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The map label for this gene is prpC [H]

Identifier: 73541498

GI number: 73541498

Start: 1976829

End: 1977983

Strand: Direct

Name: prpC [H]

Synonym: Reut_A1809

Alternate gene names: 73541498

Gene position: 1976829-1977983 (Clockwise)

Preceding gene: 73541497

Following gene: 161611260

Centisome position: 51.93

GC content: 64.07

Gene sequence:

>1155_bases
ATGTCCGAAGCACAAGCGATCGCCACCCCGAAGCCCAAGAAGTCCGTTGCCCTGTCGGGCGTGACCGCCGGTAATACCGC
GCTGTGTACCGTCGGCCGTACCGGCAACGACCTGCACTACCGCGGCTATGACATCCTGGACGTGGCAGACGCCTGCGAAT
TCGAAGAAATCGCCCACCTGCTGGTCCATGGCAAGCTGCCGAACAAGGCCGAACTGGCCGCCTACAAGACCAAGCTGAAG
TCGCTGCGCGGCCTGCCCGCCAACGTCAAGGCTGCGCTGGAATGCGTGCCCGCCTCGGCCCACCCGATGGACGTGATGCG
CACCGGCGTGTCGGTACTGGGCACCGTGCTGCCCGAGAAGGACGACCACAACACCCCGGGCGCGCGTGACATCGCCGACC
AGCTGATGGCCAGCCTGGGTTCGATGCTGCTGTACTGGTACCACTACAGCCACAATGGCCGCCGCATCGAAGTGGAAACC
GACGACGACACCATCGGCGCCCACTTCCTGCACCTGCTGCACGGCAAGAAGCCGTCCGCGCTGTGGGAGCGCGCCATGCA
CACTTCGCTGATCCTGTACGCGGAGCACGAGTTCAATGCCTCGACCTTCACCGGCCGCGTGATCGCCGGCACGGGCTCTG
ACATGCACTCGGCCATCTGCGGCGCGATCGGCGCGCTGCGCGGCCCCAAGCACGGCGGCGCCAATGAAGTGGCCTTCGAG
ATCCAGAAGCGCTACGACACCCCGGACGAAGCGCAGGCCGACATCACCCGCCGCGTGGAAAACAAGGAAGTCGTGATCGG
CTTCGGCCACCCGGTGTACACCGTGGCGGACCCGCGCAACCAGGTCATCAAGGAAACCGCGCGCAACCTGTCGAAGGACG
CCGGCTCGATGAAGATGTTCGACATCGCCGAGCGCCTGGAAACGGTGATGTGGGACATCAAGAAGATGTTCCCGAACCTG
GACTGGTTCAGCGCCGTGAGCTACCACATGATGGGCGTGCCGACCGCAATGTTCACGCCGCTGTTCGTGATCGCTCGCAC
TTCTGGCTGGGCTGCGCATATCATCGAGCAGCGCATCGACAACAAGATCATCCGCCCGAGCGCCAACTACACTGGTCCGG
AGAACCTGACGTTCGTGCCGATCGAAAAGCGCTGA

Upstream 100 bases:

>100_bases
GCTACCACGCCTACGAACAGAAACTCGACGCCCTGTTTGCACAGGGCAAGGCCAAGTAAGGCCACCCACCTGTCGACCCG
TACCTCACAAGGAGACCCAG

Downstream 100 bases:

>100_bases
TCTGAACAAGCGCCCTGCGGCAAACGTGCTTCGTTCCCGCGAAAGCGGTACGAAGCACGATACCGGACCAGGGTATTCCT
TGGCTCCTGCATTACCCAGA

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSEAQAIATPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDVADACEFEEIAHLLVHGKLPNKAELAAYKTKLK
SLRGLPANVKAALECVPASAHPMDVMRTGVSVLGTVLPEKDDHNTPGARDIADQLMASLGSMLLYWYHYSHNGRRIEVET
DDDTIGAHFLHLLHGKKPSALWERAMHTSLILYAEHEFNASTFTGRVIAGTGSDMHSAICGAIGALRGPKHGGANEVAFE
IQKRYDTPDEAQADITRRVENKEVVIGFGHPVYTVADPRNQVIKETARNLSKDAGSMKMFDIAERLETVMWDIKKMFPNL
DWFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDNKIIRPSANYTGPENLTFVPIEKR

Sequences:

>Translated_384_residues
MSEAQAIATPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDVADACEFEEIAHLLVHGKLPNKAELAAYKTKLK
SLRGLPANVKAALECVPASAHPMDVMRTGVSVLGTVLPEKDDHNTPGARDIADQLMASLGSMLLYWYHYSHNGRRIEVET
DDDTIGAHFLHLLHGKKPSALWERAMHTSLILYAEHEFNASTFTGRVIAGTGSDMHSAICGAIGALRGPKHGGANEVAFE
IQKRYDTPDEAQADITRRVENKEVVIGFGHPVYTVADPRNQVIKETARNLSKDAGSMKMFDIAERLETVMWDIKKMFPNL
DWFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDNKIIRPSANYTGPENLTFVPIEKR
>Mature_383_residues
SEAQAIATPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDVADACEFEEIAHLLVHGKLPNKAELAAYKTKLKS
LRGLPANVKAALECVPASAHPMDVMRTGVSVLGTVLPEKDDHNTPGARDIADQLMASLGSMLLYWYHYSHNGRRIEVETD
DDTIGAHFLHLLHGKKPSALWERAMHTSLILYAEHEFNASTFTGRVIAGTGSDMHSAICGAIGALRGPKHGGANEVAFEI
QKRYDTPDEAQADITRRVENKEVVIGFGHPVYTVADPRNQVIKETARNLSKDAGSMKMFDIAERLETVMWDIKKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDNKIIRPSANYTGPENLTFVPIEKR

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=374, Percent_Identity=78.8770053475936, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1786939, Length=363, Percent_Identity=31.404958677686, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17555174, Length=361, Percent_Identity=24.9307479224377, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319850, Length=341, Percent_Identity=24.0469208211144, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640124, Length=337, Percent_Identity=24.3323442136499, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640126, Length=334, Percent_Identity=23.9520958083832, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42261; Mature: 42130

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAQAIATPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDVADACEFEEIAHL
CCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEECCCCCEEHHHHCCHHHHHHH
LVHGKLPNKAELAAYKTKLKSLRGLPANVKAALECVPASAHPMDVMRTGVSVLGTVLPEK
HHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
DDHNTPGARDIADQLMASLGSMLLYWYHYSHNGRRIEVETDDDTIGAHFLHLLHGKKPSA
CCCCCCCHHHHHHHHHHHHHHHHEEHEEECCCCCEEEEECCCCHHHHHHHHHHHCCCHHH
LWERAMHTSLILYAEHEFNASTFTGRVIAGTGSDMHSAICGAIGALRGPKHGGANEVAFE
HHHHHHHCEEEEEEECCCCCCEECCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
IQKRYDTPDEAQADITRRVENKEVVIGFGHPVYTVADPRNQVIKETARNLSKDAGSMKMF
HHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHH
DIAERLETVMWDIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRID
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHEEEEEECCCHHHHHHHHHHC
NKIIRPSANYTGPENLTFVPIEKR
CCEECCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
SEAQAIATPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDVADACEFEEIAHL
CCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEECCCCCEEHHHHCCHHHHHHH
LVHGKLPNKAELAAYKTKLKSLRGLPANVKAALECVPASAHPMDVMRTGVSVLGTVLPEK
HHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
DDHNTPGARDIADQLMASLGSMLLYWYHYSHNGRRIEVETDDDTIGAHFLHLLHGKKPSA
CCCCCCCHHHHHHHHHHHHHHHHEEHEEECCCCCEEEEECCCCHHHHHHHHHHHCCCHHH
LWERAMHTSLILYAEHEFNASTFTGRVIAGTGSDMHSAICGAIGALRGPKHGGANEVAFE
HHHHHHHCEEEEEEECCCCCCEECCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
IQKRYDTPDEAQADITRRVENKEVVIGFGHPVYTVADPRNQVIKETARNLSKDAGSMKMF
HHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCHHH
DIAERLETVMWDIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRID
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHEEEEEECCCHHHHHHHHHHC
NKIIRPSANYTGPENLTFVPIEKR
CCEECCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]