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The map label for this gene is cbs [H]

Identifier: 73541493

GI number: 73541493

Start: 1970509

End: 1971513

Strand: Direct

Name: cbs [H]

Synonym: Reut_A1804

Alternate gene names: 73541493

Gene position: 1970509-1971513 (Clockwise)

Preceding gene: 73541492

Following gene: 73541494

Centisome position: 51.77

GC content: 66.17

Gene sequence:

>1005_bases
ATGGATGTCAGGGATGGTTTTGTCGGCACGGTCGGACATACGCCGCTGATCCGGCTCGGCGGGCTGAGCGCCGAGACCGG
GTGCGACATTTACGGCAAGGCGGAATTCCTGAACCCTGGCGGTTCGGTCAAGGACCGCGCGGCGCTCTACATCATCCGCG
ACGCCGAACGACGCGGCACGCTGCGCCCGGGCGGCACGGTCGTGGAAGGCACCGCCGGCAACACCGGCATCGGGCTGGCG
CACATCTGCGCGGCGCGCGGCTACCGCTGCATCGTCGTCATTCCTGATACCCAATCGCCCGAAAAAATGGAGCGCCTGCG
CATGCTGGGAGCCGAGGTACGGGCCGTCCCCGCAAAGCCGTACGCCGACCCCAACAACTACCAGAAGATCGCCGGCCGGC
TCGCCCAGGAAACGGCAAACGCGATCTGGGCCAACCAGTTCGACAACCTCGCCAACCGCCAGGCCCACTACGAAACCACG
GGCCCGGAAATCTGGCACGACACCGCCGGCCGCATCGATGCCTTCGTCTGCGCCACCGGCACCGGGGGCTCGCTGGCGGG
CATTTCGCGCTTCCTGAAGGAGCATGGCCCGCATGTGCGTATCGTGCTGGCCGACCCGTACGGCAGCAGCCTGTACAACT
TCGTCAAGCATCGCGAACTGAAGTCCGAAGGCAACTCGATCACGGAGGGCATTGGTTCGAGCCGCATCACGGCGAATCTG
CAGGACACCGTGATCGACGACGCCGTGCGGGTTGACGACCAGGCCTGCGTGAACATGGTCTACCGTCTGCTGCGCGAGGA
AGGGCTGTTTCTCGGCGGATCGACCGGCATCAACGTTGCCGCCGCCGTCGCGCTCGCACGGGAGATGGGGCCGGGACACA
CCATCGTCACGCTGCTGTGCGATCGCGGCGATCTTTACTTCGGCCGGCTCTTCAATCAGGATTGGCTCGCCGGAAAGGGG
CTGACGCCAACGCCATTTGCGCGCATGGCGCCCCGCGCGGGCTAG

Upstream 100 bases:

>100_bases
GTGCAGGCGCCTGCGCGCCACCTGTCTTGTCAATCTCCGCTGCCCGGTCTATCACTCTGGATGAAGCCCCATGCCACGCG
GGGCGCGGCAGGAGTGCGCC

Downstream 100 bases:

>100_bases
CATGGCGCCTGGCCGCCCGCTCCGGCGGCCAGATAACCCGCGCCTTGCGCATTCTTCCTGCGAGCCCCTCCGCCTCATGG
ATGTACACCTGACGATTCAC

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MDVRDGFVGTVGHTPLIRLGGLSAETGCDIYGKAEFLNPGGSVKDRAALYIIRDAERRGTLRPGGTVVEGTAGNTGIGLA
HICAARGYRCIVVIPDTQSPEKMERLRMLGAEVRAVPAKPYADPNNYQKIAGRLAQETANAIWANQFDNLANRQAHYETT
GPEIWHDTAGRIDAFVCATGTGGSLAGISRFLKEHGPHVRIVLADPYGSSLYNFVKHRELKSEGNSITEGIGSSRITANL
QDTVIDDAVRVDDQACVNMVYRLLREEGLFLGGSTGINVAAAVALAREMGPGHTIVTLLCDRGDLYFGRLFNQDWLAGKG
LTPTPFARMAPRAG

Sequences:

>Translated_334_residues
MDVRDGFVGTVGHTPLIRLGGLSAETGCDIYGKAEFLNPGGSVKDRAALYIIRDAERRGTLRPGGTVVEGTAGNTGIGLA
HICAARGYRCIVVIPDTQSPEKMERLRMLGAEVRAVPAKPYADPNNYQKIAGRLAQETANAIWANQFDNLANRQAHYETT
GPEIWHDTAGRIDAFVCATGTGGSLAGISRFLKEHGPHVRIVLADPYGSSLYNFVKHRELKSEGNSITEGIGSSRITANL
QDTVIDDAVRVDDQACVNMVYRLLREEGLFLGGSTGINVAAAVALAREMGPGHTIVTLLCDRGDLYFGRLFNQDWLAGKG
LTPTPFARMAPRAG
>Mature_334_residues
MDVRDGFVGTVGHTPLIRLGGLSAETGCDIYGKAEFLNPGGSVKDRAALYIIRDAERRGTLRPGGTVVEGTAGNTGIGLA
HICAARGYRCIVVIPDTQSPEKMERLRMLGAEVRAVPAKPYADPNNYQKIAGRLAQETANAIWANQFDNLANRQAHYETT
GPEIWHDTAGRIDAFVCATGTGGSLAGISRFLKEHGPHVRIVLADPYGSSLYNFVKHRELKSEGNSITEGIGSSRITANL
QDTVIDDAVRVDDQACVNMVYRLLREEGLFLGGSTGINVAAAVALAREMGPGHTIVTLLCDRGDLYFGRLFNQDWLAGKG
LTPTPFARMAPRAG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=318, Percent_Identity=40.251572327044, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI295821200, Length=318, Percent_Identity=40.251572327044, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557415, Length=318, Percent_Identity=40.251572327044, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=37.9084967320261, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=36.8253968253968, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=39.0322580645161, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=38.9438943894389, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=39.202657807309, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=38.4615384615385, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=35.258358662614, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=38.0794701986755, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=323, Percent_Identity=34.984520123839, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=225, Percent_Identity=34.2222222222222, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17539800, Length=346, Percent_Identity=26.5895953757225, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=318, Percent_Identity=28.9308176100629, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17539640, Length=341, Percent_Identity=24.9266862170088, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=40.9638554216867, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=35.2409638554217, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24643623, Length=322, Percent_Identity=38.5093167701863, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI20129101, Length=322, Percent_Identity=38.5093167701863, Blast_Score=214, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 35866; Mature: 35866

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRDGFVGTVGHTPLIRLGGLSAETGCDIYGKAEFLNPGGSVKDRAALYIIRDAERRGT
CCCCCCCEECCCCCCEEEECCCCCCCCCCEECCEEEECCCCCCCCCEEEEEEEECCCCCC
LRPGGTVVEGTAGNTGIGLAHICAARGYRCIVVIPDTQSPEKMERLRMLGAEVRAVPAKP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHEECCCCC
YADPNNYQKIAGRLAQETANAIWANQFDNLANRQAHYETTGPEIWHDTAGRIDAFVCATG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEEECC
TGGSLAGISRFLKEHGPHVRIVLADPYGSSLYNFVKHRELKSEGNSITEGIGSSRITANL
CCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECH
QDTVIDDAVRVDDQACVNMVYRLLREEGLFLGGSTGINVAAAVALAREMGPGHTIVTLLC
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEE
DRGDLYFGRLFNQDWLAGKGLTPTPFARMAPRAG
CCCCEEEHHHCCCCCCCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure
MDVRDGFVGTVGHTPLIRLGGLSAETGCDIYGKAEFLNPGGSVKDRAALYIIRDAERRGT
CCCCCCCEECCCCCCEEEECCCCCCCCCCEECCEEEECCCCCCCCCEEEEEEEECCCCCC
LRPGGTVVEGTAGNTGIGLAHICAARGYRCIVVIPDTQSPEKMERLRMLGAEVRAVPAKP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHEECCCCC
YADPNNYQKIAGRLAQETANAIWANQFDNLANRQAHYETTGPEIWHDTAGRIDAFVCATG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEEECC
TGGSLAGISRFLKEHGPHVRIVLADPYGSSLYNFVKHRELKSEGNSITEGIGSSRITANL
CCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECH
QDTVIDDAVRVDDQACVNMVYRLLREEGLFLGGSTGINVAAAVALAREMGPGHTIVTLLC
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEE
DRGDLYFGRLFNQDWLAGKGLTPTPFARMAPRAG
CCCCEEEHHHCCCCCCCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]