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The map label for this gene is alsR [H]

Identifier: 73541353

GI number: 73541353

Start: 1794973

End: 1795878

Strand: Direct

Name: alsR [H]

Synonym: Reut_A1663

Alternate gene names: 73541353

Gene position: 1794973-1795878 (Clockwise)

Preceding gene: 73541348

Following gene: 73541354

Centisome position: 47.16

GC content: 61.7

Gene sequence:

>906_bases
ATGATCGACGTACGTCAGTTGCAGTGCTTCCTTGCCGTGGCGGAAGAACTTCACTTTGCAAAGGCGGCGGATCGGTTAGG
CGTCGCACAATCGGGGCTCAGTACCCAGATCCAGCGCCTGGAACAAGACCTGGGCGTGACGCTCCTGAATCGGAACAAGA
GAAAGCCAGTGTCACTGACGGATGCGGGGCAGTTATTCCTGGCCGAGGCCGCCGCCGCGTTGAGGCACATCGAGCGTGCC
GACCAGGTCGGCCGCCTCGCGGCCAGAGGACTGGCTGGCGTGATCCGTGTTGGCTATGTCGCTTCCGGCGTCAGCAGCGG
CCTGCTGTCCAGGTTGCTGAGCGCGTTCCGGAAATCCCATGAGATGGTCCGGCTCGAGATCGTGCCGATGGATACGCCAA
GGCAACTCGAAGCGCTTGGCGATGGGCAGATCGATGTGGGAATCGTCAGGCCGAGACGGCTCTATCCGGCTGGCGTGGTC
AGCAAAGTCTTGCAGACGGAACGTCTTCTGGCCGCCATGGCGGAAGGCCATCCCCTTGCACGGCGCGCGACGGTTGCCGC
ACGCGCACTGGCCGATCAATCGTTCATCGTCCCACAGTTTGCCGAGGAGGAAGGGTTCGGATCTGCGTTATCGGCCTTGG
GCAAAGCAGGAGGATTCACACCGCACCTCGAATATCGCGTGCAGGATTTCATCTCGGCGATATGCCTGGCCTCGGCGGGA
TATGGCATGGCCATCGTACCCGAGTCGATGCAGAACTTCTCCCAGCCGGGCGTCATCTACAAGCCGATCAGCGACTTCCT
GCTCTCGGTGAACCTGGCGCTGGCTTACCGGCGCCGCGAAGTATCGCCAGCCGTACGGGAGTTCGTGAAGCTTGGGACTG
AGACGTTCAAGGTCAGCGCTTCGTAG

Upstream 100 bases:

>100_bases
GTACGGATGGTATGAGTGGTATGGCGCTATTTCATCCGGATTCTTTGATATGATCCAGATGTCAATCTGTAATTTTTGTT
CCGATATTCCGATTAAAACG

Downstream 100 bases:

>100_bases
GCCTCCCCAGGCAGGAGAAGTCGTCATTGGAAACTCCGGCCTGCCATGCTCTGGCAGGGTTTTCCCTCTGTTTGCGCGAA
ATGGCAAGAACGTGGCGCGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MIDVRQLQCFLAVAEELHFAKAADRLGVAQSGLSTQIQRLEQDLGVTLLNRNKRKPVSLTDAGQLFLAEAAAALRHIERA
DQVGRLAARGLAGVIRVGYVASGVSSGLLSRLLSAFRKSHEMVRLEIVPMDTPRQLEALGDGQIDVGIVRPRRLYPAGVV
SKVLQTERLLAAMAEGHPLARRATVAARALADQSFIVPQFAEEEGFGSALSALGKAGGFTPHLEYRVQDFISAICLASAG
YGMAIVPESMQNFSQPGVIYKPISDFLLSVNLALAYRRREVSPAVREFVKLGTETFKVSAS

Sequences:

>Translated_301_residues
MIDVRQLQCFLAVAEELHFAKAADRLGVAQSGLSTQIQRLEQDLGVTLLNRNKRKPVSLTDAGQLFLAEAAAALRHIERA
DQVGRLAARGLAGVIRVGYVASGVSSGLLSRLLSAFRKSHEMVRLEIVPMDTPRQLEALGDGQIDVGIVRPRRLYPAGVV
SKVLQTERLLAAMAEGHPLARRATVAARALADQSFIVPQFAEEEGFGSALSALGKAGGFTPHLEYRVQDFISAICLASAG
YGMAIVPESMQNFSQPGVIYKPISDFLLSVNLALAYRRREVSPAVREFVKLGTETFKVSAS
>Mature_301_residues
MIDVRQLQCFLAVAEELHFAKAADRLGVAQSGLSTQIQRLEQDLGVTLLNRNKRKPVSLTDAGQLFLAEAAAALRHIERA
DQVGRLAARGLAGVIRVGYVASGVSSGLLSRLLSAFRKSHEMVRLEIVPMDTPRQLEALGDGQIDVGIVRPRRLYPAGVV
SKVLQTERLLAAMAEGHPLARRATVAARALADQSFIVPQFAEEEGFGSALSALGKAGGFTPHLEYRVQDFISAICLASAG
YGMAIVPESMQNFSQPGVIYKPISDFLLSVNLALAYRRREVSPAVREFVKLGTETFKVSAS

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=290, Percent_Identity=34.8275862068965, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=31.3333333333333, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI2367136, Length=288, Percent_Identity=31.25, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790399, Length=284, Percent_Identity=27.112676056338, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787601, Length=287, Percent_Identity=27.1777003484321, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI157672245, Length=203, Percent_Identity=31.5270935960591, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081904, Length=204, Percent_Identity=30.8823529411765, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790208, Length=264, Percent_Identity=26.8939393939394, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI145693193, Length=164, Percent_Identity=31.7073170731707, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788748, Length=149, Percent_Identity=31.5436241610738, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=25.1968503937008, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32510; Mature: 32510

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDVRQLQCFLAVAEELHFAKAADRLGVAQSGLSTQIQRLEQDLGVTLLNRNKRKPVSLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEECCCCCCCCCCC
DAGQLFLAEAAAALRHIERADQVGRLAARGLAGVIRVGYVASGVSSGLLSRLLSAFRKSH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EMVRLEIVPMDTPRQLEALGDGQIDVGIVRPRRLYPAGVVSKVLQTERLLAAMAEGHPLA
CEEEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
RRATVAARALADQSFIVPQFAEEEGFGSALSALGKAGGFTPHLEYRVQDFISAICLASAG
HHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
YGMAIVPESMQNFSQPGVIYKPISDFLLSVNLALAYRRREVSPAVREFVKLGTETFKVSA
CCEEEECHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHEEEEC
S
C
>Mature Secondary Structure
MIDVRQLQCFLAVAEELHFAKAADRLGVAQSGLSTQIQRLEQDLGVTLLNRNKRKPVSLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEECCCCCCCCCCC
DAGQLFLAEAAAALRHIERADQVGRLAARGLAGVIRVGYVASGVSSGLLSRLLSAFRKSH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EMVRLEIVPMDTPRQLEALGDGQIDVGIVRPRRLYPAGVVSKVLQTERLLAAMAEGHPLA
CEEEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
RRATVAARALADQSFIVPQFAEEEGFGSALSALGKAGGFTPHLEYRVQDFISAICLASAG
HHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
YGMAIVPESMQNFSQPGVIYKPISDFLLSVNLALAYRRREVSPAVREFVKLGTETFKVSA
CCEEEECHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHEEEEC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]