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The map label for this gene is 73540844

Identifier: 73540844

GI number: 73540844

Start: 1235433

End: 1236791

Strand: Direct

Name: 73540844

Synonym: Reut_A1144

Alternate gene names: NA

Gene position: 1235433-1236791 (Clockwise)

Preceding gene: 73540843

Following gene: 73540845

Centisome position: 32.46

GC content: 64.61

Gene sequence:

>1359_bases
ATGGAACTGCAATTCCTGGGGGCCACGGATTCCGTCACAGGCTCGAAATACATACTCGACACCGGCCACAGCCGTGTCAT
GGTTGACTGCGGTCTGTTCCAAGGCTTCAAGTCATTGCGATTGCGGAACTGGGATCCGTTGCCGGCGGACCCGGCCACCC
TGGATGCCGTGATCCTGACCCATGCGCATATCGACCACAGCGGCTATCTGCCACTGCTGGTGCGCAACGGCTTCCGCGGG
ACCGTATTCTGCACCATGGGCACCGCGCAGCTTTGCGGCATCCTGTTGCCGGACAGTGCGGCACTGGCGGAGGAGGACGC
CGAGTATGCGAATCGGAAAGGCTTCTCGCGCCACCGGCCCGCTTTGCCGCTCTATACCAGCGCAGACGCAGGGCGCGCGC
TGCGCCGCCTGGAACCGAAGCCTTTCGGCACGCGATTCTCGCTGACGCCCGACATTGATGCCGAGTTTCACCATGCCGGG
CACATCATCGGCGCCGCTGCGGTGACGCTGCATGCCGGAGGCCAGCGCATCGTGTTCTCGGGAGACCTCGGCCGGCAGAA
CGATATTGTCATGCGGCCCCCCGAGTTCATCCGCGAGGCCGATTGCCTGCTGGTCGAGTCCACCTATGGCAACCGCATTC
ACCCGGACGAAGATCCCCTCGATGCGATCGCCGGCGTTGTCGGCAACACGCTTGGCCGCGGTGGCACGCTGGTCATTCCG
GCCTTTGCGGTCGGGCGCACACAGGCATTGCTGTATTGCCTGCATCGCTTGCTCGAAGAACGGCGCATGCCCGATATCCC
GATCTACCTCAACAGTCCGATGGCCATCGACGCGACGCAGATCTTTGCCCTGCATCCCGATGAACTGCGCATCGACCGGG
CCGCATGCGCGGCCGCGTGCGGACTGCCGATTCCGGTGCAGAGCATGGAGCAGTCGGTCTGGCTTAACCAGGATCGCGCG
CCGAAAATCATCTTGGCGGGCAGTGGCATGGCGACGGGCGGACGTGTGGTGCACCACCTTGCCACCTTCGGCAGGGACCC
GCGCTGCACCATTCTGCTATCCGGCTTCCAGGCACCGGGTACGCGGGGCGCGGCACTTGCGGGCGGGCAGCGCGAGTTGC
GCATCCACGGGAAGGACGTCGCGATCCACGCGGCGGTCGAGCAGATCCATGGTATGTCGGCACATGCCGATGCCAACGAA
CTGATGACGTGGCTCAACGGGTTCCAGGCGCCGCCCCGGCGCGTATTCATCGTGCATGGGGAACCGGACGCCAGCGATGC
CATGCGCCAGCGCGTGGAGCGCGGGCTGGGATGGCAGGTGACGATGCCGGAGTACAGAAAGACTTATCGTCTGGACTGA

Upstream 100 bases:

>100_bases
CACTCGCGTGTGCGCGAACTGATACTTGGCGGCACGACCCGAACCCTGATGCACGCGTGCCCGGTCCCGCTGCTGCTGTC
TCATTGATCAGGAGTCAAGC

Downstream 100 bases:

>100_bases
ACCGAACGCTGCAGCCAGTTCAGCCGCTGGCACTGGCTGTCAGCGCTCGTGCACATACTCGCCCGGGGCATTGCACAGGG
CATGCGGGGCCGGATCGCGG

Product: Beta-lactamase-like:RNA-metabolising metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MELQFLGATDSVTGSKYILDTGHSRVMVDCGLFQGFKSLRLRNWDPLPADPATLDAVILTHAHIDHSGYLPLLVRNGFRG
TVFCTMGTAQLCGILLPDSAALAEEDAEYANRKGFSRHRPALPLYTSADAGRALRRLEPKPFGTRFSLTPDIDAEFHHAG
HIIGAAAVTLHAGGQRIVFSGDLGRQNDIVMRPPEFIREADCLLVESTYGNRIHPDEDPLDAIAGVVGNTLGRGGTLVIP
AFAVGRTQALLYCLHRLLEERRMPDIPIYLNSPMAIDATQIFALHPDELRIDRAACAAACGLPIPVQSMEQSVWLNQDRA
PKIILAGSGMATGGRVVHHLATFGRDPRCTILLSGFQAPGTRGAALAGGQRELRIHGKDVAIHAAVEQIHGMSAHADANE
LMTWLNGFQAPPRRVFIVHGEPDASDAMRQRVERGLGWQVTMPEYRKTYRLD

Sequences:

>Translated_452_residues
MELQFLGATDSVTGSKYILDTGHSRVMVDCGLFQGFKSLRLRNWDPLPADPATLDAVILTHAHIDHSGYLPLLVRNGFRG
TVFCTMGTAQLCGILLPDSAALAEEDAEYANRKGFSRHRPALPLYTSADAGRALRRLEPKPFGTRFSLTPDIDAEFHHAG
HIIGAAAVTLHAGGQRIVFSGDLGRQNDIVMRPPEFIREADCLLVESTYGNRIHPDEDPLDAIAGVVGNTLGRGGTLVIP
AFAVGRTQALLYCLHRLLEERRMPDIPIYLNSPMAIDATQIFALHPDELRIDRAACAAACGLPIPVQSMEQSVWLNQDRA
PKIILAGSGMATGGRVVHHLATFGRDPRCTILLSGFQAPGTRGAALAGGQRELRIHGKDVAIHAAVEQIHGMSAHADANE
LMTWLNGFQAPPRRVFIVHGEPDASDAMRQRVERGLGWQVTMPEYRKTYRLD
>Mature_452_residues
MELQFLGATDSVTGSKYILDTGHSRVMVDCGLFQGFKSLRLRNWDPLPADPATLDAVILTHAHIDHSGYLPLLVRNGFRG
TVFCTMGTAQLCGILLPDSAALAEEDAEYANRKGFSRHRPALPLYTSADAGRALRRLEPKPFGTRFSLTPDIDAEFHHAG
HIIGAAAVTLHAGGQRIVFSGDLGRQNDIVMRPPEFIREADCLLVESTYGNRIHPDEDPLDAIAGVVGNTLGRGGTLVIP
AFAVGRTQALLYCLHRLLEERRMPDIPIYLNSPMAIDATQIFALHPDELRIDRAACAAACGLPIPVQSMEQSVWLNQDRA
PKIILAGSGMATGGRVVHHLATFGRDPRCTILLSGFQAPGTRGAALAGGQRELRIHGKDVAIHAAVEQIHGMSAHADANE
LMTWLNGFQAPPRRVFIVHGEPDASDAMRQRVERGLGWQVTMPEYRKTYRLD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=429, Percent_Identity=26.8065268065268, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI33300633, Length=462, Percent_Identity=25.3246753246753, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564696, Length=448, Percent_Identity=25.6696428571429, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32566029, Length=447, Percent_Identity=25.503355704698, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323307, Length=434, Percent_Identity=25.3456221198157, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648013, Length=449, Percent_Identity=26.2806236080178, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21358523, Length=455, Percent_Identity=25.2747252747253, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49298; Mature: 49298

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQFLGATDSVTGSKYILDTGHSRVMVDCGLFQGFKSLRLRNWDPLPADPATLDAVILT
CCEEEECCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHEEEEE
HAHIDHSGYLPLLVRNGFRGTVFCTMGTAQLCGILLPDSAALAEEDAEYANRKGFSRHRP
EEEECCCCCEEEEEECCCCEEEEEEECHHHHHEEECCCCHHHHHHHHHHHHCCCCCCCCC
ALPLYTSADAGRALRRLEPKPFGTRFSLTPDIDAEFHHAGHIIGAAAVTLHAGGQRIVFS
CCCEEECCCHHHHHHHCCCCCCCCEEECCCCCCCCHHHCCCEEEEEEEEEECCCCEEEEE
GDLGRQNDIVMRPPEFIREADCLLVESTYGNRIHPDEDPLDAIAGVVGNTLGRGGTLVIP
CCCCCCCCEEECCHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
AFAVGRTQALLYCLHRLLEERRMPDIPIYLNSPMAIDATQIFALHPDELRIDRAACAAAC
EHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEECCEEEEEECCHHHHHHHHHHHHHC
GLPIPVQSMEQSVWLNQDRAPKIILAGSGMATGGRVVHHLATFGRDPRCTILLSGFQAPG
CCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
TRGAALAGGQRELRIHGKDVAIHAAVEQIHGMSAHADANELMTWLNGFQAPPRRVFIVHG
CCCCEECCCCEEEEEECCCEEEHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEC
EPDASDAMRQRVERGLGWQVTMPEYRKTYRLD
CCCHHHHHHHHHHHCCCEEEECHHHHHHCCCC
>Mature Secondary Structure
MELQFLGATDSVTGSKYILDTGHSRVMVDCGLFQGFKSLRLRNWDPLPADPATLDAVILT
CCEEEECCCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCHHHEEEEE
HAHIDHSGYLPLLVRNGFRGTVFCTMGTAQLCGILLPDSAALAEEDAEYANRKGFSRHRP
EEEECCCCCEEEEEECCCCEEEEEEECHHHHHEEECCCCHHHHHHHHHHHHCCCCCCCCC
ALPLYTSADAGRALRRLEPKPFGTRFSLTPDIDAEFHHAGHIIGAAAVTLHAGGQRIVFS
CCCEEECCCHHHHHHHCCCCCCCCEEECCCCCCCCHHHCCCEEEEEEEEEECCCCEEEEE
GDLGRQNDIVMRPPEFIREADCLLVESTYGNRIHPDEDPLDAIAGVVGNTLGRGGTLVIP
CCCCCCCCEEECCHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
AFAVGRTQALLYCLHRLLEERRMPDIPIYLNSPMAIDATQIFALHPDELRIDRAACAAAC
EHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEECCEEEEEECCHHHHHHHHHHHHHC
GLPIPVQSMEQSVWLNQDRAPKIILAGSGMATGGRVVHHLATFGRDPRCTILLSGFQAPG
CCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
TRGAALAGGQRELRIHGKDVAIHAAVEQIHGMSAHADANELMTWLNGFQAPPRRVFIVHG
CCCCEECCCCEEEEEECCCEEEHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEC
EPDASDAMRQRVERGLGWQVTMPEYRKTYRLD
CCCHHHHHHHHHHHCCCEEEECHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA