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The map label for this gene is benK [H]

Identifier: 73541512

GI number: 73541512

Start: 1997238

End: 1998566

Strand: Direct

Name: benK [H]

Synonym: Reut_A1823

Alternate gene names: 73541512

Gene position: 1997238-1998566 (Clockwise)

Preceding gene: 73541507

Following gene: 73541513

Centisome position: 52.47

GC content: 66.74

Gene sequence:

>1329_bases
GTGCATCAATCAACACTGCCGGCCCGCAGCAGCCTGTTCGTGGTCATATTGTGCTTTCTGACGATCGTGGCCGACGGCTA
CGACCTCATCGTCTACGGAGCCACTCTCCCGAAGCTGCTGGAAGAGCCGGGCTGGGGCCTGACGCCGGCGACGGCCGGCA
TGATCGGGAGCTGGACGCTCGCCGGGCTGATGGTCGGCATGGGCGCAGCCGGCCCGCTTTCCGACCGCGTGGGCAGGCGC
AACCTCATCATGGCCGGCGTGCTGTGGTTCTCGGTCGGCTCCATCCTCTGCGCGCTCGCCGCTTCGCCGTTTTCACTGGG
CGCCGCGCGCTTTTTTACCGGCATCGGACTGGGCGGCGTGGTGCCGTCCGCCGTGGCGCTGACGGTCGAATACGCGCCTG
CGAACCGGCGCCAGTTGTACAACGCGCTGACCCTGACAGGCTATTCCGTGGGCGGCGTCATCTGCGCGCTGCTGGCGATG
ACACTGCTGCAGGAACACGGATGGCGCACGCTCTATGCGCTTGGCGCGCTCTACGCGCTGATCCTGCCCGTGATGTACAG
GTGGCTCCCCGAGTCGGTTAGCTTCCTCGTCGAGCGCGGCCGCATGGAAGAGGCGCGCGTCCTGGCCGCCCGCCATTCGC
TCGACTTGGAGCAAATGGCGCGGGAGCAACGGGCCCAGGCGGTGCACGCGGCCGCGACCGGTACGCGCGGGTACCGCCTC
CTGGCAACCGATGCACTCCGCACCTCGGCGCTGTTGTTCGGGATGGTGAGTTTCTGCGTCCAGCTGATCGTCTATGGCCT
GAACGCATGGCTTCCACAACTGATGCGCAAGGCCGGCTATCCGCTGGGGTCGTCGCTGCAGTTCCTGCTGGTGATGCAGT
TCGGCGCCGTCGCGGGCATGATCGGCGGTGCGTGGCTGGCGGACCGGTTGGGCTCCAAACGGGTGATCATTCCGTTCTTC
GCCATCGGCGGCCTGTCACTGCTCGCGCTGAGCCAGAAGCTGGCCTTCGGCTGGTTGATGCTCGCGGTGTTCGGCGCGGG
CATTGGCTCCATCGGCACGACTACACTGATCTACGGCTACATCGCCACGTACTTCCCGGCTTCCTGCCGCGGCTCCGCGC
TCGGGGCGTCACAGGCGTTCGGGCGCTTCGGCTCCATTCTCGGTCCGCTGATTGGCGGTTGGATCGTCGGCTCGAACCTC
GCGCTGCACTGGAACTTCTACGCATTCGTCGTGCCTGCCGTCGTCGCCATCCTTCTCGTGCCCCTGATCCCGAAGCCGGC
ACAGGAACCCGACGCCGCGCCAAGCGCGGATTACCGTACTGCGGACTGA

Upstream 100 bases:

>100_bases
ACGCCACTACCCTTCCGGTGGTCCCGGTCACCGCATCGCCCGCAGTCCATCCGTACCTTGCATTGGCCGGGACTCACAAC
AAGGACATCCAGGAGACAAC

Downstream 100 bases:

>100_bases
GTCCGCAACCCGCTACGCCACAGAGGTGAAATCATGAAAGCCGTCAGCATCAAGCATCAGTACTGGGATATCGCAGCAGA
CCTCCACTTCCCGCCGGACT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MHQSTLPARSSLFVVILCFLTIVADGYDLIVYGATLPKLLEEPGWGLTPATAGMIGSWTLAGLMVGMGAAGPLSDRVGRR
NLIMAGVLWFSVGSILCALAASPFSLGAARFFTGIGLGGVVPSAVALTVEYAPANRRQLYNALTLTGYSVGGVICALLAM
TLLQEHGWRTLYALGALYALILPVMYRWLPESVSFLVERGRMEEARVLAARHSLDLEQMAREQRAQAVHAAATGTRGYRL
LATDALRTSALLFGMVSFCVQLIVYGLNAWLPQLMRKAGYPLGSSLQFLLVMQFGAVAGMIGGAWLADRLGSKRVIIPFF
AIGGLSLLALSQKLAFGWLMLAVFGAGIGSIGTTTLIYGYIATYFPASCRGSALGASQAFGRFGSILGPLIGGWIVGSNL
ALHWNFYAFVVPAVVAILLVPLIPKPAQEPDAAPSADYRTAD

Sequences:

>Translated_442_residues
MHQSTLPARSSLFVVILCFLTIVADGYDLIVYGATLPKLLEEPGWGLTPATAGMIGSWTLAGLMVGMGAAGPLSDRVGRR
NLIMAGVLWFSVGSILCALAASPFSLGAARFFTGIGLGGVVPSAVALTVEYAPANRRQLYNALTLTGYSVGGVICALLAM
TLLQEHGWRTLYALGALYALILPVMYRWLPESVSFLVERGRMEEARVLAARHSLDLEQMAREQRAQAVHAAATGTRGYRL
LATDALRTSALLFGMVSFCVQLIVYGLNAWLPQLMRKAGYPLGSSLQFLLVMQFGAVAGMIGGAWLADRLGSKRVIIPFF
AIGGLSLLALSQKLAFGWLMLAVFGAGIGSIGTTTLIYGYIATYFPASCRGSALGASQAFGRFGSILGPLIGGWIVGSNL
ALHWNFYAFVVPAVVAILLVPLIPKPAQEPDAAPSADYRTAD
>Mature_442_residues
MHQSTLPARSSLFVVILCFLTIVADGYDLIVYGATLPKLLEEPGWGLTPATAGMIGSWTLAGLMVGMGAAGPLSDRVGRR
NLIMAGVLWFSVGSILCALAASPFSLGAARFFTGIGLGGVVPSAVALTVEYAPANRRQLYNALTLTGYSVGGVICALLAM
TLLQEHGWRTLYALGALYALILPVMYRWLPESVSFLVERGRMEEARVLAARHSLDLEQMAREQRAQAVHAAATGTRGYRL
LATDALRTSALLFGMVSFCVQLIVYGLNAWLPQLMRKAGYPLGSSLQFLLVMQFGAVAGMIGGAWLADRLGSKRVIIPFF
AIGGLSLLALSQKLAFGWLMLAVFGAGIGSIGTTTLIYGYIATYFPASCRGSALGASQAFGRFGSILGPLIGGWIVGSNL
ALHWNFYAFVVPAVVAILLVPLIPKPAQEPDAAPSADYRTAD

Specific function: Probable uptake of benzoate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=413, Percent_Identity=25.90799031477, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI166064021, Length=340, Percent_Identity=29.7058823529412, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI8923870, Length=386, Percent_Identity=26.9430051813472, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI7662270, Length=305, Percent_Identity=23.6065573770492, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI148664184, Length=391, Percent_Identity=24.5524296675192, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI90669191, Length=393, Percent_Identity=27.2264631043257, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081723, Length=380, Percent_Identity=28.9473684210526, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082404, Length=401, Percent_Identity=23.1920199501247, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87082231, Length=462, Percent_Identity=25.5411255411255, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786229, Length=371, Percent_Identity=25.6064690026954, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082159, Length=383, Percent_Identity=27.9373368146214, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788074, Length=372, Percent_Identity=25, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789207, Length=236, Percent_Identity=29.6610169491525, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=446, Percent_Identity=25.7847533632287, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17565978, Length=319, Percent_Identity=23.8244514106583, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17565976, Length=297, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988651, Length=237, Percent_Identity=28.2700421940928, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989525, Length=353, Percent_Identity=24.0793201133144, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989531, Length=356, Percent_Identity=25, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62484254, Length=407, Percent_Identity=25.7985257985258, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24649618, Length=349, Percent_Identity=26.0744985673352, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922874, Length=424, Percent_Identity=24.0566037735849, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355657, Length=340, Percent_Identity=25.5882352941176, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46872; Mature: 46872

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00120 LIPASE_SER ; PS00211 ABC_TRANSPORTER_1 ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQSTLPARSSLFVVILCFLTIVADGYDLIVYGATLPKLLEEPGWGLTPATAGMIGSWTL
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCCCCCHHHHHHHHHHH
AGLMVGMGAAGPLSDRVGRRNLIMAGVLWFSVGSILCALAASPFSLGAARFFTGIGLGGV
HHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHH
VPSAVALTVEYAPANRRQLYNALTLTGYSVGGVICALLAMTLLQEHGWRTLYALGALYAL
HHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ILPVMYRWLPESVSFLVERGRMEEARVLAARHSLDLEQMAREQRAQAVHAAATGTRGYRL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LATDALRTSALLFGMVSFCVQLIVYGLNAWLPQLMRKAGYPLGSSLQFLLVMQFGAVAGM
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IGGAWLADRLGSKRVIIPFFAIGGLSLLALSQKLAFGWLMLAVFGAGIGSIGTTTLIYGY
HHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IATYFPASCRGSALGASQAFGRFGSILGPLIGGWIVGSNLALHWNFYAFVVPAVVAILLV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
PLIPKPAQEPDAAPSADYRTAD
HCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHQSTLPARSSLFVVILCFLTIVADGYDLIVYGATLPKLLEEPGWGLTPATAGMIGSWTL
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCCCCCHHHHHHHHHHH
AGLMVGMGAAGPLSDRVGRRNLIMAGVLWFSVGSILCALAASPFSLGAARFFTGIGLGGV
HHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHH
VPSAVALTVEYAPANRRQLYNALTLTGYSVGGVICALLAMTLLQEHGWRTLYALGALYAL
HHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ILPVMYRWLPESVSFLVERGRMEEARVLAARHSLDLEQMAREQRAQAVHAAATGTRGYRL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LATDALRTSALLFGMVSFCVQLIVYGLNAWLPQLMRKAGYPLGSSLQFLLVMQFGAVAGM
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
IGGAWLADRLGSKRVIIPFFAIGGLSLLALSQKLAFGWLMLAVFGAGIGSIGTTTLIYGY
HHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IATYFPASCRGSALGASQAFGRFGSILGPLIGGWIVGSNLALHWNFYAFVVPAVVAILLV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHH
PLIPKPAQEPDAAPSADYRTAD
HCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9294456 [H]