDNRSRESLRNRDRDSR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=378, Percent_Identity=36.2433862433862, Blast_Score=211, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 50334; Mature: 50203

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQFSRNPESSLTPGGRFPLRAGWQRLRAIFSLNDPRWGRDGQDEEDKDGRANDRDGNRQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
QNQRPQDGPPDLDELWRDFNRRLNGLLGRKENGGGNNQGFGGPRTPGKSSGVGVGVVAAA
HCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
IVGIWLASGFFMVQEGQTAVILQFGKFKYSTGPGINWRLPWPIQSAEVVNLSAVRSVEVG
HHHHHHHCCEEEEECCCEEEEEEECCEEECCCCCCCEECCCCCCCCCEEEHHHHHHHHCC
RSTSIKDSNLKDSSMLTQDENIIDVRFTVQYAIQDASEFLFFNKTDRGGDEELVTQAAET
CCCCCCCCCCCCCHHCCCCCCEEEEEEEEEHHHHHHHHEEEEECCCCCCHHHHHHHHHHH
SVREIVGRNKMDAVLYENREQIAQGLAKSIQSILSAYKTGIRVISVNVQSVQPPEQVQAA
HHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHH
FDDVNKASQDRERAISEGQAYANDVIPRAKGTAARLKEEAEAYRARVVAQAEGDASRFRS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VQGEYAKAPQVTRDRIYIETMQQIYANSNKILVDARQGSNLLYLPLDKLMAQSQADGRGA
HCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHCCCCCCC
QTPSQPASGAGTPAPTQDSPGDNRSRESLRNRDRDSR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
PQFSRNPESSLTPGGRFPLRAGWQRLRAIFSLNDPRWGRDGQDEEDKDGRANDRDGNRQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
QNQRPQDGPPDLDELWRDFNRRLNGLLGRKENGGGNNQGFGGPRTPGKSSGVGVGVVAAA
HCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
IVGIWLASGFFMVQEGQTAVILQFGKFKYSTGPGINWRLPWPIQSAEVVNLSAVRSVEVG
HHHHHHHCCEEEEECCCEEEEEEECCEEECCCCCCCEECCCCCCCCCEEEHHHHHHHHCC
RSTSIKDSNLKDSSMLTQDENIIDVRFTVQYAIQDASEFLFFNKTDRGGDEELVTQAAET
CCCCCCCCCCCCCHHCCCCCCEEEEEEEEEHHHHHHHHEEEEECCCCCCHHHHHHHHHHH
SVREIVGRNKMDAVLYENREQIAQGLAKSIQSILSAYKTGIRVISVNVQSVQPPEQVQAA
HHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHH
FDDVNKASQDRERAISEGQAYANDVIPRAKGTAARLKEEAEAYRARVVAQAEGDASRFRS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VQGEYAKAPQVTRDRIYIETMQQIYANSNKILVDARQGSNLLYLPLDKLMAQSQADGRGA
HCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHCCCCCCC
QTPSQPASGAGTPAPTQDSPGDNRSRESLRNRDRDSR
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]