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The map label for this gene is gyaR [H]

Identifier: 73541450

GI number: 73541450

Start: 1917887

End: 1918840

Strand: Direct

Name: gyaR [H]

Synonym: Reut_A1761

Alternate gene names: 73541450

Gene position: 1917887-1918840 (Clockwise)

Preceding gene: 73541445

Following gene: 73541451

Centisome position: 50.38

GC content: 68.13

Gene sequence:

>954_bases
ATGAAGCCGCACATCCTGCAACTGAATCCCATCCTGATCCCCGCCGCCAATGACGAACTGGCCGCCCTTTACCACGTGCA
CAAGCTGTTCGAGGTCGAGGACCAGGCCGCCTGGCTCAAGGAGCATGGATCGGCCATCCAGGCCGTCATCACGGGCGGGC
ACACCGGGATTTCCCGGGCGATGCTGGAACAGTTGCCAGCGTTGAAGGTGGTGGCCGTCAACGGTGTGGGCACCGACGCG
GTGGACCTGCCCTATTGCCGCGAGCGCGGGCTGCCGGTCACCGCCACGCTAGGCGCACTGACCGAGGACGTGGCAGACCT
TGCGATTGGCCTGCTGATTGCCGCCTGCCGGAATATCTGCGCGGGCGACCGCTTTGTCCGCGATGGCCAGTGGGAACGCT
TTCCGCAACCGTCGGCCATTCCGCTCGCGCGCCGGTTCAGCGGCATGCGCGTCGGTATTGTCGGCATGGGCCGCGTCGGC
CGCGCGGTCGCCACGCGGGCCGCTGCATTTGGTTGCCCGATCCGCTACACCGACCTGCGGCGCATGGACGATTTGCCGCA
CGCGTTCGTGCCCGATCTGGTCGACCTCGCTCGCAACAGCGATGCGCTGGTGCTGTGCGCGGCGGCCGACAAGGCGGAAG
GCATCGTGAACGGCGCCGTCCTCGATGCCCTGGGGCCGCGCGGCTTCCTGGTCAATGTGGCGCGTGGGCGCCTGGTCAAT
GAAGACGACCTGGCACAAGCCATCGAAGCCGGCCGCATTGCCGGTGCTGGCCTCGATGTCTTCGTGGACGAACCGCGCGT
GCCGCTGGCGCTGCGCCGGTCGGATCGCACGACGCTGCAGGCGCATCGCGCCAGTGCCACGTGGGAAACCCGCGCCGCCA
TGATCCGGATGGTGCTGGACAGCGTGGCCGAGGGGCTGGCCGGCAAGCGCCCTGCGATGAGCCTGACTACCTGA

Upstream 100 bases:

>100_bases
GCTCCACATCTATTTATGTTGATTTTATATATCAATATTGCATTGACAATCAACTATTAACTACCATGGGTCCTACATTC
CAGCCGACTCCGACGACCAC

Downstream 100 bases:

>100_bases
GTCGACAGGCACCCCCACTCAGGAGCGCCATGATGGAATTCGTCCTGCCTGGCACGCCTGCGGGCGTAGGCCCGTTGCAG
CGCGGCGATGTGATGGATGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKPHILQLNPILIPAANDELAALYHVHKLFEVEDQAAWLKEHGSAIQAVITGGHTGISRAMLEQLPALKVVAVNGVGTDA
VDLPYCRERGLPVTATLGALTEDVADLAIGLLIAACRNICAGDRFVRDGQWERFPQPSAIPLARRFSGMRVGIVGMGRVG
RAVATRAAAFGCPIRYTDLRRMDDLPHAFVPDLVDLARNSDALVLCAAADKAEGIVNGAVLDALGPRGFLVNVARGRLVN
EDDLAQAIEAGRIAGAGLDVFVDEPRVPLALRRSDRTTLQAHRASATWETRAAMIRMVLDSVAEGLAGKRPAMSLTT

Sequences:

>Translated_317_residues
MKPHILQLNPILIPAANDELAALYHVHKLFEVEDQAAWLKEHGSAIQAVITGGHTGISRAMLEQLPALKVVAVNGVGTDA
VDLPYCRERGLPVTATLGALTEDVADLAIGLLIAACRNICAGDRFVRDGQWERFPQPSAIPLARRFSGMRVGIVGMGRVG
RAVATRAAAFGCPIRYTDLRRMDDLPHAFVPDLVDLARNSDALVLCAAADKAEGIVNGAVLDALGPRGFLVNVARGRLVN
EDDLAQAIEAGRIAGAGLDVFVDEPRVPLALRRSDRTTLQAHRASATWETRAAMIRMVLDSVAEGLAGKRPAMSLTT
>Mature_317_residues
MKPHILQLNPILIPAANDELAALYHVHKLFEVEDQAAWLKEHGSAIQAVITGGHTGISRAMLEQLPALKVVAVNGVGTDA
VDLPYCRERGLPVTATLGALTEDVADLAIGLLIAACRNICAGDRFVRDGQWERFPQPSAIPLARRFSGMRVGIVGMGRVG
RAVATRAAAFGCPIRYTDLRRMDDLPHAFVPDLVDLARNSDALVLCAAADKAEGIVNGAVLDALGPRGFLVNVARGRLVN
EDDLAQAIEAGRIAGAGLDVFVDEPRVPLALRRSDRTTLQAHRASATWETRAAMIRMVLDSVAEGLAGKRPAMSLTT

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=32.4, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=216, Percent_Identity=33.7962962962963, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4557497, Length=216, Percent_Identity=33.7962962962963, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI145580578, Length=216, Percent_Identity=34.2592592592593, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557499, Length=216, Percent_Identity=34.2592592592593, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI145580575, Length=216, Percent_Identity=34.2592592592593, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082289, Length=319, Percent_Identity=29.4670846394984, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789279, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147481, Length=222, Percent_Identity=31.0810810810811, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=27.5720164609054, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=231, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=245, Percent_Identity=28.9795918367347, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=217, Percent_Identity=29.4930875576037, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24585514, Length=286, Percent_Identity=34.6153846153846, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574282, Length=286, Percent_Identity=34.6153846153846, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45551003, Length=286, Percent_Identity=34.6153846153846, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45552429, Length=286, Percent_Identity=34.6153846153846, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI28574284, Length=286, Percent_Identity=34.6153846153846, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28574286, Length=277, Percent_Identity=34.6570397111913, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=253, Percent_Identity=33.596837944664, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646446, Length=222, Percent_Identity=34.6846846846847, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646448, Length=222, Percent_Identity=34.6846846846847, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646452, Length=222, Percent_Identity=34.6846846846847, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646450, Length=222, Percent_Identity=34.6846846846847, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI62472511, Length=218, Percent_Identity=33.9449541284404, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585516, Length=256, Percent_Identity=31.640625, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33853; Mature: 33853

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPHILQLNPILIPAANDELAALYHVHKLFEVEDQAAWLKEHGSAIQAVITGGHTGISRA
CCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHH
MLEQLPALKVVAVNGVGTDAVDLPYCRERGLPVTATLGALTEDVADLAIGLLIAACRNIC
HHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AGDRFVRDGQWERFPQPSAIPLARRFSGMRVGIVGMGRVGRAVATRAAAFGCPIRYTDLR
CCCCEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEHHHH
RMDDLPHAFVPDLVDLARNSDALVLCAAADKAEGIVNGAVLDALGPRGFLVNVARGRLVN
HHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCC
EDDLAQAIEAGRIAGAGLDVFVDEPRVPLALRRSDRTTLQAHRASATWETRAAMIRMVLD
HHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHH
SVAEGLAGKRPAMSLTT
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKPHILQLNPILIPAANDELAALYHVHKLFEVEDQAAWLKEHGSAIQAVITGGHTGISRA
CCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHH
MLEQLPALKVVAVNGVGTDAVDLPYCRERGLPVTATLGALTEDVADLAIGLLIAACRNIC
HHHHCCCEEEEEECCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
AGDRFVRDGQWERFPQPSAIPLARRFSGMRVGIVGMGRVGRAVATRAAAFGCPIRYTDLR
CCCCEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEHHHH
RMDDLPHAFVPDLVDLARNSDALVLCAAADKAEGIVNGAVLDALGPRGFLVNVARGRLVN
HHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCC
EDDLAQAIEAGRIAGAGLDVFVDEPRVPLALRRSDRTTLQAHRASATWETRAAMIRMVLD
HHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHH
SVAEGLAGKRPAMSLTT
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA