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The map label for this gene is ychM [C]

Identifier: 73540990

GI number: 73540990

Start: 1384530

End: 1386329

Strand: Reverse

Name: ychM [C]

Synonym: Reut_A1296

Alternate gene names: 73540990

Gene position: 1386329-1384530 (Counterclockwise)

Preceding gene: 73540991

Following gene: 73540986

Centisome position: 36.42

GC content: 66.28

Gene sequence:

>1800_bases
ATGACTGTCTCCGCAACCAGCCCCGGCACCCGGCTGCAGCGCCTGCTTCCCTGGACGCAACGCGTATCCCGCGCCACGTT
GCGCGCGGACGGGATAGCGGGCTTGCTCGGCGCCGTGCTCGTGCTGCCGCAAGGCGTGGCATTTGCCACGCTCGCGGGCC
TGCCGCCCGAGTACGGCATCTACACGGCTGTGGTGCCGTGCATTGTCGCCGCACTGTTTGGATCAAGCTGGCACGTGATG
TCGGGCCCGACCAACGCCAATTCGCTCGCGCTGTTTGCGATGCTGAGCCCCGTGGCATTCGCTGGGAGCCCGGCGTATAT
CGGCCTGGCGCTGTCGGTCACGATCCTGGTCGGGCTCATGCAACTGGCGGTCGGCACGCTGCGGCTTGGCACACTGGCCA
ACTTCATTTCCCCCTCCGTCTTGCTCGGCTTCACGTGTGGCGCGGCCACGCTGATCGGCCTGTACGCGCTCAAGGACCTG
TTTGGCCTGGCGGTGCCCACCGGCACAAGCGCGTTCGGCGTGCTGCGTTTCCTGTCCGACAACGTTGACGCGATCAACTG
GGGGGCTGCCACCGTGGGCGCGGTCACGCTCGGGGCAACGCTGCTGTTCAAGCGGCTTGGCAAGCGGCTGCCGTTCATGC
TGCTCGGACTCATGGCCGGCTACGGCGTCGCCCTGCTGCTGAACCGCACCGGCTGGGGCGGCGGACACCATGTCAACGTG
GTCGGGCCGATTCCCTCCGCCATCCCGGCCTTCCATGTGCCCGATATCTCGTGGCGCAGCGTGCCGGACCTGCTCGGCAT
TGCCTCGGCCCTTACCATCGTTGCGCTGGGCCAGTCGATCTCGATTGCCAAGGCCGTGGCGCTGCGGTCAGGCCAGCATA
TTGACGCCAACCGCGAGTTCATCGGCCAGGGGCTGTCCAATATCGCCGGGGGCCTGTTCTCCGGCTATATCTCGTGCGGT
TCGCTTAATCGTTCAGTACCGAACTTCGAAGCCGGCGCGAAGACGCCGCTGGCCAGCGTGTTCTCGGCACTCTGGCTCTT
GGCACTGGTCGCCGTCAGCGCGTCGCTTCTGGCGCAGATTCCGCTCGCCGCGATCGCGGCCATGCTGCTGCTTGTCGCAT
GGGGACTCTTCGACTTCGCGCGCCTGCGGCGCATCGCGGCGCTGAGTCGTACGGAGTTCGCTATCGCGGTCGGCACATTT
GCCGCCACGCTGATGATCCGCCTGGAGATGGCGGTGCTGCTTGGCACGATCCTGTCGCTGGTTGCCTACCTGTACCGTAC
TTCACGACCCGCGGTGCGCAGCCTCGTACCCGACGCCGACGATCCGGGCCGCCGCTTCACGCCACTGGACGAACTGCATC
GGCCTCAACCGGAGTGCCCGCAACTCAAACTGCTGCGCATGGAAGGCGCCATCTACTTTGGCGCCGTGCAATACGTGACG
GATCGGCTGCACTGGCTGCGCACGGTCAATGCCAGCCAGAAGCACTTGCTGGCGATGACCAAGAGCATGAACTTCATCGA
CCTGGCCGGCGCGGAGATGTGGGAAGCCGAACTGTCGGAGCGGCGTGCCGCCGGCGGCGACCTGTACTTCCACCGTCCGC
GCACGCAGGTGCTGCAGACGTGGGAGCAGACCGGGTTCACCGGCAAGCTCGGTCCCGACCACGTCTTCTCGACGAAGCGT
CAGGCGCTGCACACCATCATCGGCCAGCTGCCGCCCGATGTCTGCGCGCAGTGCAAGGTGCGCATCTTCGAAGAGTGCGC
CCAACGCCCCGGCGCGCAAACGCACGCAGAAACGCTATGA

Upstream 100 bases:

>100_bases
GCCAACGCACTGGTTTGCCAAGGCTGGCCCGCCATACGGCGCCGGCCGCGTCATCGCGCAGCGTGCTGCCGATGCCTGCC
CTCCTCCCTTTTCCCCGCCC

Downstream 100 bases:

>100_bases
CGTCAGCGTCGGAAAAACAGAATCCAGTGGATTGAGACGGGAAGCTGACACCGGAGAGAGCCCGTGCAGCGAGGGTATGA
CAAGTTAGCCGTAGCGGCTG

Product: Sulfate transporter/antisigma-factor antagonist STAS:xanthine/uracil/vitamin C permease:sulphate transporter

Products: Proton [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTVSATSPGTRLQRLLPWTQRVSRATLRADGIAGLLGAVLVLPQGVAFATLAGLPPEYGIYTAVVPCIVAALFGSSWHVM
SGPTNANSLALFAMLSPVAFAGSPAYIGLALSVTILVGLMQLAVGTLRLGTLANFISPSVLLGFTCGAATLIGLYALKDL
FGLAVPTGTSAFGVLRFLSDNVDAINWGAATVGAVTLGATLLFKRLGKRLPFMLLGLMAGYGVALLLNRTGWGGGHHVNV
VGPIPSAIPAFHVPDISWRSVPDLLGIASALTIVALGQSISIAKAVALRSGQHIDANREFIGQGLSNIAGGLFSGYISCG
SLNRSVPNFEAGAKTPLASVFSALWLLALVAVSASLLAQIPLAAIAAMLLLVAWGLFDFARLRRIAALSRTEFAIAVGTF
AATLMIRLEMAVLLGTILSLVAYLYRTSRPAVRSLVPDADDPGRRFTPLDELHRPQPECPQLKLLRMEGAIYFGAVQYVT
DRLHWLRTVNASQKHLLAMTKSMNFIDLAGAEMWEAELSERRAAGGDLYFHRPRTQVLQTWEQTGFTGKLGPDHVFSTKR
QALHTIIGQLPPDVCAQCKVRIFEECAQRPGAQTHAETL

Sequences:

>Translated_599_residues
MTVSATSPGTRLQRLLPWTQRVSRATLRADGIAGLLGAVLVLPQGVAFATLAGLPPEYGIYTAVVPCIVAALFGSSWHVM
SGPTNANSLALFAMLSPVAFAGSPAYIGLALSVTILVGLMQLAVGTLRLGTLANFISPSVLLGFTCGAATLIGLYALKDL
FGLAVPTGTSAFGVLRFLSDNVDAINWGAATVGAVTLGATLLFKRLGKRLPFMLLGLMAGYGVALLLNRTGWGGGHHVNV
VGPIPSAIPAFHVPDISWRSVPDLLGIASALTIVALGQSISIAKAVALRSGQHIDANREFIGQGLSNIAGGLFSGYISCG
SLNRSVPNFEAGAKTPLASVFSALWLLALVAVSASLLAQIPLAAIAAMLLLVAWGLFDFARLRRIAALSRTEFAIAVGTF
AATLMIRLEMAVLLGTILSLVAYLYRTSRPAVRSLVPDADDPGRRFTPLDELHRPQPECPQLKLLRMEGAIYFGAVQYVT
DRLHWLRTVNASQKHLLAMTKSMNFIDLAGAEMWEAELSERRAAGGDLYFHRPRTQVLQTWEQTGFTGKLGPDHVFSTKR
QALHTIIGQLPPDVCAQCKVRIFEECAQRPGAQTHAETL
>Mature_598_residues
TVSATSPGTRLQRLLPWTQRVSRATLRADGIAGLLGAVLVLPQGVAFATLAGLPPEYGIYTAVVPCIVAALFGSSWHVMS
GPTNANSLALFAMLSPVAFAGSPAYIGLALSVTILVGLMQLAVGTLRLGTLANFISPSVLLGFTCGAATLIGLYALKDLF
GLAVPTGTSAFGVLRFLSDNVDAINWGAATVGAVTLGATLLFKRLGKRLPFMLLGLMAGYGVALLLNRTGWGGGHHVNVV
GPIPSAIPAFHVPDISWRSVPDLLGIASALTIVALGQSISIAKAVALRSGQHIDANREFIGQGLSNIAGGLFSGYISCGS
LNRSVPNFEAGAKTPLASVFSALWLLALVAVSASLLAQIPLAAIAAMLLLVAWGLFDFARLRRIAALSRTEFAIAVGTFA
ATLMIRLEMAVLLGTILSLVAYLYRTSRPAVRSLVPDADDPGRRFTPLDELHRPQPECPQLKLLRMEGAIYFGAVQYVTD
RLHWLRTVNASQKHLLAMTKSMNFIDLAGAEMWEAELSERRAAGGDLYFHRPRTQVLQTWEQTGFTGKLGPDHVFSTKRQ
ALHTIIGQLPPDVCAQCKVRIFEECAQRPGAQTHAETL

Specific function: Expression in E.coli induces sulfate uptake during early-to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein [H]

COG id: COG0659

COG function: function code P; Sulfate permease and related transporters (MFS superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

Organism=Homo sapiens, GI39752683, Length=525, Percent_Identity=28.3809523809524, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI45827800, Length=525, Percent_Identity=28.3809523809524, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI94721253, Length=478, Percent_Identity=28.4518828451883, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI94721259, Length=478, Percent_Identity=28.4518828451883, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI94721255, Length=478, Percent_Identity=28.4518828451883, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI94721257, Length=478, Percent_Identity=28.4518828451883, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI45827802, Length=432, Percent_Identity=30.0925925925926, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI269784651, Length=524, Percent_Identity=26.9083969465649, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI4557535, Length=506, Percent_Identity=26.4822134387352, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI20336282, Length=521, Percent_Identity=23.8003838771593, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI16306483, Length=521, Percent_Identity=23.8003838771593, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI4505697, Length=504, Percent_Identity=24.4047619047619, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI47131207, Length=531, Percent_Identity=28.060263653484, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI20336272, Length=531, Percent_Identity=28.060263653484, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI100913030, Length=518, Percent_Identity=23.3590733590734, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI217272867, Length=376, Percent_Identity=23.4042553191489, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI16418413, Length=392, Percent_Identity=22.9591836734694, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI262206105, Length=155, Percent_Identity=41.9354838709677, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI262206075, Length=155, Percent_Identity=41.9354838709677, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI262206069, Length=155, Percent_Identity=41.9354838709677, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI262206063, Length=155, Percent_Identity=41.9354838709677, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI65506789, Length=375, Percent_Identity=26.9333333333333, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI45827804, Length=243, Percent_Identity=29.6296296296296, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI87081859, Length=439, Percent_Identity=30.5239179954442, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI86565215, Length=472, Percent_Identity=27.5423728813559, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562578, Length=613, Percent_Identity=23.1647634584013, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17566848, Length=607, Percent_Identity=23.0642504118616, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI86564196, Length=478, Percent_Identity=25.1046025104602, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193203292, Length=508, Percent_Identity=23.6220472440945, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17551690, Length=503, Percent_Identity=21.8687872763419, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI86564876, Length=393, Percent_Identity=23.4096692111959, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86565209, Length=253, Percent_Identity=28.8537549407115, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI86565211, Length=253, Percent_Identity=28.8537549407115, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI86565213, Length=267, Percent_Identity=28.0898876404494, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323121, Length=462, Percent_Identity=24.4588744588745, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319771, Length=408, Percent_Identity=23.7745098039216, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24647160, Length=443, Percent_Identity=28.6681715575621, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355087, Length=443, Percent_Identity=28.6681715575621, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24663084, Length=560, Percent_Identity=26.7857142857143, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357695, Length=560, Percent_Identity=26.7857142857143, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922482, Length=517, Percent_Identity=24.9516441005803, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24666186, Length=529, Percent_Identity=25.5198487712665, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21358229, Length=463, Percent_Identity=25.2699784017279, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24649801, Length=458, Percent_Identity=24.8908296943231, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24651449, Length=466, Percent_Identity=25.1072961373391, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI85815873, Length=454, Percent_Identity=27.9735682819383, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21358633, Length=505, Percent_Identity=24.5544554455446, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002645
- InterPro:   IPR001902
- InterPro:   IPR011547 [H]

Pfam domain/function: PF01740 STAS; PF00916 Sulfate_transp [H]

EC number: NA

Molecular weight: Translated: 63635; Mature: 63504

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSATSPGTRLQRLLPWTQRVSRATLRADGIAGLLGAVLVLPQGVAFATLAGLPPEYGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHH
YTAVVPCIVAALFGSSWHVMSGPTNANSLALFAMLSPVAFAGSPAYIGLALSVTILVGLM
HHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QLAVGTLRLGTLANFISPSVLLGFTCGAATLIGLYALKDLFGLAVPTGTSAFGVLRFLSD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NVDAINWGAATVGAVTLGATLLFKRLGKRLPFMLLGLMAGYGVALLLNRTGWGGGHHVNV
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEE
VGPIPSAIPAFHVPDISWRSVPDLLGIASALTIVALGQSISIAKAVALRSGQHIDANREF
ECCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHH
IGQGLSNIAGGLFSGYISCGSLNRSVPNFEAGAKTPLASVFSALWLLALVAVSASLLAQI
HHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PLAAIAAMLLLVAWGLFDFARLRRIAALSRTEFAIAVGTFAATLMIRLEMAVLLGTILSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAYLYRTSRPAVRSLVPDADDPGRRFTPLDELHRPQPECPQLKLLRMEGAIYFGAVQYVT
HHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEHCCCCHHHHHHHHHH
DRLHWLRTVNASQKHLLAMTKSMNFIDLAGAEMWEAELSERRAAGGDLYFHRPRTQVLQT
HHHHHHHHCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
WEQTGFTGKLGPDHVFSTKRQALHTIIGQLPPDVCAQCKVRIFEECAQRPGAQTHAETL
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TVSATSPGTRLQRLLPWTQRVSRATLRADGIAGLLGAVLVLPQGVAFATLAGLPPEYGI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHH
YTAVVPCIVAALFGSSWHVMSGPTNANSLALFAMLSPVAFAGSPAYIGLALSVTILVGLM
HHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QLAVGTLRLGTLANFISPSVLLGFTCGAATLIGLYALKDLFGLAVPTGTSAFGVLRFLSD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NVDAINWGAATVGAVTLGATLLFKRLGKRLPFMLLGLMAGYGVALLLNRTGWGGGHHVNV
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEE
VGPIPSAIPAFHVPDISWRSVPDLLGIASALTIVALGQSISIAKAVALRSGQHIDANREF
ECCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHH
IGQGLSNIAGGLFSGYISCGSLNRSVPNFEAGAKTPLASVFSALWLLALVAVSASLLAQI
HHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PLAAIAAMLLLVAWGLFDFARLRRIAALSRTEFAIAVGTFAATLMIRLEMAVLLGTILSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAYLYRTSRPAVRSLVPDADDPGRRFTPLDELHRPQPECPQLKLLRMEGAIYFGAVQYVT
HHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEHCCCCHHHHHHHHHH
DRLHWLRTVNASQKHLLAMTKSMNFIDLAGAEMWEAELSERRAAGGDLYFHRPRTQVLQT
HHHHHHHHCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
WEQTGFTGKLGPDHVFSTKRQALHTIIGQLPPDVCAQCKVRIFEECAQRPGAQTHAETL
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; SO42- [Periplasm] [C]

Specific reaction: Proton [Periplasm] + SO42- [Periplasm] = Proton [Cytoplasm] + SO42- [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]