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The map label for this gene is lysC [H]

Identifier: 73540828

GI number: 73540828

Start: 1218755

End: 1220005

Strand: Direct

Name: lysC [H]

Synonym: Reut_A1126

Alternate gene names: 73540828

Gene position: 1218755-1220005 (Clockwise)

Preceding gene: 73540827

Following gene: 73540830

Centisome position: 32.02

GC content: 62.67

Gene sequence:

>1251_bases
ATGGCTCTCATCGTTCACAAATACGGCGGCACTTCGATGGGTTCCACGGAACGCATCAAGAATGTCGCCAAGCGCGTGGC
CAAGTGGCACCGCGCCGGTCACCGCGTAGTCGTGGTGCCTTCGGCCATGTCAGGCGAAACCAATCGCCTGCTGGGACTCG
CCAAGGAAATTTCGGCACAGCCGGACCCGCGTGAACTGGACATGCTCGCCTCGACCGGCGAACAGGCCAGCGTCGCGCTG
CTGGCCATCGCGCTGCATGGCGAAAACATCGACGCGGTCAGCTACACGGGCTGGCAGGTGCCGGTGAAGACCGACTCGTC
CTACACCAAGGCGCGTATCGAGTCGATCGACGACGAGCGCATCCTCGGCGATCTCGATGCGGGCCGCGTGGTGGTGATCA
CCGGCTTCCAGGGCATCGACGACGACGGCAACATCACGACGCTGGGCCGTGGCGGCTCGGATACCTCGGCTGTGGCTATC
GCCGCCGCGATCGAGGCCGATGAGTGCCTGATCTACACCGACGTGGACGGCGTCTACACGACCGATCCGCGTGTAGTGGA
AGACGCGCGCCGGCTGGACAAGATTACCTTCGAAGAGATGCTGGAAATGGCCAGCCTCGGCTCCAAGGTGCTGCAGATCC
GCTCCGTGGAGTTCGCCGGCAAGTACCGCGTGAAGACCCGCGTACTGTCGTCGCTGACCGACCCGCTTATGCCGCTCGAG
AACGAAATCAACTCGGGCACGCTGATCACTTTTGAGGAAGATTCCAACATGGAAGCCGCCGTTATCTCGGGCATCGCCTT
CGCCCGTGACGAAGCCAAGATCACCGTTCTGGGCGTGCCGGACAAGCCGGGCATCGCGTACCAGATCCTGGGCCCGGTCG
CCGACGCCAACATCGACGTCGACATGATCATCCAGAACCAGTCGGTGGACGGTAAGACCGACTTCACATTCACCGTGCCG
CGCGGCGACTACCAGCGTACGCTGACGCTCCTGACGGACAGCGTCAAGCCGCACGTCGGTGCCGCCAACGTTTCGGGCGA
CCCGAAGGTGTCGAAGGTGTCGGTGGTGGGCGTGGGCATGCGCTCGCACGTGGGCGTCGCCAGCAAGATGTTCCGCACGC
TGTCGGAAGAGGGCATCAACATCCAGATGATCTCCACCTCGGAAATCAAGATCTCGGTGCTGATCGACGAAAAGTACATG
GAACTCGCCGTGCGCGCACTGCACAAGGCGTTCGAACTGGAACAGGCCTGA

Upstream 100 bases:

>100_bases
CATCACATTCCATCCGCCGGCGAAGCCGCTACGCCTTGCCTGATGGTCGCGGTTCGTGTATTTTCAAGAGCTTTGCACAA
TCGCTGGCGTCGACAAGAAG

Downstream 100 bases:

>100_bases
TCCGTTCGTAAGGACCTCTAGCGGGGCTGAGAATTTTTGTGTTGAGTTATCGATTTTTCGTTGACTAACCAGGAAGGCAT
CGCTAGAATTTGCGCTTCGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQPDPRELDMLASTGEQASVAL
LAIALHGENIDAVSYTGWQVPVKTDSSYTKARIESIDDERILGDLDAGRVVVITGFQGIDDDGNITTLGRGGSDTSAVAI
AAAIEADECLIYTDVDGVYTTDPRVVEDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
NEINSGTLITFEEDSNMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPVADANIDVDMIIQNQSVDGKTDFTFTVP
RGDYQRTLTLLTDSVKPHVGAANVSGDPKVSKVSVVGVGMRSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELEQA

Sequences:

>Translated_416_residues
MALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQPDPRELDMLASTGEQASVAL
LAIALHGENIDAVSYTGWQVPVKTDSSYTKARIESIDDERILGDLDAGRVVVITGFQGIDDDGNITTLGRGGSDTSAVAI
AAAIEADECLIYTDVDGVYTTDPRVVEDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
NEINSGTLITFEEDSNMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPVADANIDVDMIIQNQSVDGKTDFTFTVP
RGDYQRTLTLLTDSVKPHVGAANVSGDPKVSKVSVVGVGMRSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELEQA
>Mature_415_residues
ALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQPDPRELDMLASTGEQASVALL
AIALHGENIDAVSYTGWQVPVKTDSSYTKARIESIDDERILGDLDAGRVVVITGFQGIDDDGNITTLGRGGSDTSAVAIA
AAIEADECLIYTDVDGVYTTDPRVVEDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLEN
EINSGTLITFEEDSNMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPVADANIDVDMIIQNQSVDGKTDFTFTVPR
GDYQRTLTLLTDSVKPHVGAANVSGDPKVSKVSVVGVGMRSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYME
LAVRALHKAFELEQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=358, Percent_Identity=29.608938547486, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790455, Length=382, Percent_Identity=29.3193717277487, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790376, Length=90, Percent_Identity=40, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=407, Percent_Identity=27.027027027027, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44869; Mature: 44737

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQ
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
PDPRELDMLASTGEQASVALLAIALHGENIDAVSYTGWQVPVKTDSSYTKARIESIDDER
CCCHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCC
ILGDLDAGRVVVITGFQGIDDDGNITTLGRGGSDTSAVAIAAAIEADECLIYTDVDGVYT
EEECCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCEEEEEECCCEEE
TDPRVVEDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
CCCHHHHHHHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCHHHHHHHHHHCCCCCCHH
NEINSGTLITFEEDSNMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPVADANIDV
CCCCCCEEEEEECCCCCCHHHHHCEEEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVDGKTDFTFTVPRGDYQRTLTLLTDSVKPHVGAANVSGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEECCCCCHHHEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECH
RSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELEQA
HHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQ
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
PDPRELDMLASTGEQASVALLAIALHGENIDAVSYTGWQVPVKTDSSYTKARIESIDDER
CCCHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCC
ILGDLDAGRVVVITGFQGIDDDGNITTLGRGGSDTSAVAIAAAIEADECLIYTDVDGVYT
EEECCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCEEEEEECCCEEE
TDPRVVEDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
CCCHHHHHHHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCHHHHHHHHHHCCCCCCHH
NEINSGTLITFEEDSNMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPVADANIDV
CCCCCCEEEEEECCCCCCHHHHHCEEEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVDGKTDFTFTVPRGDYQRTLTLLTDSVKPHVGAANVSGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEECCCCCHHHEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECH
RSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELEQA
HHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]